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2 similar compounds to monomer 50287291

Compile data set for download or QSAR
Wt: 501.9
BDBM50287289
Wt: 467.5
BDBM50287293

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50287289,50287293   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50287289
PNG
(2-Chloro-N-[5-ethyl-3-[2'-(1H-tetrazol-5-yl)-biphe...)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=NC(=O)c2ccccc2Cl)s1
Show InChI InChI=1S/C25H20ClN7OS/c1-2-22-30-33(25(35-22)27-24(34)20-9-5-6-10-21(20)26)15-16-11-13-17(14-12-16)18-7-3-4-8-19(18)23-28-31-32-29-23/h3-14H,2,15H2,1H3,(H,28,29,31,32)
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Similars

3.40n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes


Citation and Details

BindingDB Entry DOI: 10.7270/Q29S1T6B
More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50287293
PNG
(CHEMBL286537 | N-[5-Ethyl-3-[2'-(1H-tetrazol-5-yl)...)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=NC(=O)c2ccccc2)s1
Show InChI InChI=1S/C25H21N7OS/c1-2-22-29-32(25(34-22)26-24(33)19-8-4-3-5-9-19)16-17-12-14-18(15-13-17)20-10-6-7-11-21(20)23-27-30-31-28-23/h3-15H,2,16H2,1H3,(H,27,28,30,31)
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36n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of binding of [125I]All at the angiotensin II type 1 receptor (AT1 receptor) in rat liver membranes


Citation and Details

BindingDB Entry DOI: 10.7270/Q29S1T6B
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50287289
PNG
(2-Chloro-N-[5-ethyl-3-[2'-(1H-tetrazol-5-yl)-biphe...)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=NC(=O)c2ccccc2Cl)s1
Show InChI InChI=1S/C25H20ClN7OS/c1-2-22-30-33(25(35-22)27-24(34)20-9-5-6-10-21(20)26)15-16-11-13-17(14-12-16)18-7-3-4-8-19(18)23-28-31-32-29-23/h3-14H,2,15H2,1H3,(H,28,29,31,32)
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Article
n/an/a 3.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for the ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)


Bioorg Med Chem Lett 6: 1469-1474 (1996)


Article DOI: 10.1016/S0960-894X(96)00250-8
BindingDB Entry DOI: 10.7270/Q2SN08XQ
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50287293
PNG
(CHEMBL286537 | N-[5-Ethyl-3-[2'-(1H-tetrazol-5-yl)...)
Show SMILES CCc1nn(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=NC(=O)c2ccccc2)s1
Show InChI InChI=1S/C25H21N7OS/c1-2-22-29-32(25(34-22)26-24(33)19-8-4-3-5-9-19)16-17-12-14-18(15-13-17)20-10-6-7-11-21(20)23-27-30-31-28-23/h3-15H,2,16H2,1H3,(H,27,28,30,31)
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Article
n/an/a 37n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested in vitro for the ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)


Bioorg Med Chem Lett 6: 1469-1474 (1996)


Article DOI: 10.1016/S0960-894X(96)00250-8
BindingDB Entry DOI: 10.7270/Q2SN08XQ
More data for this
Ligand-Target Pair