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23 similar compounds to monomer 50276484

Compile data set for download or QSAR
Wt: 437.6
BDBM50276481
Wt: 465.6
BDBM50276482
Wt: 499.6
BDBM50276483
Wt: 514.7
BDBM50276485
Wt: 544.7
BDBM50276486
Wt: 544.7
BDBM50276487
Wt: 544.7
BDBM50276488
Wt: 544.7
BDBM50276489
Wt: 514.7
BDBM50276491
Wt: 532.6
BDBM50276492
Wt: 544.7
BDBM50276494
Wt: 586.8
BDBM50276562
Wt: 544.7
BDBM50276563
Wt: 598.6
BDBM50276564
Wt: 423.5
BDBM50276443
Displayed 1 to 15 (of 23 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50276481,50276482,50276483,50276485,50276486,50276487,50276488,50276489,50276491,50276492,50276494,50276562,50276563,50276564,50276443   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276443
PNG
(1-(2,6-diisopropylphenyl)-3-((4-(3-methoxyphenyl)p...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cccc2C(C)C)C(C)C)CCNCC1
Show InChI InChI=1S/C26H37N3O2/c1-18(2)22-10-7-11-23(19(3)4)24(22)29-25(30)28-17-26(12-14-27-15-13-26)20-8-6-9-21(16-20)31-5/h6-11,16,18-19,27H,12-15,17H2,1-5H3,(H2,28,29,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276485
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1
Show InChI InChI=1S/C32H42N4O2/c1-22(2)28-19-25(33)20-29(23(3)4)30(28)35-31(37)34-21-32(24-10-9-13-27(18-24)38-5)14-16-36(17-15-32)26-11-7-6-8-12-26/h6-13,18-20,22-23H,14-17,21,33H2,1-5H3,(H2,34,35,37)
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n/an/a 40n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276562
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-butoxyp...)
Show SMILES CCCCOc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1
Show InChI InChI=1S/C36H50N4O3/c1-7-8-20-43-33-15-10-9-14-32(33)40-18-16-36(17-19-40,27-12-11-13-29(21-27)42-6)24-38-35(41)39-34-30(25(2)3)22-28(37)23-31(34)26(4)5/h9-15,21-23,25-26H,7-8,16-20,24,37H2,1-6H3,(H2,38,39,41)
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n/an/a 32n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276563
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)
Show SMILES COc1ccc(cc1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C33H44N4O3/c1-22(2)27-19-25(34)20-28(23(3)4)31(27)36-32(38)35-21-33(24-11-13-26(39-5)14-12-24)15-17-37(18-16-33)29-9-7-8-10-30(29)40-6/h7-14,19-20,22-23H,15-18,21,34H2,1-6H3,(H2,35,36,38)
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n/an/a 49n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276494
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1,4-bis(2-me...)
Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1ccccc1OC
Show InChI InChI=1S/C33H44N4O3/c1-22(2)25-19-24(34)20-26(23(3)4)31(25)36-32(38)35-21-33(27-11-7-9-13-29(27)39-5)15-17-37(18-16-33)28-12-8-10-14-30(28)40-6/h7-14,19-20,22-23H,15-18,21,34H2,1-6H3,(H2,35,36,38)
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n/an/a 43n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276492
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-fluorop...)
Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(F)c1
Show InChI InChI=1S/C32H41FN4O2/c1-21(2)26-18-25(34)19-27(22(3)4)30(26)36-31(38)35-20-32(23-9-8-10-24(33)17-23)13-15-37(16-14-32)28-11-6-7-12-29(28)39-5/h6-12,17-19,21-22H,13-16,20,34H2,1-5H3,(H2,35,36,38)
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n/an/a 77n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276491
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)
Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1ccccc1
Show InChI InChI=1S/C32H42N4O2/c1-22(2)26-19-25(33)20-27(23(3)4)30(26)35-31(37)34-21-32(24-11-7-6-8-12-24)15-17-36(18-16-32)28-13-9-10-14-29(28)38-5/h6-14,19-20,22-23H,15-18,21,33H2,1-5H3,(H2,34,35,37)
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n/an/a 82n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276489
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)
Show SMILES COc1ccc(cc1)N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1
Show InChI InChI=1S/C33H44N4O3/c1-22(2)29-19-25(34)20-30(23(3)4)31(29)36-32(38)35-21-33(24-8-7-9-28(18-24)40-6)14-16-37(17-15-33)26-10-12-27(39-5)13-11-26/h7-13,18-20,22-23H,14-17,21,34H2,1-6H3,(H2,35,36,38)
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n/an/a 142n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276488
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1,4-bis(3-me...)
Show SMILES COc1cccc(c1)N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1
Show InChI InChI=1S/C33H44N4O3/c1-22(2)29-18-25(34)19-30(23(3)4)31(29)36-32(38)35-21-33(24-9-7-11-27(17-24)39-5)13-15-37(16-14-33)26-10-8-12-28(20-26)40-6/h7-12,17-20,22-23H,13-16,21,34H2,1-6H3,(H2,35,36,38)
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n/an/a 48n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276487
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C33H44N4O3/c1-22(2)27-19-25(34)20-28(23(3)4)31(27)36-32(38)35-21-33(24-10-9-11-26(18-24)39-5)14-16-37(17-15-33)29-12-7-8-13-30(29)40-6/h7-13,18-20,22-23H,14-17,21,34H2,1-6H3,(H2,35,36,38)
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n/an/a 37n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276486
PNG
(1-(3-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(ccc(N)c2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C33H44N4O3/c1-22(2)26-14-15-27(34)30(23(3)4)31(26)36-32(38)35-21-33(24-10-9-11-25(20-24)39-5)16-18-37(19-17-33)28-12-7-8-13-29(28)40-6/h7-15,20,22-23H,16-19,21,34H2,1-6H3,(H2,35,36,38)
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n/an/a 81n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276485
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1
Show InChI InChI=1S/C32H42N4O2/c1-22(2)28-19-25(33)20-29(23(3)4)30(28)35-31(37)34-21-32(24-10-9-13-27(18-24)38-5)14-16-36(17-15-32)26-11-7-6-8-12-26/h6-13,18-20,22-23H,14-17,21,33H2,1-5H3,(H2,34,35,37)
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n/an/a 40n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276483
PNG
(1-(2,6-diisopropylphenyl)-3-((4-(3-methoxyphenyl)-...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cccc2C(C)C)C(C)C)CCN(CC1)c1ccccc1
Show InChI InChI=1S/C32H41N3O2/c1-23(2)28-15-10-16-29(24(3)4)30(28)34-31(36)33-22-32(25-11-9-14-27(21-25)37-5)17-19-35(20-18-32)26-12-7-6-8-13-26/h6-16,21,23-24H,17-20,22H2,1-5H3,(H2,33,34,36)
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n/an/a 35n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276482
PNG
(1-(2,6-diisopropylphenyl)-3-((4-(3-methoxyphenyl)-...)
Show SMILES CCCN1CCC(CNC(=O)Nc2c(cccc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1
Show InChI InChI=1S/C29H43N3O2/c1-7-16-32-17-14-29(15-18-32,23-10-8-11-24(19-23)34-6)20-30-28(33)31-27-25(21(2)3)12-9-13-26(27)22(4)5/h8-13,19,21-22H,7,14-18,20H2,1-6H3,(H2,30,31,33)
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n/an/a 547n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276481
PNG
(1-(2,6-diisopropylphenyl)-3-((4-(3-methoxyphenyl)-...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cccc2C(C)C)C(C)C)CCN(C)CC1
Show InChI InChI=1S/C27H39N3O2/c1-19(2)23-11-8-12-24(20(3)4)25(23)29-26(31)28-18-27(13-15-30(5)16-14-27)21-9-7-10-22(17-21)32-6/h7-12,17,19-20H,13-16,18H2,1-6H3,(H2,28,29,31)
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n/an/a 664n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276483
PNG
(1-(2,6-diisopropylphenyl)-3-((4-(3-methoxyphenyl)-...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cccc2C(C)C)C(C)C)CCN(CC1)c1ccccc1
Show InChI InChI=1S/C32H41N3O2/c1-23(2)28-15-10-16-29(24(3)4)30(28)34-31(36)33-22-32(25-11-9-14-27(21-25)37-5)17-19-35(20-18-32)26-12-7-6-8-13-26/h6-16,21,23-24H,17-20,22H2,1-5H3,(H2,33,34,36)
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n/an/a 35n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276562
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-butoxyp...)
Show SMILES CCCCOc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1
Show InChI InChI=1S/C36H50N4O3/c1-7-8-20-43-33-15-10-9-14-32(33)40-18-16-36(17-19-40,27-12-11-13-29(21-27)42-6)24-38-35(41)39-34-30(25(2)3)22-28(37)23-31(34)26(4)5/h9-15,21-23,25-26H,7-8,16-20,24,37H2,1-6H3,(H2,38,39,41)
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n/an/a 32n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276564
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C33H41F3N4O3/c1-21(2)26-18-24(37)19-27(22(3)4)30(26)39-31(41)38-20-32(23-9-8-10-25(17-23)42-5)13-15-40(16-14-32)28-11-6-7-12-29(28)43-33(34,35)36/h6-12,17-19,21-22H,13-16,20,37H2,1-5H3,(H2,38,39,41)
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n/an/a 68n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276491
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)
Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1ccccc1
Show InChI InChI=1S/C32H42N4O2/c1-22(2)26-19-25(33)20-27(23(3)4)30(26)35-31(37)34-21-32(24-11-7-6-8-12-24)15-17-36(18-16-32)28-13-9-10-14-29(28)38-5/h6-14,19-20,22-23H,15-18,21,33H2,1-5H3,(H2,34,35,37)
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n/an/a 82n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276489
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)
Show SMILES COc1ccc(cc1)N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1
Show InChI InChI=1S/C33H44N4O3/c1-22(2)29-19-25(34)20-30(23(3)4)31(29)36-32(38)35-21-33(24-8-7-9-28(18-24)40-6)14-16-37(17-15-33)26-10-12-27(39-5)13-11-26/h7-13,18-20,22-23H,14-17,21,34H2,1-6H3,(H2,35,36,38)
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n/an/a 142n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276488
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1,4-bis(3-me...)
Show SMILES COc1cccc(c1)N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1
Show InChI InChI=1S/C33H44N4O3/c1-22(2)29-18-25(34)19-30(23(3)4)31(29)36-32(38)35-21-33(24-9-7-11-27(17-24)39-5)13-15-37(16-14-33)26-10-8-12-28(20-26)40-6/h7-12,17-20,22-23H,13-16,21,34H2,1-6H3,(H2,35,36,38)
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n/an/a 48n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50276487
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C33H44N4O3/c1-22(2)27-19-25(34)20-28(23(3)4)31(27)36-32(38)35-21-33(24-10-9-11-26(18-24)39-5)14-16-37(17-15-33)29-12-7-8-13-30(29)40-6/h7-13,18-20,22-23H,14-17,21,34H2,1-6H3,(H2,35,36,38)
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n/an/a 37n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester...


Bioorg Med Chem 17: 4636-46 (2009)


Article DOI: 10.1016/j.bmc.2009.04.059
BindingDB Entry DOI: 10.7270/Q24M94KR
More data for this
Ligand-Target Pair
Sterol O-acyltransferase 1


(Homo sapiens (Human))
BDBM50276564
PNG
(1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)
Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C33H41F3N4O3/c1-21(2)26-18-24(37)19-27(22(3)4)30(26)39-31(41)38-20-32(23-9-8-10-25(17-23)42-5)13-15-40(16-14-32)28-11-6-7-12-29(28)43-33(34,35)36/h6-12,17-19,21-22H,13-16,20,37H2,1-5H3,(H2,38,39,41)
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n/an/a 68n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of ACAT in human HepG2 cells


Bioorg Med Chem Lett 19: 1062-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.020
BindingDB Entry DOI: 10.7270/Q2R78F3M
More data for this
Ligand-Target Pair