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2 similar compounds to monomer 55880

Compile data set for download or QSAR
Wt: 365.8
BDBM50193623
Wt: 400.3
BDBM50241094

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50193623,50241094   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50241094
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(2,4-dichl...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C21H19Cl2N3O/c1-2-3-15-12-19(24)17-11-16(7-8-20(17)25-15)26-21(27)9-5-13-4-6-14(22)10-18(13)23/h4-12H,2-3H2,1H3,(H2,24,25)(H,26,27)/b9-5+
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Article
PubMed
n/an/a 6.60n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50241094
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(2,4-dichl...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C21H19Cl2N3O/c1-2-3-15-12-19(24)17-11-16(7-8-20(17)25-15)26-21(27)9-5-13-4-6-14(22)10-18(13)23/h4-12H,2-3H2,1H3,(H2,24,25)(H,26,27)/b9-5+
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PC sid
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Article
PubMed
n/an/an/an/a 904n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193623
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(2-chlorop...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccccc3Cl)ccc2n1
Show InChI InChI=1S/C21H20ClN3O/c1-2-5-15-13-19(23)17-12-16(9-10-20(17)24-15)25-21(26)11-8-14-6-3-4-7-18(14)22/h3-4,6-13H,2,5H2,1H3,(H2,23,24)(H,25,26)/b11-8+
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Article
PubMed
n/an/an/an/a 500n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193623
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(2-chlorop...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccccc3Cl)ccc2n1
Show InChI InChI=1S/C21H20ClN3O/c1-2-5-15-13-19(23)17-12-16(9-10-20(17)24-15)25-21(26)11-8-14-6-3-4-7-18(14)22/h3-4,6-13H,2,5H2,1H3,(H2,23,24)(H,25,26)/b11-8+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair