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19 similar compounds to monomer 50276347

Compile data set for download or QSAR
Wt: 543.4
BDBM50278055
Wt: 511.4
BDBM50277884
Wt: 565.4
BDBM50277885
Wt: 565.4
BDBM50277886
Wt: 547.8
BDBM50277959
Wt: 531.4
BDBM50278011
Wt: 581.4
BDBM50278012
Wt: 582.3
BDBM50277921
Wt: 555.5
BDBM50277557
Wt: 571.5
BDBM50277558
Wt: 514.4
BDBM50277492
Wt: 529.4
BDBM50277773
Wt: 538.4
BDBM50277459
Wt: 597.4
BDBM50277460
Wt: 545.9
BDBM50277811
Displayed 1 to 15 (of 19 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50278055,50277884,50277885,50277886,50277959,50278011,50278012,50277921,50277557,50277558,50277492,50277773,50277459,50277460,50277811   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50277921
PNG
(3-(5-(2,3-dichlorophenyl )-2-(3-(1,1,2,2-tetrafluo...)
Show SMILES OC(CN1C(CCc2c1cccc2-c1cccc(Cl)c1Cl)c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F
Show InChI InChI=1/C26H20Cl2F7NO2/c27-19-8-2-7-18(23(19)28)16-6-3-9-21-17(16)10-11-20(36(21)13-22(37)25(31,32)33)14-4-1-5-15(12-14)38-26(34,35)24(29)30/h1-9,12,20,22,24,37H,10-11,13H2
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n/an/a 400n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50277886
PNG
(CHEMBL491072 | Tetrahydroquinoline B)
Show SMILES O[C@H](CN1[C@H](CCc2c1cccc2-c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)F)c1)C(F)(F)F
Show InChI InChI=1/C26H20F9NO3/c27-24(28,29)23(37)14-36-21(16-5-2-7-18(13-16)39-26(33,34)35)11-10-20-19(8-3-9-22(20)36)15-4-1-6-17(12-15)38-25(30,31)32/h1-9,12-13,21,23,37H,10-11,14H2/t21-,23-/s2
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50278011
PNG
(1,1,1-trifluoro-3-(5-(3-fluorophenyl) -2-(3-(1,1,2...)
Show SMILES OC(CN1C(CCc2c1cccc2-c1cccc(F)c1)c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F
Show InChI InChI=1/C26H21F8NO2/c27-17-6-1-4-15(12-17)19-8-3-9-22-20(19)10-11-21(35(22)14-23(36)25(30,31)32)16-5-2-7-18(13-16)37-26(33,34)24(28)29/h1-9,12-13,21,23-24,36H,10-11,14H2
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n/an/a 117n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50278012
PNG
(1,1,1-tri fluoro-3-(2-(3-(1,1,2,2-tetrafluoroethox...)
Show SMILES OC(CN1C(CCc2c1cccc2-c1cccc(c1)C(F)(F)F)c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F
Show InChI InChI=1/C27H21F10NO2/c28-24(29)27(36,37)40-18-7-2-5-16(13-18)21-11-10-20-19(15-4-1-6-17(12-15)25(30,31)32)8-3-9-22(20)38(21)14-23(39)26(33,34)35/h1-9,12-13,21,23-24,39H,10-11,14H2
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n/an/a 96n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50278055
PNG
(1,1,1-trifluoro -3-(5-(3-methoxyphenyl)-2-(3-(1,1,...)
Show SMILES COc1cccc(c1)-c1cccc2N(CC(O)C(F)(F)F)C(CCc12)c1cccc(OC(F)(F)C(F)F)c1
Show InChI InChI=1/C27H24F7NO3/c1-37-18-7-2-5-16(13-18)20-9-4-10-23-21(20)11-12-22(35(23)15-24(36)26(30,31)32)17-6-3-8-19(14-17)38-27(33,34)25(28)29/h2-10,13-14,22,24-25,36H,11-12,15H2,1H3
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n/an/a 126n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50277459
PNG
(3-(2-(3-(1,1,2,2-tetrafluoroethoxy)phenyl )-1-(3,3...)
Show SMILES OC(CN1C(CCc2c1cccc2-c1cccc(c1)C#N)c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F
Show InChI InChI=1/C27H21F7N2O2/c28-25(29)27(33,34)38-19-7-2-6-18(13-19)22-11-10-21-20(17-5-1-4-16(12-17)14-35)8-3-9-23(21)36(22)15-24(37)26(30,31)32/h1-9,12-13,22,24-25,37H,10-11,15H2
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n/an/a 235n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50277460
PNG
(1,1,1-trifluoro-3-(2-(3-(1,1,2,2-tetrafluoroethoxy...)
Show SMILES OC(CN1C(CCc2c1cccc2-c1ccc(OC(F)(F)F)cc1)c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F
Show InChI InChI=1/C27H21F10NO3/c28-24(29)26(33,34)40-18-4-1-3-16(13-18)21-12-11-20-19(15-7-9-17(10-8-15)41-27(35,36)37)5-2-6-22(20)38(21)14-23(39)25(30,31)32/h1-10,13,21,23-24,39H,11-12,14H2
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n/an/a 500n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50277492
PNG
(1,1,1-trifluoro-3-(5-(pyridin-3-yl)-2-(3-(1,1,2,2-...)
Show SMILES OC(CN1C(CCc2c1cccc2-c1cccnc1)c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F
Show InChI InChI=1/C25H21F7N2O2/c26-23(27)25(31,32)36-17-6-1-4-15(12-17)20-10-9-19-18(16-5-3-11-33-13-16)7-2-8-21(19)34(20)14-22(35)24(28,29)30/h1-8,11-13,20,22-23,35H,9-10,14H2
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n/an/a>3.00E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50277557
PNG
(1,1,1-trifluoro-3-(5-(3-isopropylphenyl)-2-(3-(1,1...)
Show SMILES CC(C)c1cccc(c1)-c1cccc2N(CC(O)C(F)(F)F)C(CCc12)c1cccc(OC(F)(F)C(F)F)c1
Show InChI InChI=1/C29H28F7NO2/c1-17(2)18-6-3-7-19(14-18)22-10-5-11-25-23(22)12-13-24(37(25)16-26(38)28(32,33)34)20-8-4-9-21(15-20)39-29(35,36)27(30)31/h3-11,14-15,17,24,26-27,38H,12-13,16H2,1-2H3
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n/an/a 2.77E+5n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50277558
PNG
(1,1,1-trifluoro-3-(5-(3-isopropoxyphenyl)-2-(3-(1,...)
Show SMILES CC(C)Oc1cccc(c1)-c1cccc2N(CC(O)C(F)(F)F)C(CCc12)c1cccc(OC(F)(F)C(F)F)c1
Show InChI InChI=1/C29H28F7NO3/c1-17(2)39-20-8-3-6-18(14-20)22-10-5-11-25-23(22)12-13-24(37(25)16-26(38)28(32,33)34)19-7-4-9-21(15-19)40-29(35,36)27(30)31/h3-11,14-15,17,24,26-27,38H,12-13,16H2,1-2H3
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n/an/a 3.45E+5n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50277773
PNG
(1-(2,5-bis(3-(trifluoromethoxy)phenyl)-3,4-dihydro...)
Show SMILES OC(CF)CN1C(CCc2c1cccc2-c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1/C26H22F7NO3/c27-14-18(35)15-34-23(17-5-2-7-20(13-17)37-26(31,32)33)11-10-22-21(8-3-9-24(22)34)16-4-1-6-19(12-16)36-25(28,29)30/h1-9,12-13,18,23,35H,10-11,14-15H2
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n/an/a 331n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50277811
PNG
(1-(2,5-bis(3-(trifluoromethoxy)phenyl)-3,4-dihydro...)
Show SMILES OC(CCl)CN1C(CCc2c1cccc2-c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1/C26H22ClF6NO3/c27-14-18(35)15-34-23(17-5-2-7-20(13-17)37-26(31,32)33)11-10-22-21(8-3-9-24(22)34)16-4-1-6-19(12-16)36-25(28,29)30/h1-9,12-13,18,23,35H,10-11,14-15H2
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n/an/a 744n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50277884
PNG
((R)-1-((R)-2,5-bis(3-(trifluoromethoxy)phenyl)-3,4...)
Show SMILES C[C@@H](O)CN1[C@H](CCc2c1cccc2-c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1/C26H23F6NO3/c1-16(34)15-33-23(18-6-3-8-20(14-18)36-26(30,31)32)12-11-22-21(9-4-10-24(22)33)17-5-2-7-19(13-17)35-25(27,28)29/h2-10,13-14,16,23,34H,11-12,15H2,1H3/t16-,23-/s2
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n/an/a 125n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50277885
PNG
(CHEMBL490868 | Tetrahydroquinline A)
Show SMILES O[C@@H](CN1[C@H](CCc2c1cccc2-c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)F)c1)C(F)(F)F
Show InChI InChI=1/C26H20F9NO3/c27-24(28,29)23(37)14-36-21(16-5-2-7-18(13-16)39-26(33,34)35)11-10-20-19(8-3-9-22(20)36)15-4-1-6-17(12-15)38-25(30,31)32/h1-9,12-13,21,23,37H,10-11,14H2/t21-,23+/s2
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n/an/a 39n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair
Cholesteryl ester transfer protein


(Homo sapiens (Human))
BDBM50277959
PNG
(3-(5-(3-chlorophenyl)-2-(3-(1,1,2,2-te trafluoroet...)
Show SMILES OC(CN1C(CCc2c1cccc2-c1cccc(Cl)c1)c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F
Show InChI InChI=1/C26H21ClF7NO2/c27-17-6-1-4-15(12-17)19-8-3-9-22-20(19)10-11-21(35(22)14-23(36)25(30,31)32)16-5-2-7-18(13-16)37-26(33,34)24(28)29/h1-9,12-13,21,23-24,36H,10-11,14H2
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n/an/a 64n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human plasma derived CETP


Bioorg Med Chem Lett 19: 2456-60 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.051
BindingDB Entry DOI: 10.7270/Q2W37W6T
More data for this
Ligand-Target Pair