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13 similar compounds to monomer 50286270

Compile data set for download or QSAR
Wt: 461.6
BDBM50450377
Wt: 483.5
BDBM50450379
Wt: 482.0
BDBM50450381
Wt: 492.6
BDBM50450385
Wt: 531.7
BDBM50450388
Wt: 447.6
BDBM50450373
Wt: 477.6
BDBM50450376
Wt: 482.0
BDBM50450392
Wt: 515.6
BDBM50450383
Wt: 516.5
BDBM50450387
Wt: 515.6
BDBM50450382
Wt: 517.7
BDBM50286284
Wt: 405.5
BDBM50286287

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50450377,50450379,50450381,50450385,50450388,50450373,50450376,50450392,50450383,50450387,50450382,50286284,50286287   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50450392
PNG
(CHEMBL101883)
Show SMILES CCCCCCCCCCCCn1nnc(n1)C(NC(=O)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C27H36ClN5O/c1-2-3-4-5-6-7-8-9-10-14-20-33-31-26(30-32-33)25(22-16-12-11-13-17-22)29-27(34)23-18-15-19-24(28)21-23/h11-13,15-19,21,25H,2-10,14,20H2,1H3,(H,29,34)
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n/an/a 250n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...


Bioorg Med Chem Lett 5: 289-294 (1995)


Article DOI: 10.1016/0960-894X(95)00024-N
BindingDB Entry DOI: 10.7270/Q2FQ9WKP
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50450377
PNG
(CHEMBL100533)
Show SMILES CCCCCCCCCCCCn1nnc(n1)C(NC(=O)c1ccc(C)cc1)c1ccccc1
Show InChI InChI=1S/C28H39N5O/c1-3-4-5-6-7-8-9-10-11-15-22-33-31-27(30-32-33)26(24-16-13-12-14-17-24)29-28(34)25-20-18-23(2)19-21-25/h12-14,16-21,26H,3-11,15,22H2,1-2H3,(H,29,34)
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n/an/a 510n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...


Bioorg Med Chem Lett 5: 289-294 (1995)


Article DOI: 10.1016/0960-894X(95)00024-N
BindingDB Entry DOI: 10.7270/Q2FQ9WKP
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50450376
PNG
(CHEMBL101865)
Show SMILES CCCCCCCCCCCCn1nnc(n1)C(NC(=O)c1ccc(OC)cc1)c1ccccc1
Show InChI InChI=1S/C28H39N5O2/c1-3-4-5-6-7-8-9-10-11-15-22-33-31-27(30-32-33)26(23-16-13-12-14-17-23)29-28(34)24-18-20-25(35-2)21-19-24/h12-14,16-21,26H,3-11,15,22H2,1-2H3,(H,29,34)
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n/an/a 600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...


Bioorg Med Chem Lett 5: 289-294 (1995)


Article DOI: 10.1016/0960-894X(95)00024-N
BindingDB Entry DOI: 10.7270/Q2FQ9WKP
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50450373
PNG
(CHEMBL98742)
Show SMILES CCCCCCCCCCCCn1nnc(n1)C(NC(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H37N5O/c1-2-3-4-5-6-7-8-9-10-17-22-32-30-26(29-31-32)25(23-18-13-11-14-19-23)28-27(33)24-20-15-12-16-21-24/h11-16,18-21,25H,2-10,17,22H2,1H3,(H,28,33)
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n/an/a 350n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...


Bioorg Med Chem Lett 5: 289-294 (1995)


Article DOI: 10.1016/0960-894X(95)00024-N
BindingDB Entry DOI: 10.7270/Q2FQ9WKP
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50450381
PNG
(CHEMBL97926)
Show SMILES CCCCCCCCCCCCn1nnc(n1)C(NC(=O)c1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1S/C27H36ClN5O/c1-2-3-4-5-6-7-8-9-10-14-21-33-31-26(30-32-33)25(22-15-12-11-13-16-22)29-27(34)23-17-19-24(28)20-18-23/h11-13,15-20,25H,2-10,14,21H2,1H3,(H,29,34)
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n/an/a 440n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...


Bioorg Med Chem Lett 5: 289-294 (1995)


Article DOI: 10.1016/0960-894X(95)00024-N
BindingDB Entry DOI: 10.7270/Q2FQ9WKP
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50450382
PNG
(CHEMBL101629)
Show SMILES CCCCCCCCCCCCn1nnc(n1)C(NC(=O)c1ccccc1C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C28H36F3N5O/c1-2-3-4-5-6-7-8-9-10-16-21-36-34-26(33-35-36)25(22-17-12-11-13-18-22)32-27(37)23-19-14-15-20-24(23)28(29,30)31/h11-15,17-20,25H,2-10,16,21H2,1H3,(H,32,37)
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n/an/a 120n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...


Bioorg Med Chem Lett 5: 289-294 (1995)


Article DOI: 10.1016/0960-894X(95)00024-N
BindingDB Entry DOI: 10.7270/Q2FQ9WKP
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50286284
PNG
(2,6-Dimethyl-N-[(2-pentadecyl-2H-tetrazol-5-yl)-ph...)
Show SMILES CCCCCCCCCCCCCCCn1nnc(n1)C(NC(=O)c1c(C)cccc1C)c1ccccc1
Show InChI InChI=1S/C32H47N5O/c1-4-5-6-7-8-9-10-11-12-13-14-15-19-25-37-35-31(34-36-37)30(28-23-17-16-18-24-28)33-32(38)29-26(2)21-20-22-27(29)3/h16-18,20-24,30H,4-15,19,25H2,1-3H3,(H,33,38)
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n/an/a 440n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...


Bioorg Med Chem Lett 5: 289-294 (1995)


Article DOI: 10.1016/0960-894X(95)00024-N
BindingDB Entry DOI: 10.7270/Q2FQ9WKP
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50450385
PNG
(CHEMBL98598)
Show SMILES CCCCCCCCCCCCn1nnc(n1)C(NC(=O)c1ccc(cc1)[N+]([O-])=O)c1ccccc1
Show InChI InChI=1S/C27H36N6O3/c1-2-3-4-5-6-7-8-9-10-14-21-32-30-26(29-31-32)25(22-15-12-11-13-16-22)28-27(34)23-17-19-24(20-18-23)33(35)36/h11-13,15-20,25H,2-10,14,21H2,1H3,(H,28,34)
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n/an/a 540n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...


Bioorg Med Chem Lett 5: 289-294 (1995)


Article DOI: 10.1016/0960-894X(95)00024-N
BindingDB Entry DOI: 10.7270/Q2FQ9WKP
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50450387
PNG
(CHEMBL100993)
Show SMILES CCCCCCCCCCCCn1nnc(n1)C(NC(=O)c1c(Cl)cccc1Cl)c1ccccc1
Show InChI InChI=1S/C27H35Cl2N5O/c1-2-3-4-5-6-7-8-9-10-14-20-34-32-26(31-33-34)25(21-16-12-11-13-17-21)30-27(35)24-22(28)18-15-19-23(24)29/h11-13,15-19,25H,2-10,14,20H2,1H3,(H,30,35)
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n/an/a 460n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...


Bioorg Med Chem Lett 5: 289-294 (1995)


Article DOI: 10.1016/0960-894X(95)00024-N
BindingDB Entry DOI: 10.7270/Q2FQ9WKP
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50450388
PNG
(CHEMBL321102)
Show SMILES CCCCCCCCCCCCn1nnc(n1)C(NC(=O)c1c(cccc1C(C)C)C(C)C)c1ccccc1
Show InChI InChI=1S/C33H49N5O/c1-6-7-8-9-10-11-12-13-14-18-24-38-36-32(35-37-38)31(27-20-16-15-17-21-27)34-33(39)30-28(25(2)3)22-19-23-29(30)26(4)5/h15-17,19-23,25-26,31H,6-14,18,24H2,1-5H3,(H,34,39)
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n/an/a 810n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...


Bioorg Med Chem Lett 5: 289-294 (1995)


Article DOI: 10.1016/0960-894X(95)00024-N
BindingDB Entry DOI: 10.7270/Q2FQ9WKP
More data for this
Ligand-Target Pair
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)
BDBM50286287
PNG
(CHEMBL101259 | N-[(2-Heptyl-2H-tetrazol-5-yl)-phen...)
Show SMILES CCCCCCCn1nnc(n1)C(NC(=O)c1c(C)cccc1C)c1ccccc1
Show InChI InChI=1S/C24H31N5O/c1-4-5-6-7-11-17-29-27-23(26-28-29)22(20-15-9-8-10-16-20)25-24(30)21-18(2)13-12-14-19(21)3/h8-10,12-16,22H,4-7,11,17H2,1-3H3,(H,25,30)
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n/an/a 3.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...


Bioorg Med Chem Lett 5: 289-294 (1995)


Article DOI: 10.1016/0960-894X(95)00024-N
BindingDB Entry DOI: 10.7270/Q2FQ9WKP
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50450379
PNG
(CHEMBL101937)
Show SMILES CCCCCCCCCCCCn1nnc(n1)C(NC(=O)c1ccc(F)cc1F)c1ccccc1
Show InChI InChI=1S/C27H35F2N5O/c1-2-3-4-5-6-7-8-9-10-14-19-34-32-26(31-33-34)25(21-15-12-11-13-16-21)30-27(35)23-18-17-22(28)20-24(23)29/h11-13,15-18,20,25H,2-10,14,19H2,1H3,(H,30,35)
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n/an/a 490n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...


Bioorg Med Chem Lett 5: 289-294 (1995)


Article DOI: 10.1016/0960-894X(95)00024-N
BindingDB Entry DOI: 10.7270/Q2FQ9WKP
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50450383
PNG
(CHEMBL98365)
Show SMILES CCCCCCCCCCCCn1nnc(n1)C(NC(=O)c1ccc(cc1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C28H36F3N5O/c1-2-3-4-5-6-7-8-9-10-14-21-36-34-26(33-35-36)25(22-15-12-11-13-16-22)32-27(37)23-17-19-24(20-18-23)28(29,30)31/h11-13,15-20,25H,2-10,14,21H2,1H3,(H,32,37)
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n/an/a 850n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Concentration required for the in vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in liver microsomes isolated from cholestero...


Bioorg Med Chem Lett 5: 289-294 (1995)


Article DOI: 10.1016/0960-894X(95)00024-N
BindingDB Entry DOI: 10.7270/Q2FQ9WKP
More data for this
Ligand-Target Pair