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42 similar compounds to monomer 50199456

Compile data set for download or QSAR
Wt: 428.2
BDBM50137410
Wt: 379.3
BDBM50137411
Wt: 381.3
BDBM50137412
Wt: 401.7
BDBM50137413
Wt: 383.8
BDBM50137414
Wt: 411.3
BDBM50137415
Wt: 385.3
BDBM50137416
Wt: 377.4
BDBM50137417
Wt: 363.3
BDBM50137418
Wt: 446.2
BDBM50137419
Wt: 411.3
BDBM50137420
Wt: 415.3
BDBM50137421
Wt: 397.3
BDBM50137422
Wt: 383.8
BDBM50137423
Wt: 349.3
BDBM50137425
Displayed 1 to 15 (of 42 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50137410,50137411,50137412,50137413,50137414,50137415,50137416,50137417,50137418,50137419,50137420,50137421,50137422,50137423,50137425   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclooxygenase-1


(Canis familiaris)
BDBM50137413
PNG
(2-[5-(4-Chloro-phenyl)-3-trifluoromethyl-pyrazol-1...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C16H11ClF3N3O2S/c1-26(24,25)12-6-7-15(21-9-12)23-13(8-14(22-23)16(18,19)20)10-2-4-11(17)5-3-10/h2-9H,1H3
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n/an/a 1.94E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137425
PNG
(2-(3-(difluoromethyl)-5-phenyl-1H-pyrazol-1-yl)-5-...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccccc1)C(F)F
Show InChI InChI=1S/C16H13F2N3O2S/c1-24(22,23)12-7-8-15(19-10-12)21-14(9-13(20-21)16(17)18)11-5-3-2-4-6-11/h2-10,16H,1H3
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n/an/a 310n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX2 by canine whole blood assay


Bioorg Med Chem Lett 16: 1202-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.110
BindingDB Entry DOI: 10.7270/Q2FT8KKM
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137415
PNG
(5-Methanesulfonyl-2-[5-(4-methoxy-3-methyl-phenyl)...)
Show SMILES COc1ccc(cc1C)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C18H16F3N3O3S/c1-11-8-12(4-6-15(11)27-2)14-9-16(18(19,20)21)23-24(14)17-7-5-13(10-22-17)28(3,25)26/h4-10H,1-3H3
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n/an/a 4.07E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137420
PNG
(2-[5-(4-Ethoxy-phenyl)-3-trifluoromethyl-pyrazol-1...)
Show SMILES CCOc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C18H16F3N3O3S/c1-3-27-13-6-4-12(5-7-13)15-10-16(18(19,20)21)23-24(15)17-9-8-14(11-22-17)28(2,25)26/h4-11H,3H2,1-2H3
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n/an/a 50n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137422
PNG
(2-[3-Difluoromethyl-5-(2-fluoro-4-methoxy-phenyl)-...)
Show SMILES COc1ccc(-c2cc(nn2-c2ccc(cn2)S(C)(=O)=O)C(F)F)c(F)c1
Show InChI InChI=1S/C17H14F3N3O3S/c1-26-10-3-5-12(13(18)7-10)15-8-14(17(19)20)22-23(15)16-6-4-11(9-21-16)27(2,24)25/h3-9,17H,1-2H3
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n/an/a 3.64E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137421
PNG
(2-[5-(3-Fluoro-4-methoxy-phenyl)-3-trifluoromethyl...)
Show SMILES COc1ccc(cc1F)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H13F4N3O3S/c1-27-14-5-3-10(7-12(14)18)13-8-15(17(19,20)21)23-24(13)16-6-4-11(9-22-16)28(2,25)26/h3-9H,1-2H3
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n/an/a 4.78E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137416
PNG
(2-(5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyraz...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C16H11F4N3O2S/c1-26(24,25)12-6-7-15(21-9-12)23-13(8-14(22-23)16(18,19)20)10-2-4-11(17)5-3-10/h2-9H,1H3
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n/an/a 2.79E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137417
PNG
(2-[3-Difluoromethyl-5-(4-ethyl-phenyl)-pyrazol-1-y...)
Show SMILES CCc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C18H17F2N3O2S/c1-3-12-4-6-13(7-5-12)16-10-15(18(19)20)22-23(16)17-9-8-14(11-21-17)26(2,24)25/h4-11,18H,3H2,1-2H3
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n/an/a 1.20E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137418
PNG
(2-(3-Difluoromethyl-5-p-tolyl-pyrazol-1-yl)-5-meth...)
Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C17H15F2N3O2S/c1-11-3-5-12(6-4-11)15-9-14(17(18)19)21-22(15)16-8-7-13(10-20-16)25(2,23)24/h3-10,17H,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137411
PNG
(2-[3-Difluoromethyl-5-(4-methoxy-phenyl)-pyrazol-1...)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C17H15F2N3O3S/c1-25-12-5-3-11(4-6-12)15-9-14(17(18)19)21-22(15)16-8-7-13(10-20-16)26(2,23)24/h3-10,17H,1-2H3
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n/an/a 200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137425
PNG
(2-(3-(difluoromethyl)-5-phenyl-1H-pyrazol-1-yl)-5-...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccccc1)C(F)F
Show InChI InChI=1S/C16H13F2N3O2S/c1-24(22,23)12-7-8-15(19-10-12)21-14(9-13(20-21)16(17)18)11-5-3-2-4-6-11/h2-10,16H,1H3
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n/an/a 4.80E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137423
PNG
(2-(4-Chloro-3-difluoromethyl-5-phenyl-pyrazol-1-yl...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(C(F)F)c(Cl)c1-c1ccccc1
Show InChI InChI=1S/C16H12ClF2N3O2S/c1-25(23,24)11-7-8-12(20-9-11)22-15(10-5-3-2-4-6-10)13(17)14(21-22)16(18)19/h2-9,16H,1H3
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n/an/a 330n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137412
PNG
(5-Methanesulfonyl-2-(4-methyl-5-phenyl-3-trifluoro...)
Show SMILES Cc1c(nn(c1-c1ccccc1)-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2S/c1-11-15(12-6-4-3-5-7-12)23(22-16(11)17(18,19)20)14-9-8-13(10-21-14)26(2,24)25/h3-10H,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137419
PNG
(2-[5-(4-Bromo-phenyl)-3-trifluoromethyl-pyrazol-1-...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(Br)cc1)C(F)(F)F
Show InChI InChI=1S/C16H11BrF3N3O2S/c1-26(24,25)12-6-7-15(21-9-12)23-13(8-14(22-23)16(18,19)20)10-2-4-11(17)5-3-10/h2-9H,1H3
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n/an/a 2.86E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137410
PNG
(2-[5-(4-Bromo-phenyl)-3-difluoromethyl-pyrazol-1-y...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(Br)cc1)C(F)F
Show InChI InChI=1S/C16H12BrF2N3O2S/c1-25(23,24)12-6-7-15(20-9-12)22-14(8-13(21-22)16(18)19)10-2-4-11(17)5-3-10/h2-9,16H,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137425
PNG
(2-(3-(difluoromethyl)-5-phenyl-1H-pyrazol-1-yl)-5-...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccccc1)C(F)F
Show InChI InChI=1S/C16H13F2N3O2S/c1-24(22,23)12-7-8-15(19-10-12)21-14(9-13(20-21)16(17)18)11-5-3-2-4-6-11/h2-10,16H,1H3
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n/an/a 4.80E+4n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against COX1 in canine whole blood


Bioorg Med Chem Lett 16: 288-92 (2005)


Article DOI: 10.1016/j.bmcl.2005.10.006
BindingDB Entry DOI: 10.7270/Q2NZ876S
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137412
PNG
(5-Methanesulfonyl-2-(4-methyl-5-phenyl-3-trifluoro...)
Show SMILES Cc1c(nn(c1-c1ccccc1)-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2S/c1-11-15(12-6-4-3-5-7-12)23(22-16(11)17(18,19)20)14-9-8-13(10-21-14)26(2,24)25/h3-10H,1-2H3
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n/an/a 170n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137416
PNG
(2-(5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyraz...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(F)cc1)C(F)(F)F
Show InChI InChI=1S/C16H11F4N3O2S/c1-26(24,25)12-6-7-15(21-9-12)23-13(8-14(22-23)16(18,19)20)10-2-4-11(17)5-3-10/h2-9H,1H3
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n/an/a 240n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137415
PNG
(5-Methanesulfonyl-2-[5-(4-methoxy-3-methyl-phenyl)...)
Show SMILES COc1ccc(cc1C)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C18H16F3N3O3S/c1-11-8-12(4-6-15(11)27-2)14-9-16(18(19,20)21)23-24(14)17-7-5-13(10-22-17)28(3,25)26/h4-10H,1-3H3
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n/an/a 270n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137417
PNG
(2-[3-Difluoromethyl-5-(4-ethyl-phenyl)-pyrazol-1-y...)
Show SMILES CCc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C18H17F2N3O2S/c1-3-12-4-6-13(7-5-12)16-10-15(18(19)20)22-23(16)17-9-8-14(11-21-17)26(2,24)25/h4-11,18H,3H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137418
PNG
(2-(3-Difluoromethyl-5-p-tolyl-pyrazol-1-yl)-5-meth...)
Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C17H15F2N3O2S/c1-11-3-5-12(6-4-11)15-9-14(17(18)19)21-22(15)16-8-7-13(10-20-16)25(2,23)24/h3-10,17H,1-2H3
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n/an/a 180n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137422
PNG
(2-[3-Difluoromethyl-5-(2-fluoro-4-methoxy-phenyl)-...)
Show SMILES COc1ccc(-c2cc(nn2-c2ccc(cn2)S(C)(=O)=O)C(F)F)c(F)c1
Show InChI InChI=1S/C17H14F3N3O3S/c1-26-10-3-5-12(13(18)7-10)15-8-14(17(19)20)22-23(15)16-6-4-11(9-21-16)27(2,24)25/h3-9,17H,1-2H3
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n/an/a 390n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137419
PNG
(2-[5-(4-Bromo-phenyl)-3-trifluoromethyl-pyrazol-1-...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(Br)cc1)C(F)(F)F
Show InChI InChI=1S/C16H11BrF3N3O2S/c1-26(24,25)12-6-7-15(21-9-12)23-13(8-14(22-23)16(18,19)20)10-2-4-11(17)5-3-10/h2-9H,1H3
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n/an/a 450n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137413
PNG
(2-[5-(4-Chloro-phenyl)-3-trifluoromethyl-pyrazol-1...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C16H11ClF3N3O2S/c1-26(24,25)12-6-7-15(21-9-12)23-13(8-14(22-23)16(18,19)20)10-2-4-11(17)5-3-10/h2-9H,1H3
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n/an/a 250n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137420
PNG
(2-[5-(4-Ethoxy-phenyl)-3-trifluoromethyl-pyrazol-1...)
Show SMILES CCOc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C18H16F3N3O3S/c1-3-27-13-6-4-12(5-7-13)15-10-16(18(19,20)21)23-24(15)17-9-8-14(11-22-17)28(2,25)26/h4-11H,3H2,1-2H3
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n/an/a 130n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137425
PNG
(2-(3-(difluoromethyl)-5-phenyl-1H-pyrazol-1-yl)-5-...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccccc1)C(F)F
Show InChI InChI=1S/C16H13F2N3O2S/c1-24(22,23)12-7-8-15(19-10-12)21-14(9-13(20-21)16(17)18)11-5-3-2-4-6-11/h2-10,16H,1H3
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n/an/a 310n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137414
PNG
(2-[5-(4-Chloro-phenyl)-3-difluoromethyl-pyrazol-1-...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(Cl)cc1)C(F)F
Show InChI InChI=1S/C16H12ClF2N3O2S/c1-25(23,24)12-6-7-15(20-9-12)22-14(8-13(21-22)16(18)19)10-2-4-11(17)5-3-10/h2-9,16H,1H3
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n/an/a 120n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137421
PNG
(2-[5-(3-Fluoro-4-methoxy-phenyl)-3-trifluoromethyl...)
Show SMILES COc1ccc(cc1F)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H13F4N3O3S/c1-27-14-5-3-10(7-12(14)18)13-8-15(17(19,20)21)23-24(13)16-6-4-11(9-22-16)28(2,25)26/h3-9H,1-2H3
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n/an/a 310n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137410
PNG
(2-[5-(4-Bromo-phenyl)-3-difluoromethyl-pyrazol-1-y...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(Br)cc1)C(F)F
Show InChI InChI=1S/C16H12BrF2N3O2S/c1-25(23,24)12-6-7-15(20-9-12)22-14(8-13(21-22)16(18)19)10-2-4-11(17)5-3-10/h2-9,16H,1H3
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n/an/a 290n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137411
PNG
(2-[3-Difluoromethyl-5-(4-methoxy-phenyl)-pyrazol-1...)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C17H15F2N3O3S/c1-25-12-5-3-11(4-6-12)15-9-14(17(18)19)21-22(15)16-8-7-13(10-20-16)26(2,23)24/h3-10,17H,1-2H3
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n/an/a 64n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137423
PNG
(2-(4-Chloro-3-difluoromethyl-5-phenyl-pyrazol-1-yl...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(C(F)F)c(Cl)c1-c1ccccc1
Show InChI InChI=1S/C16H12ClF2N3O2S/c1-25(23,24)11-7-8-12(20-9-11)22-15(10-5-3-2-4-6-10)13(17)14(21-22)16(18)19/h2-9,16H,1H3
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n/an/a 44n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair
Cyclooxygenase-2


(Canis familiaris)
BDBM50137425
PNG
(2-(3-(difluoromethyl)-5-phenyl-1H-pyrazol-1-yl)-5-...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccccc1)C(F)F
Show InChI InChI=1S/C16H13F2N3O2S/c1-24(22,23)12-7-8-15(19-10-12)21-14(9-13(20-21)16(17)18)11-5-3-2-4-6-11/h2-10,16H,1H3
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n/an/a 310n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against COX2 in canine whole blood


Bioorg Med Chem Lett 16: 288-92 (2005)


Article DOI: 10.1016/j.bmcl.2005.10.006
BindingDB Entry DOI: 10.7270/Q2NZ876S
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137414
PNG
(2-[5-(4-Chloro-phenyl)-3-difluoromethyl-pyrazol-1-...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(Cl)cc1)C(F)F
Show InChI InChI=1S/C16H12ClF2N3O2S/c1-25(23,24)12-6-7-15(20-9-12)22-14(8-13(21-22)16(18)19)10-2-4-11(17)5-3-10/h2-9,16H,1H3
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n/an/a 2.07E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.004
BindingDB Entry DOI: 10.7270/Q25B01WP
More data for this
Ligand-Target Pair