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17 similar compounds to monomer 50098450

Compile data set for download or QSAR
Wt: 447.6
BDBM50089153
Wt: 475.6
BDBM50089156
Wt: 433.5
BDBM50089155
Wt: 421.5
BDBM50088733
Wt: 461.6
BDBM50089154
Wt: 435.6
BDBM50098447
Wt: 409.5
BDBM50098448
Wt: 435.6
BDBM50098453
Wt: 449.6
BDBM50098455
Wt: 449.6
BDBM50098456
Wt: 463.6
BDBM50098458
Wt: 449.6
BDBM50098459
Wt: 511.6
BDBM50098461
Wt: 421.5
BDBM50098462
Wt: 485.6
BDBM50302775
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 48 hits for monomerid = 50089153,50089156,50089155,50088733,50089154,50098447,50098448,50098453,50098455,50098456,50098458,50098459,50098461,50098462,50302775   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50089155
PNG
(4-[(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-(3-hydro...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2CC=C)c1cccc(O)c1
Show InChI InChI=1S/C27H35N3O2/c1-4-16-29-22-14-15-23(29)18-25(17-22)30(24-8-7-9-26(31)19-24)21-12-10-20(11-13-21)27(32)28(5-2)6-3/h4,7-13,19,22-23,25,31H,1,5-6,14-18H2,2-3H3/t22-,23+,25+
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1.30n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligand


Bioorg Med Chem Lett 10: 1281-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00209-2
BindingDB Entry DOI: 10.7270/Q2P84B3K
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50098462
PNG
(4-[(1-Allyl-3-methyl-piperidin-4-yl)-(3-hydroxy-ph...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC=C)C[C@@H]1C)c1cccc(O)c1
Show InChI InChI=1S/C26H35N3O2/c1-5-16-27-17-15-25(20(4)19-27)29(23-9-8-10-24(30)18-23)22-13-11-21(12-14-22)26(31)28(6-2)7-3/h5,8-14,18,20,25,30H,1,6-7,15-17,19H2,2-4H3/t20-,25+/m0/s1
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1.85n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [H]DADLE to the delta opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50089153
PNG
(4-[(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-(3-metho...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2CC=C)c1cccc(OC)c1
Show InChI InChI=1S/C28H37N3O2/c1-5-17-30-23-15-16-24(30)19-26(18-23)31(25-9-8-10-27(20-25)33-4)22-13-11-21(12-14-22)28(32)29(6-2)7-3/h5,8-14,20,23-24,26H,1,6-7,15-19H2,2-4H3/t23-,24+,26+
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3.30n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligand


Bioorg Med Chem Lett 10: 1281-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00209-2
BindingDB Entry DOI: 10.7270/Q2P84B3K
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50089156
PNG
(CHEMBL3085003 | N,N-Diethyl-4-{(3-methoxy-phenyl)-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2CC=C(C)C)c1cccc(OC)c1
Show InChI InChI=1S/C30H41N3O2/c1-6-31(7-2)30(34)23-11-13-24(14-12-23)33(27-9-8-10-29(21-27)35-5)28-19-25-15-16-26(20-28)32(25)18-17-22(3)4/h8-14,17,21,25-26,28H,6-7,15-16,18-20H2,1-5H3/t25-,26+,28+
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3.5n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligand


Bioorg Med Chem Lett 10: 1281-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00209-2
BindingDB Entry DOI: 10.7270/Q2P84B3K
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50089154
PNG
(4-[[((Z)-8-But-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-y...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CC2CCC(C1)N2C\C=C/C)c1cccc(OC)c1
Show InChI InChI=1S/C29H39N3O2/c1-5-8-18-31-24-16-17-25(31)20-27(19-24)32(26-10-9-11-28(21-26)34-4)23-14-12-22(13-15-23)29(33)30(6-2)7-3/h5,8-15,21,24-25,27H,6-7,16-20H2,1-4H3/b8-5-
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3.70n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Opioid receptor delta 1 by displacement of [3H]-DADLE radioligand


Bioorg Med Chem Lett 10: 1281-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00209-2
BindingDB Entry DOI: 10.7270/Q2P84B3K
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50088733
PNG
(CHEMBL12912 | N,N-Diethyl-4-[(3-methoxy-phenyl)-((...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@H]1C[C@@H]2CC[C@H](C1)N2C)c1cccc(OC)c1
Show InChI InChI=1S/C26H35N3O2/c1-5-28(6-2)26(30)19-10-12-20(13-11-19)29(23-8-7-9-25(18-23)31-4)24-16-21-14-15-22(17-24)27(21)3/h7-13,18,21-22,24H,5-6,14-17H2,1-4H3/t21-,22+,24-
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21n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DPDPE radioligand binding to rat opioid receptor delta 1 site from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50098447
PNG
(4-[(1-Allyl-3-methyl-piperidin-4-yl)-(3-methoxy-ph...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC=C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C27H37N3O2/c1-6-17-28-18-16-26(21(4)20-28)30(24-10-9-11-25(19-24)32-5)23-14-12-22(13-15-23)27(31)29(7-2)8-3/h6,9-15,19,21,26H,1,7-8,16-18,20H2,2-5H3/t21-,26+/m0/s1
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22n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [H]DADLE to the delta opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50098458
PNG
(CHEMBL177610 | N,N-Diethyl-4-{(3-methoxy-phenyl)-[...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC=C(C)C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C29H41N3O2/c1-7-31(8-2)29(33)24-12-14-25(15-13-24)32(26-10-9-11-27(20-26)34-6)28-17-19-30(21-23(28)5)18-16-22(3)4/h9-16,20,23,28H,7-8,17-19,21H2,1-6H3/t23-,28+/m0/s1
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36n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [H]DADLE to the delta opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50098455
PNG
(4-[(1-Cyclopropylmethyl-3-methyl-piperidin-4-yl)-(...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC2CC2)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C28H39N3O2/c1-5-30(6-2)28(32)23-12-14-24(15-13-23)31(25-8-7-9-26(18-25)33-4)27-16-17-29(19-21(27)3)20-22-10-11-22/h7-9,12-15,18,21-22,27H,5-6,10-11,16-17,19-20H2,1-4H3/t21-,27+/m0/s1
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36n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [H]DADLE to the delta opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50302775
PNG
(CHEMBL569084 | N,N-diethyl-4-((3-methoxyphenyl)(1-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(CCc2ccccc2)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C31H39N3O2/c1-4-33(5-2)31(35)26-14-16-27(17-15-26)34(29-12-9-13-30(24-29)36-3)28-19-22-32(23-20-28)21-18-25-10-7-6-8-11-25/h6-17,24,28H,4-5,18-23H2,1-3H3
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50n/an/an/an/an/an/an/an/a



AstraZeneca R & D Montr£al

Curated by ChEMBL


Assay Description
Displacement of [125I]-[D-Ala2]deltorphin 2 from human cloned delta opioid receptor


Bioorg Med Chem Lett 19: 5994-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.072
BindingDB Entry DOI: 10.7270/Q22J6BX8
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50098459
PNG
(CHEMBL434685 | N,N-Diethyl-4-{(3-methoxy-phenyl)-[...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC(C)=C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C28H39N3O2/c1-7-30(8-2)28(32)23-12-14-24(15-13-23)31(25-10-9-11-26(18-25)33-6)27-16-17-29(19-21(3)4)20-22(27)5/h9-15,18,22,27H,3,7-8,16-17,19-20H2,1-2,4-6H3/t22-,27+/m0/s1
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72n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [H]DADLE to the delta opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50089155
PNG
(4-[(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-(3-hydro...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2CC=C)c1cccc(O)c1
Show InChI InChI=1S/C27H35N3O2/c1-4-16-29-22-14-15-23(29)18-25(17-22)30(24-8-7-9-26(31)19-24)21-12-10-20(11-13-21)27(32)28(5-2)6-3/h4,7-13,19,22-23,25,31H,1,5-6,14-18H2,2-3H3/t22-,23+,25+
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73n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Opioid receptor kappa 1 by displacement of [3H]-U-69,593 radioligand


Bioorg Med Chem Lett 10: 1281-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00209-2
BindingDB Entry DOI: 10.7270/Q2P84B3K
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098462
PNG
(4-[(1-Allyl-3-methyl-piperidin-4-yl)-(3-hydroxy-ph...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC=C)C[C@@H]1C)c1cccc(O)c1
Show InChI InChI=1S/C26H35N3O2/c1-5-16-27-17-15-25(20(4)19-27)29(23-9-8-10-24(30)18-23)22-13-11-21(12-14-22)26(31)28(6-2)7-3/h5,8-14,18,20,25,30H,1,6-7,15-17,19H2,2-4H3/t20-,25+/m0/s1
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76.7n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]U-69593 to opioid receptor kappa 1 from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50098461
PNG
(CHEMBL355580 | N,N-Diethyl-4-{(3-methoxy-phenyl)-[...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(C\C=C\c2ccccc2)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C33H41N3O2/c1-5-35(6-2)33(37)28-17-19-29(20-18-28)36(30-15-10-16-31(24-30)38-4)32-21-23-34(25-26(32)3)22-11-14-27-12-8-7-9-13-27/h7-20,24,26,32H,5-6,21-23,25H2,1-4H3/b14-11+/t26-,32+/m0/s1
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93n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [H]DADLE to the delta opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098462
PNG
(4-[(1-Allyl-3-methyl-piperidin-4-yl)-(3-hydroxy-ph...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC=C)C[C@@H]1C)c1cccc(O)c1
Show InChI InChI=1S/C26H35N3O2/c1-5-16-27-17-15-25(20(4)19-27)29(23-9-8-10-24(30)18-23)22-13-11-21(12-14-22)26(31)28(6-2)7-3/h5,8-14,18,20,25,30H,1,6-7,15-17,19H2,2-4H3/t20-,25+/m0/s1
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126n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]DAMGO to the mu opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50098448
PNG
(4-[(1,3-Dimethyl-piperidin-4-yl)-(3-methoxy-phenyl...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C25H35N3O2/c1-6-27(7-2)25(29)20-11-13-21(14-12-20)28(22-9-8-10-23(17-22)30-5)24-15-16-26(4)18-19(24)3/h8-14,17,19,24H,6-7,15-16,18H2,1-5H3/t19-,24?/m0/s1
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141n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [H]DADLE to the delta opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50098448
PNG
(4-[(1,3-Dimethyl-piperidin-4-yl)-(3-methoxy-phenyl...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C25H35N3O2/c1-6-27(7-2)25(29)20-11-13-21(14-12-20)28(22-9-8-10-23(17-22)30-5)24-15-16-26(4)18-19(24)3/h8-14,17,19,24H,6-7,15-16,18H2,1-5H3/t19-,24?/m0/s1
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178n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [H]DADLE to the delta opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50098456
PNG
(4-[(1-Cyclopropylmethyl-3-methyl-piperidin-4-yl)-(...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC2CC2)C[C@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C28H39N3O2/c1-5-30(6-2)28(32)23-12-14-24(15-13-23)31(25-8-7-9-26(18-25)33-4)27-16-17-29(19-21(27)3)20-22-10-11-22/h7-9,12-15,18,21-22,27H,5-6,10-11,16-17,19-20H2,1-4H3/t21-,27-/m1/s1
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230n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [H]DADLE to the delta opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Opioid receptors; mu & delta


(Rattus norvegicus (rat))
BDBM50098453
PNG
(4-[(1-Allyl-3-methyl-piperidin-4-yl)-(3-methoxy-ph...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC=C)C[C@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C27H37N3O2/c1-6-17-28-18-16-26(21(4)20-28)30(24-10-9-11-25(19-24)32-5)23-14-12-22(13-15-23)27(31)29(7-2)8-3/h6,9-15,19,21,26H,1,7-8,16-18,20H2,2-5H3/t21-,26-/m1/s1
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379n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [H]DADLE to the delta opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50089155
PNG
(4-[(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-(3-hydro...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2CC=C)c1cccc(O)c1
Show InChI InChI=1S/C27H35N3O2/c1-4-16-29-22-14-15-23(29)18-25(17-22)30(24-8-7-9-26(31)19-24)21-12-10-20(11-13-21)27(32)28(5-2)6-3/h4,7-13,19,22-23,25,31H,1,5-6,14-18H2,2-3H3/t22-,23+,25+
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686n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Opioid receptor mu 1 by displacement of [3H]-DAMGO radioligand


Bioorg Med Chem Lett 10: 1281-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00209-2
BindingDB Entry DOI: 10.7270/Q2P84B3K
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50089156
PNG
(CHEMBL3085003 | N,N-Diethyl-4-{(3-methoxy-phenyl)-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2CC=C(C)C)c1cccc(OC)c1
Show InChI InChI=1S/C30H41N3O2/c1-6-31(7-2)30(34)23-11-13-24(14-12-23)33(27-9-8-10-29(21-27)35-5)28-19-25-15-16-26(20-28)32(25)18-17-22(3)4/h8-14,17,21,25-26,28H,6-7,15-16,18-20H2,1-5H3/t25-,26+,28+
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788n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Opioid receptor kappa 1 by displacement of [3H]-U-69,593 radioligand


Bioorg Med Chem Lett 10: 1281-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00209-2
BindingDB Entry DOI: 10.7270/Q2P84B3K
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50089153
PNG
(4-[(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-(3-metho...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2CC=C)c1cccc(OC)c1
Show InChI InChI=1S/C28H37N3O2/c1-5-17-30-23-15-16-24(30)19-26(18-23)31(25-9-8-10-27(20-25)33-4)22-13-11-21(12-14-22)28(32)29(6-2)7-3/h5,8-14,20,23-24,26H,1,6-7,15-19H2,2-4H3/t23-,24+,26+
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1.08E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Opioid receptor kappa 1 by displacement of [3H]-U-69,593 radioligand


Bioorg Med Chem Lett 10: 1281-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00209-2
BindingDB Entry DOI: 10.7270/Q2P84B3K
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50089156
PNG
(CHEMBL3085003 | N,N-Diethyl-4-{(3-methoxy-phenyl)-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2CC=C(C)C)c1cccc(OC)c1
Show InChI InChI=1S/C30H41N3O2/c1-6-31(7-2)30(34)23-11-13-24(14-12-23)33(27-9-8-10-29(21-27)35-5)28-19-25-15-16-26(20-28)32(25)18-17-22(3)4/h8-14,17,21,25-26,28H,6-7,15-16,18-20H2,1-5H3/t25-,26+,28+
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1.11E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Opioid receptor mu 1 by displacement of [3H]-DAMGO radioligand


Bioorg Med Chem Lett 10: 1281-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00209-2
BindingDB Entry DOI: 10.7270/Q2P84B3K
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50089154
PNG
(4-[[((Z)-8-But-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-y...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CC2CCC(C1)N2C\C=C/C)c1cccc(OC)c1
Show InChI InChI=1S/C29H39N3O2/c1-5-8-18-31-24-16-17-25(31)20-27(19-24)32(26-10-9-11-28(21-26)34-4)23-14-12-22(13-15-23)29(33)30(6-2)7-3/h5,8-15,21,24-25,27H,6-7,16-20H2,1-4H3/b8-5-
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1.17E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Opioid receptor kappa 1 by displacement of [3H]-U-69,593 radioligand


Bioorg Med Chem Lett 10: 1281-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00209-2
BindingDB Entry DOI: 10.7270/Q2P84B3K
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50302775
PNG
(CHEMBL569084 | N,N-diethyl-4-((3-methoxyphenyl)(1-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(CCc2ccccc2)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C31H39N3O2/c1-4-33(5-2)31(35)26-14-16-27(17-15-26)34(29-12-9-13-30(24-29)36-3)28-19-22-32(23-20-28)21-18-25-10-7-6-8-11-25/h6-17,24,28H,4-5,18-23H2,1-3H3
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2.11E+3n/an/an/an/an/an/an/an/a



AstraZeneca R & D Montr£al

Curated by ChEMBL


Assay Description
Displacement of [125I]FK33824 from human cloned mu opioid receptor


Bioorg Med Chem Lett 19: 5994-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.072
BindingDB Entry DOI: 10.7270/Q22J6BX8
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50089153
PNG
(4-[(8-Allyl-8-aza-bicyclo[3.2.1]oct-3-yl)-(3-metho...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1C[C@@H]2CC[C@H](C1)N2CC=C)c1cccc(OC)c1
Show InChI InChI=1S/C28H37N3O2/c1-5-17-30-23-15-16-24(30)19-26(18-23)31(25-9-8-10-27(20-25)33-4)22-13-11-21(12-14-22)28(32)29(6-2)7-3/h5,8-14,20,23-24,26H,1,6-7,15-19H2,2-4H3/t23-,24+,26+
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2.55E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Opioid receptor mu 1 by displacement of [3H]-DAMGO radioligand


Bioorg Med Chem Lett 10: 1281-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00209-2
BindingDB Entry DOI: 10.7270/Q2P84B3K
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098448
PNG
(4-[(1,3-Dimethyl-piperidin-4-yl)-(3-methoxy-phenyl...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C25H35N3O2/c1-6-27(7-2)25(29)20-11-13-21(14-12-20)28(22-9-8-10-23(17-22)30-5)24-15-16-26(4)18-19(24)3/h8-14,17,19,24H,6-7,15-16,18H2,1-5H3/t19-,24?/m0/s1
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3.32E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]DAMGO to the mu opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098458
PNG
(CHEMBL177610 | N,N-Diethyl-4-{(3-methoxy-phenyl)-[...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC=C(C)C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C29H41N3O2/c1-7-31(8-2)29(33)24-12-14-25(15-13-24)32(26-10-9-11-27(20-26)34-6)28-17-19-30(21-23(28)5)18-16-22(3)4/h9-16,20,23,28H,7-8,17-19,21H2,1-6H3/t23-,28+/m0/s1
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3.39E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]DAMGO to the mu opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50089154
PNG
(4-[[((Z)-8-But-2-enyl)-8-aza-bicyclo[3.2.1]oct-3-y...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CC2CCC(C1)N2C\C=C/C)c1cccc(OC)c1
Show InChI InChI=1S/C29H39N3O2/c1-5-8-18-31-24-16-17-25(31)20-27(19-24)32(26-10-9-11-28(21-26)34-4)23-14-12-22(13-15-23)29(33)30(6-2)7-3/h5,8-15,21,24-25,27H,6-7,16-20H2,1-4H3/b8-5-
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>3.40E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity towards Opioid receptor mu 1 by displacement of [3H]-DAMGO radioligand


Bioorg Med Chem Lett 10: 1281-4 (2000)


Article DOI: 10.1016/s0960-894x(00)00209-2
BindingDB Entry DOI: 10.7270/Q2P84B3K
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50302775
PNG
(CHEMBL569084 | N,N-diethyl-4-((3-methoxyphenyl)(1-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(CCc2ccccc2)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C31H39N3O2/c1-4-33(5-2)31(35)26-14-16-27(17-15-26)34(29-12-9-13-30(24-29)36-3)28-19-22-32(23-20-28)21-18-25-10-7-6-8-11-25/h6-17,24,28H,4-5,18-23H2,1-3H3
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3.61E+3n/an/an/an/an/an/an/an/a



AstraZeneca R & D Montr£al

Curated by ChEMBL


Assay Description
Displacement of [125I]D-pro10-dynorphin from human cloned kappa opioid receptor


Bioorg Med Chem Lett 19: 5994-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.072
BindingDB Entry DOI: 10.7270/Q22J6BX8
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50088733
PNG
(CHEMBL12912 | N,N-Diethyl-4-[(3-methoxy-phenyl)-((...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@H]1C[C@@H]2CC[C@H](C1)N2C)c1cccc(OC)c1
Show InChI InChI=1S/C26H35N3O2/c1-5-28(6-2)26(30)19-10-12-20(13-11-19)29(23-8-7-9-25(18-23)31-4)24-16-21-14-15-22(17-24)27(21)3/h7-13,18,21-22,24H,5-6,14-17H2,1-4H3/t21-,22+,24-
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3.70E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined by inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from rat brain membranes


Bioorg Med Chem Lett 10: 1109-11 (2000)


Article DOI: 10.1016/s0960-894x(00)00182-7
BindingDB Entry DOI: 10.7270/Q2X0668B
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098453
PNG
(4-[(1-Allyl-3-methyl-piperidin-4-yl)-(3-methoxy-ph...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC=C)C[C@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C27H37N3O2/c1-6-17-28-18-16-26(21(4)20-28)30(24-10-9-11-25(19-24)32-5)23-14-12-22(13-15-23)27(31)29(7-2)8-3/h6,9-15,19,21,26H,1,7-8,16-18,20H2,2-5H3/t21-,26-/m1/s1
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4.87E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]DAMGO to the mu opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098447
PNG
(4-[(1-Allyl-3-methyl-piperidin-4-yl)-(3-methoxy-ph...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC=C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C27H37N3O2/c1-6-17-28-18-16-26(21(4)20-28)30(24-10-9-11-25(19-24)32-5)23-14-12-22(13-15-23)27(31)29(7-2)8-3/h6,9-15,19,21,26H,1,7-8,16-18,20H2,2-5H3/t21-,26+/m0/s1
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5.33E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]DAMGO to the mu opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098459
PNG
(CHEMBL434685 | N,N-Diethyl-4-{(3-methoxy-phenyl)-[...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC(C)=C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C28H39N3O2/c1-7-30(8-2)28(32)23-12-14-24(15-13-23)31(25-10-9-11-26(18-25)33-6)27-16-17-29(19-21(3)4)20-22(27)5/h9-15,18,22,27H,3,7-8,16-17,19-20H2,1-2,4-6H3/t22-,27+/m0/s1
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5.69E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]DAMGO to the mu opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098448
PNG
(4-[(1,3-Dimethyl-piperidin-4-yl)-(3-methoxy-phenyl...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C25H35N3O2/c1-6-27(7-2)25(29)20-11-13-21(14-12-20)28(22-9-8-10-23(17-22)30-5)24-15-16-26(4)18-19(24)3/h8-14,17,19,24H,6-7,15-16,18H2,1-5H3/t19-,24?/m0/s1
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>5.92E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]DAMGO to the mu opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098458
PNG
(CHEMBL177610 | N,N-Diethyl-4-{(3-methoxy-phenyl)-[...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC=C(C)C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C29H41N3O2/c1-7-31(8-2)29(33)24-12-14-25(15-13-24)32(26-10-9-11-27(20-26)34-6)28-17-19-30(21-23(28)5)18-16-22(3)4/h9-16,20,23,28H,7-8,17-19,21H2,1-6H3/t23-,28+/m0/s1
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6.02E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]U-69593 to opioid receptor kappa 1 from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098448
PNG
(4-[(1,3-Dimethyl-piperidin-4-yl)-(3-methoxy-phenyl...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C25H35N3O2/c1-6-27(7-2)25(29)20-11-13-21(14-12-20)28(22-9-8-10-23(17-22)30-5)24-15-16-26(4)18-19(24)3/h8-14,17,19,24H,6-7,15-16,18H2,1-5H3/t19-,24?/m0/s1
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>6.06E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]U-69593 to opioid receptor kappa 1 from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098448
PNG
(4-[(1,3-Dimethyl-piperidin-4-yl)-(3-methoxy-phenyl...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C25H35N3O2/c1-6-27(7-2)25(29)20-11-13-21(14-12-20)28(22-9-8-10-23(17-22)30-5)24-15-16-26(4)18-19(24)3/h8-14,17,19,24H,6-7,15-16,18H2,1-5H3/t19-,24?/m0/s1
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6.30E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]U-69593 to opioid receptor kappa 1 from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098461
PNG
(CHEMBL355580 | N,N-Diethyl-4-{(3-methoxy-phenyl)-[...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(C\C=C\c2ccccc2)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C33H41N3O2/c1-5-35(6-2)33(37)28-17-19-29(20-18-28)36(30-15-10-16-31(24-30)38-4)32-21-23-34(25-26(32)3)22-11-14-27-12-8-7-9-13-27/h7-20,24,26,32H,5-6,21-23,25H2,1-4H3/b14-11+/t26-,32+/m0/s1
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>6.54E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]DAMGO to the mu opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098456
PNG
(4-[(1-Cyclopropylmethyl-3-methyl-piperidin-4-yl)-(...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC2CC2)C[C@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C28H39N3O2/c1-5-30(6-2)28(32)23-12-14-24(15-13-23)31(25-8-7-9-26(18-25)33-4)27-16-17-29(19-21(27)3)20-22-10-11-22/h7-9,12-15,18,21-22,27H,5-6,10-11,16-17,19-20H2,1-4H3/t21-,27-/m1/s1
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>6.54E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]DAMGO to the mu opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098455
PNG
(4-[(1-Cyclopropylmethyl-3-methyl-piperidin-4-yl)-(...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC2CC2)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C28H39N3O2/c1-5-30(6-2)28(32)23-12-14-24(15-13-23)31(25-8-7-9-26(18-25)33-4)27-16-17-29(19-21(27)3)20-22-10-11-22/h7-9,12-15,18,21-22,27H,5-6,10-11,16-17,19-20H2,1-4H3/t21-,27+/m0/s1
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>6.54E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]DAMGO to the mu opioid receptor from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098455
PNG
(4-[(1-Cyclopropylmethyl-3-methyl-piperidin-4-yl)-(...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC2CC2)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C28H39N3O2/c1-5-30(6-2)28(32)23-12-14-24(15-13-23)31(25-8-7-9-26(18-25)33-4)27-16-17-29(19-21(27)3)20-22-10-11-22/h7-9,12-15,18,21-22,27H,5-6,10-11,16-17,19-20H2,1-4H3/t21-,27+/m0/s1
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>7.46E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]U-69593 to opioid receptor kappa 1 from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098447
PNG
(4-[(1-Allyl-3-methyl-piperidin-4-yl)-(3-methoxy-ph...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC=C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C27H37N3O2/c1-6-17-28-18-16-26(21(4)20-28)30(24-10-9-11-25(19-24)32-5)23-14-12-22(13-15-23)27(31)29(7-2)8-3/h6,9-15,19,21,26H,1,7-8,16-18,20H2,2-5H3/t21-,26+/m0/s1
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>7.46E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]U-69593 to opioid receptor kappa 1 from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098453
PNG
(4-[(1-Allyl-3-methyl-piperidin-4-yl)-(3-methoxy-ph...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC=C)C[C@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C27H37N3O2/c1-6-17-28-18-16-26(21(4)20-28)30(24-10-9-11-25(19-24)32-5)23-14-12-22(13-15-23)27(31)29(7-2)8-3/h6,9-15,19,21,26H,1,7-8,16-18,20H2,2-5H3/t21-,26-/m1/s1
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>7.46E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]U-69593 to opioid receptor kappa 1 from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098459
PNG
(CHEMBL434685 | N,N-Diethyl-4-{(3-methoxy-phenyl)-[...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC(C)=C)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C28H39N3O2/c1-7-30(8-2)28(32)23-12-14-24(15-13-23)31(25-10-9-11-26(18-25)33-6)27-16-17-29(19-21(3)4)20-22(27)5/h9-15,18,22,27H,3,7-8,16-17,19-20H2,1-2,4-6H3/t22-,27+/m0/s1
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>7.46E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]U-69593 to opioid receptor kappa 1 from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098456
PNG
(4-[(1-Cyclopropylmethyl-3-methyl-piperidin-4-yl)-(...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(CC2CC2)C[C@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C28H39N3O2/c1-5-30(6-2)28(32)23-12-14-24(15-13-23)31(25-8-7-9-26(18-25)33-4)27-16-17-29(19-21(27)3)20-22-10-11-22/h7-9,12-15,18,21-22,27H,5-6,10-11,16-17,19-20H2,1-4H3/t21-,27-/m1/s1
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>7.46E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]U-69593 to opioid receptor kappa 1 from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Rattus norvegicus (rat))
BDBM50098461
PNG
(CHEMBL355580 | N,N-Diethyl-4-{(3-methoxy-phenyl)-[...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N([C@@H]1CCN(C\C=C\c2ccccc2)C[C@@H]1C)c1cccc(OC)c1
Show InChI InChI=1S/C33H41N3O2/c1-5-35(6-2)33(37)28-17-19-29(20-18-28)36(30-15-10-16-31(24-30)38-4)32-21-23-34(25-26(32)3)22-11-14-27-12-8-7-9-13-27/h7-20,24,26,32H,5-6,21-23,25H2,1-4H3/b14-11+/t26-,32+/m0/s1
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>7.46E+3n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Affinity of [3H]U-69593 to opioid receptor kappa 1 from rat brain


J Med Chem 44: 972-87 (2001)


Article DOI: 10.1021/jm000427g
BindingDB Entry DOI: 10.7270/Q2V69K8G
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50302775
PNG
(CHEMBL569084 | N,N-diethyl-4-((3-methoxyphenyl)(1-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)N(C1CCN(CCc2ccccc2)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C31H39N3O2/c1-4-33(5-2)31(35)26-14-16-27(17-15-26)34(29-12-9-13-30(24-29)36-3)28-19-22-32(23-20-28)21-18-25-10-7-6-8-11-25/h6-17,24,28H,4-5,18-23H2,1-3H3
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n/an/an/an/a 141n/an/an/an/a



AstraZeneca R & D Montr£al

Curated by ChEMBL


Assay Description
Agonist activity at human delta opioid receptor by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 5994-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.072
BindingDB Entry DOI: 10.7270/Q22J6BX8
More data for this
Ligand-Target Pair