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11 similar compounds to monomer 50253328

Compile data set for download or QSAR
Wt: 558.8
BDBM50253470
Wt: 448.6
BDBM50253471
Wt: 490.7
BDBM50253393
Wt: 504.7
BDBM50253394
Wt: 518.7
BDBM50253395
Wt: 478.6
BDBM50400511
Purchase
Wt: 478.6
BDBM50400512
Wt: 462.6
BDBM50400513
Wt: 462.6
BDBM50400514
Wt: 506.7
BDBM50400515
Wt: 506.7
BDBM50400516

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50253470,50253471,50253393,50253394,50253395,50400511,50400512,50400513,50400514,50400515,50400516   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50400513
PNG
(CHEMBL2203404)
Show SMILES CCCN(CC[C@H]1C[C@H](C1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C27H34N4OS/c1-2-12-31(23-9-10-24-25(17-23)33-27(28)30-24)13-11-18-14-22(15-18)29-26(32)21-8-7-19-5-3-4-6-20(19)16-21/h3-8,16,18,22-23H,2,9-15,17H2,1H3,(H2,28,30)(H,29,32)/t18-,22+,23-/m0/s1
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0.350n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 mins


ACS Med Chem Lett 2: 620-625 (2011)


Article DOI: 10.1021/ml200100t
BindingDB Entry DOI: 10.7270/Q2028SQ8
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50400512
PNG
(CHEMBL2203405)
Show SMILES CCCN(CC[C@@]1(O)C[C@@H](C1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C27H34N4O2S/c1-2-12-31(22-9-10-23-24(15-22)34-26(28)30-23)13-11-27(33)16-21(17-27)29-25(32)20-8-7-18-5-3-4-6-19(18)14-20/h3-8,14,21-22,33H,2,9-13,15-17H2,1H3,(H2,28,30)(H,29,32)/t21-,22-,27+/m0/s1
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0.400n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]R-(+)-7-OHDPAT from dopamine D3 receptor in Sprague-Dawley rat ventral striatum after 90 mins


J Med Chem 57: 4962-8 (2014)


Article DOI: 10.1021/jm401798r
BindingDB Entry DOI: 10.7270/Q2BV7J5V
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50400512
PNG
(CHEMBL2203405)
Show SMILES CCCN(CC[C@@]1(O)C[C@@H](C1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C27H34N4O2S/c1-2-12-31(22-9-10-23-24(15-22)34-26(28)30-23)13-11-27(33)16-21(17-27)29-25(32)20-8-7-18-5-3-4-6-19(18)14-20/h3-8,14,21-22,33H,2,9-13,15-17H2,1H3,(H2,28,30)(H,29,32)/t21-,22-,27+/m0/s1
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0.400n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 mins


ACS Med Chem Lett 2: 620-625 (2011)


Article DOI: 10.1021/ml200100t
BindingDB Entry DOI: 10.7270/Q2028SQ8
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50253393
PNG
(CHEMBL495327 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES CCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C29H38N4OS/c1-2-16-33(25-13-14-26-27(19-25)35-29(30)32-26)17-15-20-7-11-24(12-8-20)31-28(34)23-10-9-21-5-3-4-6-22(21)18-23/h3-6,9-10,18,20,24-25H,2,7-8,11-17,19H2,1H3,(H2,30,32)(H,31,34)/t20-,24-,25-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]PD128907 from dopamine D3 receptor in Sprague-Dawley rat ventral striatum


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50400514
PNG
(CHEMBL2203403)
Show SMILES CCCN(CC[C@H]1C[C@@H](C1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C27H34N4OS/c1-2-12-31(23-9-10-24-25(17-23)33-27(28)30-24)13-11-18-14-22(15-18)29-26(32)21-8-7-19-5-3-4-6-20(19)16-21/h3-8,16,18,22-23H,2,9-15,17H2,1H3,(H2,28,30)(H,29,32)/t18-,22-,23-/m0/s1
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0.410n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 mins


ACS Med Chem Lett 2: 620-625 (2011)


Article DOI: 10.1021/ml200100t
BindingDB Entry DOI: 10.7270/Q2028SQ8
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50400511
PNG
(CHEMBL2203406)
Show SMILES CCCN(CC[C@]1(O)C[C@@H](C1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C27H34N4O2S/c1-2-12-31(22-9-10-23-24(15-22)34-26(28)30-23)13-11-27(33)16-21(17-27)29-25(32)20-8-7-18-5-3-4-6-19(18)14-20/h3-8,14,21-22,33H,2,9-13,15-17H2,1H3,(H2,28,30)(H,29,32)/t21-,22-,27-/m0/s1
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0.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 mins


ACS Med Chem Lett 2: 620-625 (2011)


Article DOI: 10.1021/ml200100t
BindingDB Entry DOI: 10.7270/Q2028SQ8
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50253394
PNG
(CHEMBL494308 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES CCCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C30H40N4OS/c1-2-3-17-34(26-14-15-27-28(20-26)36-30(31)33-27)18-16-21-8-12-25(13-9-21)32-29(35)24-11-10-22-6-4-5-7-23(22)19-24/h4-7,10-11,19,21,25-26H,2-3,8-9,12-18,20H2,1H3,(H2,31,33)(H,32,35)/t21-,25-,26-/m0/s1
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0.740n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]PD128907 from dopamine D3 receptor in Sprague-Dawley rat ventral striatum


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50253393
PNG
(CHEMBL495327 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES CCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C29H38N4OS/c1-2-16-33(25-13-14-26-27(19-25)35-29(30)32-26)17-15-20-7-11-24(12-8-20)31-28(34)23-10-9-21-5-3-4-6-22(21)18-23/h3-6,9-10,18,20,24-25H,2,7-8,11-17,19H2,1H3,(H2,30,32)(H,31,34)/t20-,24-,25-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 mins


ACS Med Chem Lett 2: 620-625 (2011)


Article DOI: 10.1021/ml200100t
BindingDB Entry DOI: 10.7270/Q2028SQ8
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50400515
PNG
(CHEMBL2203402)
Show SMILES CCCN(CC[C@]1(O)CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C29H38N4O2S/c1-2-16-33(24-9-10-25-26(19-24)36-28(30)32-25)17-15-29(35)13-11-23(12-14-29)31-27(34)22-8-7-20-5-3-4-6-21(20)18-22/h3-8,18,23-24,35H,2,9-17,19H2,1H3,(H2,30,32)(H,31,34)/t23-,24-,29-/m0/s1
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0.930n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 mins


ACS Med Chem Lett 2: 620-625 (2011)


Article DOI: 10.1021/ml200100t
BindingDB Entry DOI: 10.7270/Q2028SQ8
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50253393
PNG
(CHEMBL495327 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES CCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C29H38N4OS/c1-2-16-33(25-13-14-26-27(19-25)35-29(30)32-26)17-15-20-7-11-24(12-8-20)31-28(34)23-10-9-21-5-3-4-6-22(21)18-23/h3-6,9-10,18,20,24-25H,2,7-8,11-17,19H2,1H3,(H2,30,32)(H,31,34)/t20-,24-,25-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]-R(+)-7-OHDPAT from dopamine D3 receptor in rat brain homogenates


Bioorg Med Chem Lett 22: 5612-7 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.003
BindingDB Entry DOI: 10.7270/Q2V69KPV
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50400516
PNG
(CHEMBL2203407)
Show SMILES CCCN(CC[C@@]1(O)CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C29H38N4O2S/c1-2-16-33(24-9-10-25-26(19-24)36-28(30)32-25)17-15-29(35)13-11-23(12-14-29)31-27(34)22-8-7-20-5-3-4-6-21(20)18-22/h3-8,18,23-24,35H,2,9-17,19H2,1H3,(H2,30,32)(H,31,34)/t23-,24-,29+/m0/s1
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1.60n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 mins


ACS Med Chem Lett 2: 620-625 (2011)


Article DOI: 10.1021/ml200100t
BindingDB Entry DOI: 10.7270/Q2028SQ8
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50253395
PNG
(CHEMBL494309 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES CC(C)CCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C31H42N4OS/c1-21(2)15-17-35(27-13-14-28-29(20-27)37-31(32)34-28)18-16-22-7-11-26(12-8-22)33-30(36)25-10-9-23-5-3-4-6-24(23)19-25/h3-6,9-10,19,21-22,26-27H,7-8,11-18,20H2,1-2H3,(H2,32,34)(H,33,36)/t22-,26-,27-/m0/s1
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2.20n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]PD128907 from dopamine D3 receptor in Sprague-Dawley rat ventral striatum


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50400511
PNG
(CHEMBL2203406)
Show SMILES CCCN(CC[C@]1(O)C[C@@H](C1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C27H34N4O2S/c1-2-12-31(22-9-10-23-24(15-22)34-26(28)30-23)13-11-27(33)16-21(17-27)29-25(32)20-8-7-18-5-3-4-6-19(18)14-20/h3-8,14,21-22,33H,2,9-13,15-17H2,1H3,(H2,28,30)(H,29,32)/t21-,22-,27-/m0/s1
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3.61n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]YM-09151-2 from human cloned dopamine D3 receptor expressed in CHOp cells after 60 mins by scintillation counter


ACS Med Chem Lett 2: 620-625 (2011)


Article DOI: 10.1021/ml200100t
BindingDB Entry DOI: 10.7270/Q2028SQ8
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50253471
PNG
(CHEMBL494510 | Naphthalene-2-carboxylic acid {4-[2...)
Show SMILES Nc1nc2CC[C@@H](Cc2s1)NCC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H32N4OS/c27-26-30-23-12-11-22(16-24(23)32-26)28-14-13-17-5-9-21(10-6-17)29-25(31)20-8-7-18-3-1-2-4-19(18)15-20/h1-4,7-8,15,17,21-22,28H,5-6,9-14,16H2,(H2,27,30)(H,29,31)/t17-,21-,22-/m0/s1
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7.60n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]PD128907 from dopamine D3 receptor in Sprague-Dawley rat ventral striatum


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
Dopamine receptor


(Rattus norvegicus (Rat))
BDBM50253470
PNG
(CHEMBL494509 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES Nc1nc2CC[C@@H](Cc2s1)N(CCC1CCCCC1)CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C34H46N4OS/c35-34-37-31-17-16-30(23-32(31)40-34)38(20-18-24-6-2-1-3-7-24)21-19-25-10-14-29(15-11-25)36-33(39)28-13-12-26-8-4-5-9-27(26)22-28/h4-5,8-9,12-13,22,24-25,29-30H,1-3,6-7,10-11,14-21,23H2,(H2,35,37)(H,36,39)/t25-,29-,30-/m0/s1
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23n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]PD128907 from dopamine D3 receptor in Sprague-Dawley rat ventral striatum


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50253394
PNG
(CHEMBL494308 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES CCCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C30H40N4OS/c1-2-3-17-34(26-14-15-27-28(20-26)36-30(31)33-27)18-16-21-8-12-25(13-9-21)32-29(35)24-11-10-22-6-4-5-7-23(22)19-24/h4-7,10-11,19,21,25-26H,2-3,8-9,12-18,20H2,1H3,(H2,31,33)(H,32,35)/t21-,25-,26-/m0/s1
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55n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from D2 receptor in Sprague-Dawley rat caudate-putamen


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50253393
PNG
(CHEMBL495327 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES CCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C29H38N4OS/c1-2-16-33(25-13-14-26-27(19-25)35-29(30)32-26)17-15-20-7-11-24(12-8-20)31-28(34)23-10-9-21-5-3-4-6-22(21)18-23/h3-6,9-10,18,20,24-25H,2,7-8,11-17,19H2,1H3,(H2,30,32)(H,31,34)/t20-,24-,25-/m0/s1
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307n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from D2 receptor in Sprague-Dawley rat caudate-putamen


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50253395
PNG
(CHEMBL494309 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES CC(C)CCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C31H42N4OS/c1-21(2)15-17-35(27-13-14-28-29(20-27)37-31(32)34-28)18-16-22-7-11-26(12-8-22)33-30(36)25-10-9-23-5-3-4-6-24(23)19-25/h3-6,9-10,19,21-22,26-27H,7-8,11-18,20H2,1-2H3,(H2,32,34)(H,33,36)/t22-,26-,27-/m0/s1
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345n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from D2 receptor in Sprague-Dawley rat caudate-putamen


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50253471
PNG
(CHEMBL494510 | Naphthalene-2-carboxylic acid {4-[2...)
Show SMILES Nc1nc2CC[C@@H](Cc2s1)NCC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H32N4OS/c27-26-30-23-12-11-22(16-24(23)32-26)28-14-13-17-5-9-21(10-6-17)29-25(31)20-8-7-18-3-1-2-4-19(18)15-20/h1-4,7-8,15,17,21-22,28H,5-6,9-14,16H2,(H2,27,30)(H,29,31)/t17-,21-,22-/m0/s1
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670n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from D2 receptor in Sprague-Dawley rat caudate-putamen


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50253470
PNG
(CHEMBL494509 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES Nc1nc2CC[C@@H](Cc2s1)N(CCC1CCCCC1)CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C34H46N4OS/c35-34-37-31-17-16-30(23-32(31)40-34)38(20-18-24-6-2-1-3-7-24)21-19-25-10-14-29(15-11-25)36-33(39)28-13-12-26-8-4-5-9-27(26)22-28/h4-5,8-9,12-13,22,24-25,29-30H,1-3,6-7,10-11,14-21,23H2,(H2,35,37)(H,36,39)/t25-,29-,30-/m0/s1
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1.20E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from D2 receptor in Sprague-Dawley rat caudate-putamen


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50253393
PNG
(CHEMBL495327 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES CCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C29H38N4OS/c1-2-16-33(25-13-14-26-27(19-25)35-29(30)32-26)17-15-20-7-11-24(12-8-20)31-28(34)23-10-9-21-5-3-4-6-22(21)18-23/h3-6,9-10,18,20,24-25H,2,7-8,11-17,19H2,1H3,(H2,30,32)(H,31,34)/t20-,24-,25-/m0/s1
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3.40E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50400511
PNG
(CHEMBL2203406)
Show SMILES CCCN(CC[C@]1(O)C[C@@H](C1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C27H34N4O2S/c1-2-12-31(22-9-10-23-24(15-22)34-26(28)30-23)13-11-27(33)16-21(17-27)29-25(32)20-8-7-18-5-3-4-6-19(18)14-20/h3-8,14,21-22,33H,2,9-13,15-17H2,1H3,(H2,28,30)(H,29,32)/t21-,22-,27-/m0/s1
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>4.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]YM-09151-2 from human cloned dopamine D2 receptor expressed in CHOp cells after 60 mins by scintillation counter


ACS Med Chem Lett 2: 620-625 (2011)


Article DOI: 10.1021/ml200100t
BindingDB Entry DOI: 10.7270/Q2028SQ8
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50253470
PNG
(CHEMBL494509 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES Nc1nc2CC[C@@H](Cc2s1)N(CCC1CCCCC1)CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C34H46N4OS/c35-34-37-31-17-16-30(23-32(31)40-34)38(20-18-24-6-2-1-3-7-24)21-19-25-10-14-29(15-11-25)36-33(39)28-13-12-26-8-4-5-9-27(26)22-28/h4-5,8-9,12-13,22,24-25,29-30H,1-3,6-7,10-11,14-21,23H2,(H2,35,37)(H,36,39)/t25-,29-,30-/m0/s1
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4.40E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50253394
PNG
(CHEMBL494308 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES CCCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C30H40N4OS/c1-2-3-17-34(26-14-15-27-28(20-26)36-30(31)33-27)18-16-21-8-12-25(13-9-21)32-29(35)24-11-10-22-6-4-5-7-23(22)19-24/h4-7,10-11,19,21,25-26H,2-3,8-9,12-18,20H2,1H3,(H2,31,33)(H,32,35)/t21-,25-,26-/m0/s1
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5.40E+3n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50253395
PNG
(CHEMBL494309 | Naphthalene-2-carboxylic acid (4-{2...)
Show SMILES CC(C)CCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C31H42N4OS/c1-21(2)15-17-35(27-13-14-28-29(20-27)37-31(32)34-28)18-16-22-7-11-26(12-8-22)33-30(36)25-10-9-23-5-3-4-6-24(23)19-25/h3-6,9-10,19,21-22,26-27H,7-8,11-18,20H2,1-2H3,(H2,32,34)(H,33,36)/t22-,26-,27-/m0/s1
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1.30E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50253471
PNG
(CHEMBL494510 | Naphthalene-2-carboxylic acid {4-[2...)
Show SMILES Nc1nc2CC[C@@H](Cc2s1)NCC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H32N4OS/c27-26-30-23-12-11-22(16-24(23)32-26)28-14-13-17-5-9-21(10-6-17)29-25(31)20-8-7-18-3-1-2-4-19(18)15-20/h1-4,7-8,15,17,21-22,28H,5-6,9-14,16H2,(H2,27,30)(H,29,31)/t17-,21-,22-/m0/s1
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6.40E+4n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum


J Med Chem 51: 5905-8 (2008)


Article DOI: 10.1021/jm800471h
BindingDB Entry DOI: 10.7270/Q2FN161H
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50400511
PNG
(CHEMBL2203406)
Show SMILES CCCN(CC[C@]1(O)C[C@@H](C1)NC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1
Show InChI InChI=1S/C27H34N4O2S/c1-2-12-31(22-9-10-23-24(15-22)34-26(28)30-23)13-11-27(33)16-21(17-27)29-25(32)20-8-7-18-5-3-4-6-19(18)14-20/h3-8,14,21-22,33H,2,9-13,15-17H2,1H3,(H2,28,30)(H,29,32)/t21-,22-,27-/m0/s1
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n/an/an/an/a 1.70n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinopirole-induced mitogenisis after 24 hrs


ACS Med Chem Lett 2: 620-625 (2011)


Article DOI: 10.1021/ml200100t
BindingDB Entry DOI: 10.7270/Q2028SQ8
More data for this
Ligand-Target Pair