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10 similar compounds to monomer 50194526

Compile data set for download or QSAR
Wt: 502.6
BDBM50194513
Wt: 507.0
BDBM50194515
Wt: 490.6
BDBM50194523
Wt: 486.6
BDBM50194524
Wt: 490.6
BDBM50194527
Wt: 486.6
BDBM50194529
Wt: 486.6
BDBM50194535
Wt: 551.5
BDBM50194536
Wt: 486.6
BDBM50194541
Wt: 486.6
BDBM50194547

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50194513,50194515,50194523,50194524,50194527,50194529,50194535,50194536,50194541,50194547   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194536
PNG
(4-(3-(4-bromobenzyl)ureido)-N,N-diisopropyl-3-phen...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)NCc1ccc(Br)cc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C29H35BrN4O2/c1-20(2)34(21(3)4)28(35)27(24-11-8-16-31-18-24)26(23-9-6-5-7-10-23)19-33-29(36)32-17-22-12-14-25(30)15-13-22/h5-16,18,20-21,26-27H,17,19H2,1-4H3,(H2,32,33,36)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 362n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194541
PNG
(CHEMBL385960 | N,N-diisopropyl-4-(3-phenethylureid...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)NCCc1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C30H38N4O2/c1-22(2)34(23(3)4)29(35)28(26-16-11-18-31-20-26)27(25-14-9-6-10-15-25)21-33-30(36)32-19-17-24-12-7-5-8-13-24/h5-16,18,20,22-23,27-28H,17,19,21H2,1-4H3,(H2,32,33,36)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 298n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194547
PNG
(CHEMBL384780 | N,N-diisopropyl-4-(3-(3-methylbenzy...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)NCc1cccc(C)c1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C30H38N4O2/c1-21(2)34(22(3)4)29(35)28(26-15-10-16-31-19-26)27(25-13-7-6-8-14-25)20-33-30(36)32-18-24-12-9-11-23(5)17-24/h6-17,19,21-22,27-28H,18,20H2,1-5H3,(H2,32,33,36)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 252n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194513
PNG
(CHEMBL384095 | N,N-diisopropyl-4-(3-(4-methoxybenz...)
Show SMILES COc1ccc(CNC(=O)NCC(C(C(=O)N(C(C)C)C(C)C)c2cccnc2)c2ccccc2)cc1
Show InChI InChI=1S/C30H38N4O3/c1-21(2)34(22(3)4)29(35)28(25-12-9-17-31-19-25)27(24-10-7-6-8-11-24)20-33-30(36)32-18-23-13-15-26(37-5)16-14-23/h6-17,19,21-22,27-28H,18,20H2,1-5H3,(H2,32,33,36)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 256n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194535
PNG
(CHEMBL216436 | N,N-diisopropyl-3-phenyl-4-(3-((R)-...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)N[C@H](C)c1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C30H38N4O2/c1-21(2)34(22(3)4)29(35)28(26-17-12-18-31-19-26)27(25-15-10-7-11-16-25)20-32-30(36)33-23(5)24-13-8-6-9-14-24/h6-19,21-23,27-28H,20H2,1-5H3,(H2,32,33,36)/t23-,27?,28?/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 283n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194523
PNG
(4-(3-(4-fluorobenzyl)ureido)-N,N-diisopropyl-3-phe...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)NCc1ccc(F)cc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C29H35FN4O2/c1-20(2)34(21(3)4)28(35)27(24-11-8-16-31-18-24)26(23-9-6-5-7-10-23)19-33-29(36)32-17-22-12-14-25(30)15-13-22/h5-16,18,20-21,26-27H,17,19H2,1-4H3,(H2,32,33,36)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 353n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194524
PNG
(CHEMBL217291 | N,N-diisopropyl-4-(3-(4-methylbenzy...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)NCc1ccc(C)cc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C30H38N4O2/c1-21(2)34(22(3)4)29(35)28(26-12-9-17-31-19-26)27(25-10-7-6-8-11-25)20-33-30(36)32-18-24-15-13-23(5)14-16-24/h6-17,19,21-22,27-28H,18,20H2,1-5H3,(H2,32,33,36)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194527
PNG
(4-(3-(2-fluorobenzyl)ureido)-N,N-diisopropyl-3-phe...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)NCc1ccccc1F)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C29H35FN4O2/c1-20(2)34(21(3)4)28(35)27(24-14-10-16-31-17-24)25(22-11-6-5-7-12-22)19-33-29(36)32-18-23-13-8-9-15-26(23)30/h5-17,20-21,25,27H,18-19H2,1-4H3,(H2,32,33,36)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
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Patents


Similars

Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194529
PNG
(CHEMBL216254 | N,N-diisopropyl-3-phenyl-4-(3-((S)-...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)N[C@@H](C)c1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C30H38N4O2/c1-21(2)34(22(3)4)29(35)28(26-17-12-18-31-19-26)27(25-15-10-7-11-16-25)20-32-30(36)33-23(5)24-13-8-6-9-14-24/h6-19,21-23,27-28H,20H2,1-5H3,(H2,32,33,36)/t23-,27?,28?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 490n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50194515
PNG
(4-(3-(2-chlorobenzyl)ureido)-N,N-diisopropyl-3-phe...)
Show SMILES CC(C)N(C(C)C)C(=O)C(C(CNC(=O)NCc1ccccc1Cl)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C29H35ClN4O2/c1-20(2)34(21(3)4)28(35)27(24-14-10-16-31-17-24)25(22-11-6-5-7-12-22)19-33-29(36)32-18-23-13-8-9-15-26(23)30/h5-17,20-21,25,27H,18-19H2,1-4H3,(H2,32,33,36)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 757n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.5


Bioorg Med Chem Lett 16: 5897-901 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.054
BindingDB Entry DOI: 10.7270/Q2Z60NP6
More data for this
Ligand-Target Pair