BindingDB logo
myBDB logout

21 similar compounds to monomer 50099821

Compile data set for download or QSAR
Wt: 471.4
BDBM50099793
Wt: 445.3
BDBM50099794
Wt: 459.4
BDBM50099797
Wt: 453.3
BDBM50099799
Wt: 483.4
BDBM50099800
Wt: 499.4
BDBM50099801
Wt: 417.3
BDBM50099802
Wt: 445.3
BDBM50099803
Wt: 431.3
BDBM50099806
Wt: 445.3
BDBM50099808
Wt: 497.4
BDBM50099810
Wt: 485.4
BDBM50099811
Wt: 417.3
BDBM50099812
Wt: 439.3
BDBM50099814
Wt: 485.4
BDBM50099816
Displayed 1 to 15 (of 21 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 55 hits for monomerid = 50099793,50099794,50099797,50099799,50099800,50099801,50099802,50099803,50099806,50099808,50099810,50099811,50099812,50099814,50099816   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50099794
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1CCCCCC1
Show InChI InChI=1S/C23H29BrN2O2/c1-28-22-19-11-7-6-10-18(19)21(24)14-20(22)23(27)25-16-12-13-26(15-16)17-8-4-2-3-5-9-17/h6-7,10-11,14,16-17H,2-5,8-9,12-13,15H2,1H3,(H,25,27)/t16-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.200n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50099800
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2
Show InChI InChI=1S/C26H31BrN2O2/c1-31-25-21-5-3-2-4-20(21)23(27)13-22(25)26(30)28-19-6-7-29(14-19)24-17-9-15-8-16(11-17)12-18(24)10-15/h2-5,13,15-19,24H,6-12,14H2,1H3,(H,28,30)/t15-,16+,17-,18+,19-,24?/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.400n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099802
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(C1)C1CCCC1
Show InChI InChI=1S/C21H25BrN2O2/c1-26-20-17-9-5-4-8-16(17)19(22)12-18(20)21(25)23-14-10-11-24(13-14)15-6-2-3-7-15/h4-5,8-9,12,14-15H,2-3,6-7,10-11,13H2,1H3,(H,23,25)/t14-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.700n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50099806
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1CCCCC1
Show InChI InChI=1S/C22H27BrN2O2/c1-27-21-18-10-6-5-9-17(18)20(23)13-19(21)22(26)24-15-11-12-25(14-15)16-7-3-2-4-8-16/h5-6,9-10,13,15-16H,2-4,7-8,11-12,14H2,1H3,(H,24,26)/t15-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.800n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50099799
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C24H25BrN2O2/c1-29-23-20-10-6-5-9-19(20)22(25)15-21(23)24(28)26-18-11-13-27(14-12-18)16-17-7-3-2-4-8-17/h2-10,15,18H,11-14,16H2,1H3,(H,26,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.10n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099797
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CCN(CC1)C1CCCCCC1
Show InChI InChI=1S/C24H31BrN2O2/c1-29-23-20-11-7-6-10-19(20)22(25)16-21(23)24(28)26-17-12-14-27(15-13-17)18-8-4-2-3-5-9-18/h6-7,10-11,16-18H,2-5,8-9,12-15H2,1H3,(H,26,28)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.10n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099808
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C23H29BrN2O2/c1-28-22-19-10-6-5-9-18(19)21(24)15-20(22)23(27)25-16-11-13-26(14-12-16)17-7-3-2-4-8-17/h5-6,9-10,15-17H,2-4,7-8,11-14H2,1H3,(H,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.10n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50099814
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid ((...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C23H23BrN2O2/c1-28-22-19-10-6-5-9-18(19)21(24)13-20(22)23(27)25-17-11-12-26(15-17)14-16-7-3-2-4-8-16/h2-10,13,17H,11-12,14-15H2,1H3,(H,25,27)/t17-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.60n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099803
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(C1)C1CCCCCC1
Show InChI InChI=1S/C23H29BrN2O2/c1-28-22-19-11-7-6-10-18(19)21(24)14-20(22)23(27)25-16-12-13-26(15-16)17-8-4-2-3-5-9-17/h6-7,10-11,14,16-17H,2-5,8-9,12-13,15H2,1H3,(H,25,27)/t16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.70n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099794
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1CCCCCC1
Show InChI InChI=1S/C23H29BrN2O2/c1-28-22-19-11-7-6-10-18(19)21(24)14-20(22)23(27)25-16-12-13-26(15-16)17-8-4-2-3-5-9-17/h6-7,10-11,14,16-17H,2-5,8-9,12-13,15H2,1H3,(H,25,27)/t16-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.80n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099816
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CCN(CC1)C1C2CCCC1CCC2
Show InChI InChI=1S/C26H33BrN2O2/c1-31-25-21-11-3-2-10-20(21)23(27)16-22(25)26(30)28-19-12-14-29(15-13-19)24-17-6-4-7-18(24)9-5-8-17/h2-3,10-11,16-19,24H,4-9,12-15H2,1H3,(H,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.90n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50099812
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1CCCC1
Show InChI InChI=1S/C21H25BrN2O2/c1-26-20-17-9-5-4-8-16(17)19(22)12-18(20)21(25)23-14-10-11-24(13-14)15-6-2-3-7-15/h4-5,8-9,12,14-15H,2-3,6-7,10-11,13H2,1H3,(H,23,25)/t14-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.5n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50099803
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(C1)C1CCCCCC1
Show InChI InChI=1S/C23H29BrN2O2/c1-28-22-19-11-7-6-10-18(19)21(24)14-20(22)23(27)25-16-12-13-26(15-16)17-8-4-2-3-5-9-17/h6-7,10-11,14,16-17H,2-5,8-9,12-13,15H2,1H3,(H,25,27)/t16-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.90n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099812
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1CCCC1
Show InChI InChI=1S/C21H25BrN2O2/c1-26-20-17-9-5-4-8-16(17)19(22)12-18(20)21(25)23-14-10-11-24(13-14)15-6-2-3-7-15/h4-5,8-9,12,14-15H,2-3,6-7,10-11,13H2,1H3,(H,23,25)/t14-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.60n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099794
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1CCCCCC1
Show InChI InChI=1S/C23H29BrN2O2/c1-28-22-19-11-7-6-10-18(19)21(24)14-20(22)23(27)25-16-12-13-26(15-16)17-8-4-2-3-5-9-17/h6-7,10-11,14,16-17H,2-5,8-9,12-13,15H2,1H3,(H,25,27)/t16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.80n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50099814
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid ((...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C23H23BrN2O2/c1-28-22-19-10-6-5-9-18(19)21(24)13-20(22)23(27)25-17-11-12-26(15-17)14-16-7-3-2-4-8-16/h2-10,13,17H,11-12,14-15H2,1H3,(H,25,27)/t17-/m1/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Ability to displace [3H]-spiperone [0.5 nM (Kd=0.1-0.45 nM)] from human recombinant dopamine receptor D4 expressed in CHO cells


Bioorg Med Chem Lett 13: 3293-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00678-4
BindingDB Entry DOI: 10.7270/Q2639P5F
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099799
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C24H25BrN2O2/c1-29-23-20-10-6-5-9-19(20)22(25)15-21(23)24(28)26-18-11-13-27(14-12-18)16-17-7-3-2-4-8-17/h2-10,15,18H,11-14,16H2,1H3,(H,26,28)
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
5.5n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099799
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C24H25BrN2O2/c1-29-23-20-10-6-5-9-19(20)22(25)15-21(23)24(28)26-18-11-13-27(14-12-18)16-17-7-3-2-4-8-17/h2-10,15,18H,11-14,16H2,1H3,(H,26,28)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
5.60n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099800
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2
Show InChI InChI=1S/C26H31BrN2O2/c1-31-25-21-5-3-2-4-20(21)23(27)13-22(25)26(30)28-19-6-7-29(14-19)24-17-9-15-8-16(11-17)12-18(24)10-15/h2-5,13,15-19,24H,6-12,14H2,1H3,(H,28,30)/t15-,16+,17-,18+,19-,24?/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.80n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099806
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1CCCCC1
Show InChI InChI=1S/C22H27BrN2O2/c1-27-21-18-10-6-5-9-17(18)20(23)13-19(21)22(26)24-15-11-12-25(14-15)16-7-3-2-4-8-16/h5-6,9-10,13,15-16H,2-4,7-8,11-12,14H2,1H3,(H,24,26)/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.80n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099814
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid ((...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C23H23BrN2O2/c1-28-22-19-10-6-5-9-18(19)21(24)13-20(22)23(27)25-17-11-12-26(15-17)14-16-7-3-2-4-8-16/h2-10,13,17H,11-12,14-15H2,1H3,(H,25,27)/t17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.90n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099806
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1CCCCC1
Show InChI InChI=1S/C22H27BrN2O2/c1-27-21-18-10-6-5-9-17(18)20(23)13-19(21)22(26)24-15-11-12-25(14-15)16-7-3-2-4-8-16/h5-6,9-10,13,15-16H,2-4,7-8,11-12,14H2,1H3,(H,24,26)/t15-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.90n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099814
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid ((...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C23H23BrN2O2/c1-28-22-19-10-6-5-9-18(19)21(24)13-20(22)23(27)25-17-11-12-26(15-17)14-16-7-3-2-4-8-16/h2-10,13,17H,11-12,14-15H2,1H3,(H,25,27)/t17-/m1/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
12n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50099793
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1C2CCCC1CCC2
Show InChI InChI=1S/C25H31BrN2O2/c1-30-24-20-11-3-2-10-19(20)22(26)14-21(24)25(29)27-18-12-13-28(15-18)23-16-6-4-7-17(23)9-5-8-16/h2-3,10-11,14,16-18,23H,4-9,12-13,15H2,1H3,(H,27,29)/t16?,17?,18-,23?/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
12n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099803
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(C1)C1CCCCCC1
Show InChI InChI=1S/C23H29BrN2O2/c1-28-22-19-11-7-6-10-18(19)21(24)14-20(22)23(27)25-16-12-13-26(15-16)17-8-4-2-3-5-9-17/h6-7,10-11,14,16-17H,2-5,8-9,12-13,15H2,1H3,(H,25,27)/t16-/m1/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
19n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099812
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1CCCC1
Show InChI InChI=1S/C21H25BrN2O2/c1-26-20-17-9-5-4-8-16(17)19(22)12-18(20)21(25)23-14-10-11-24(13-14)15-6-2-3-7-15/h4-5,8-9,12,14-15H,2-3,6-7,10-11,13H2,1H3,(H,23,25)/t14-/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
19n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine receptor


(Homo sapiens (Human))
BDBM50099814
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid ((...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C23H23BrN2O2/c1-28-22-19-10-6-5-9-18(19)21(24)13-20(22)23(27)25-17-11-12-26(15-17)14-16-7-3-2-4-8-16/h2-10,13,17H,11-12,14-15H2,1H3,(H,25,27)/t17-/m1/s1
Reactome pathway
KEGG

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
21n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Ability to displace [3H]spiperone [0.5 nM (Kd=0.1-0.45 nM)] from human recombinant dopamine receptor D4 expressed in CHO cells


Bioorg Med Chem Lett 13: 3293-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00678-4
BindingDB Entry DOI: 10.7270/Q2639P5F
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099797
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CCN(CC1)C1CCCCCC1
Show InChI InChI=1S/C24H31BrN2O2/c1-29-23-20-11-7-6-10-19(20)22(25)16-21(23)24(28)26-17-12-14-27(15-13-17)18-8-4-2-3-5-9-18/h6-7,10-11,16-18H,2-5,8-9,12-15H2,1H3,(H,26,28)
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
23n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099800
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2
Show InChI InChI=1S/C26H31BrN2O2/c1-31-25-21-5-3-2-4-20(21)23(27)13-22(25)26(30)28-19-6-7-29(14-19)24-17-9-15-8-16(11-17)12-18(24)10-15/h2-5,13,15-19,24H,6-12,14H2,1H3,(H,28,30)/t15-,16+,17-,18+,19-,24?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
28n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50099801
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (9...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CC2CCCC(C1)N2C1CCCCCC1
Show InChI InChI=1S/C27H35BrN2O2/c1-32-26-23-14-7-6-13-22(23)25(28)17-24(26)27(31)29-18-15-20-11-8-12-21(16-18)30(20)19-9-4-2-3-5-10-19/h6-7,13-14,17-21H,2-5,8-12,15-16H2,1H3,(H,29,31)
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
41n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50099811
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (9...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CC2CCCC(C1)N2C1CCCCC1
Show InChI InChI=1S/C26H33BrN2O2/c1-31-25-22-13-6-5-12-21(22)24(27)16-23(25)26(30)28-17-14-19-10-7-11-20(15-17)29(19)18-8-3-2-4-9-18/h5-6,12-13,16-20H,2-4,7-11,14-15H2,1H3,(H,28,30)
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
48n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50099797
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CCN(CC1)C1CCCCCC1
Show InChI InChI=1S/C24H31BrN2O2/c1-29-23-20-11-7-6-10-19(20)22(25)16-21(23)24(28)26-17-12-14-27(15-13-17)18-8-4-2-3-5-9-18/h6-7,10-11,16-18H,2-5,8-9,12-15H2,1H3,(H,26,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
58n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099811
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (9...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CC2CCCC(C1)N2C1CCCCC1
Show InChI InChI=1S/C26H33BrN2O2/c1-31-25-22-13-6-5-12-21(22)24(27)16-23(25)26(30)28-17-14-19-10-7-11-20(15-17)29(19)18-8-3-2-4-9-18/h5-6,12-13,16-20H,2-4,7-11,14-15H2,1H3,(H,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
69n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50099802
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(C1)C1CCCC1
Show InChI InChI=1S/C21H25BrN2O2/c1-26-20-17-9-5-4-8-16(17)19(22)12-18(20)21(25)23-14-10-11-24(13-14)15-6-2-3-7-15/h4-5,8-9,12,14-15H,2-3,6-7,10-11,13H2,1H3,(H,23,25)/t14-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
75n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50099814
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid ((...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C23H23BrN2O2/c1-28-22-19-10-6-5-9-18(19)21(24)13-20(22)23(27)25-17-11-12-26(15-17)14-16-7-3-2-4-8-16/h2-10,13,17H,11-12,14-15H2,1H3,(H,25,27)/t17-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
84n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone [0.5 nM (Kd=0.1 nM)] from recombinant human dopamine receptor D3 expressed in CHO cells at 0.5 nM concentration


Bioorg Med Chem Lett 13: 3293-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00678-4
BindingDB Entry DOI: 10.7270/Q2639P5F
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50099810
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CCN(CC1)C1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2
Show InChI InChI=1S/C27H33BrN2O2/c1-32-26-22-5-3-2-4-21(22)24(28)15-23(26)27(31)29-20-6-8-30(9-7-20)25-18-11-16-10-17(13-18)14-19(25)12-16/h2-5,15-20,25H,6-14H2,1H3,(H,29,31)/t16-,17+,18-,19+,25?
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
92n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]-IABN the radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099808
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C23H29BrN2O2/c1-28-22-19-10-6-5-9-18(19)21(24)15-20(22)23(27)25-16-11-13-26(14-12-16)17-7-3-2-4-8-17/h5-6,9-10,15-17H,2-4,7-8,11-14H2,1H3,(H,25,27)
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
94n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099801
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (9...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CC2CCCC(C1)N2C1CCCCCC1
Show InChI InChI=1S/C27H35BrN2O2/c1-32-26-23-14-7-6-13-22(23)25(28)17-24(26)27(31)29-18-15-20-11-8-12-21(16-18)30(20)19-9-4-2-3-5-10-19/h6-7,13-14,17-21H,2-5,8-12,15-16H2,1H3,(H,29,31)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
96n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099810
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CCN(CC1)C1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2
Show InChI InChI=1S/C27H33BrN2O2/c1-32-26-22-5-3-2-4-21(22)24(28)15-23(26)27(31)29-20-6-8-30(9-7-20)25-18-11-16-10-17(13-18)14-19(25)12-16/h2-5,15-20,25H,6-14H2,1H3,(H,29,31)/t16-,17+,18-,19+,25?
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
96n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099810
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CCN(CC1)C1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2
Show InChI InChI=1S/C27H33BrN2O2/c1-32-26-22-5-3-2-4-21(22)24(28)15-23(26)27(31)29-20-6-8-30(9-7-20)25-18-11-16-10-17(13-18)14-19(25)12-16/h2-5,15-20,25H,6-14H2,1H3,(H,29,31)/t16-,17+,18-,19+,25?
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
121n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50099814
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid ((...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C23H23BrN2O2/c1-28-22-19-10-6-5-9-18(19)21(24)13-20(22)23(27)25-17-11-12-26(15-17)14-16-7-3-2-4-8-16/h2-10,13,17H,11-12,14-15H2,1H3,(H,25,27)/t17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
130n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone [0.5 nM (Kd=0.1 nM)] from human recombinant dopamine receptor D2L expressed in CHO cells


Bioorg Med Chem Lett 13: 3293-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00678-4
BindingDB Entry DOI: 10.7270/Q2639P5F
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099793
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1C2CCCC1CCC2
Show InChI InChI=1S/C25H31BrN2O2/c1-30-24-20-11-3-2-10-19(20)22(26)14-21(24)25(29)27-18-12-13-28(15-18)23-16-6-4-7-17(23)9-5-8-16/h2-3,10-11,14,16-18,23H,4-9,12-13,15H2,1H3,(H,27,29)/t16?,17?,18-,23?/m0/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
132n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099811
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (9...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CC2CCCC(C1)N2C1CCCCC1
Show InChI InChI=1S/C26H33BrN2O2/c1-31-25-22-13-6-5-12-21(22)24(27)16-23(25)26(30)28-17-14-19-10-7-11-20(15-17)29(19)18-8-3-2-4-9-18/h5-6,12-13,16-20H,2-4,7-11,14-15H2,1H3,(H,28,30)
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
150n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50099814
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid ((...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C23H23BrN2O2/c1-28-22-19-10-6-5-9-18(19)21(24)13-20(22)23(27)25-17-11-12-26(15-17)14-16-7-3-2-4-8-16/h2-10,13,17H,11-12,14-15H2,1H3,(H,25,27)/t17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
150n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone [0.5 nM (Kd=0.1 nM)] from human recombinant dopamine receptor D2L expressed in CHO cells


Bioorg Med Chem Lett 13: 3293-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00678-4
BindingDB Entry DOI: 10.7270/Q2639P5F
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50099814
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid ((...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C23H23BrN2O2/c1-28-22-19-10-6-5-9-18(19)21(24)13-20(22)23(27)25-17-11-12-26(15-17)14-16-7-3-2-4-8-16/h2-10,13,17H,11-12,14-15H2,1H3,(H,25,27)/t17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
150n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone [0.5 nM (Kd=0.2-0.45 nM)] from human recombinant dopamine receptor D2S expressed in CHO cells at 0.5 nM concentration


Bioorg Med Chem Lett 13: 3293-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00678-4
BindingDB Entry DOI: 10.7270/Q2639P5F
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099801
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (9...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)NC1CC2CCCC(C1)N2C1CCCCCC1
Show InChI InChI=1S/C27H35BrN2O2/c1-32-26-23-14-7-6-13-22(23)25(28)17-24(26)27(31)29-18-15-20-11-8-12-21(16-18)30(20)19-9-4-2-3-5-10-19/h6-7,13-14,17-21H,2-5,8-12,15-16H2,1H3,(H,29,31)
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
152n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50099814
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid ((...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C23H23BrN2O2/c1-28-22-19-10-6-5-9-18(19)21(24)13-20(22)23(27)25-17-11-12-26(15-17)14-16-7-3-2-4-8-16/h2-10,13,17H,11-12,14-15H2,1H3,(H,25,27)/t17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
180n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone [0.5 nM (Kd=0.1 nM)] from human recombinant dopamine receptor D2L expressed in CHO cells


Bioorg Med Chem Lett 13: 3293-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00678-4
BindingDB Entry DOI: 10.7270/Q2639P5F
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50099814
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid ((...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C23H23BrN2O2/c1-28-22-19-10-6-5-9-18(19)21(24)13-20(22)23(27)25-17-11-12-26(15-17)14-16-7-3-2-4-8-16/h2-10,13,17H,11-12,14-15H2,1H3,(H,25,27)/t17-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
250n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone [0.5 nM (Kd=0.1 nM)] from recombinant human dopamine receptor D3 expressed in CHO cells at 0.5 nM concentration


Bioorg Med Chem Lett 13: 3293-6 (2003)


Article DOI: 10.1016/s0960-894x(03)00678-4
BindingDB Entry DOI: 10.7270/Q2639P5F
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50099802
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@@H]1CCN(C1)C1CCCC1
Show InChI InChI=1S/C21H25BrN2O2/c1-26-20-17-9-5-4-8-16(17)19(22)12-18(20)21(25)23-14-10-11-24(13-14)15-6-2-3-7-15/h4-5,8-9,12,14-15H,2-3,6-7,10-11,13H2,1H3,(H,23,25)/t14-/m1/s1
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
283n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for dopamine receptor D2 long expressed in Sf9 cells using [125I]-IABN radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50099793
PNG
(4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1...)
Show SMILES COc1c(cc(Br)c2ccccc12)C(=O)N[C@H]1CCN(C1)C1C2CCCC1CCC2
Show InChI InChI=1S/C25H31BrN2O2/c1-30-24-20-11-3-2-10-19(20)22(26)14-21(24)25(29)27-18-12-13-28(15-18)23-16-6-4-7-17(23)9-5-8-16/h2-3,10-11,14,16-18,23H,4-9,12-13,15H2,1H3,(H,27,29)/t16?,17?,18-,23?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
400n/an/an/an/an/an/an/an/a



Wake Forest University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for sigma-1 receptor measured on guinea pig brain membranes using [3H]-(+)-pentazocine as radioligand.


J Med Chem 44: 1815-26 (2001)


Article DOI: 10.1021/jm0100077
BindingDB Entry DOI: 10.7270/Q2NK3DBZ
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 55 total )  |  Next  |  Last  >>