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11 similar compounds to monomer 50237599

Compile data set for download or QSAR
Wt: 451.4
BDBM50162140
Wt: 433.4
BDBM50162142
Wt: 469.4
BDBM50162147
Purchase
Wt: 451.4
BDBM50162148
Wt: 451.4
BDBM50162156
Wt: 469.4
BDBM50162160
Wt: 433.4
BDBM50162162
Wt: 451.4
BDBM50162163
Wt: 451.4
BDBM50162169
Wt: 451.4
BDBM50162170
Wt: 456.7
BDBM50237598

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50162140,50162142,50162147,50162148,50162156,50162160,50162162,50162163,50162169,50162170,50237598   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162147
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Meiji Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR2


J Nat Prod 77: 963-8 (2014)


Article DOI: 10.1021/np401046z
BindingDB Entry DOI: 10.7270/Q24F1S8T
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50237598
PNG
(CHEMBL395428)
Show SMILES CC1(C)CC[C@]2(C)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@@H](O)[C@@](C)([C@@H]5CC[C@@]34C)C(O)=O)[C@@H]2C1
Show InChI InChI=1S/C30H48O3/c1-25(2)14-15-26(3)16-17-28(5)19(20(26)18-25)8-9-21-27(4)12-11-23(31)30(7,24(32)33)22(27)10-13-29(21,28)6/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21+,22+,23+,26+,27+,28+,29+,30+/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Universidad de Chile

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX (unknown origin)


Bioorg Med Chem Lett 27: 1649-1653 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.017
BindingDB Entry DOI: 10.7270/Q22Z17TX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162142
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-17-20(14-23(22)31-2)26-12-11-21(17)32-16-9-7-15(8-10-16)27-24(29)28-19-6-4-3-5-18(19)25/h3-14H,1-2H3,(H2,27,28,29)
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n/an/a 0.5n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162162
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c2cc1OC
Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-11-10-21(19)32-18-8-6-16(7-9-18)27-24(29)28-17-5-3-4-15(25)12-17/h3-14H,1-2H3,(H2,27,28,29)
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n/an/a 1.20n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162147
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a 0.900n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2 in cell-intact assay


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162163
PNG
(1-(3,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)cc(F)c4)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-19-20(13-23(22)32-2)27-8-7-21(19)33-18-5-3-16(4-6-18)28-24(30)29-17-10-14(25)9-15(26)11-17/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 1.80n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162140
PNG
(1-(3,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)c(F)c4)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-3-14(4-7-16)28-24(30)29-15-5-8-18(25)19(26)11-15/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 1.10n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162169
PNG
(1-(2,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)ccc4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-19(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-20-11-14(25)3-8-18(20)26/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 0.400n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162148
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-19-8-3-14(25)11-18(19)26/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 0.700n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162147
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a 4n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2 in cell-free assay


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162156
PNG
(1-(2,3-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-18-5-3-4-17(25)23(18)26/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 0.700n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162160
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3F)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-19(12-23(22)33-2)28-8-7-20(15)34-21-6-4-14(10-17(21)27)29-24(31)30-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a<1n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50162147
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of epidermal growth factor receptor in cell-intact assay


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162142
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(2...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-17-20(14-23(22)31-2)26-12-11-21(17)32-16-9-7-15(8-10-16)27-24(29)28-19-6-4-3-5-18(19)25/h3-14H,1-2H3,(H2,27,28,29)
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n/an/a 3.90n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor alpha


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50162147
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a 40n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of proto-oncogene tyrosine-protein kinase kit in cell-intact assay


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162148
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-19-8-3-14(25)11-18(19)26/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 3.40n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor alpha


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162163
PNG
(1-(3,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)cc(F)c4)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-19-20(13-23(22)32-2)27-8-7-21(19)33-18-5-3-16(4-6-18)28-24(30)29-17-10-14(25)9-15(26)11-17/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 10n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor alpha


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 3


(Homo sapiens (Human))
BDBM50162147
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of mitogen activated protein kinase in cell-free assay


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50162147
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of epidermal growth factor receptor in cell-free assay


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162162
PNG
(1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenyl]-3-(3...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c2cc1OC
Show InChI InChI=1S/C24H20FN3O4/c1-30-22-13-19-20(14-23(22)31-2)26-11-10-21(19)32-18-8-6-16(7-9-18)27-24(29)28-17-5-3-4-15(25)12-17/h3-14H,1-2H3,(H2,27,28,29)
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n/an/a 6.40n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor alpha


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM50162147
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a 170n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of fibroblast growth factor receptor 2 in cell-intact assay


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50162147
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of hepatocyte growth factor receptor in cell-intact assay


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162160
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3F)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-19(12-23(22)33-2)28-8-7-20(15)34-21-6-4-14(10-17(21)27)29-24(31)30-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a 17n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor alpha in cell-intact assay


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162156
PNG
(1-(2,3-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-18-5-3-4-17(25)23(18)26/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 1.60n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor alpha


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162147
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a 67n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor alpha in cell-intact assay


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162170
PNG
(1-(2,6-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(F)cccc4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-23-17(25)4-3-5-18(23)26/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 3.5n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor alpha


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162169
PNG
(1-(2,5-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)ccc4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-19(13-23(22)32-2)27-10-9-21(17)33-16-6-4-15(5-7-16)28-24(30)29-20-11-14(25)3-8-18(20)26/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 4.70n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor alpha


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162140
PNG
(1-(3,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)c(F)c4)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-22-12-17-20(13-23(22)32-2)27-10-9-21(17)33-16-6-3-14(4-7-16)28-24(30)29-15-5-8-18(25)19(26)11-15/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 6.80n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor alpha


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50162160
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3F)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-19(12-23(22)33-2)28-8-7-20(15)34-21-6-4-14(10-17(21)27)29-24(31)30-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a>500n/an/an/an/an/an/a



Hadassah Hebrew University Hospital

Curated by ChEMBL


Assay Description
Inhibition of EGFR expressed in DHER14 cells by western blot analysis


Bioorg Med Chem 16: 4242-51 (2008)


Article DOI: 10.1016/j.bmc.2008.02.081
BindingDB Entry DOI: 10.7270/Q2B85903
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50162160
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3F)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-19(12-23(22)33-2)28-8-7-20(15)34-21-6-4-14(10-17(21)27)29-24(31)30-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a>500n/an/an/an/an/an/a



Hadassah Hebrew University Hospital

Curated by ChEMBL


Assay Description
Inhibition of Her2 expressed in CSH12 cells by western blot analysis


Bioorg Med Chem 16: 4242-51 (2008)


Article DOI: 10.1016/j.bmc.2008.02.081
BindingDB Entry DOI: 10.7270/Q2B85903
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50162160
PNG
(1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3F)c2cc1OC
Show InChI InChI=1S/C24H18F3N3O4/c1-32-22-11-15-19(12-23(22)33-2)28-8-7-20(15)34-21-6-4-14(10-17(21)27)29-24(31)30-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a>2.00E+3n/an/an/an/an/an/a



Hadassah Hebrew University Hospital

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by ELISA


Bioorg Med Chem 16: 4242-51 (2008)


Article DOI: 10.1016/j.bmc.2008.02.081
BindingDB Entry DOI: 10.7270/Q2B85903
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162170
PNG
(1-(2,6-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(F)cccc4F)cc3)c2cc1OC
Show InChI InChI=1S/C24H19F2N3O4/c1-31-21-12-16-19(13-22(21)32-2)27-11-10-20(16)33-15-8-6-14(7-9-15)28-24(30)29-23-17(25)4-3-5-18(23)26/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 1.80n/an/an/an/an/an/a



Kirin Brewery Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor receptor 2


J Med Chem 48: 1359-66 (2005)


Article DOI: 10.1021/jm030427r
BindingDB Entry DOI: 10.7270/Q23J3CG1
More data for this
Ligand-Target Pair