BindingDB logo
myBDB logout

34 similar compounds to monomer 50303774

Compile data set for download or QSAR
Wt: 602.7
BDBM50303775
Wt: 714.9
BDBM50303776
Wt: 707.8
BDBM50303779
Wt: 686.9
BDBM50303781
Wt: 665.8
BDBM50303787
Wt: 707.8
BDBM50303788
Wt: 665.8
BDBM50303789
Wt: 693.7
BDBM50349588
Wt: 666.7
BDBM50349589
Wt: 676.8
BDBM50349590
Wt: 636.7
BDBM50349591
Wt: 708.8
BDBM50349592
Wt: 650.8
BDBM50349594
Wt: 679.8
BDBM50349595
Wt: 678.8
BDBM50349597
Displayed 1 to 15 (of 34 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50303775,50303776,50303779,50303781,50303787,50303788,50303789,50349588,50349589,50349590,50349591,50349592,50349594,50349595,50349597   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50303775
PNG
((S)-2-acetamido-N-((S)-1-((S)-1-(4-carbamimidoylbe...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H46N12O4/c1-15(2)21(39-24(42)20(37-16(3)40)7-5-13-35-27(32)33)25(43)38-19(6-4-12-34-26(30)31)23(41)36-14-17-8-10-18(11-9-17)22(28)29/h8-11,15,19-21H,4-7,12-14H2,1-3H3,(H3,28,29)(H,36,41)(H,37,40)(H,38,43)(H,39,42)(H4,30,31,34)(H4,32,33,35)/t19-,20-,21-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50303776
PNG
(CHEMBL568525 | N-((6S,9S,12S)-1,17-diamino-6-(4-ca...)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C35H62N12O4/c1-4-5-6-7-8-9-10-15-28(48)45-27(14-12-21-43-35(40)41)32(50)47-29(23(2)3)33(51)46-26(13-11-20-42-34(38)39)31(49)44-22-24-16-18-25(19-17-24)30(36)37/h16-19,23,26-27,29H,4-15,20-22H2,1-3H3,(H3,36,37)(H,44,49)(H,45,48)(H,46,51)(H,47,50)(H4,38,39,42)(H4,40,41,43)/t26-,27-,29-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.60n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Prohormone convertase 1


(Homo sapiens (Human))
BDBM50303775
PNG
((S)-2-acetamido-N-((S)-1-((S)-1-(4-carbamimidoylbe...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H46N12O4/c1-15(2)21(39-24(42)20(37-16(3)40)7-5-13-35-27(32)33)25(43)38-19(6-4-12-34-26(30)31)23(41)36-14-17-8-10-18(11-9-17)22(28)29/h8-11,15,19-21H,4-7,12-14H2,1-3H3,(H3,28,29)(H,36,41)(H,37,40)(H,38,43)(H,39,42)(H4,30,31,34)(H4,32,33,35)/t19-,20-,21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.70n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PC1/3 expressed in Drosophila schneider 2 cells by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens (Human))
BDBM50303775
PNG
((S)-2-acetamido-N-((S)-1-((S)-1-(4-carbamimidoylbe...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H46N12O4/c1-15(2)21(39-24(42)20(37-16(3)40)7-5-13-35-27(32)33)25(43)38-19(6-4-12-34-26(30)31)23(41)36-14-17-8-10-18(11-9-17)22(28)29/h8-11,15,19-21H,4-7,12-14H2,1-3H3,(H3,28,29)(H,36,41)(H,37,40)(H,38,43)(H,39,42)(H4,30,31,34)(H4,32,33,35)/t19-,20-,21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.40n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PACE4 expressed in Drosophila schneider 2 cells by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Subtilisin/kexin type 6


(Homo sapiens (Human))
BDBM50303776
PNG
(CHEMBL568525 | N-((6S,9S,12S)-1,17-diamino-6-(4-ca...)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C35H62N12O4/c1-4-5-6-7-8-9-10-15-28(48)45-27(14-12-21-43-35(40)41)32(50)47-29(23(2)3)33(51)46-26(13-11-20-42-34(38)39)31(49)44-22-24-16-18-25(19-17-24)30(36)37/h16-19,23,26-27,29H,4-15,20-22H2,1-3H3,(H3,36,37)(H,44,49)(H,45,48)(H,46,51)(H,47,50)(H4,38,39,42)(H4,40,41,43)/t26-,27-,29-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PACE4 expressed in Drosophila schneider 2 cells by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50303781
PNG
(CHEMBL565931 | N-((4S,7S,10S)-15-amino-4-(4-aminob...)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C35H62N10O4/c1-4-5-6-7-8-9-10-16-29(46)43-28(15-13-22-41-35(39)40)33(48)45-30(24(2)3)34(49)44-27(14-11-12-21-36)32(47)42-23-25-17-19-26(20-18-25)31(37)38/h17-20,24,27-28,30H,4-16,21-23,36H2,1-3H3,(H3,37,38)(H,42,47)(H,43,46)(H,44,49)(H,45,48)(H4,39,40,41)/t27-,28-,30-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.30n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Subtilisin/kexin type 5


(Homo sapiens (Human))
BDBM50303775
PNG
((S)-2-acetamido-N-((S)-1-((S)-1-(4-carbamimidoylbe...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H46N12O4/c1-15(2)21(39-24(42)20(37-16(3)40)7-5-13-35-27(32)33)25(43)38-19(6-4-12-34-26(30)31)23(41)36-14-17-8-10-18(11-9-17)22(28)29/h8-11,15,19-21H,4-7,12-14H2,1-3H3,(H3,28,29)(H,36,41)(H,37,40)(H,38,43)(H,39,42)(H4,30,31,34)(H4,32,33,35)/t19-,20-,21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.60n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PC5/6 expressed in Drosophila schneider 2 cells by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Prohormone convertase 1


(Homo sapiens (Human))
BDBM50303776
PNG
(CHEMBL568525 | N-((6S,9S,12S)-1,17-diamino-6-(4-ca...)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C35H62N12O4/c1-4-5-6-7-8-9-10-15-28(48)45-27(14-12-21-43-35(40)41)32(50)47-29(23(2)3)33(51)46-26(13-11-20-42-34(38)39)31(49)44-22-24-16-18-25(19-17-24)30(36)37/h16-19,23,26-27,29H,4-15,20-22H2,1-3H3,(H3,36,37)(H,44,49)(H,45,48)(H,46,51)(H,47,50)(H4,38,39,42)(H4,40,41,43)/t26-,27-,29-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.70n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PC1/3 expressed in Drosophila schneider 2 cells by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Subtilisin/kexin type 5


(Homo sapiens (Human))
BDBM50303776
PNG
(CHEMBL568525 | N-((6S,9S,12S)-1,17-diamino-6-(4-ca...)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C35H62N12O4/c1-4-5-6-7-8-9-10-15-28(48)45-27(14-12-21-43-35(40)41)32(50)47-29(23(2)3)33(51)46-26(13-11-20-42-34(38)39)31(49)44-22-24-16-18-25(19-17-24)30(36)37/h16-19,23,26-27,29H,4-15,20-22H2,1-3H3,(H3,36,37)(H,44,49)(H,45,48)(H,46,51)(H,47,50)(H4,38,39,42)(H4,40,41,43)/t26-,27-,29-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.30n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PC5/6 expressed in Drosophila schneider 2 cells by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349588
PNG
(CHEMBL1808917)
Show SMILES NC(=O)C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C32H47N13O5/c33-25(46)17-24(45-29(49)23(9-5-15-41-32(38)39)43-26(47)16-19-6-2-1-3-7-19)30(50)44-22(8-4-14-40-31(36)37)28(48)42-18-20-10-12-21(13-11-20)27(34)35/h1-3,6-7,10-13,22-24H,4-5,8-9,14-18H2,(H2,33,46)(H3,34,35)(H,42,48)(H,43,47)(H,44,50)(H,45,49)(H4,36,37,40)(H4,38,39,41)/t22-,23-,24-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
23n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349589
PNG
(CHEMBL1808918)
Show SMILES NC(N)=NCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C31H46N12O5/c32-26(33)21-12-10-20(11-13-21)17-40-27(46)22(8-4-14-38-30(34)35)42-29(48)24(18-44)43-28(47)23(9-5-15-39-31(36)37)41-25(45)16-19-6-2-1-3-7-19/h1-3,6-7,10-13,22-24,44H,4-5,8-9,14-18H2,(H3,32,33)(H,40,46)(H,41,45)(H,42,48)(H,43,47)(H4,34,35,38)(H4,36,37,39)/t22-,23-,24-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
24n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349590
PNG
(CHEMBL1808919)
Show SMILES NC(N)=NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H48N12O4/c34-28(35)23-14-12-22(13-15-23)20-42-29(47)24(9-4-16-40-32(36)37)44-30(48)26-11-6-18-45(26)31(49)25(10-5-17-41-33(38)39)43-27(46)19-21-7-2-1-3-8-21/h1-3,7-8,12-15,24-26H,4-6,9-11,16-20H2,(H3,34,35)(H,42,47)(H,43,46)(H,44,48)(H4,36,37,40)(H4,38,39,41)/t24-,25-,26-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
37n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349591
PNG
(CHEMBL1808920)
Show SMILES NC(N)=NCCC[C@H](NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C30H44N12O4/c31-26(32)21-12-10-20(11-13-21)17-39-27(45)23(9-5-15-38-30(35)36)42-25(44)18-40-28(46)22(8-4-14-37-29(33)34)41-24(43)16-19-6-2-1-3-7-19/h1-3,6-7,10-13,22-23H,4-5,8-9,14-18H2,(H3,31,32)(H,39,45)(H,40,46)(H,41,43)(H,42,44)(H4,33,34,37)(H4,35,36,38)/t22-,23-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
40n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Prohormone convertase 2


(Homo sapiens (Human))
BDBM50303776
PNG
(CHEMBL568525 | N-((6S,9S,12S)-1,17-diamino-6-(4-ca...)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C35H62N12O4/c1-4-5-6-7-8-9-10-15-28(48)45-27(14-12-21-43-35(40)41)32(50)47-29(23(2)3)33(51)46-26(13-11-20-42-34(38)39)31(49)44-22-24-16-18-25(19-17-24)30(36)37/h16-19,23,26-27,29H,4-15,20-22H2,1-3H3,(H3,36,37)(H,44,49)(H,45,48)(H,46,51)(H,47,50)(H4,38,39,42)(H4,40,41,43)/t26-,27-,29-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
55n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PC2 expressed in Drosophila schneider 2 cells by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349592
PNG
(CHEMBL1808921)
Show SMILES NC(N)=NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H48N12O6/c34-28(35)22-12-10-21(11-13-22)19-42-29(49)23(8-4-16-40-32(36)37)44-31(51)25(14-15-27(47)48)45-30(50)24(9-5-17-41-33(38)39)43-26(46)18-20-6-2-1-3-7-20/h1-3,6-7,10-13,23-25H,4-5,8-9,14-19H2,(H3,34,35)(H,42,49)(H,43,46)(H,44,51)(H,45,50)(H,47,48)(H4,36,37,40)(H4,38,39,41)/t23-,24-,25-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
102n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349595
PNG
(CHEMBL1808924)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=O)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H49N11O5/c1-20(2)27(44-30(47)25(11-7-17-40-33(38)49)42-26(45)18-21-8-4-3-5-9-21)31(48)43-24(10-6-16-39-32(36)37)29(46)41-19-22-12-14-23(15-13-22)28(34)35/h3-5,8-9,12-15,20,24-25,27H,6-7,10-11,16-19H2,1-2H3,(H3,34,35)(H,41,46)(H,42,45)(H,43,48)(H,44,47)(H4,36,37,39)(H3,38,40,49)/t24-,25-,27-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
238n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349594
PNG
(CHEMBL1808923)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H50N10O4/c1-21(2)28(43-31(46)26(11-6-7-17-34)41-27(44)19-22-9-4-3-5-10-22)32(47)42-25(12-8-18-39-33(37)38)30(45)40-20-23-13-15-24(16-14-23)29(35)36/h3-5,9-10,13-16,21,25-26,28H,6-8,11-12,17-20,34H2,1-2H3,(H3,35,36)(H,40,45)(H,41,44)(H,42,47)(H,43,46)(H4,37,38,39)/t25-,26-,28-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
285n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50303787
PNG
((S)-N-(4-(aminomethyl)benzyl)-5-guanidino-2-((S)-2...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(CN)cc1
Show InChI InChI=1S/C33H51N11O4/c1-21(2)28(44-30(47)26(11-7-17-40-33(37)38)42-27(45)18-22-8-4-3-5-9-22)31(48)43-25(10-6-16-39-32(35)36)29(46)41-20-24-14-12-23(19-34)13-15-24/h3-5,8-9,12-15,21,25-26,28H,6-7,10-11,16-20,34H2,1-2H3,(H,41,46)(H,42,45)(H,43,48)(H,44,47)(H4,35,36,39)(H4,37,38,40)/t25-,26-,28-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
627n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Subtilisin/kexin type 7


(Homo sapiens (Human))
BDBM50303776
PNG
(CHEMBL568525 | N-((6S,9S,12S)-1,17-diamino-6-(4-ca...)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C35H62N12O4/c1-4-5-6-7-8-9-10-15-28(48)45-27(14-12-21-43-35(40)41)32(50)47-29(23(2)3)33(51)46-26(13-11-20-42-34(38)39)31(49)44-22-24-16-18-25(19-17-24)30(36)37/h16-19,23,26-27,29H,4-15,20-22H2,1-3H3,(H3,36,37)(H,44,49)(H,45,48)(H,46,51)(H,47,50)(H4,38,39,42)(H4,40,41,43)/t26-,27-,29-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
968n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PC7 expressed in Drosophila schneider 2 cells by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349597
PNG
(CHEMBL1808926)
Show SMILES CC(C)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H50N12O4/c1-20(2)27(45-30(48)25(11-7-17-41-33(38)39)43-26(46)18-21-8-4-3-5-9-21)31(49)44-24(10-6-16-40-32(36)37)29(47)42-19-22-12-14-23(15-13-22)28(34)35/h3-5,8-9,12-15,20,24-25,27H,6-7,10-11,16-19H2,1-2H3,(H3,34,35)(H,42,47)(H,43,46)(H,44,49)(H,45,48)(H4,36,37,40)(H4,38,39,41)/t24-,25-,27+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.11E+3n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50303789
PNG
((S)-N-(3-(aminomethyl)benzyl)-5-guanidino-2-((S)-2...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1cccc(CN)c1
Show InChI InChI=1S/C33H51N11O4/c1-21(2)28(44-30(47)26(14-8-16-40-33(37)38)42-27(45)18-22-9-4-3-5-10-22)31(48)43-25(13-7-15-39-32(35)36)29(46)41-20-24-12-6-11-23(17-24)19-34/h3-6,9-12,17,21,25-26,28H,7-8,13-16,18-20,34H2,1-2H3,(H,41,46)(H,42,45)(H,43,48)(H,44,47)(H4,35,36,39)(H4,37,38,40)/t25-,26-,28-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.32E+3n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Prohormone convertase 2


(Homo sapiens (Human))
BDBM50303775
PNG
((S)-2-acetamido-N-((S)-1-((S)-1-(4-carbamimidoylbe...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H46N12O4/c1-15(2)21(39-24(42)20(37-16(3)40)7-5-13-35-27(32)33)25(43)38-19(6-4-12-34-26(30)31)23(41)36-14-17-8-10-18(11-9-17)22(28)29/h8-11,15,19-21H,4-7,12-14H2,1-3H3,(H3,28,29)(H,36,41)(H,37,40)(H,38,43)(H,39,42)(H4,30,31,34)(H4,32,33,35)/t19-,20-,21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.39E+3n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PC2 expressed in Drosophila schneider 2 cells by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50303788
PNG
((S)-5-guanidino-N-((S)-1-((S)-5-guanidino-1-(4-(gu...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(CN=C(N)N)cc1
Show InChI InChI=1S/C34H53N13O4/c1-21(2)28(47-30(50)26(11-7-17-42-33(37)38)45-27(48)18-22-8-4-3-5-9-22)31(51)46-25(10-6-16-41-32(35)36)29(49)43-19-23-12-14-24(15-13-23)20-44-34(39)40/h3-5,8-9,12-15,21,25-26,28H,6-7,10-11,16-20H2,1-2H3,(H,43,49)(H,45,48)(H,46,51)(H,47,50)(H4,35,36,41)(H4,37,38,42)(H4,39,40,44)/t25-,26-,28-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.43E+3n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50303779
PNG
((S)-5-guanidino-N-((S)-1-((S)-5-guanidino-1-(3-(gu...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1cccc(CN=C(N)N)c1
Show InChI InChI=1S/C34H53N13O4/c1-21(2)28(47-30(50)26(14-8-16-42-33(37)38)45-27(48)18-22-9-4-3-5-10-22)31(51)46-25(13-7-15-41-32(35)36)29(49)43-19-23-11-6-12-24(17-23)20-44-34(39)40/h3-6,9-12,17,21,25-26,28H,7-8,13-16,18-20H2,1-2H3,(H,43,49)(H,45,48)(H,46,51)(H,47,50)(H4,35,36,41)(H4,37,38,42)(H4,39,40,44)/t25-,26-,28-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.73E+3n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Subtilisin/kexin type 7


(Homo sapiens (Human))
BDBM50303775
PNG
((S)-2-acetamido-N-((S)-1-((S)-1-(4-carbamimidoylbe...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H46N12O4/c1-15(2)21(39-24(42)20(37-16(3)40)7-5-13-35-27(32)33)25(43)38-19(6-4-12-34-26(30)31)23(41)36-14-17-8-10-18(11-9-17)22(28)29/h8-11,15,19-21H,4-7,12-14H2,1-3H3,(H3,28,29)(H,36,41)(H,37,40)(H,38,43)(H,39,42)(H4,30,31,34)(H4,32,33,35)/t19-,20-,21-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.13E+3n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human PC7 expressed in Drosophila schneider 2 cells by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair