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5 similar compounds to monomer 50119121

Compile data set for download or QSAR
Wt: 334.3
BDBM50119115
Wt: 347.3
BDBM50119119
Wt: 347.3
BDBM50119122
Wt: 333.3
BDBM50119130
Wt: 347.3
BDBM50119112

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50119115,50119119,50119122,50119130,50119112   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50119112
PNG
(CHEMBL98700 | N''-cyano-N-[3-methoxy-4-(1,3-oxazol...)
Show SMILES COc1cc(NC(Nc2ccc(C)cc2)=NC#N)ccc1-c1cnco1
Show InChI InChI=1S/C19H17N5O2/c1-13-3-5-14(6-4-13)23-19(22-11-20)24-15-7-8-16(17(9-15)25-2)18-10-21-12-26-18/h3-10,12H,1-2H3,(H2,22,23,24)
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PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2.


Bioorg Med Chem Lett 12: 2931-4 (2002)


Article DOI: 10.1016/s0960-894x(02)00600-5
BindingDB Entry DOI: 10.7270/Q2SB454K
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50119115
PNG
(CHEMBL101822 | N''-cyano-N-[3-methoxy-4-(1,3-oxazo...)
Show SMILES COc1cc(NC(Nc2cccnc2)=NC#N)ccc1-c1cnco1
Show InChI InChI=1S/C17H14N6O2/c1-24-15-7-12(4-5-14(15)16-9-20-11-25-16)22-17(21-10-18)23-13-3-2-6-19-8-13/h2-9,11H,1H3,(H2,21,22,23)
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Article
PubMed
n/an/a 320n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2.


Bioorg Med Chem Lett 12: 2931-4 (2002)


Article DOI: 10.1016/s0960-894x(02)00600-5
BindingDB Entry DOI: 10.7270/Q2SB454K
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50119130
PNG
(CHEMBL60730 | N''-cyano-N-[3-methoxy-4-(1,3-oxazol...)
Show SMILES COc1cc(NC(Nc2ccccc2)=NC#N)ccc1-c1cnco1
Show InChI InChI=1S/C18H15N5O2/c1-24-16-9-14(7-8-15(16)17-10-20-12-25-17)23-18(21-11-19)22-13-5-3-2-4-6-13/h2-10,12H,1H3,(H2,21,22,23)
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Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2.


Bioorg Med Chem Lett 13: 2059-63 (2003)


Article DOI: 10.1016/s0960-894x(03)00258-0
BindingDB Entry DOI: 10.7270/Q22Z14X1
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50119122
PNG
(CHEMBL316946 | N''-cyano-N-[3-methoxy-4-(1,3-oxazo...)
Show SMILES COc1cc(NC(Nc2ccccc2C)=NC#N)ccc1-c1cnco1
Show InChI InChI=1S/C19H17N5O2/c1-13-5-3-4-6-16(13)24-19(22-11-20)23-14-7-8-15(17(9-14)25-2)18-10-21-12-26-18/h3-10,12H,1-2H3,(H2,22,23,24)
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PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2.


Bioorg Med Chem Lett 12: 2931-4 (2002)


Article DOI: 10.1016/s0960-894x(02)00600-5
BindingDB Entry DOI: 10.7270/Q2SB454K
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50119130
PNG
(CHEMBL60730 | N''-cyano-N-[3-methoxy-4-(1,3-oxazol...)
Show SMILES COc1cc(NC(Nc2ccccc2)=NC#N)ccc1-c1cnco1
Show InChI InChI=1S/C18H15N5O2/c1-24-16-9-14(7-8-15(16)17-10-20-12-25-17)23-18(21-11-19)22-13-5-3-2-4-6-13/h2-10,12H,1H3,(H2,21,22,23)
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Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2.


Bioorg Med Chem Lett 12: 2931-4 (2002)


Article DOI: 10.1016/s0960-894x(02)00600-5
BindingDB Entry DOI: 10.7270/Q2SB454K
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50119119
PNG
(CHEMBL98740 | N''-cyano-N-[3-methoxy-4-(1,3-oxazol...)
Show SMILES COc1cc(NC(Nc2cccc(C)c2)=NC#N)ccc1-c1cnco1
Show InChI InChI=1S/C19H17N5O2/c1-13-4-3-5-14(8-13)23-19(22-11-20)24-15-6-7-16(17(9-15)25-2)18-10-21-12-26-18/h3-10,12H,1-2H3,(H2,22,23,24)
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Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2.


Bioorg Med Chem Lett 12: 2931-4 (2002)


Article DOI: 10.1016/s0960-894x(02)00600-5
BindingDB Entry DOI: 10.7270/Q2SB454K
More data for this
Ligand-Target Pair