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8 similar compounds to monomer 50321356

Compile data set for download or QSAR
Wt: 385.4
BDBM50321352
Wt: 369.4
BDBM50321353
Wt: 385.4
BDBM50321354
Wt: 369.4
BDBM50321355
Wt: 369.4
BDBM50321357
Wt: 384.4
BDBM50321358
Wt: 383.4
BDBM50321361
Wt: 368.4
BDBM50321362

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50321352,50321353,50321354,50321355,50321357,50321358,50321361,50321362   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321352
PNG
(4-(4-(4-cyano-1H-imidazole-2-carboxamido)-3-cycloh...)
Show SMILES [O-][n+]1ccc(cc1)-c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C22H19N5O2/c23-13-18-14-24-21(25-18)22(28)26-20-7-6-17(15-8-10-27(29)11-9-15)12-19(20)16-4-2-1-3-5-16/h4,6-12,14H,1-3,5H2,(H,24,25)(H,26,28)
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n/an/a 1.5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321353
PNG
(4-cyano-N-(2-cyclohexenyl-4-(pyridin-4-yl)phenyl)-...)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)-c1ccncc1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H19N5O/c23-13-18-14-25-21(26-18)22(28)27-20-7-6-17(15-8-10-24-11-9-15)12-19(20)16-4-2-1-3-5-16/h4,6-12,14H,1-3,5H2,(H,25,26)(H,27,28)
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n/an/a 4.5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321354
PNG
(3-(4-(4-cyano-1H-imidazole-2-carboxamido)-3-cycloh...)
Show SMILES [O-][n+]1cccc(c1)-c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C22H19N5O2/c23-12-18-13-24-21(25-18)22(28)26-20-9-8-16(17-7-4-10-27(29)14-17)11-19(20)15-5-2-1-3-6-15/h4-5,7-11,13-14H,1-3,6H2,(H,24,25)(H,26,28)
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n/an/a 1.40n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321355
PNG
(4-cyano-N-(2-cyclohexenyl-4-(pyridin-3-yl)phenyl)-...)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)-c1cccnc1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H19N5O/c23-12-18-14-25-21(26-18)22(28)27-20-9-8-16(17-7-4-10-24-13-17)11-19(20)15-5-2-1-3-6-15/h4-5,7-11,13-14H,1-3,6H2,(H,25,26)(H,27,28)
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n/an/a 2.30n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50321353
PNG
(4-cyano-N-(2-cyclohexenyl-4-(pyridin-4-yl)phenyl)-...)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)-c1ccncc1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H19N5O/c23-13-18-14-25-21(26-18)22(28)27-20-7-6-17(15-8-10-24-11-9-15)12-19(20)16-4-2-1-3-5-16/h4,6-12,14H,1-3,5H2,(H,25,26)(H,27,28)
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n/an/a 87n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321358
PNG
(CHEMBL1172313 | N-(4-(6-aminopyridin-3-yl)-2-cyclo...)
Show SMILES Nc1ccc(cn1)-c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C22H20N6O/c23-11-17-13-26-21(27-17)22(29)28-19-8-6-15(16-7-9-20(24)25-12-16)10-18(19)14-4-2-1-3-5-14/h4,6-10,12-13H,1-3,5H2,(H2,24,25)(H,26,27)(H,28,29)
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n/an/a 4.5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321361
PNG
(CHEMBL1172530 | N-(4'-amino-3-cyclohexenylbiphenyl...)
Show SMILES Nc1ccc(cc1)-c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H21N5O/c24-13-19-14-26-22(27-19)23(29)28-21-11-8-17(15-6-9-18(25)10-7-15)12-20(21)16-4-2-1-3-5-16/h4,6-12,14H,1-3,5,25H2,(H,26,27)(H,28,29)
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n/an/a 23n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321362
PNG
(4-cyano-N-(3-cyclohexenylbiphenyl-4-yl)-1H-imidazo...)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)-c1ccccc1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C23H20N4O/c24-14-19-15-25-22(26-19)23(28)27-21-12-11-18(16-7-3-1-4-8-16)13-20(21)17-9-5-2-6-10-17/h1,3-4,7-9,11-13,15H,2,5-6,10H2,(H,25,26)(H,27,28)
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n/an/a>60n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50321353
PNG
(4-cyano-N-(2-cyclohexenyl-4-(pyridin-4-yl)phenyl)-...)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)-c1ccncc1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H19N5O/c23-13-18-14-25-21(26-18)22(28)27-20-7-6-17(15-8-10-24-11-9-15)12-19(20)16-4-2-1-3-5-16/h4,6-12,14H,1-3,5H2,(H,25,26)(H,27,28)
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n/an/a 3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321357
PNG
(4-cyano-N-(2-cyclohexenyl-4-(pyridin-2-yl)phenyl)-...)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)-c1ccccn1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H19N5O/c23-13-17-14-25-21(26-17)22(28)27-20-10-9-16(19-8-4-5-11-24-19)12-18(20)15-6-2-1-3-7-15/h4-6,8-12,14H,1-3,7H2,(H,25,26)(H,27,28)
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n/an/a 11n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair