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18 similar compounds to monomer 50229524

Compile data set for download or QSAR
Wt: 193.2
BDBM50229520
Wt: 183.2
BDBM50229522
Wt: 169.2
BDBM50229523
Wt: 179.2
BDBM50229525
Wt: 193.2
BDBM50229527
Wt: 193.2
BDBM50229529
Wt: 155.1
BDBM50229532
Wt: 458.9
BDBM50229507
Wt: 327.4
BDBM50229516
Wt: 169.2
BDBM50229530
Wt: 257.2
BDBM50229509
Wt: 275.2
BDBM50229510
Wt: 275.2
BDBM50229511
Wt: 259.2
BDBM50229512
Wt: 223.3
BDBM50229513
Displayed 1 to 15 (of 18 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50229520,50229522,50229523,50229525,50229527,50229529,50229532,50229507,50229516,50229530,50229509,50229510,50229511,50229512,50229513   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II receptor


(RAT)
BDBM50229507
PNG
(CHEMBL311702)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1cc(OC)c(c(OC)c1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H27ClN2O5/c1-4-5-10-21-26-23(25)18(14-28)27(21)13-15-11-19(31-2)22(20(12-15)32-3)16-8-6-7-9-17(16)24(29)30/h6-9,11-12,28H,4-5,10,13-14H2,1-3H3,(H,29,30)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Searle R&D and MCR

Curated by ChEMBL


Assay Description
Ability to displace [125I]-labeled angiotensin II from its receptor of a rat uterus membrane


J Med Chem 34: 2410-4 (1991)


Article DOI: 10.1021/jm00112a015
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229513
PNG
(CHEMBL4092903)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccn(C)n1
Show InChI InChI=1S/C12H21N3O/c1-6-12(2,3)11(16)14(4)9-10-7-8-15(5)13-10/h7-8H,6,9H2,1-5H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Opioid receptors; mu/kappa/delta


(Homo sapiens (Human))
BDBM50229516
PNG
(CHEMBL2367763)
Show SMILES C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2C[C@@H]1CC(=C)C(=O)O1
Show InChI InChI=1S/C20H25NO3/c1-12-8-16(24-19(12)23)11-21-7-6-20(3)13(2)18(21)9-14-4-5-15(22)10-17(14)20/h4-5,10,13,16,18,22H,1,6-9,11H2,2-3H3/t13-,16+,18+,20-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Displacement of 0.5 nM [3H]bremazocine from opioid receptor sites in guinea pig membranes


J Med Chem 34: 2438-44 (1991)


Article DOI: 10.1021/jm00112a019
BindingDB Entry DOI: 10.7270/Q2NC605T
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229520
PNG
(CHEMBL93430)
Show SMILES Cc1noc(n1)[C@@H]1C[C@H]2CC[N@@](C2)C1
Show InChI InChI=1S/C10H15N3O/c1-7-11-10(14-12-7)9-4-8-2-3-13(5-8)6-9/h8-9H,2-6H2,1H3/t8-,9-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229522
PNG
(CHEMBL329316)
Show SMILES COC(=O)[C@@H]1C[C@H]2CCC[N@@](C2)C1
Show InChI InChI=1S/C10H17NO2/c1-13-10(12)9-5-8-3-2-4-11(6-8)7-9/h8-9H,2-7H2,1H3/t8-,9-/m1/s1
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n/an/a 130n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229523
PNG
(CHEMBL328267)
Show SMILES COC(=O)[C@@H]1C[N@@]2C[C@H]1CCC2
Show InChI InChI=1S/C9H15NO2/c1-12-9(11)8-6-10-4-2-3-7(8)5-10/h7-8H,2-6H2,1H3/t7-,8-/m1/s1
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n/an/a 6.20E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]quinuclidinyl benzilate from rat cerebral cor...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229523
PNG
(CHEMBL328267)
Show SMILES COC(=O)[C@@H]1C[N@@]2C[C@H]1CCC2
Show InChI InChI=1S/C9H15NO2/c1-12-9(11)8-6-10-4-2-3-7(8)5-10/h7-8H,2-6H2,1H3/t7-,8-/m1/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229525
PNG
(CHEMBL94065)
Show SMILES Cc1nnc(o1)C12CCN(CC1)C2
Show InChI InChI=1S/C9H13N3O/c1-7-10-11-8(13-7)9-2-4-12(6-9)5-3-9/h2-6H2,1H3
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n/an/a 180n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229527
PNG
(CHEMBL94072)
Show SMILES Cc1nnc(o1)C12CCN(C1)CCC2
Show InChI InChI=1S/C10H15N3O/c1-8-11-12-9(14-8)10-3-2-5-13(7-10)6-4-10/h2-7H2,1H3
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n/an/a 9.40E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]quinuclidinyl benzilate from rat cerebral cor...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229529
PNG
(CHEMBL14879)
Show SMILES Cc1nnc(o1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H15N3O/c1-7-11-12-10(14-7)9-6-13-4-2-8(9)3-5-13/h8-9H,2-6H2,1H3
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n/an/a 980n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229530
PNG
(CHEMBL329434)
Show SMILES COC(=O)C12CCN(C1)CCC2
Show InChI InChI=1S/C9H15NO2/c1-12-8(11)9-3-2-5-10(7-9)6-4-9/h2-7H2,1H3
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n/an/a 6.40E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]quinuclidinyl benzilate from rat cerebral cor...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229532
PNG
(CHEMBL445119)
Show SMILES COC(=O)[C@@H]1C[N@]2CC[C@@H]1C2
Show InChI InChI=1S/C8H13NO2/c1-11-8(10)7-5-9-3-2-6(7)4-9/h6-7H,2-5H2,1H3/t6-,7-/m1/s1
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n/an/a 5.10E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]quinuclidinyl benzilate from rat cerebral cor...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229525
PNG
(CHEMBL94065)
Show SMILES Cc1nnc(o1)C12CCN(CC1)C2
Show InChI InChI=1S/C9H13N3O/c1-7-10-11-8(13-7)9-2-4-12(6-9)5-3-9/h2-6H2,1H3
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n/an/a 7.00E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]quinuclidinyl benzilate from rat cerebral cor...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229522
PNG
(CHEMBL329316)
Show SMILES COC(=O)[C@@H]1C[C@H]2CCC[N@@](C2)C1
Show InChI InChI=1S/C10H17NO2/c1-13-10(12)9-5-8-3-2-4-11(6-8)7-9/h8-9H,2-7H2,1H3/t8-,9-/m1/s1
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n/an/a 4.80E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]quinuclidinyl benzilate from rat cerebral cor...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229527
PNG
(CHEMBL94072)
Show SMILES Cc1nnc(o1)C12CCN(C1)CCC2
Show InChI InChI=1S/C10H15N3O/c1-8-11-12-9(14-8)10-3-2-5-13(7-10)6-4-10/h2-7H2,1H3
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n/an/a 42n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229520
PNG
(CHEMBL93430)
Show SMILES Cc1noc(n1)[C@@H]1C[C@H]2CC[N@@](C2)C1
Show InChI InChI=1S/C10H15N3O/c1-7-11-10(14-12-7)9-4-8-2-3-13(5-8)6-9/h8-9H,2-6H2,1H3/t8-,9-/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]quinuclidinyl benzilate from rat cerebral cor...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229529
PNG
(CHEMBL14879)
Show SMILES Cc1nnc(o1)C1CN2CCC1CC2
Show InChI InChI=1S/C10H15N3O/c1-7-11-12-10(14-7)9-6-13-4-2-8(9)3-5-13/h8-9H,2-6H2,1H3
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n/an/a 1.90E+4n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]quinuclidinyl benzilate from rat cerebral cor...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229530
PNG
(CHEMBL329434)
Show SMILES COC(=O)C12CCN(C1)CCC2
Show InChI InChI=1S/C9H15NO2/c1-12-8(11)9-3-2-5-10(7-9)6-4-9/h2-7H2,1H3
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n/an/a 19n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229532
PNG
(CHEMBL445119)
Show SMILES COC(=O)[C@@H]1C[N@]2CC[C@@H]1C2
Show InChI InChI=1S/C8H13NO2/c1-11-8(10)7-5-9-3-2-6(7)4-9/h6-7H,2-5H2,1H3/t6-,7-/m1/s1
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n/an/a 230n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229509
PNG
(CHEMBL4100395)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C1(C)CC1
Show InChI InChI=1S/C13H14F3NO/c1-13(3-4-13)12(18)17(2)7-8-5-9(14)6-10(15)11(8)16/h5-6H,3-4,7H2,1-2H3
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National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229510
PNG
(CHEMBL4073564)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C(C)(C)CO
Show InChI InChI=1S/C13H16F3NO2/c1-13(2,7-18)12(19)17(3)6-8-4-9(14)5-10(15)11(8)16/h4-5,18H,6-7H2,1-3H3
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n/an/an/an/a>3.00E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229511
PNG
(CHEMBL4062217)
Show SMILES COC(C)(C)C(=O)N(C)Cc1cc(F)cc(F)c1F
Show InChI InChI=1S/C13H16F3NO2/c1-13(2,19-4)12(18)17(3)7-8-5-9(14)6-10(15)11(8)16/h5-6H,7H2,1-4H3
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National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50229512
PNG
(CHEMBL4083937)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C(C)(C)C
Show InChI InChI=1S/C13H16F3NO/c1-13(2,3)12(18)17(4)7-8-5-9(14)6-10(15)11(8)16/h5-6H,7H2,1-4H3
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n/an/an/an/a 98n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229507
PNG
(CHEMBL311702)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1cc(OC)c(c(OC)c1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H27ClN2O5/c1-4-5-10-21-26-23(25)18(14-28)27(21)13-15-11-19(31-2)22(20(12-15)32-3)16-8-6-7-9-17(16)24(29)30/h6-9,11-12,28H,4-5,10,13-14H2,1-3H3,(H,29,30)
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UniChem

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n/an/a 1.20E+5n/an/an/an/an/an/a



Searle R&D and MCR

Curated by ChEMBL


Assay Description
Ability to displace [125I]-labeled angiotensin II from its receptor of a rat uterus membrane


J Med Chem 34: 2410-4 (1991)


Article DOI: 10.1021/jm00112a015
More data for this
Ligand-Target Pair