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1 similar compounds to monomer 50302270

Compile data set for download or QSAR
Wt: 560.6
BDBM50302271

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50302271   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urotensin II receptor


(Homo sapiens (Human))
BDBM50302271
PNG
((R)-2-(1-(3,4-dimethoxyphenyl)-4-(6-methoxypyrazin...)
Show SMILES CCN1CCN(CC1)c1cccc2C(=O)N(Cc12)[C@H](CCCNc1cncc(OC)n1)c1ccc(OC)c(OC)c1
Show InChI InChI=1/C31H40N6O4/c1-5-35-14-16-36(17-15-35)26-9-6-8-23-24(26)21-37(31(23)38)25(22-11-12-27(39-2)28(18-22)40-3)10-7-13-33-29-19-32-20-30(34-29)41-4/h6,8-9,11-12,18-20,25H,5,7,10,13-17,21H2,1-4H3,(H,33,34)/t25-/s2
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PC sid
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Article
PubMed
8n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]urotensin 2 from urotensin 2 receptor in human RMS13 cells by scintillation proximity assay


J Med Chem 52: 7432-45 (2009)


Article DOI: 10.1021/jm900683d
BindingDB Entry DOI: 10.7270/Q2S75GD7
More data for this
Ligand-Target Pair
Urotensin II receptor


(Homo sapiens (Human))
BDBM50302271
PNG
((R)-2-(1-(3,4-dimethoxyphenyl)-4-(6-methoxypyrazin...)
Show SMILES CCN1CCN(CC1)c1cccc2C(=O)N(Cc12)[C@H](CCCNc1cncc(OC)n1)c1ccc(OC)c(OC)c1
Show InChI InChI=1/C31H40N6O4/c1-5-35-14-16-36(17-15-35)26-9-6-8-23-24(26)21-37(31(23)38)25(22-11-12-27(39-2)28(18-22)40-3)10-7-13-33-29-19-32-20-30(34-29)41-4/h6,8-9,11-12,18-20,25H,5,7,10,13-17,21H2,1-4H3,(H,33,34)/t25-/s2
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Article
PubMed
n/an/a 62n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at urotensin 2 receptor in human RMS13 cells assessed as inhibition of urotensin 2-induced intracellular calcium mobilization aft...


J Med Chem 52: 7432-45 (2009)


Article DOI: 10.1021/jm900683d
BindingDB Entry DOI: 10.7270/Q2S75GD7
More data for this
Ligand-Target Pair
UTS2R


(RAT)
BDBM50302271
PNG
((R)-2-(1-(3,4-dimethoxyphenyl)-4-(6-methoxypyrazin...)
Show SMILES CCN1CCN(CC1)c1cccc2C(=O)N(Cc12)[C@H](CCCNc1cncc(OC)n1)c1ccc(OC)c(OC)c1
Show InChI InChI=1/C31H40N6O4/c1-5-35-14-16-36(17-15-35)26-9-6-8-23-24(26)21-37(31(23)38)25(22-11-12-27(39-2)28(18-22)40-3)10-7-13-33-29-19-32-20-30(34-29)41-4/h6,8-9,11-12,18-20,25H,5,7,10,13-17,21H2,1-4H3,(H,33,34)/t25-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Antagonist activity at rat urotensin 2 receptor expressed in CHOK1 cells assessed as inhibition of urotensin 2-induced intracellular calcium mobiliza...


J Med Chem 52: 7432-45 (2009)


Article DOI: 10.1021/jm900683d
BindingDB Entry DOI: 10.7270/Q2S75GD7
More data for this
Ligand-Target Pair