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8 similar compounds to monomer 50196234

Compile data set for download or QSAR
Wt: 290.4
BDBM50088341
Purchase
Wt: 304.4
BDBM50180920
Wt: 330.4
BDBM50180904
Wt: 304.4
BDBM50180907
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Wt: 380.5
BDBM50180909
Wt: 304.4
BDBM50196235
Wt: 304.4
BDBM50363963
Wt: 304.4
BDBM50363964

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 60 hits for monomerid = 50088341,50180920,50180904,50180907,50180909,50196235,50363963,50363964   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DOPAMINE


(RAT)
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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0.0800n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390


J Med Chem 43: 2079-81 (2000)


Article DOI: 10.1021/jm9911478
BindingDB Entry DOI: 10.7270/Q2C53MJH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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1.86n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universit£t Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human cloned dopamine D1 receptor


Bioorg Med Chem Lett 18: 3809-13 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.081
BindingDB Entry DOI: 10.7270/Q23F4QWW
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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1.90n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells


Bioorg Med Chem Lett 17: 1399-402 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.093
BindingDB Entry DOI: 10.7270/Q24T6J1G
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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1.90n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from D1 dopamine receptor


J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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1.90n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50363963
PNG
(CHEMBL1949725)
Show SMILES C[C@H]1Cc2c(Cc3ccccc3CCN1C)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-15-13-19-18-9-5-6-10-20(18)22-21(19)14-17-8-4-3-7-16(17)11-12-23(15)2/h3-10,15,22H,11-14H2,1-2H3/t15-/m0/s1
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4.40n/an/an/an/an/an/an/an/a



Martin Luther Universit£t Halle-Wittenberg

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells


J Med Chem 54: 7422-6 (2011)


Article DOI: 10.1021/jm200676f
BindingDB Entry DOI: 10.7270/Q27M08DP
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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6n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 of rat striatal mambranes using [3H]spiperone


J Med Chem 43: 2079-81 (2000)


Article DOI: 10.1021/jm9911478
BindingDB Entry DOI: 10.7270/Q2C53MJH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50363963
PNG
(CHEMBL1949725)
Show SMILES C[C@H]1Cc2c(Cc3ccccc3CCN1C)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-15-13-19-18-9-5-6-10-20(18)22-21(19)14-17-8-4-3-7-16(17)11-12-23(15)2/h3-10,15,22H,11-14H2,1-2H3/t15-/m0/s1
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6.10n/an/an/an/an/an/an/an/a



Martin Luther Universit£t Halle-Wittenberg

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells


J Med Chem 54: 7422-6 (2011)


Article DOI: 10.1021/jm200676f
BindingDB Entry DOI: 10.7270/Q27M08DP
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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7.5n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cells


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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7.5n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells


Bioorg Med Chem Lett 17: 1399-402 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.093
BindingDB Entry DOI: 10.7270/Q24T6J1G
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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7.5n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity to D5 dopamine receptor by radioligand binding assay


J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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<10n/an/an/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Antagonist activity at dopamine D1 receptor (unknown origin)


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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<10n/an/an/an/an/an/an/an/a



State Key Laboratory of Drug Research

Curated by ChEMBL


Assay Description
Antagonist activity at dopamine D5 receptor (unknown origin)


ACS Med Chem Lett 5: 304-8 (2014)


Article DOI: 10.1021/ml400373j
BindingDB Entry DOI: 10.7270/Q2CN75F4
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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12.7n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay


J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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12.7n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50180920
PNG
(7-ethyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2...)
Show SMILES CCN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-2-23-13-11-16-7-3-4-8-17(16)15-21-19(12-14-23)18-9-5-6-10-20(18)22-21/h3-10,22H,2,11-15H2,1H3
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14.7n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay


J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50180920
PNG
(7-ethyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2...)
Show SMILES CCN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-2-23-13-11-16-7-3-4-8-17(16)15-21-19(12-14-23)18-9-5-6-10-20(18)22-21/h3-10,22H,2,11-15H2,1H3
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16.4n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay


J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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19n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Activity at human D2L dopamine receptor expressed in HEK293 cells by calcium fluorescence assay


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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19n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Inhibition of D2L dopamine receptor in HEK 293 cells by intracellular calcium assay


J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50180920
PNG
(7-ethyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2...)
Show SMILES CCN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-2-23-13-11-16-7-3-4-8-17(16)15-21-19(12-14-23)18-9-5-6-10-20(18)22-21/h3-10,22H,2,11-15H2,1H3
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22.3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay


J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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25.9n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human D3 receptor expressed in CHO cells


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50196235
PNG
(7-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g]...)
Show SMILES CN1CCCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-23-13-6-10-19-18-9-4-5-11-20(18)22-21(19)15-17-8-3-2-7-16(17)12-14-23/h2-5,7-9,11,22H,6,10,12-15H2,1H3
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38n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Activity at human D2L dopamine receptor expressed in HEK293 cells by calcium fluorescence assay


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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40.3n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D3 receptor expressed in CHO cells


Bioorg Med Chem Lett 17: 1399-402 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.093
BindingDB Entry DOI: 10.7270/Q24T6J1G
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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41.7n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universit£t Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human cloned dopamine D2L receptor


Bioorg Med Chem Lett 18: 3809-13 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.081
BindingDB Entry DOI: 10.7270/Q23F4QWW
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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44.5n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human cloned dopamine D2L receptor expressed in CHO cells


Bioorg Med Chem Lett 17: 1399-402 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.093
BindingDB Entry DOI: 10.7270/Q24T6J1G
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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44.5n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human D2L dopamine receptor expressed in CHO cells


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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44.7n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from D2L dopamine receptor


J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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60.4n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay


J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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60.4n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50196235
PNG
(7-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g]...)
Show SMILES CN1CCCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-23-13-6-10-19-18-9-4-5-11-20(18)22-21(19)15-17-8-3-2-7-16(17)12-14-23/h2-5,7-9,11,22H,6,10,12-15H2,1H3
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71.6n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50180920
PNG
(7-ethyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2...)
Show SMILES CCN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-2-23-13-11-16-7-3-4-8-17(16)15-21-19(12-14-23)18-9-5-6-10-20(18)22-21/h3-10,22H,2,11-15H2,1H3
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82.6n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D2L receptor expressed in HEK 293 cells by functional calcium assay


J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50363963
PNG
(CHEMBL1949725)
Show SMILES C[C@H]1Cc2c(Cc3ccccc3CCN1C)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-15-13-19-18-9-5-6-10-20(18)22-21(19)14-17-8-4-3-7-16(17)11-12-23(15)2/h3-10,15,22H,11-14H2,1-2H3/t15-/m0/s1
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85.3n/an/an/an/an/an/an/an/a



Martin Luther Universit£t Halle-Wittenberg

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2L receptor expressed in human HEK293 cells


J Med Chem 54: 7422-6 (2011)


Article DOI: 10.1021/jm200676f
BindingDB Entry DOI: 10.7270/Q27M08DP
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50196235
PNG
(7-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g]...)
Show SMILES CN1CCCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-23-13-6-10-19-18-9-4-5-11-20(18)22-21(19)15-17-8-3-2-7-16(17)12-14-23/h2-5,7-9,11,22H,6,10,12-15H2,1H3
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92n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cells


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50088341
PNG
(11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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108n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human D4 dopamine receptor expressed in CHO cells


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50196235
PNG
(7-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g]...)
Show SMILES CN1CCCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-23-13-6-10-19-18-9-4-5-11-20(18)22-21(19)15-17-8-3-2-7-16(17)12-14-23/h2-5,7-9,11,22H,6,10,12-15H2,1H3
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115n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universit£t Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human cloned dopamine D2L receptor


Bioorg Med Chem Lett 18: 3809-13 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.081
BindingDB Entry DOI: 10.7270/Q23F4QWW
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50196235
PNG
(7-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g]...)
Show SMILES CN1CCCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-23-13-6-10-19-18-9-4-5-11-20(18)22-21(19)15-17-8-3-2-7-16(17)12-14-23/h2-5,7-9,11,22H,6,10,12-15H2,1H3
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143n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human D2L dopamine receptor expressed in CHO cells


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50196235
PNG
(7-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g]...)
Show SMILES CN1CCCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-23-13-6-10-19-18-9-4-5-11-20(18)22-21(19)15-17-8-3-2-7-16(17)12-14-23/h2-5,7-9,11,22H,6,10,12-15H2,1H3
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158n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universit£t Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human cloned dopamine D1 receptor


Bioorg Med Chem Lett 18: 3809-13 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.081
BindingDB Entry DOI: 10.7270/Q23F4QWW
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50196235
PNG
(7-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g]...)
Show SMILES CN1CCCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-23-13-6-10-19-18-9-4-5-11-20(18)22-21(19)15-17-8-3-2-7-16(17)12-14-23/h2-5,7-9,11,22H,6,10,12-15H2,1H3
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164n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50180920
PNG
(7-ethyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2...)
Show SMILES CCN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-2-23-13-11-16-7-3-4-8-17(16)15-21-19(12-14-23)18-9-5-6-10-20(18)22-21/h3-10,22H,2,11-15H2,1H3
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170n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay


J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50196235
PNG
(7-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g]...)
Show SMILES CN1CCCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-23-13-6-10-19-18-9-4-5-11-20(18)22-21(19)15-17-8-3-2-7-16(17)12-14-23/h2-5,7-9,11,22H,6,10,12-15H2,1H3
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184n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human D4 dopamine receptor expressed in CHO cells


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50180920
PNG
(7-ethyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2...)
Show SMILES CCN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-2-23-13-11-16-7-3-4-8-17(16)15-21-19(12-14-23)18-9-5-6-10-20(18)22-21/h3-10,22H,2,11-15H2,1H3
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253n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D2L receptor expressed in HEK 293 cells by radioligand binding assay


J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50363963
PNG
(CHEMBL1949725)
Show SMILES C[C@H]1Cc2c(Cc3ccccc3CCN1C)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-15-13-19-18-9-5-6-10-20(18)22-21(19)14-17-8-4-3-7-16(17)11-12-23(15)2/h3-10,15,22H,11-14H2,1-2H3/t15-/m0/s1
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304n/an/an/an/an/an/an/an/a



Martin Luther Universit£t Halle-Wittenberg

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in human HEK293 cells


J Med Chem 54: 7422-6 (2011)


Article DOI: 10.1021/jm200676f
BindingDB Entry DOI: 10.7270/Q27M08DP
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50196235
PNG
(7-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g]...)
Show SMILES CN1CCCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-23-13-6-10-19-18-9-4-5-11-20(18)22-21(19)15-17-8-3-2-7-16(17)12-14-23/h2-5,7-9,11,22H,6,10,12-15H2,1H3
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304n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50180920
PNG
(7-ethyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2...)
Show SMILES CCN1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-2-23-13-11-16-7-3-4-8-17(16)15-21-19(12-14-23)18-9-5-6-10-20(18)22-21/h3-10,22H,2,11-15H2,1H3
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379n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D4 receptor expressed in HEK 293 cells by radioligand binding assay


J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50363964
PNG
(CHEMBL1949726)
Show SMILES C[C@@H]1Cc2c(Cc3ccccc3CCN1C)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-15-13-19-18-9-5-6-10-20(18)22-21(19)14-17-8-4-3-7-16(17)11-12-23(15)2/h3-10,15,22H,11-14H2,1-2H3/t15-/m1/s1
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389n/an/an/an/an/an/an/an/a



Martin Luther Universit£t Halle-Wittenberg

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cells


J Med Chem 54: 7422-6 (2011)


Article DOI: 10.1021/jm200676f
BindingDB Entry DOI: 10.7270/Q27M08DP
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50196235
PNG
(7-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g]...)
Show SMILES CN1CCCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-23-13-6-10-19-18-9-4-5-11-20(18)22-21(19)15-17-8-3-2-7-16(17)12-14-23/h2-5,7-9,11,22H,6,10,12-15H2,1H3
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521n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human D3 receptor expressed in CHO cells


J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50363964
PNG
(CHEMBL1949726)
Show SMILES C[C@@H]1Cc2c(Cc3ccccc3CCN1C)[nH]c1ccccc21
Show InChI InChI=1S/C21H24N2/c1-15-13-19-18-9-5-6-10-20(18)22-21(19)14-17-8-4-3-7-16(17)11-12-23(15)2/h3-10,15,22H,11-14H2,1-2H3/t15-/m1/s1
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640n/an/an/an/an/an/an/an/a



Martin Luther Universit£t Halle-Wittenberg

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells


J Med Chem 54: 7422-6 (2011)


Article DOI: 10.1021/jm200676f
BindingDB Entry DOI: 10.7270/Q27M08DP
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50180904
PNG
(7-cyclopropylmethyl-6,7,8,9,14,15-hexahydro-5H-ben...)
Show SMILES C(C1CC1)N1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C23H26N2/c1-2-6-19-15-23-21(20-7-3-4-8-22(20)24-23)12-14-25(16-17-9-10-17)13-11-18(19)5-1/h1-8,17,24H,9-16H2
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767n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay


J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50180904
PNG
(7-cyclopropylmethyl-6,7,8,9,14,15-hexahydro-5H-ben...)
Show SMILES C(C1CC1)N1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C23H26N2/c1-2-6-19-15-23-21(20-7-3-4-8-22(20)24-23)12-14-25(16-17-9-10-17)13-11-18(19)5-1/h1-8,17,24H,9-16H2
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893n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay


J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50180904
PNG
(7-cyclopropylmethyl-6,7,8,9,14,15-hexahydro-5H-ben...)
Show SMILES C(C1CC1)N1CCc2c(Cc3ccccc3CC1)[nH]c1ccccc21
Show InChI InChI=1S/C23H26N2/c1-2-6-19-15-23-21(20-7-3-4-8-22(20)24-23)12-14-25(16-17-9-10-17)13-11-18(19)5-1/h1-8,17,24H,9-16H2
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>5.00E+3n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D4 receptor expressed in HEK 293 cells by radioligand binding assay


J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
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