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21 similar compounds to monomer 50301977

Compile data set for download or QSAR
Wt: 478.4
BDBM50301973
Wt: 491.4
BDBM50301974
Wt: 477.4
BDBM50301975
Wt: 477.4
BDBM50301976
Wt: 490.4
BDBM50301978
Wt: 462.4
BDBM50301979
Wt: 462.4
BDBM50301980
Wt: 448.4
BDBM50301981
Wt: 534.5
BDBM50301986
Wt: 520.5
BDBM50301987
Wt: 491.4
BDBM50301988
Wt: 518.5
BDBM50301989
Wt: 477.4
BDBM50301990
Wt: 493.4
BDBM50301991
Wt: 462.4
BDBM50301992
Displayed 1 to 15 (of 21 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50301973,50301974,50301975,50301976,50301978,50301979,50301980,50301981,50301986,50301987,50301988,50301989,50301990,50301991,50301992   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasminogen


(Homo sapiens (Human))
BDBM50301973
PNG
(2-(6-(3'-(aminomethyl)-5-hydroxybiphenyl-3-yloxy)-...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(O)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H20F2N2O5/c1-14-5-6-20(26(32)33)23(7-14)35-25-22(28)12-21(27)24(30-25)34-19-10-17(9-18(31)11-19)16-4-2-3-15(8-16)13-29/h2-12,31H,13,29H2,1H3,(H,32,33)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301989
PNG
(2-(6-(3'-carbamimidoylbiphenyl-3-yloxy)-3,5-difluo...)
Show SMILES CN(C)c1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(c3)C(N)=N)c(F)c(C)c2F)c1
Show InChI InChI=1S/C28H24F2N4O4/c1-15-23(29)26(37-20-9-5-7-17(13-20)16-6-4-8-18(12-16)25(31)32)33-27(24(15)30)38-22-14-19(34(2)3)10-11-21(22)28(35)36/h4-14H,1-3H3,(H3,31,32)(H,35,36)
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n/an/a 98n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50301975
PNG
(2-(6-(5-amino-3'-(aminomethyl)biphenyl-3-yloxy)-3,...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(N)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H21F2N3O4/c1-14-5-6-20(26(32)33)23(7-14)35-25-22(28)12-21(27)24(31-25)34-19-10-17(9-18(30)11-19)16-4-2-3-15(8-16)13-29/h2-12H,13,29-30H2,1H3,(H,32,33)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50301976
PNG
(2-(6-(4-amino-3'-(aminomethyl)biphenyl-3-yloxy)-3,...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(ccc3N)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H21F2N3O4/c1-14-5-7-18(26(32)33)22(9-14)34-24-19(27)12-20(28)25(31-24)35-23-11-17(6-8-21(23)30)16-4-2-3-15(10-16)13-29/h2-12H,13,29-30H2,1H3,(H,32,33)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50301978
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES CC(C)c1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C28H24F2N2O4/c1-16(2)18-9-10-22(28(33)34)25(13-18)36-27-24(30)14-23(29)26(32-27)35-21-8-4-7-20(12-21)19-6-3-5-17(11-19)15-31/h3-14,16H,15,31H2,1-2H3,(H,33,34)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50301979
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES Cc1cccc(C(O)=O)c1Oc1nc(Oc2cccc(c2)-c2cccc(CN)c2)c(F)cc1F
Show InChI InChI=1S/C26H20F2N2O4/c1-15-5-2-10-20(26(31)32)23(15)34-25-22(28)13-21(27)24(30-25)33-19-9-4-8-18(12-19)17-7-3-6-16(11-17)14-29/h2-13H,14,29H2,1H3,(H,31,32)
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n/an/a 8.60E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50301980
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H20F2N2O4/c1-15-8-9-20(26(31)32)23(10-15)34-25-22(28)13-21(27)24(30-25)33-19-7-3-6-18(12-19)17-5-2-4-16(11-17)14-29/h2-13H,14,29H2,1H3,(H,31,32)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50301981
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES NCc1cccc(c1)-c1cccc(Oc2nc(Oc3ccccc3C(O)=O)c(F)cc2F)c1
Show InChI InChI=1S/C25H18F2N2O4/c26-20-13-21(27)24(33-22-10-2-1-9-19(22)25(30)31)29-23(20)32-18-8-4-7-17(12-18)16-6-3-5-15(11-16)14-28/h1-13H,14,28H2,(H,30,31)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50301986
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-4-(dimethy...)
Show SMILES CN(C)c1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)c(N(C)C)c2F)c1
Show InChI InChI=1S/C29H28F2N4O4/c1-34(2)20-11-12-22(29(36)37)23(15-20)39-28-25(31)26(35(3)4)24(30)27(33-28)38-21-10-6-9-19(14-21)18-8-5-7-17(13-18)16-32/h5-15H,16,32H2,1-4H3,(H,36,37)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50301987
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES CNc1c(F)c(Oc2cccc(c2)-c2cccc(CN)c2)nc(Oc2cc(ccc2C(O)=O)N(C)C)c1F
Show InChI InChI=1S/C28H26F2N4O4/c1-32-25-23(29)26(37-20-9-5-8-18(13-20)17-7-4-6-16(12-17)15-31)33-27(24(25)30)38-22-14-19(34(2)3)10-11-21(22)28(35)36/h4-14H,15,31H2,1-3H3,(H,32,33)(H,35,36)
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n/an/a 3.60E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50301988
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES CN(C)c1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C27H23F2N3O4/c1-32(2)19-9-10-21(27(33)34)24(13-19)36-26-23(29)14-22(28)25(31-26)35-20-8-4-7-18(12-20)17-6-3-5-16(11-17)15-30/h3-14H,15,30H2,1-2H3,(H,33,34)
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n/an/a 6.50E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50301989
PNG
(2-(6-(3'-carbamimidoylbiphenyl-3-yloxy)-3,5-difluo...)
Show SMILES CN(C)c1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(c3)C(N)=N)c(F)c(C)c2F)c1
Show InChI InChI=1S/C28H24F2N4O4/c1-15-23(29)26(37-20-9-5-7-17(13-20)16-6-4-8-18(12-16)25(31)32)33-27(24(15)30)38-22-14-19(34(2)3)10-11-21(22)28(35)36/h4-14H,1-3H3,(H3,31,32)(H,35,36)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50301973
PNG
(2-(6-(3'-(aminomethyl)-5-hydroxybiphenyl-3-yloxy)-...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(O)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H20F2N2O5/c1-14-5-6-20(26(32)33)23(7-14)35-25-22(28)12-21(27)24(30-25)34-19-10-17(9-18(31)11-19)16-4-2-3-15(8-16)13-29/h2-12,31H,13,29H2,1H3,(H,32,33)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of tPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50301975
PNG
(2-(6-(5-amino-3'-(aminomethyl)biphenyl-3-yloxy)-3,...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(N)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H21F2N3O4/c1-14-5-6-20(26(32)33)23(7-14)35-25-22(28)12-21(27)24(31-25)34-19-10-17(9-18(30)11-19)16-4-2-3-15(8-16)13-29/h2-12H,13,29-30H2,1H3,(H,32,33)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of tPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50301976
PNG
(2-(6-(4-amino-3'-(aminomethyl)biphenyl-3-yloxy)-3,...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(ccc3N)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H21F2N3O4/c1-14-5-7-18(26(32)33)22(9-14)34-24-19(27)12-20(28)25(31-24)35-23-11-17(6-8-21(23)30)16-4-2-3-15(10-16)13-29/h2-12H,13,29-30H2,1H3,(H,32,33)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of tPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50301980
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H20F2N2O4/c1-15-8-9-20(26(31)32)23(10-15)34-25-22(28)13-21(27)24(30-25)33-19-7-3-6-18(12-19)17-5-2-4-16(11-17)14-29/h2-13H,14,29H2,1H3,(H,31,32)
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n/an/a 2.20E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of tPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50301981
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES NCc1cccc(c1)-c1cccc(Oc2nc(Oc3ccccc3C(O)=O)c(F)cc2F)c1
Show InChI InChI=1S/C25H18F2N2O4/c26-20-13-21(27)24(33-22-10-2-1-9-19(22)25(30)31)29-23(20)32-18-8-4-7-17(12-18)16-6-3-5-15(11-16)14-28/h1-13H,14,28H2,(H,30,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of tPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50301986
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-4-(dimethy...)
Show SMILES CN(C)c1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)c(N(C)C)c2F)c1
Show InChI InChI=1S/C29H28F2N4O4/c1-34(2)20-11-12-22(29(36)37)23(15-20)39-28-25(31)26(35(3)4)24(30)27(33-28)38-21-10-6-9-19(14-21)18-8-5-7-17(13-18)16-32/h5-15H,16,32H2,1-4H3,(H,36,37)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of tPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50301987
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES CNc1c(F)c(Oc2cccc(c2)-c2cccc(CN)c2)nc(Oc2cc(ccc2C(O)=O)N(C)C)c1F
Show InChI InChI=1S/C28H26F2N4O4/c1-32-25-23(29)26(37-20-9-5-8-18(13-20)17-7-4-6-16(12-17)15-31)33-27(24(25)30)38-22-14-19(34(2)3)10-11-21(22)28(35)36/h4-14H,15,31H2,1-3H3,(H,32,33)(H,35,36)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of tPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50301988
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES CN(C)c1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C27H23F2N3O4/c1-32(2)19-9-10-21(27(33)34)24(13-19)36-26-23(29)14-22(28)25(31-26)35-20-8-4-7-18(12-20)17-6-3-5-16(11-17)15-30/h3-14H,15,30H2,1-2H3,(H,33,34)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of tPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Tissue-type plasminogen activator


(Homo sapiens (Human))
BDBM50301989
PNG
(2-(6-(3'-carbamimidoylbiphenyl-3-yloxy)-3,5-difluo...)
Show SMILES CN(C)c1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(c3)C(N)=N)c(F)c(C)c2F)c1
Show InChI InChI=1S/C28H24F2N4O4/c1-15-23(29)26(37-20-9-5-7-17(13-20)16-6-4-8-18(12-16)25(31)32)33-27(24(15)30)38-22-14-19(34(2)3)10-11-21(22)28(35)36/h4-14H,1-3H3,(H3,31,32)(H,35,36)
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n/an/a 3.90E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of tPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301973
PNG
(2-(6-(3'-(aminomethyl)-5-hydroxybiphenyl-3-yloxy)-...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(O)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H20F2N2O5/c1-14-5-6-20(26(32)33)23(7-14)35-25-22(28)12-21(27)24(30-25)34-19-10-17(9-18(31)11-19)16-4-2-3-15(8-16)13-29/h2-12,31H,13,29H2,1H3,(H,32,33)
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n/an/a 23n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301974
PNG
(2-(6-(3',5-bis(aminomethyl)biphenyl-3-yloxy)-3,5-d...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(CN)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C27H23F2N3O4/c1-15-5-6-21(27(33)34)24(7-15)36-26-23(29)12-22(28)25(32-26)35-20-10-17(14-31)9-19(11-20)18-4-2-3-16(8-18)13-30/h2-12H,13-14,30-31H2,1H3,(H,33,34)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301990
PNG
(2-(6-(6-amino-3'-(aminomethyl)biphenyl-3-yloxy)-3,...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3ccc(N)c(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H21F2N3O4/c1-14-5-7-18(26(32)33)23(9-14)35-25-21(28)12-20(27)24(31-25)34-17-6-8-22(30)19(11-17)16-4-2-3-15(10-16)13-29/h2-12H,13,29-30H2,1H3,(H,32,33)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301975
PNG
(2-(6-(5-amino-3'-(aminomethyl)biphenyl-3-yloxy)-3,...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(N)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H21F2N3O4/c1-14-5-6-20(26(32)33)23(7-14)35-25-22(28)12-21(27)24(31-25)34-19-10-17(9-18(30)11-19)16-4-2-3-15(8-16)13-29/h2-12H,13,29-30H2,1H3,(H,32,33)
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n/an/a 39n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301976
PNG
(2-(6-(4-amino-3'-(aminomethyl)biphenyl-3-yloxy)-3,...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(ccc3N)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H21F2N3O4/c1-14-5-7-18(26(32)33)22(9-14)34-24-19(27)12-20(28)25(31-24)35-23-11-17(6-8-21(23)30)16-4-2-3-15(10-16)13-29/h2-12H,13,29-30H2,1H3,(H,32,33)
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n/an/a 89n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301991
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES NCc1cccc(c1)-c1cccc(Oc2nc(Oc3cc(ccc3C(O)=O)[N+]([O-])=O)c(F)cc2F)c1
Show InChI InChI=1S/C25H17F2N3O6/c26-20-12-21(27)24(36-22-11-17(30(33)34)7-8-19(22)25(31)32)29-23(20)35-18-6-2-5-16(10-18)15-4-1-3-14(9-15)13-28/h1-12H,13,28H2,(H,31,32)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301978
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES CC(C)c1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C28H24F2N2O4/c1-16(2)18-9-10-22(28(33)34)25(13-18)36-27-24(30)14-23(29)26(32-27)35-21-8-4-7-20(12-21)19-6-3-5-17(11-19)15-31/h3-14,16H,15,31H2,1-2H3,(H,33,34)
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n/an/a 680n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301979
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES Cc1cccc(C(O)=O)c1Oc1nc(Oc2cccc(c2)-c2cccc(CN)c2)c(F)cc1F
Show InChI InChI=1S/C26H20F2N2O4/c1-15-5-2-10-20(26(31)32)23(15)34-25-22(28)13-21(27)24(30-25)33-19-9-4-8-18(12-19)17-7-3-6-16(11-17)14-29/h2-13H,14,29H2,1H3,(H,31,32)
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n/an/a 540n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301980
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H20F2N2O4/c1-15-8-9-20(26(31)32)23(10-15)34-25-22(28)13-21(27)24(30-25)33-19-7-3-6-18(12-19)17-5-2-4-16(11-17)14-29/h2-13H,14,29H2,1H3,(H,31,32)
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n/an/a 240n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301992
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES Cc1ccc(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)cc2F)c(c1)C(O)=O
Show InChI InChI=1S/C26H20F2N2O4/c1-15-8-9-23(20(10-15)26(31)32)34-25-22(28)13-21(27)24(30-25)33-19-7-3-6-18(12-19)17-5-2-4-16(11-17)14-29/h2-13H,14,29H2,1H3,(H,31,32)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301981
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES NCc1cccc(c1)-c1cccc(Oc2nc(Oc3ccccc3C(O)=O)c(F)cc2F)c1
Show InChI InChI=1S/C25H18F2N2O4/c26-20-13-21(27)24(33-22-10-2-1-9-19(22)25(30)31)29-23(20)32-18-8-4-7-17(12-18)16-6-3-5-15(11-16)14-28/h1-13H,14,28H2,(H,30,31)
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n/an/a 840n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301986
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-4-(dimethy...)
Show SMILES CN(C)c1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)c(N(C)C)c2F)c1
Show InChI InChI=1S/C29H28F2N4O4/c1-34(2)20-11-12-22(29(36)37)23(15-20)39-28-25(31)26(35(3)4)24(30)27(33-28)38-21-10-6-9-19(14-21)18-8-5-7-17(13-18)16-32/h5-15H,16,32H2,1-4H3,(H,36,37)
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n/an/a 530n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301987
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES CNc1c(F)c(Oc2cccc(c2)-c2cccc(CN)c2)nc(Oc2cc(ccc2C(O)=O)N(C)C)c1F
Show InChI InChI=1S/C28H26F2N4O4/c1-32-25-23(29)26(37-20-9-5-8-18(13-20)17-7-4-6-16(12-17)15-31)33-27(24(25)30)38-22-14-19(34(2)3)10-11-21(22)28(35)36/h4-14H,15,31H2,1-3H3,(H,32,33)(H,35,36)
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n/an/a 130n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301988
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-3,5-difluo...)
Show SMILES CN(C)c1ccc(C(O)=O)c(Oc2nc(Oc3cccc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C27H23F2N3O4/c1-32(2)19-9-10-21(27(33)34)24(13-19)36-26-23(29)14-22(28)25(31-26)35-20-8-4-7-18(12-20)17-6-3-5-16(11-17)15-30/h3-14H,15,30H2,1-2H3,(H,33,34)
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n/an/a 100n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (Human))
BDBM50301974
PNG
(2-(6-(3',5-bis(aminomethyl)biphenyl-3-yloxy)-3,5-d...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(CN)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C27H23F2N3O4/c1-15-5-6-21(27(33)34)24(7-15)36-26-23(29)12-22(28)25(32-26)35-20-10-17(14-31)9-19(11-20)18-4-2-3-16(8-18)13-30/h2-12H,13-14,30-31H2,1H3,(H,33,34)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of plasmin


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair