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9 similar compounds to monomer 50229063

Compile data set for download or QSAR
Wt: 487.5
BDBM50229008
Wt: 313.3
BDBM50229061
Wt: 299.2
BDBM50229062
Wt: 372.3
BDBM50229037
Wt: 405.4
BDBM50229038
Wt: 386.4
BDBM50229039
Wt: 452.5
BDBM50229009
Wt: 427.6
BDBM50229034
Wt: 353.4
BDBM50229060

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50229008,50229061,50229062,50229037,50229038,50229039,50229009,50229034,50229060   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50229037
PNG
(CHEMBL156328)
Show SMILES OC(=O)c1cccc(c1)-n1c2ccccc2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H16N2O4/c25-20-18-11-4-5-12-19(18)24(17-10-6-9-16(13-17)21(26)27)22(28)23(20)14-15-7-2-1-3-8-15/h1-13H,14H2,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 from rat brain cortex


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair
Cannabinoid receptor


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229034
PNG
(CHEMBL112438)
Show SMILES CCCCCc1cc(OCCN2CCOCC2)c2[C@@H]3CC(C)=CC[C@H]3C(C)(C)Oc2c1
Show InChI InChI=1S/C27H41NO3/c1-5-6-7-8-21-18-24(30-16-13-28-11-14-29-15-12-28)26-22-17-20(2)9-10-23(22)27(3,4)31-25(26)19-21/h9,18-19,22-23H,5-8,10-17H2,1-4H3/t22-,23-/m1/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
The compound was tested in vitro for binding activity against THC cannabinoid receptor site, using 3H-CP-55940 as the radioligand.


J Med Chem 34: 3310-6 (1991)


Article DOI: 10.1021/jm00115a023
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50229039
PNG
(CHEMBL351568)
Show SMILES COC(=O)c1cccc(c1)-n1c2ccccc2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H18N2O4/c1-29-22(27)17-10-7-11-18(14-17)25-20-13-6-5-12-19(20)21(26)24(23(25)28)15-16-8-3-2-4-9-16/h2-14H,15H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 from rat brain cortex


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50229038
PNG
(CHEMBL345917)
Show SMILES COC(=O)c1cccc(c1)-n1c2ncccc2c(=O)n(CC2CC3CCC2C3)c1=O
Show InChI InChI=1S/C23H23N3O4/c1-30-22(28)16-4-2-5-18(12-16)26-20-19(6-3-9-24-20)21(27)25(23(26)29)13-17-11-14-7-8-15(17)10-14/h2-6,9,12,14-15,17H,7-8,10-11,13H2,1H3
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n/an/a 100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 from rat brain cortex


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50229039
PNG
(CHEMBL351568)
Show SMILES COC(=O)c1cccc(c1)-n1c2ccccc2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H18N2O4/c1-29-22(27)17-10-7-11-18(14-17)25-20-13-6-5-12-19(20)21(26)24(23(25)28)15-16-8-3-2-4-9-16/h2-14H,15H2,1H3
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n/an/a 180n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brain


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50229037
PNG
(CHEMBL156328)
Show SMILES OC(=O)c1cccc(c1)-n1c2ccccc2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H16N2O4/c25-20-18-11-4-5-12-19(18)24(17-10-6-9-16(13-17)21(26)27)22(28)23(20)14-15-7-2-1-3-8-15/h1-13H,14H2,(H,26,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brain


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229060
PNG
(CHEMBL161007)
Show SMILES OC(=O)C(O)=O.CCCCCCCc1noc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C15H25N3O.C2H2O4/c1-3-4-5-6-7-10-14-16-15(19-17-14)13-9-8-11-18(2)12-13;3-1(4)2(5)6/h9H,3-8,10-12H2,1-2H3;(H,3,4)(H,5,6)
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n/an/a 9.10E+3n/an/an/an/an/an/a



Ferrosan A/S

Curated by ChEMBL


Assay Description
In Vitro binding affinity to the muscarinic acetylcholine receptor site in rat brain by using [3H]QNB as the radioligand.


J Med Chem 34: 687-92 (1991)


Article DOI: 10.1021/jm00106a033
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229061
PNG
(CHEMBL162134)
Show SMILES OC(=O)C(O)=O.COCCc1noc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C11H17N3O2.C2H2O4/c1-14-6-3-4-9(8-14)11-12-10(13-16-11)5-7-15-2;3-1(4)2(5)6/h4H,3,5-8H2,1-2H3;(H,3,4)(H,5,6)
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n/an/a 144n/an/an/an/an/an/a



Ferrosan A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity to muscarinic acetylcholine receptor site in rat brain assayed using [3H]oxotremorine-M as the radioligand.


J Med Chem 34: 687-92 (1991)


Article DOI: 10.1021/jm00106a033
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229062
PNG
(CHEMBL422538)
Show SMILES OC(=O)C(O)=O.COCc1noc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C10H15N3O2.C2H2O4/c1-13-5-3-4-8(6-13)10-11-9(7-14-2)12-15-10;3-1(4)2(5)6/h4H,3,5-7H2,1-2H3;(H,3,4)(H,5,6)
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n/an/a 44n/an/an/an/an/an/a



Ferrosan A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity to muscarinic acetylcholine receptor site in rat brain assayed using [3H]oxotremorine-M as the radioligand.


J Med Chem 34: 687-92 (1991)


Article DOI: 10.1021/jm00106a033
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229062
PNG
(CHEMBL422538)
Show SMILES OC(=O)C(O)=O.COCc1noc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C10H15N3O2.C2H2O4/c1-13-5-3-4-8(6-13)10-11-9(7-14-2)12-15-10;3-1(4)2(5)6/h4H,3,5-7H2,1-2H3;(H,3,4)(H,5,6)
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n/an/a 6.69E+4n/an/an/an/an/an/a



Ferrosan A/S

Curated by ChEMBL


Assay Description
In Vitro binding affinity to the muscarinic acetylcholine receptor site in rat brain by using [3H]QNB as the radioligand.


J Med Chem 34: 687-92 (1991)


Article DOI: 10.1021/jm00106a033
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50229062
PNG
(CHEMBL422538)
Show SMILES OC(=O)C(O)=O.COCc1noc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C10H15N3O2.C2H2O4/c1-13-5-3-4-8(6-13)10-11-9(7-14-2)12-15-10;3-1(4)2(5)6/h4H,3,5-7H2,1-2H3;(H,3,4)(H,5,6)
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n/an/an/an/a 420n/an/an/an/a



Ferrosan A/S

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.


J Med Chem 34: 687-92 (1991)


Article DOI: 10.1021/jm00106a033
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229060
PNG
(CHEMBL161007)
Show SMILES OC(=O)C(O)=O.CCCCCCCc1noc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C15H25N3O.C2H2O4/c1-3-4-5-6-7-10-14-16-15(19-17-14)13-9-8-11-18(2)12-13;3-1(4)2(5)6/h9H,3-8,10-12H2,1-2H3;(H,3,4)(H,5,6)
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n/an/a 28n/an/an/an/an/an/a



Ferrosan A/S

Curated by ChEMBL


Assay Description
In vitro binding affinity to muscarinic acetylcholine receptor site in rat brain assayed using [3H]oxotremorine-M as the radioligand.


J Med Chem 34: 687-92 (1991)


Article DOI: 10.1021/jm00106a033
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229061
PNG
(CHEMBL162134)
Show SMILES OC(=O)C(O)=O.COCCc1noc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C11H17N3O2.C2H2O4/c1-14-6-3-4-9(8-14)11-12-10(13-16-11)5-7-15-2;3-1(4)2(5)6/h4H,3,5-8H2,1-2H3;(H,3,4)(H,5,6)
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n/an/a 4.15E+4n/an/an/an/an/an/a



Ferrosan A/S

Curated by ChEMBL


Assay Description
In Vitro binding affinity to the muscarinic acetylcholine receptor site in rat brain by using [3H]QNB as the radioligand.


J Med Chem 34: 687-92 (1991)


Article DOI: 10.1021/jm00106a033
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50229061
PNG
(CHEMBL162134)
Show SMILES OC(=O)C(O)=O.COCCc1noc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C11H17N3O2.C2H2O4/c1-14-6-3-4-9(8-14)11-12-10(13-16-11)5-7-15-2;3-1(4)2(5)6/h4H,3,5-8H2,1-2H3;(H,3,4)(H,5,6)
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n/an/an/an/a 720n/an/an/an/a



Ferrosan A/S

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.


J Med Chem 34: 687-92 (1991)


Article DOI: 10.1021/jm00106a033
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Homo sapiens (Human))
BDBM50229060
PNG
(CHEMBL161007)
Show SMILES OC(=O)C(O)=O.CCCCCCCc1noc(n1)C1=CCCN(C)C1
Show InChI InChI=1S/C15H25N3O.C2H2O4/c1-3-4-5-6-7-10-14-16-15(19-17-14)13-9-8-11-18(2)12-13;3-1(4)2(5)6/h9H,3-8,10-12H2,1-2H3;(H,3,4)(H,5,6)
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n/an/an/an/a 130n/an/an/an/a



Ferrosan A/S

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.


J Med Chem 34: 687-92 (1991)


Article DOI: 10.1021/jm00106a033
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229008
PNG
(CHEMBL109562)
Show SMILES COc1ccc(Cn2cnc3CN([C@@H](Cc23)C(O)=O)C(=O)C2(CCCCC2)c2ccccc2)cc1C
Show InChI InChI=1S/C29H33N3O4/c1-20-15-21(11-12-26(20)36-2)17-31-19-30-23-18-32(25(27(33)34)16-24(23)31)28(35)29(13-7-4-8-14-29)22-9-5-3-6-10-22/h3,5-6,9-12,15,19,25H,4,7-8,13-14,16-18H2,1-2H3,(H,33,34)/t25-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Warner Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity against Angiotensin II receptor, from rat adrenal gland


J Med Chem 34: 3248-60 (1991)


Article DOI: 10.1021/jm00115a014
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229009
PNG
(CHEMBL111977)
Show SMILES OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1cccnc1
Show InChI InChI=1S/C27H24N4O3/c32-26(25(20-9-3-1-4-10-20)21-11-5-2-6-12-21)31-17-22-23(14-24(31)27(33)34)30(18-29-22)16-19-8-7-13-28-15-19/h1-13,15,18,24-25H,14,16-17H2,(H,33,34)/t24-/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Warner Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity against Angiotensin II receptor, from rat adrenal gland


J Med Chem 34: 3248-60 (1991)


Article DOI: 10.1021/jm00115a014
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50229038
PNG
(CHEMBL345917)
Show SMILES COC(=O)c1cccc(c1)-n1c2ncccc2c(=O)n(CC2CC3CCC2C3)c1=O
Show InChI InChI=1S/C23H23N3O4/c1-30-22(28)16-4-2-5-18(12-16)26-20-19(6-3-9-24-20)21(27)25(23(26)29)13-17-11-14-7-8-15(17)10-14/h2-6,9,12,14-15,17H,7-8,10-11,13H2,1H3
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n/an/a 3.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brain


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair