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6 similar compounds to monomer 50119022

Compile data set for download or QSAR
Wt: 320.3
BDBM50119009
Wt: 354.7
BDBM50119015
Wt: 334.3
BDBM50119031
Wt: 350.3
BDBM50119034
Wt: 350.3
BDBM50119037
Wt: 334.3
BDBM50119042

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50119009,50119015,50119031,50119034,50119037,50119042   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50119015
PNG
((E)-3-(4-Chloro-phenyl)-N-(3-methoxy-4-oxazol-5-yl...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccc(Cl)cc2)ccc1-c1cnco1
Show InChI InChI=1S/C19H15ClN2O3/c1-24-17-10-15(7-8-16(17)18-11-21-12-25-18)22-19(23)9-4-13-2-5-14(20)6-3-13/h2-12H,1H3,(H,22,23)/b9-4+
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n/an/a 230n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2


Bioorg Med Chem Lett 12: 2879-82 (2002)


Article DOI: 10.1016/s0960-894x(02)00601-7
BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50119009
PNG
((E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-phenyl-ac...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccccc2)ccc1-c1cnco1
Show InChI InChI=1S/C19H16N2O3/c1-23-17-11-15(8-9-16(17)18-12-20-13-24-18)21-19(22)10-7-14-5-3-2-4-6-14/h2-13H,1H3,(H,21,22)/b10-7+
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Article
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n/an/a 73n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2


Bioorg Med Chem Lett 12: 2879-82 (2002)


Article DOI: 10.1016/s0960-894x(02)00601-7
BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50119031
PNG
((E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-p-tolyl-a...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccc(C)cc2)ccc1-c1cnco1
Show InChI InChI=1S/C20H18N2O3/c1-14-3-5-15(6-4-14)7-10-20(23)22-16-8-9-17(18(11-16)24-2)19-12-21-13-25-19/h3-13H,1-2H3,(H,22,23)/b10-7+
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n/an/a 210n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2


Bioorg Med Chem Lett 12: 2879-82 (2002)


Article DOI: 10.1016/s0960-894x(02)00601-7
BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50119034
PNG
((E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-(2-methox...)
Show SMILES COc1ccccc1\C=C\C(=O)Nc1ccc(-c2cnco2)c(OC)c1
Show InChI InChI=1S/C20H18N2O4/c1-24-17-6-4-3-5-14(17)7-10-20(23)22-15-8-9-16(18(11-15)25-2)19-12-21-13-26-19/h3-13H,1-2H3,(H,22,23)/b10-7+
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2


Bioorg Med Chem Lett 12: 2879-82 (2002)


Article DOI: 10.1016/s0960-894x(02)00601-7
BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50119037
PNG
((Z)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-(2-methox...)
Show SMILES COc1ccccc1\C=C/C(=O)Nc1ccc(-c2cnco2)c(OC)c1
Show InChI InChI=1S/C20H18N2O4/c1-24-17-6-4-3-5-14(17)7-10-20(23)22-15-8-9-16(18(11-15)25-2)19-12-21-13-26-19/h3-13H,1-2H3,(H,22,23)/b10-7-
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n/an/a 960n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2


Bioorg Med Chem Lett 12: 2879-82 (2002)


Article DOI: 10.1016/s0960-894x(02)00601-7
BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50119042
PNG
((E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-o-tolyl-a...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccccc2C)ccc1-c1cnco1
Show InChI InChI=1S/C20H18N2O3/c1-14-5-3-4-6-15(14)7-10-20(23)22-16-8-9-17(18(11-16)24-2)19-12-21-13-25-19/h3-13H,1-2H3,(H,22,23)/b10-7+
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n/an/a 35n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2


Bioorg Med Chem Lett 12: 2879-82 (2002)


Article DOI: 10.1016/s0960-894x(02)00601-7
BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair