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7 similar compounds to monomer 50194545

Compile data set for download or QSAR
Wt: 485.6
BDBM50194512
Wt: 485.6
BDBM50194516
Wt: 483.7
BDBM50194534
Wt: 381.5
BDBM50194537
Wt: 471.6
BDBM50194543
Wt: 471.6
BDBM50194544
Wt: 471.6
BDBM50194549

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50194512,50194516,50194534,50194537,50194543,50194544,50194549   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194537
PNG
(CHEMBL217473 | N1,N1-diisopropyl-N5-methyl-3-pheny...)
Show SMILES CNC(=O)CC(C(C(=O)N(C(C)C)C(C)C)c1cccnc1)c1ccccc1
Show InChI InChI=1S/C23H31N3O2/c1-16(2)26(17(3)4)23(28)22(19-12-9-13-25-15-19)20(14-21(27)24-5)18-10-7-6-8-11-18/h6-13,15-17,20,22H,14H2,1-5H3,(H,24,27)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.67E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194544
PNG
(CHEMBL218128 | N1,N1-diisopropyl-3-phenyl-N5-(1-ph...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CC(=O)NC(C)c1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C30H37N3O2/c1-21(2)33(22(3)4)30(35)29(26-17-12-18-31-20-26)27(25-15-10-7-11-16-25)19-28(34)32-23(5)24-13-8-6-9-14-24/h6-18,20-23,27,29H,19H2,1-5H3,(H,32,34)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 249n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194543
PNG
(CHEMBL384706 | N1,N1-diisopropyl-N5-phenethyl-3-ph...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CC(=O)NCCc1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C30H37N3O2/c1-22(2)33(23(3)4)30(35)29(26-16-11-18-31-21-26)27(25-14-9-6-10-15-25)20-28(34)32-19-17-24-12-7-5-8-13-24/h5-16,18,21-23,27,29H,17,19-20H2,1-4H3,(H,32,34)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 410n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194534
PNG
(CHEMBL216338 | N5-(2-(tert-butylthio)ethyl)-N1,N1-...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CC(=O)NCCSC(C)(C)C)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C28H41N3O2S/c1-20(2)31(21(3)4)27(33)26(23-14-11-15-29-19-23)24(22-12-9-8-10-13-22)18-25(32)30-16-17-34-28(5,6)7/h8-15,19-21,24,26H,16-18H2,1-7H3,(H,30,32)
PDB

UniProtKB/SwissProt

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Article
PubMed
n/an/a 1.59E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194512
PNG
(CHEMBL216955 | N,N-diisopropyl-3-phenyl-4-(3-pheny...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)CC(C)c1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C31H39N3O2/c1-22(2)34(23(3)4)31(36)30(27-17-12-18-32-20-27)28(26-15-10-7-11-16-26)21-33-29(35)19-24(5)25-13-8-6-9-14-25/h6-18,20,22-24,28,30H,19,21H2,1-5H3,(H,33,35)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 94n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194516
PNG
(CHEMBL217684 | N,N-diisopropyl-3-phenyl-4-(4-pheny...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)CCCc1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C31H39N3O2/c1-23(2)34(24(3)4)31(36)30(27-18-12-20-32-21-27)28(26-16-9-6-10-17-26)22-33-29(35)19-11-15-25-13-7-5-8-14-25/h5-10,12-14,16-18,20-21,23-24,28,30H,11,15,19,22H2,1-4H3,(H,33,35)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194549
PNG
(CHEMBL217222 | N,N-diisopropyl-3-phenyl-4-(3-pheny...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)CCc1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C30H37N3O2/c1-22(2)33(23(3)4)30(35)29(26-16-11-19-31-20-26)27(25-14-9-6-10-15-25)21-32-28(34)18-17-24-12-7-5-8-13-24/h5-16,19-20,22-23,27,29H,17-18,21H2,1-4H3,(H,32,34)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair