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36 similar compounds to monomer 50304845

Compile data set for download or QSAR
Wt: 317.3
BDBM50304835
Wt: 331.3
BDBM50304836
Wt: 317.3
BDBM50304837
Wt: 331.3
BDBM50304838
Wt: 316.3
BDBM50304839
Wt: 330.3
BDBM50304840
Wt: 332.3
BDBM50304841
Wt: 332.3
BDBM50304842
Wt: 332.3
BDBM50304843
Wt: 331.3
BDBM50304844
Wt: 331.3
BDBM50304846
Wt: 341.3
BDBM50304847
Wt: 341.3
BDBM50304848
Wt: 344.4
BDBM50304849
Wt: 342.3
BDBM50304850
Displayed 1 to 15 (of 36 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50304835,50304836,50304837,50304838,50304839,50304840,50304841,50304842,50304843,50304844,50304846,50304847,50304848,50304849,50304850   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304836
PNG
(1,2-dimethyl-4-(6-methylpyridin-2-yl)-5-(quinoxali...)
Show SMILES Cc1cccc(n1)-c1c(-c2ccc3nccnc3c2)n(C)n(C)c1=O
Show InChI InChI=1S/C19H17N5O/c1-12-5-4-6-15(22-12)17-18(23(2)24(3)19(17)25)13-7-8-14-16(11-13)21-10-9-20-14/h4-11H,1-3H3
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5n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304849
PNG
(4-(3-ethylphenyl)-1,2-dimethyl-5-(quinoxalin-6-yl)...)
Show SMILES CCc1cccc(c1)-c1c(-c2ccc3nccnc3c2)n(C)n(C)c1=O
Show InChI InChI=1S/C21H20N4O/c1-4-14-6-5-7-15(12-14)19-20(24(2)25(3)21(19)26)16-8-9-17-18(13-16)23-11-10-22-17/h5-13H,4H2,1-3H3
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6n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304835
PNG
(1,2-dimethyl-4-(pyridin-2-yl)-5-(quinoxalin-6-yl)-...)
Show SMILES Cn1c(c(-c2ccccn2)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C18H15N5O/c1-22-17(12-6-7-13-15(11-12)21-10-9-20-13)16(18(24)23(22)2)14-5-3-4-8-19-14/h3-11H,1-2H3
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11n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304850
PNG
(1,2-dimethyl-5-(quinoxalin-6-yl)-4-(3-vinylphenyl)...)
Show SMILES Cn1c(c(-c2cccc(C=C)c2)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C21H18N4O/c1-4-14-6-5-7-15(12-14)19-20(24(2)25(3)21(19)26)16-8-9-17-18(13-16)23-11-10-22-17/h4-13H,1H2,2-3H3
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12n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304840
PNG
(1,2-dimethyl-5-(quinoxalin-6-yl)-4-m-tolyl-1H-pyra...)
Show SMILES Cc1cccc(c1)-c1c(-c2ccc3nccnc3c2)n(C)n(C)c1=O
Show InChI InChI=1S/C20H18N4O/c1-13-5-4-6-14(11-13)18-19(23(2)24(3)20(18)25)15-7-8-16-17(12-15)22-10-9-21-16/h4-12H,1-3H3
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20n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304839
PNG
(1,2-dimethyl-4-phenyl-5-(quinoxalin-6-yl)-1H-pyraz...)
Show SMILES Cn1c(c(-c2ccccc2)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C19H16N4O/c1-22-18(14-8-9-15-16(12-14)21-11-10-20-15)17(19(24)23(22)2)13-6-4-3-5-7-13/h3-12H,1-2H3
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78n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304838
PNG
(1,2-dimethyl-4-(2-methylpyridin-4-yl)-5-(quinoxali...)
Show SMILES Cc1cc(ccn1)-c1c(-c2ccc3nccnc3c2)n(C)n(C)c1=O
Show InChI InChI=1S/C19H17N5O/c1-12-10-13(6-7-20-12)17-18(23(2)24(3)19(17)25)14-4-5-15-16(11-14)22-9-8-21-15/h4-11H,1-3H3
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>2.80E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304837
PNG
(1,2-dimethyl-4-(pyridin-3-yl)-5-(quinoxalin-6-yl)-...)
Show SMILES Cn1c(c(-c2cccnc2)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C18H15N5O/c1-22-17(12-5-6-14-15(10-12)21-9-8-20-14)16(18(24)23(22)2)13-4-3-7-19-11-13/h3-11H,1-2H3
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>2.80E+3n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304848
PNG
(3-(1,2-dimethyl-3-oxo-5-(quinoxalin-6-yl)-2,3-dihy...)
Show SMILES Cn1c(c(-c2cccc(c2)C#N)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C20H15N5O/c1-24-19(15-6-7-16-17(11-15)23-9-8-22-16)18(20(26)25(24)2)14-5-3-4-13(10-14)12-21/h3-11H,1-2H3
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4.50E+4n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304842
PNG
(4-(3-hydroxyphenyl)-1,2-dimethyl-5-(quinoxalin-6-y...)
Show SMILES Cn1c(c(-c2cccc(O)c2)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C19H16N4O2/c1-22-18(13-6-7-15-16(11-13)21-9-8-20-15)17(19(25)23(22)2)12-4-3-5-14(24)10-12/h3-11,24H,1-2H3
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5.30E+4n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304841
PNG
(4-(2-hydroxyphenyl)-1,2-dimethyl-5-(quinoxalin-6-y...)
Show SMILES Cn1c(c(-c2ccccc2O)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C19H16N4O2/c1-22-18(12-7-8-14-15(11-12)21-10-9-20-14)17(19(25)23(22)2)13-5-3-4-6-16(13)24/h3-11,24H,1-2H3
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7.70E+4n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304847
PNG
(2-(1,2-dimethyl-3-oxo-5-(quinoxalin-6-yl)-2,3-dihy...)
Show SMILES Cn1c(c(-c2ccccc2C#N)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C20H15N5O/c1-24-19(13-7-8-16-17(11-13)23-10-9-22-16)18(20(26)25(24)2)15-6-4-3-5-14(15)12-21/h3-11H,1-2H3
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4.50E+5n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304846
PNG
(4-(4-aminophenyl)-1,2-dimethyl-5-(quinoxalin-6-yl)...)
Show SMILES Cn1c(c(-c2ccc(N)cc2)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C19H17N5O/c1-23-18(13-5-8-15-16(11-13)22-10-9-21-15)17(19(25)24(23)2)12-3-6-14(20)7-4-12/h3-11H,20H2,1-2H3
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6.40E+5n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304843
PNG
(4-(4-hydroxyphenyl)-1,2-dimethyl-5-(quinoxalin-6-y...)
Show SMILES Cn1c(c(-c2ccc(O)cc2)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C19H16N4O2/c1-22-18(13-5-8-15-16(11-13)21-10-9-20-15)17(19(25)23(22)2)12-3-6-14(24)7-4-12/h3-11,24H,1-2H3
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9.50E+5n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304844
PNG
(4-(2-aminophenyl)-1,2-dimethyl-5-(quinoxalin-6-yl)...)
Show SMILES Cn1c(c(-c2ccccc2N)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C19H17N5O/c1-23-18(12-7-8-15-16(11-12)22-10-9-21-15)17(19(25)24(23)2)13-5-3-4-6-14(13)20/h3-11H,20H2,1-2H3
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9.52E+5n/an/an/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304848
PNG
(3-(1,2-dimethyl-3-oxo-5-(quinoxalin-6-yl)-2,3-dihy...)
Show SMILES Cn1c(c(-c2cccc(c2)C#N)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C20H15N5O/c1-24-19(15-6-7-16-17(11-15)23-9-8-22-16)18(20(26)25(24)2)14-5-3-4-13(10-14)12-21/h3-11H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304836
PNG
(1,2-dimethyl-4-(6-methylpyridin-2-yl)-5-(quinoxali...)
Show SMILES Cc1cccc(n1)-c1c(-c2ccc3nccnc3c2)n(C)n(C)c1=O
Show InChI InChI=1S/C19H17N5O/c1-12-5-4-6-15(22-12)17-18(23(2)24(3)19(17)25)13-7-8-14-16(11-13)21-10-9-20-14/h4-11H,1-3H3
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n/an/a 1.03E+3n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304849
PNG
(4-(3-ethylphenyl)-1,2-dimethyl-5-(quinoxalin-6-yl)...)
Show SMILES CCc1cccc(c1)-c1c(-c2ccc3nccnc3c2)n(C)n(C)c1=O
Show InChI InChI=1S/C21H20N4O/c1-4-14-6-5-7-15(12-14)19-20(24(2)25(3)21(19)26)16-8-9-17-18(13-16)23-11-10-22-17/h5-13H,4H2,1-3H3
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n/an/a 390n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304835
PNG
(1,2-dimethyl-4-(pyridin-2-yl)-5-(quinoxalin-6-yl)-...)
Show SMILES Cn1c(c(-c2ccccn2)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C18H15N5O/c1-22-17(12-6-7-13-15(11-12)21-10-9-20-13)16(18(24)23(22)2)14-5-3-4-8-19-14/h3-11H,1-2H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304839
PNG
(1,2-dimethyl-4-phenyl-5-(quinoxalin-6-yl)-1H-pyraz...)
Show SMILES Cn1c(c(-c2ccccc2)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C19H16N4O/c1-22-18(14-8-9-15-16(12-14)21-11-10-20-15)17(19(24)23(22)2)13-6-4-3-5-7-13/h3-12H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304847
PNG
(2-(1,2-dimethyl-3-oxo-5-(quinoxalin-6-yl)-2,3-dihy...)
Show SMILES Cn1c(c(-c2ccccc2C#N)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C20H15N5O/c1-24-19(13-7-8-16-17(11-13)23-10-9-22-16)18(20(26)25(24)2)15-6-4-3-5-14(15)12-21/h3-11H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304842
PNG
(4-(3-hydroxyphenyl)-1,2-dimethyl-5-(quinoxalin-6-y...)
Show SMILES Cn1c(c(-c2cccc(O)c2)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C19H16N4O2/c1-22-18(13-6-7-15-16(11-13)21-9-8-20-15)17(19(25)23(22)2)12-4-3-5-14(24)10-12/h3-11,24H,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304850
PNG
(1,2-dimethyl-5-(quinoxalin-6-yl)-4-(3-vinylphenyl)...)
Show SMILES Cn1c(c(-c2cccc(C=C)c2)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C21H18N4O/c1-4-14-6-5-7-15(12-14)19-20(24(2)25(3)21(19)26)16-8-9-17-18(13-16)23-11-10-22-17/h4-13H,1H2,2-3H3
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n/an/a 560n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304840
PNG
(1,2-dimethyl-5-(quinoxalin-6-yl)-4-m-tolyl-1H-pyra...)
Show SMILES Cc1cccc(c1)-c1c(-c2ccc3nccnc3c2)n(C)n(C)c1=O
Show InChI InChI=1S/C20H18N4O/c1-13-5-4-6-14(11-13)18-19(23(2)24(3)20(18)25)15-7-8-16-17(12-15)22-10-9-21-16/h4-12H,1-3H3
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n/an/a 3.05E+3n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50304841
PNG
(4-(2-hydroxyphenyl)-1,2-dimethyl-5-(quinoxalin-6-y...)
Show SMILES Cn1c(c(-c2ccccc2O)c(=O)n1C)-c1ccc2nccnc2c1
Show InChI InChI=1S/C19H16N4O2/c1-22-18(12-7-8-14-15(11-12)21-10-9-20-14)17(19(25)23(22)2)13-5-3-4-6-16(13)24/h3-11,24H,1-2H3
PDB

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B.MOAD
GoogleScholar
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PC cid
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UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Biogen Idec Inc.

Curated by ChEMBL


Assay Description
Inhibition of TGFR-1 in human HepG2 cells expressing PAI-luciferase by luciferase reporter gene assay


Bioorg Med Chem Lett 20: 326-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.108
BindingDB Entry DOI: 10.7270/Q2RN37ZK
More data for this
Ligand-Target Pair