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1 similar compounds to monomer 50211440

Compile data set for download or QSAR
Wt: 365.4
BDBM50211427

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50211427   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transcription factor AP-1


(Homo sapiens (Human))
BDBM50211427
PNG
(4-(4-(H-imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yla...)
Show SMILES CCNC(=O)N1CCC(CC1)Nc1nccc(n1)-c1cnc2ccccn12
Show InChI InChI=1S/C19H23N7O/c1-2-20-19(27)25-11-7-14(8-12-25)23-18-21-9-6-15(24-18)16-13-22-17-5-3-4-10-26(16)17/h3-6,9-10,13-14H,2,7-8,11-12H2,1H3,(H,20,27)(H,21,23,24)
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n/an/a 1.93E+4n/an/an/an/an/an/a



UCB

Curated by ChEMBL


Assay Description
Inhibition of cJun translocation in IL1beta-stimulated A549 cells


Bioorg Med Chem Lett 17: 3463-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.078
BindingDB Entry DOI: 10.7270/Q2959H7W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (human))
BDBM50211427
PNG
(4-(4-(H-imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yla...)
Show SMILES CCNC(=O)N1CCC(CC1)Nc1nccc(n1)-c1cnc2ccccn12
Show InChI InChI=1S/C19H23N7O/c1-2-20-19(27)25-11-7-14(8-12-25)23-18-21-9-6-15(24-18)16-13-22-17-5-3-4-10-26(16)17/h3-6,9-10,13-14H,2,7-8,11-12H2,1H3,(H,20,27)(H,21,23,24)
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n/an/a 4.22E+3n/an/an/an/an/an/a



UCB

Curated by ChEMBL


Assay Description
Inhibition of CDK2 by IMAP technology


Bioorg Med Chem Lett 17: 3463-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.078
BindingDB Entry DOI: 10.7270/Q2959H7W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50211427
PNG
(4-(4-(H-imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yla...)
Show SMILES CCNC(=O)N1CCC(CC1)Nc1nccc(n1)-c1cnc2ccccn12
Show InChI InChI=1S/C19H23N7O/c1-2-20-19(27)25-11-7-14(8-12-25)23-18-21-9-6-15(24-18)16-13-22-17-5-3-4-10-26(16)17/h3-6,9-10,13-14H,2,7-8,11-12H2,1H3,(H,20,27)(H,21,23,24)
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n/an/a 59n/an/an/an/an/an/a



UCB

Curated by ChEMBL


Assay Description
Inhibition of JNK1


Bioorg Med Chem Lett 17: 3463-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.078
BindingDB Entry DOI: 10.7270/Q2959H7W
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50211427
PNG
(4-(4-(H-imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yla...)
Show SMILES CCNC(=O)N1CCC(CC1)Nc1nccc(n1)-c1cnc2ccccn12
Show InChI InChI=1S/C19H23N7O/c1-2-20-19(27)25-11-7-14(8-12-25)23-18-21-9-6-15(24-18)16-13-22-17-5-3-4-10-26(16)17/h3-6,9-10,13-14H,2,7-8,11-12H2,1H3,(H,20,27)(H,21,23,24)
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n/an/a 281n/an/an/an/an/an/a



UCB

Curated by ChEMBL


Assay Description
Inhibition of JNK2


Bioorg Med Chem Lett 17: 3463-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.078
BindingDB Entry DOI: 10.7270/Q2959H7W
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50211427
PNG
(4-(4-(H-imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yla...)
Show SMILES CCNC(=O)N1CCC(CC1)Nc1nccc(n1)-c1cnc2ccccn12
Show InChI InChI=1S/C19H23N7O/c1-2-20-19(27)25-11-7-14(8-12-25)23-18-21-9-6-15(24-18)16-13-22-17-5-3-4-10-26(16)17/h3-6,9-10,13-14H,2,7-8,11-12H2,1H3,(H,20,27)(H,21,23,24)
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Article
PubMed
n/an/a 708n/an/an/an/an/an/a



UCB

Curated by ChEMBL


Assay Description
Inhibition of JNK3


Bioorg Med Chem Lett 17: 3463-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.078
BindingDB Entry DOI: 10.7270/Q2959H7W
More data for this
Ligand-Target Pair