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46 similar compounds to monomer 50169872

Compile data set for download or QSAR
Wt: 383.4
BDBM50169849
Wt: 367.4
BDBM50169850
Wt: 397.4
BDBM50169851
Wt: 397.4
BDBM50169852
Wt: 369.4
BDBM50169853
Wt: 410.5
BDBM50169854
Wt: 395.4
BDBM50169855
Wt: 410.5
BDBM50169856
Wt: 369.4
BDBM50169857
Wt: 383.4
BDBM50169858
Wt: 383.4
BDBM50169859
Wt: 355.4
BDBM50169860
Wt: 355.4
BDBM50169861
Wt: 396.4
BDBM50169862
Wt: 381.4
BDBM50169863
Displayed 1 to 15 (of 46 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50169849,50169850,50169851,50169852,50169853,50169854,50169855,50169856,50169857,50169858,50169859,50169860,50169861,50169862,50169863   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetylcholinesterase


(Homo sapiens (Human))
BDBM50169850
PNG
(5,6-Dimethoxy-2-(4-pyrrolidin-1-ylmethyl-phenoxy)-...)
Show SMILES COc1cc2CC(Oc3ccc(CN4CCCC4)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C22H25NO4/c1-25-19-11-16-12-21(22(24)18(16)13-20(19)26-2)27-17-7-5-15(6-8-17)14-23-9-3-4-10-23/h5-8,11,13,21H,3-4,9-10,12,14H2,1-2H3
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n/an/a 50n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of AChE


Bioorg Med Chem 19: 7158-67 (2011)


Article DOI: 10.1016/j.bmc.2011.09.061
BindingDB Entry DOI: 10.7270/Q24F1R52
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169852
PNG
(5,6-Dimethoxy-2-[4-(1-morpholin-4-yl-ethyl)-phenox...)
Show SMILES COc1cc2CC(Oc3ccc(cc3)C(C)N3CCOCC3)C(=O)c2cc1OC
Show InChI InChI=1S/C23H27NO5/c1-15(24-8-10-28-11-9-24)16-4-6-18(7-5-16)29-22-13-17-12-20(26-2)21(27-3)14-19(17)23(22)25/h4-7,12,14-15,22H,8-11,13H2,1-3H3
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n/an/a 3.14E+3n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169849
PNG
(5,6-Dimethoxy-2-(3-morpholin-4-ylmethyl-phenoxy)-i...)
Show SMILES COc1cc2CC(Oc3cccc(CN4CCOCC4)c3)C(=O)c2cc1OC
Show InChI InChI=1S/C22H25NO5/c1-25-19-11-16-12-21(22(24)18(16)13-20(19)26-2)28-17-5-3-4-15(10-17)14-23-6-8-27-9-7-23/h3-5,10-11,13,21H,6-9,12,14H2,1-2H3
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n/an/a 1.46E+4n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169851
PNG
(5,6-Dimethoxy-2-[3-(1-morpholin-4-yl-ethyl)-phenox...)
Show SMILES COc1cc2CC(Oc3cccc(c3)C(C)N3CCOCC3)C(=O)c2cc1OC
Show InChI InChI=1S/C23H27NO5/c1-15(24-7-9-28-10-8-24)16-5-4-6-18(11-16)29-22-13-17-12-20(26-2)21(27-3)14-19(17)23(22)25/h4-6,11-12,14-15,22H,7-10,13H2,1-3H3
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n/an/a 2.47E+5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169853
PNG
(2-(3-Diethylaminomethyl-phenoxy)-5,6-dimethoxy-ind...)
Show SMILES CCN(CC)Cc1cccc(OC2Cc3cc(OC)c(OC)cc3C2=O)c1
Show InChI InChI=1S/C22H27NO4/c1-5-23(6-2)14-15-8-7-9-17(10-15)27-21-12-16-11-19(25-3)20(26-4)13-18(16)22(21)24/h7-11,13,21H,5-6,12,14H2,1-4H3
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n/an/a 1.90E+5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169853
PNG
(2-(3-Diethylaminomethyl-phenoxy)-5,6-dimethoxy-ind...)
Show SMILES CCN(CC)Cc1cccc(OC2Cc3cc(OC)c(OC)cc3C2=O)c1
Show InChI InChI=1S/C22H27NO4/c1-5-23(6-2)14-15-8-7-9-17(10-15)27-21-12-16-11-19(25-3)20(26-4)13-18(16)22(21)24/h7-11,13,21H,5-6,12,14H2,1-4H3
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n/an/a 2.28E+3n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169852
PNG
(5,6-Dimethoxy-2-[4-(1-morpholin-4-yl-ethyl)-phenox...)
Show SMILES COc1cc2CC(Oc3ccc(cc3)C(C)N3CCOCC3)C(=O)c2cc1OC
Show InChI InChI=1S/C23H27NO5/c1-15(24-8-10-28-11-9-24)16-4-6-18(7-5-16)29-22-13-17-12-20(26-2)21(27-3)14-19(17)23(22)25/h4-7,12,14-15,22H,8-11,13H2,1-3H3
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n/an/a 3.46E+5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169854
PNG
(5,6-Dimethoxy-2-{4-[1-(4-methyl-piperazin-1-yl)-et...)
Show SMILES COc1cc2CC(Oc3ccc(cc3)C(C)N3CCN(C)CC3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H30N2O4/c1-16(26-11-9-25(2)10-12-26)17-5-7-19(8-6-17)30-23-14-18-13-21(28-3)22(29-4)15-20(18)24(23)27/h5-8,13,15-16,23H,9-12,14H2,1-4H3
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n/an/a 3.93E+5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169855
PNG
(5,6-Dimethoxy-2-[3-(1-piperidin-1-yl-ethyl)-phenox...)
Show SMILES COc1cc2CC(Oc3cccc(c3)C(C)N3CCCCC3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H29NO4/c1-16(25-10-5-4-6-11-25)17-8-7-9-19(12-17)29-23-14-18-13-21(27-2)22(28-3)15-20(18)24(23)26/h7-9,12-13,15-16,23H,4-6,10-11,14H2,1-3H3
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n/an/a 1.58E+5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169849
PNG
(5,6-Dimethoxy-2-(3-morpholin-4-ylmethyl-phenoxy)-i...)
Show SMILES COc1cc2CC(Oc3cccc(CN4CCOCC4)c3)C(=O)c2cc1OC
Show InChI InChI=1S/C22H25NO5/c1-25-19-11-16-12-21(22(24)18(16)13-20(19)26-2)28-17-5-3-4-15(10-17)14-23-6-8-27-9-7-23/h3-5,10-11,13,21H,6-9,12,14H2,1-2H3
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n/an/a 2.19E+5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169850
PNG
(5,6-Dimethoxy-2-(4-pyrrolidin-1-ylmethyl-phenoxy)-...)
Show SMILES COc1cc2CC(Oc3ccc(CN4CCCC4)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C22H25NO4/c1-25-19-11-16-12-21(22(24)18(16)13-20(19)26-2)27-17-7-5-15(6-8-17)14-23-9-3-4-10-23/h5-8,11,13,21H,3-4,9-10,12,14H2,1-2H3
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n/an/a 50n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169856
PNG
(5,6-Dimethoxy-2-{3-[1-(4-methyl-piperazin-1-yl)-et...)
Show SMILES COc1cc2CC(Oc3cccc(c3)C(C)N3CCN(C)CC3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H30N2O4/c1-16(26-10-8-25(2)9-11-26)17-6-5-7-19(12-17)30-23-14-18-13-21(28-3)22(29-4)15-20(18)24(23)27/h5-7,12-13,15-16,23H,8-11,14H2,1-4H3
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n/an/a 2.52E+5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169857
PNG
(2-(4-Diethylaminomethyl-phenoxy)-5,6-dimethoxy-ind...)
Show SMILES CCN(CC)Cc1ccc(OC2Cc3cc(OC)c(OC)cc3C2=O)cc1
Show InChI InChI=1S/C22H27NO4/c1-5-23(6-2)14-15-7-9-17(10-8-15)27-21-12-16-11-19(25-3)20(26-4)13-18(16)22(21)24/h7-11,13,21H,5-6,12,14H2,1-4H3
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n/an/a 100n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169858
PNG
(5,6-Dimethoxy-2-(4-morpholin-4-ylmethyl-phenoxy)-i...)
Show SMILES COc1cc2CC(Oc3ccc(CN4CCOCC4)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C22H25NO5/c1-25-19-11-16-12-21(22(24)18(16)13-20(19)26-2)28-17-5-3-15(4-6-17)14-23-7-9-27-10-8-23/h3-6,11,13,21H,7-10,12,14H2,1-2H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169860
PNG
(2-[4-(1-Dimethylamino-ethyl)-phenoxy]-5,6-dimethox...)
Show SMILES COc1cc2CC(Oc3ccc(cc3)C(C)N(C)C)C(=O)c2cc1OC
Show InChI InChI=1S/C21H25NO4/c1-13(22(2)3)14-6-8-16(9-7-14)26-20-11-15-10-18(24-4)19(25-5)12-17(15)21(20)23/h6-10,12-13,20H,11H2,1-5H3
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n/an/a 1.37E+6n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169859
PNG
(2-[4-(1-Diethylamino-ethyl)-phenoxy]-5,6-dimethoxy...)
Show SMILES CCN(CC)C(C)c1ccc(OC2Cc3cc(OC)c(OC)cc3C2=O)cc1
Show InChI InChI=1S/C23H29NO4/c1-6-24(7-2)15(3)16-8-10-18(11-9-16)28-22-13-17-12-20(26-4)21(27-5)14-19(17)23(22)25/h8-12,14-15,22H,6-7,13H2,1-5H3
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n/an/a 2.34E+5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169857
PNG
(2-(4-Diethylaminomethyl-phenoxy)-5,6-dimethoxy-ind...)
Show SMILES CCN(CC)Cc1ccc(OC2Cc3cc(OC)c(OC)cc3C2=O)cc1
Show InChI InChI=1S/C22H27NO4/c1-5-23(6-2)14-15-7-9-17(10-8-15)27-21-12-16-11-19(25-3)20(26-4)13-18(16)22(21)24/h7-11,13,21H,5-6,12,14H2,1-4H3
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n/an/a 2.51E+5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169861
PNG
(2-[3-(1-Dimethylamino-ethyl)-phenoxy]-5,6-dimethox...)
Show SMILES COc1cc2CC(Oc3cccc(c3)C(C)N(C)C)C(=O)c2cc1OC
Show InChI InChI=1S/C21H25NO4/c1-13(22(2)3)14-7-6-8-16(9-14)26-20-11-15-10-18(24-4)19(25-5)12-17(15)21(20)23/h6-10,12-13,20H,11H2,1-5H3
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n/an/a 820n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169854
PNG
(5,6-Dimethoxy-2-{4-[1-(4-methyl-piperazin-1-yl)-et...)
Show SMILES COc1cc2CC(Oc3ccc(cc3)C(C)N3CCN(C)CC3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H30N2O4/c1-16(26-11-9-25(2)10-12-26)17-5-7-19(8-6-17)30-23-14-18-13-21(28-3)22(29-4)15-20(18)24(23)27/h5-8,13,15-16,23H,9-12,14H2,1-4H3
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n/an/a 2.98E+3n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169862
PNG
(5,6-Dimethoxy-2-[3-(4-methyl-piperazin-1-ylmethyl)...)
Show SMILES COc1cc2CC(Oc3cccc(CN4CCN(C)CC4)c3)C(=O)c2cc1OC
Show InChI InChI=1S/C23H28N2O4/c1-24-7-9-25(10-8-24)15-16-5-4-6-18(11-16)29-22-13-17-12-20(27-2)21(28-3)14-19(17)23(22)26/h4-6,11-12,14,22H,7-10,13,15H2,1-3H3
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n/an/a 2.09E+5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169863
PNG
(5,6-Dimethoxy-2-(4-piperidin-1-ylmethyl-phenoxy)-i...)
Show SMILES COc1cc2CC(Oc3ccc(CN4CCCCC4)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C23H27NO4/c1-26-20-12-17-13-22(23(25)19(17)14-21(20)27-2)28-18-8-6-16(7-9-18)15-24-10-4-3-5-11-24/h6-9,12,14,22H,3-5,10-11,13,15H2,1-2H3
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n/an/a 2.62E+5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169855
PNG
(5,6-Dimethoxy-2-[3-(1-piperidin-1-yl-ethyl)-phenox...)
Show SMILES COc1cc2CC(Oc3cccc(c3)C(C)N3CCCCC3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H29NO4/c1-16(25-10-5-4-6-11-25)17-8-7-9-19(12-17)29-23-14-18-13-21(27-2)22(28-3)15-20(18)24(23)26/h7-9,12-13,15-16,23H,4-6,10-11,14H2,1-3H3
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n/an/a 3.58E+3n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169861
PNG
(2-[3-(1-Dimethylamino-ethyl)-phenoxy]-5,6-dimethox...)
Show SMILES COc1cc2CC(Oc3cccc(c3)C(C)N(C)C)C(=O)c2cc1OC
Show InChI InChI=1S/C21H25NO4/c1-13(22(2)3)14-7-6-8-16(9-14)26-20-11-15-10-18(24-4)19(25-5)12-17(15)21(20)23/h6-10,12-13,20H,11H2,1-5H3
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n/an/a 2.88E+5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169863
PNG
(5,6-Dimethoxy-2-(4-piperidin-1-ylmethyl-phenoxy)-i...)
Show SMILES COc1cc2CC(Oc3ccc(CN4CCCCC4)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C23H27NO4/c1-26-20-12-17-13-22(23(25)19(17)14-21(20)27-2)28-18-8-6-16(7-9-18)15-24-10-4-3-5-11-24/h6-9,12,14,22H,3-5,10-11,13,15H2,1-2H3
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n/an/a 150n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169858
PNG
(5,6-Dimethoxy-2-(4-morpholin-4-ylmethyl-phenoxy)-i...)
Show SMILES COc1cc2CC(Oc3ccc(CN4CCOCC4)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C22H25NO5/c1-25-19-11-16-12-21(22(24)18(16)13-20(19)26-2)28-17-5-3-15(4-6-17)14-23-7-9-27-10-8-23/h3-6,11,13,21H,7-10,12,14H2,1-2H3
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n/an/a 3.84E+5n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169859
PNG
(2-[4-(1-Diethylamino-ethyl)-phenoxy]-5,6-dimethoxy...)
Show SMILES CCN(CC)C(C)c1ccc(OC2Cc3cc(OC)c(OC)cc3C2=O)cc1
Show InChI InChI=1S/C23H29NO4/c1-6-24(7-2)15(3)16-8-10-18(11-9-16)28-22-13-17-12-20(26-4)21(27-5)14-19(17)23(22)25/h8-12,14-15,22H,6-7,13H2,1-5H3
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n/an/a 220n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169862
PNG
(5,6-Dimethoxy-2-[3-(4-methyl-piperazin-1-ylmethyl)...)
Show SMILES COc1cc2CC(Oc3cccc(CN4CCN(C)CC4)c3)C(=O)c2cc1OC
Show InChI InChI=1S/C23H28N2O4/c1-24-7-9-25(10-8-24)15-16-5-4-6-18(11-16)29-22-13-17-12-20(27-2)21(28-3)14-19(17)23(22)26/h4-6,11-12,14,22H,7-10,13,15H2,1-3H3
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n/an/a 6.41E+3n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169851
PNG
(5,6-Dimethoxy-2-[3-(1-morpholin-4-yl-ethyl)-phenox...)
Show SMILES COc1cc2CC(Oc3cccc(c3)C(C)N3CCOCC3)C(=O)c2cc1OC
Show InChI InChI=1S/C23H27NO5/c1-15(24-7-9-28-10-8-24)16-5-4-6-18(11-16)29-22-13-17-12-20(26-2)21(27-3)14-19(17)23(22)25/h4-6,11-12,14-15,22H,7-10,13H2,1-3H3
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n/an/a 2.21E+4n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169860
PNG
(2-[4-(1-Dimethylamino-ethyl)-phenoxy]-5,6-dimethox...)
Show SMILES COc1cc2CC(Oc3ccc(cc3)C(C)N(C)C)C(=O)c2cc1OC
Show InChI InChI=1S/C21H25NO4/c1-13(22(2)3)14-6-8-16(9-7-14)26-20-11-15-10-18(24-4)19(25-5)12-17(15)21(20)23/h6-10,12-13,20H,11H2,1-5H3
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n/an/a 150n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Rattus norvegicus (rat))
BDBM50169856
PNG
(5,6-Dimethoxy-2-{3-[1-(4-methyl-piperazin-1-yl)-et...)
Show SMILES COc1cc2CC(Oc3cccc(c3)C(C)N3CCN(C)CC3)C(=O)c2cc1OC
Show InChI InChI=1S/C24H30N2O4/c1-16(26-10-8-25(2)9-11-26)17-6-5-7-19(12-17)30-23-14-18-13-21(28-3)22(29-4)15-20(18)24(23)27/h5-7,12-13,15-16,23H,8-11,14H2,1-4H3
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n/an/a 1.76E+4n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against rat cortex acetylcholinesterase


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM50169850
PNG
(5,6-Dimethoxy-2-(4-pyrrolidin-1-ylmethyl-phenoxy)-...)
Show SMILES COc1cc2CC(Oc3ccc(CN4CCCC4)cc3)C(=O)c2cc1OC
Show InChI InChI=1S/C22H25NO4/c1-25-19-11-16-12-21(22(24)18(16)13-20(19)26-2)27-17-7-5-15(6-8-17)14-23-9-3-4-10-23/h5-8,11,13,21H,3-4,9-10,12,14H2,1-2H3
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n/an/a 8.43E+4n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate


Bioorg Med Chem Lett 15: 3834-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.132
BindingDB Entry DOI: 10.7270/Q27H1KBV
More data for this
Ligand-Target Pair