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1 similar compounds to monomer 50230877

Compile data set for download or QSAR
Wt: 405.4
BDBM50230859

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50230859   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50230859
PNG
(CHEMBL309150)
Show SMILES COC1=Nc2ccccc2C2=NC(CN3CCN(CC3)c3ccccc3OC)CN12
Show InChI InChI=1S/C23H27N5O2/c1-29-21-10-6-5-9-20(21)27-13-11-26(12-14-27)15-17-16-28-22(24-17)18-7-3-4-8-19(18)25-23(28)30-2/h3-10,17H,11-16H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0700n/an/an/an/an/an/an/an/a



National Defense Medical Center

Curated by ChEMBL


Assay Description
Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro).


J Med Chem 36: 2196-207 (1993)


Article DOI: 10.1021/jm00067a017
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50230859
PNG
(CHEMBL309150)
Show SMILES COC1=Nc2ccccc2C2=NC(CN3CCN(CC3)c3ccccc3OC)CN12
Show InChI InChI=1S/C23H27N5O2/c1-29-21-10-6-5-9-20(21)27-13-11-26(12-14-27)15-17-16-28-22(24-17)18-7-3-4-8-19(18)25-23(28)30-2/h3-10,17H,11-16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
472n/an/an/an/an/an/an/an/a



National Defense Medical Center

Curated by ChEMBL


Assay Description
Binding affinity against alpha-2 adrenergic receptor by measuring displacement of [3H]clonidine from rat brain cortex membranes (in vitro).


J Med Chem 36: 2196-207 (1993)


Article DOI: 10.1021/jm00067a017
More data for this
Ligand-Target Pair