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17 similar compounds to monomer 50086422

Compile data set for download or QSAR
Wt: 312.3
BDBM50086398
Wt: 371.4
BDBM50086405
Wt: 347.3
BDBM50086406
Wt: 382.4
BDBM50086407
Wt: 397.4
BDBM50086408
Wt: 383.4
BDBM50086409
Wt: 318.3
BDBM50086411
Wt: 318.3
BDBM50086413
Wt: 322.3
BDBM50086414
Wt: 338.8
BDBM50086417
Wt: 338.8
BDBM50086418
Wt: 356.8
BDBM50086420
Wt: 304.3
BDBM50086421
Wt: 372.3
BDBM50086410
Wt: 318.3
BDBM50086412
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50086398,50086405,50086406,50086407,50086408,50086409,50086411,50086413,50086414,50086417,50086418,50086420,50086421,50086410,50086412   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086398
PNG
(CHEMBL3426181)
Show SMILES C1COCC(C1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C16H16N4OS/c1-2-12(8-21-5-1)20-16-13-6-11(15-7-17-10-22-15)3-4-14(13)18-9-19-16/h3-4,6-7,9-10,12H,1-2,5,8H2,(H,18,19,20)
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n/an/a 45n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086421
PNG
(CHEMBL3426069)
Show SMILES N(c1ccccc1)c1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C17H12N4S/c1-2-4-13(5-3-1)21-17-14-8-12(16-9-18-11-22-16)6-7-15(14)19-10-20-17/h1-11H,(H,19,20,21)
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n/an/a 840n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086420
PNG
(CHEMBL3426070)
Show SMILES Fc1ccc(Nc2ncnc3ccc(cc23)-c2cncs2)cc1Cl
Show InChI InChI=1S/C17H10ClFN4S/c18-13-6-11(2-3-14(13)19)23-17-12-5-10(16-7-20-9-24-16)1-4-15(12)21-8-22-17/h1-9H,(H,21,22,23)
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n/an/a 32n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086418
PNG
(CHEMBL3426072)
Show SMILES Clc1cccc(Nc2ncnc3ccc(cc23)-c2cncs2)c1
Show InChI InChI=1S/C17H11ClN4S/c18-12-2-1-3-13(7-12)22-17-14-6-11(16-8-19-10-23-16)4-5-15(14)20-9-21-17/h1-10H,(H,20,21,22)
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n/an/a 19n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086417
PNG
(CHEMBL3426073)
Show SMILES Clc1ccccc1Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C17H11ClN4S/c18-13-3-1-2-4-15(13)22-17-12-7-11(16-8-19-10-23-16)5-6-14(12)20-9-21-17/h1-10H,(H,20,21,22)
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n/an/a 58n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086414
PNG
(CHEMBL3426076)
Show SMILES Fc1ccccc1Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C17H11FN4S/c18-13-3-1-2-4-15(13)22-17-12-7-11(16-8-19-10-23-16)5-6-14(12)20-9-21-17/h1-10H,(H,20,21,22)
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n/an/a 45n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086413
PNG
(CHEMBL3426077)
Show SMILES Cc1ccc(Nc2ncnc3ccc(cc23)-c2cncs2)cc1
Show InChI InChI=1S/C18H14N4S/c1-12-2-5-14(6-3-12)22-18-15-8-13(17-9-19-11-23-17)4-7-16(15)20-10-21-18/h2-11H,1H3,(H,20,21,22)
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n/an/a 22n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086412
PNG
(CHEMBL3426078)
Show SMILES Cc1cccc(Nc2ncnc3ccc(cc23)-c2cncs2)c1
Show InChI InChI=1S/C18H14N4S/c1-12-3-2-4-14(7-12)22-18-15-8-13(17-9-19-11-23-17)5-6-16(15)20-10-21-18/h2-11H,1H3,(H,20,21,22)
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n/an/a 17n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086411
PNG
(CHEMBL3426079)
Show SMILES Cc1ccccc1Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C18H14N4S/c1-12-4-2-3-5-15(12)22-18-14-8-13(17-9-19-11-23-17)6-7-16(14)20-10-21-18/h2-11H,1H3,(H,20,21,22)
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n/an/a 65n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086410
PNG
(CHEMBL3426080)
Show SMILES FC(F)(F)c1cccc(Nc2ncnc3ccc(cc23)-c2cncs2)c1
Show InChI InChI=1S/C18H11F3N4S/c19-18(20,21)12-2-1-3-13(7-12)25-17-14-6-11(16-8-22-10-26-16)4-5-15(14)23-9-24-17/h1-10H,(H,23,24,25)
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n/an/a 42n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086409
PNG
(CHEMBL3426081)
Show SMILES NS(=O)(=O)c1ccc(Nc2ncnc3ccc(cc23)-c2cncs2)cc1
Show InChI InChI=1S/C17H13N5O2S2/c18-26(23,24)13-4-2-12(3-5-13)22-17-14-7-11(16-8-19-10-25-16)1-6-15(14)20-9-21-17/h1-10H,(H2,18,23,24)(H,20,21,22)
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n/an/a 27n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086408
PNG
(CHEMBL3426082)
Show SMILES CS(=O)(=O)Nc1ccc(Nc2ncnc3ccc(cc23)-c2cncs2)cc1
Show InChI InChI=1S/C18H15N5O2S2/c1-27(24,25)23-14-5-3-13(4-6-14)22-18-15-8-12(17-9-19-11-26-17)2-7-16(15)20-10-21-18/h2-11,23H,1H3,(H,20,21,22)
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n/an/a 50n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086407
PNG
(CHEMBL3426083)
Show SMILES CS(=O)(=O)c1cccc(Nc2ncnc3ccc(cc23)-c2cncs2)c1
Show InChI InChI=1S/C18H14N4O2S2/c1-26(23,24)14-4-2-3-13(8-14)22-18-15-7-12(17-9-19-11-25-17)5-6-16(15)20-10-21-18/h2-11H,1H3,(H,20,21,22)
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n/an/a 31n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086406
PNG
(CHEMBL3426084)
Show SMILES NC(=O)c1ccc(Nc2ncnc3ccc(cc23)-c2cncs2)cc1
Show InChI InChI=1S/C18H13N5OS/c19-17(24)11-1-4-13(5-2-11)23-18-14-7-12(16-8-20-10-25-16)3-6-15(14)21-9-22-18/h1-10H,(H2,19,24)(H,21,22,23)
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n/an/a 24n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086405
PNG
(CHEMBL3426085)
Show SMILES N(c1ccc(cc1)-c1cnco1)c1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C20H13N5OS/c1-4-15(5-2-13(1)18-8-21-11-26-18)25-20-16-7-14(19-9-22-12-27-19)3-6-17(16)23-10-24-20/h1-12H,(H,23,24,25)
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086398
PNG
(CHEMBL3426181)
Show SMILES C1COCC(C1)Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C16H16N4OS/c1-2-12(8-21-5-1)20-16-13-6-11(15-7-17-10-22-15)3-4-14(13)18-9-19-16/h3-4,6-7,9-10,12H,1-2,5,8H2,(H,18,19,20)
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n/an/a 1.03E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086405
PNG
(CHEMBL3426085)
Show SMILES N(c1ccc(cc1)-c1cnco1)c1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C20H13N5OS/c1-4-15(5-2-13(1)18-8-21-11-26-18)25-20-16-7-14(19-9-22-12-27-19)3-6-17(16)23-10-24-20/h1-12H,(H,23,24,25)
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n/an/a 840n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086406
PNG
(CHEMBL3426084)
Show SMILES NC(=O)c1ccc(Nc2ncnc3ccc(cc23)-c2cncs2)cc1
Show InChI InChI=1S/C18H13N5OS/c19-17(24)11-1-4-13(5-2-11)23-18-14-7-12(16-8-20-10-25-16)3-6-15(14)21-9-22-18/h1-10H,(H2,19,24)(H,21,22,23)
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n/an/a 560n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086407
PNG
(CHEMBL3426083)
Show SMILES CS(=O)(=O)c1cccc(Nc2ncnc3ccc(cc23)-c2cncs2)c1
Show InChI InChI=1S/C18H14N4O2S2/c1-26(23,24)14-4-2-3-13(8-14)22-18-15-7-12(17-9-19-11-25-17)5-6-16(15)20-10-21-18/h2-11H,1H3,(H,20,21,22)
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n/an/a 2.69E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086408
PNG
(CHEMBL3426082)
Show SMILES CS(=O)(=O)Nc1ccc(Nc2ncnc3ccc(cc23)-c2cncs2)cc1
Show InChI InChI=1S/C18H15N5O2S2/c1-27(24,25)23-14-5-3-13(4-6-14)22-18-15-8-12(17-9-19-11-26-17)2-7-16(15)20-10-21-18/h2-11,23H,1H3,(H,20,21,22)
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n/an/a 970n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086409
PNG
(CHEMBL3426081)
Show SMILES NS(=O)(=O)c1ccc(Nc2ncnc3ccc(cc23)-c2cncs2)cc1
Show InChI InChI=1S/C17H13N5O2S2/c18-26(23,24)13-4-2-12(3-5-13)22-17-14-7-11(16-8-19-10-25-16)1-6-15(14)20-9-21-17/h1-10H,(H2,18,23,24)(H,20,21,22)
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n/an/a 700n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086410
PNG
(CHEMBL3426080)
Show SMILES FC(F)(F)c1cccc(Nc2ncnc3ccc(cc23)-c2cncs2)c1
Show InChI InChI=1S/C18H11F3N4S/c19-18(20,21)12-2-1-3-13(7-12)25-17-14-6-11(16-8-22-10-26-16)4-5-15(14)23-9-24-17/h1-10H,(H,23,24,25)
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n/an/a 2.15E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086411
PNG
(CHEMBL3426079)
Show SMILES Cc1ccccc1Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C18H14N4S/c1-12-4-2-3-5-15(12)22-18-14-8-13(17-9-19-11-23-17)6-7-16(14)20-10-21-18/h2-11H,1H3,(H,20,21,22)
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n/an/a 1.28E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086412
PNG
(CHEMBL3426078)
Show SMILES Cc1cccc(Nc2ncnc3ccc(cc23)-c2cncs2)c1
Show InChI InChI=1S/C18H14N4S/c1-12-3-2-4-14(7-12)22-18-15-8-13(17-9-19-11-23-17)5-6-16(15)20-10-21-18/h2-11H,1H3,(H,20,21,22)
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n/an/a 1.16E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086413
PNG
(CHEMBL3426077)
Show SMILES Cc1ccc(Nc2ncnc3ccc(cc23)-c2cncs2)cc1
Show InChI InChI=1S/C18H14N4S/c1-12-2-5-14(6-3-12)22-18-15-8-13(17-9-19-11-23-17)4-7-16(15)20-10-21-18/h2-11H,1H3,(H,20,21,22)
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n/an/a 1.23E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086414
PNG
(CHEMBL3426076)
Show SMILES Fc1ccccc1Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C17H11FN4S/c18-13-3-1-2-4-15(13)22-17-12-7-11(16-8-19-10-23-16)5-6-14(12)20-9-21-17/h1-10H,(H,20,21,22)
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n/an/a 4.68E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086417
PNG
(CHEMBL3426073)
Show SMILES Clc1ccccc1Nc1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C17H11ClN4S/c18-13-3-1-2-4-15(13)22-17-12-7-11(16-8-19-10-23-16)5-6-14(12)20-9-21-17/h1-10H,(H,20,21,22)
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n/an/a 3.61E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086418
PNG
(CHEMBL3426072)
Show SMILES Clc1cccc(Nc2ncnc3ccc(cc23)-c2cncs2)c1
Show InChI InChI=1S/C17H11ClN4S/c18-12-2-1-3-13(7-12)22-17-14-6-11(16-8-19-10-23-16)4-5-15(14)20-9-21-17/h1-10H,(H,20,21,22)
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n/an/a 700n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
Lymphocyte differentiation antigen CD38


(Homo sapiens (Human))
BDBM50086420
PNG
(CHEMBL3426070)
Show SMILES Fc1ccc(Nc2ncnc3ccc(cc23)-c2cncs2)cc1Cl
Show InChI InChI=1S/C17H10ClFN4S/c18-13-6-11(2-3-14(13)19)23-17-12-5-10(16-7-20-9-24-16)1-4-15(12)21-8-22-17/h1-9H,(H,21,22,23)
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n/an/a 1.20E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1


(Mus musculus)
BDBM50086421
PNG
(CHEMBL3426069)
Show SMILES N(c1ccccc1)c1ncnc2ccc(cc12)-c1cncs1
Show InChI InChI=1S/C17H12N4S/c1-2-4-13(5-3-1)21-17-14-8-12(16-9-18-11-22-16)6-7-15(14)19-10-20-17/h1-11H,(H,19,20,21)
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n/an/a 46n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis


J Med Chem 58: 3548-71 (2015)


Article DOI: 10.1021/jm502009h
BindingDB Entry DOI: 10.7270/Q2NV9M00
More data for this
Ligand-Target Pair