BindingDB logo
myBDB logout

1 similar compounds to monomer 50302271

Compile data set for download or QSAR
Wt: 565.1
BDBM50302270

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50302270   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urotensin II receptor


(Homo sapiens (Human))
BDBM50302270
PNG
((R)-2-(4-(6-chloropyrazin-2-ylamino)-1-(3,4-dimeth...)
Show SMILES CCN1CCN(CC1)c1cccc2C(=O)N(Cc12)[C@H](CCCNc1cncc(Cl)n1)c1ccc(OC)c(OC)c1
Show InChI InChI=1/C30H37ClN6O3/c1-4-35-13-15-36(16-14-35)25-8-5-7-22-23(25)20-37(30(22)38)24(21-10-11-26(39-2)27(17-21)40-3)9-6-12-33-29-19-32-18-28(31)34-29/h5,7-8,10-11,17-19,24H,4,6,9,12-16,20H2,1-3H3,(H,33,34)/t24-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
62n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]urotensin 2 from urotensin 2 receptor in human RMS13 cells by scintillation proximity assay


J Med Chem 52: 7432-45 (2009)


Article DOI: 10.1021/jm900683d
BindingDB Entry DOI: 10.7270/Q2S75GD7
More data for this
Ligand-Target Pair
Urotensin II receptor


(Homo sapiens (Human))
BDBM50302270
PNG
((R)-2-(4-(6-chloropyrazin-2-ylamino)-1-(3,4-dimeth...)
Show SMILES CCN1CCN(CC1)c1cccc2C(=O)N(Cc12)[C@H](CCCNc1cncc(Cl)n1)c1ccc(OC)c(OC)c1
Show InChI InChI=1/C30H37ClN6O3/c1-4-35-13-15-36(16-14-35)25-8-5-7-22-23(25)20-37(30(22)38)24(21-10-11-26(39-2)27(17-21)40-3)9-6-12-33-29-19-32-18-28(31)34-29/h5,7-8,10-11,17-19,24H,4,6,9,12-16,20H2,1-3H3,(H,33,34)/t24-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at urotensin 2 receptor in human RMS13 cells assessed as inhibition of urotensin 2-induced intracellular calcium mobilization aft...


J Med Chem 52: 7432-45 (2009)


Article DOI: 10.1021/jm900683d
BindingDB Entry DOI: 10.7270/Q2S75GD7
More data for this
Ligand-Target Pair
UTS2R


(RAT)
BDBM50302270
PNG
((R)-2-(4-(6-chloropyrazin-2-ylamino)-1-(3,4-dimeth...)
Show SMILES CCN1CCN(CC1)c1cccc2C(=O)N(Cc12)[C@H](CCCNc1cncc(Cl)n1)c1ccc(OC)c(OC)c1
Show InChI InChI=1/C30H37ClN6O3/c1-4-35-13-15-36(16-14-35)25-8-5-7-22-23(25)20-37(30(22)38)24(21-10-11-26(39-2)27(17-21)40-3)9-6-12-33-29-19-32-18-28(31)34-29/h5,7-8,10-11,17-19,24H,4,6,9,12-16,20H2,1-3H3,(H,33,34)/t24-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat urotensin 2 receptor expressed in CHOK1 cells assessed as inhibition of urotensin 2-induced intracellular calcium mobiliza...


J Med Chem 52: 7432-45 (2009)


Article DOI: 10.1021/jm900683d
BindingDB Entry DOI: 10.7270/Q2S75GD7
More data for this
Ligand-Target Pair