Found 8 hits for monomerid = 50185583,50185584,50185589,50185591,50185593,50185597,50185604 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)
(Homo sapiens (Human)) | BDBM50185583
((E)-2-(N-(4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,...)Show SMILES COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CN(CCP(O)(O)=O)C(C)=O Show InChI InChI=1S/C19H26NO8P/c1-11(9-20(13(3)21)7-8-29(24,25)26)5-6-14-17(22)16-15(10-28-19(16)23)12(2)18(14)27-4/h5,22H,6-10H2,1-4H3,(H2,24,25,26)/b11-5+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 785 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
Curated by ChEMBL
| Assay Description
Inhibition of human IMPDH2 |
Bioorg Med Chem Lett 16: 3479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.097
BindingDB Entry DOI: 10.7270/Q2HH6JP9 |
More data for this
Ligand-Target Pair | |
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)
(Homo sapiens (Human)) | BDBM50185584
((E)-(4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)Show SMILES COc1c(C)c2COC(=O)c2c(O)c1CC=C(C)CNCP(O)(O)=O Show InChI InChI=1S/C16H22NO7P/c1-9(6-17-8-25(20,21)22)4-5-11-14(18)13-12(7-24-16(13)19)10(2)15(11)23-3/h4,17-18H,5-8H2,1-3H3,(H2,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
Curated by ChEMBL
| Assay Description
Inhibition of human IMPDH2 |
Bioorg Med Chem Lett 16: 3479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.097
BindingDB Entry DOI: 10.7270/Q2HH6JP9 |
More data for this
Ligand-Target Pair | |
Inosine Monophosphate Dehydrogenase Type 1 (IMPDH1)
(Homo sapiens (Human)) | BDBM50185589
((E)-2-(4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dih...)Show SMILES CCc1c(C)c2COC(=O)c2c(O)c1CC=C(C)CNCCP(O)(O)=O Show InChI InChI=1S/C18H26NO6P/c1-4-13-12(3)15-10-25-18(21)16(15)17(20)14(13)6-5-11(2)9-19-7-8-26(22,23)24/h5,19-20H,4,6-10H2,1-3H3,(H2,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
Curated by ChEMBL
| Assay Description
Inhibition of human IMPDH1 |
Bioorg Med Chem Lett 16: 3479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.097
BindingDB Entry DOI: 10.7270/Q2HH6JP9 |
More data for this
Ligand-Target Pair | |
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)
(Homo sapiens (Human)) | BDBM50185604
((E)-2-((4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-di...)Show SMILES CCc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CN(C)CCP(O)(O)=O Show InChI InChI=1S/C19H28NO6P/c1-5-14-13(3)16-11-26-19(22)17(16)18(21)15(14)7-6-12(2)10-20(4)8-9-27(23,24)25/h6,21H,5,7-11H2,1-4H3,(H2,23,24,25)/b12-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 132 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
Curated by ChEMBL
| Assay Description
Inhibition of human IMPDH2 |
Bioorg Med Chem Lett 16: 3479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.097
BindingDB Entry DOI: 10.7270/Q2HH6JP9 |
More data for this
Ligand-Target Pair | |
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)
(Homo sapiens (Human)) | BDBM50185593
((E)-diethyl 2-(4-(4-hydroxy-6-methoxy-7-methyl-3-o...)Show SMILES CCOP(=O)(CCNCC(C)=CCc1c(O)c2C(=O)OCc2c(C)c1OC)OCC Show InChI InChI=1S/C21H32NO7P/c1-6-28-30(25,29-7-2)11-10-22-12-14(3)8-9-16-19(23)18-17(13-27-21(18)24)15(4)20(16)26-5/h8,22-23H,6-7,9-13H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
Curated by ChEMBL
| Assay Description
Inhibition of human IMPDH2 |
Bioorg Med Chem Lett 16: 3479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.097
BindingDB Entry DOI: 10.7270/Q2HH6JP9 |
More data for this
Ligand-Target Pair | |
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)
(Homo sapiens (Human)) | BDBM50185589
((E)-2-(4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dih...)Show SMILES CCc1c(C)c2COC(=O)c2c(O)c1CC=C(C)CNCCP(O)(O)=O Show InChI InChI=1S/C18H26NO6P/c1-4-13-12(3)15-10-25-18(21)16(15)17(20)14(13)6-5-11(2)9-19-7-8-26(22,23)24/h5,19-20H,4,6-10H2,1-3H3,(H2,22,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
Curated by ChEMBL
| Assay Description
Inhibition of human IMPDH2 |
Bioorg Med Chem Lett 16: 3479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.097
BindingDB Entry DOI: 10.7270/Q2HH6JP9 |
More data for this
Ligand-Target Pair | |
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)
(Homo sapiens (Human)) | BDBM50185597
((E)-2-(N-(4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,...)Show SMILES COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CN(CCP(O)(O)=O)C=O Show InChI InChI=1S/C18H24NO8P/c1-11(8-19(10-20)6-7-28(23,24)25)4-5-13-16(21)15-14(9-27-18(15)22)12(2)17(13)26-3/h4,10,21H,5-9H2,1-3H3,(H2,23,24,25)/b11-4+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 749 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
Curated by ChEMBL
| Assay Description
Inhibition of human IMPDH2 |
Bioorg Med Chem Lett 16: 3479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.097
BindingDB Entry DOI: 10.7270/Q2HH6JP9 |
More data for this
Ligand-Target Pair | |
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)
(Homo sapiens (Human)) | BDBM50185591
((E)-2-((4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-...)Show SMILES COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CN(C)CCP(O)(O)=O Show InChI InChI=1S/C18H26NO7P/c1-11(9-19(3)7-8-27(22,23)24)5-6-13-16(20)15-14(10-26-18(15)21)12(2)17(13)25-4/h5,20H,6-10H2,1-4H3,(H2,22,23,24)/b11-5+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc
Curated by ChEMBL
| Assay Description
Inhibition of human IMPDH2 |
Bioorg Med Chem Lett 16: 3479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.097
BindingDB Entry DOI: 10.7270/Q2HH6JP9 |
More data for this
Ligand-Target Pair | |
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