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17 similar compounds to monomer 50333510

Compile data set for download or QSAR
Wt: 328.4
BDBM50333505
Wt: 353.4
BDBM50333507
Wt: 346.4
BDBM50333508
Wt: 362.9
BDBM50333509
Wt: 370.5
BDBM50333511
Wt: 378.4
BDBM50333518
Wt: 358.5
BDBM50333525
Wt: 344.4
BDBM50333529
Wt: 346.4
BDBM50333531
Wt: 342.5
BDBM50333533
Wt: 353.4
BDBM50333535
Wt: 346.4
BDBM50333536
Wt: 362.9
BDBM50333537
Wt: 342.5
BDBM50333538
Wt: 370.5
BDBM50333539
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50333505,50333507,50333508,50333509,50333511,50333518,50333525,50333529,50333531,50333533,50333535,50333536,50333537,50333538,50333539   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333511
PNG
(1-(3-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-...)
Show SMILES CC(=O)c1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H26N4OS/c1-15(25)16-6-5-7-17(14-16)19-21-22-20(26-19)24-12-8-18(9-13-24)23-10-3-2-4-11-23/h5-7,14,18H,2-4,8-13H2,1H3
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4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333518
PNG
(5-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-y...)
Show SMILES N#Cc1cc(cc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1)C#N
Show InChI InChI=1S/C20H22N6S/c21-13-15-10-16(14-22)12-17(11-15)19-23-24-20(27-19)26-8-4-18(5-9-26)25-6-2-1-3-7-25/h10-12,18H,1-9H2
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23n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333533
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-o-tolyl-1,3,4-thiadia...)
Show SMILES Cc1ccccc1-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H26N4S/c1-15-7-3-4-8-17(15)18-20-21-19(24-18)23-13-9-16(10-14-23)22-11-5-2-6-12-22/h3-4,7-8,16H,2,5-6,9-14H2,1H3
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36n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333531
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(2-fluorophenyl)-1,3,...)
Show SMILES Fc1ccccc1-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H23FN4S/c19-16-7-3-2-6-15(16)17-20-21-18(24-17)23-12-8-14(9-13-23)22-10-4-1-5-11-22/h2-3,6-7,14H,1,4-5,8-13H2
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36n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333535
PNG
(4-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-y...)
Show SMILES N#Cc1ccc(cc1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H23N5S/c20-14-15-4-6-16(7-5-15)18-21-22-19(25-18)24-12-8-17(9-13-24)23-10-2-1-3-11-23/h4-7,17H,1-3,8-13H2
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36.4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333536
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(4-fluorophenyl)-1,3,...)
Show SMILES Fc1ccc(cc1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H23FN4S/c19-15-6-4-14(5-7-15)17-20-21-18(24-17)23-12-8-16(9-13-23)22-10-2-1-3-11-22/h4-7,16H,1-3,8-13H2
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39n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333525
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(4-methoxyphenyl)-1,3...)
Show SMILES COc1ccc(cc1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H26N4OS/c1-24-17-7-5-15(6-8-17)18-20-21-19(25-18)23-13-9-16(10-14-23)22-11-3-2-4-12-22/h5-8,16H,2-4,9-14H2,1H3
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40.1n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333507
PNG
(3-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-2-y...)
Show SMILES N#Cc1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H23N5S/c20-14-15-5-4-6-16(13-15)18-21-22-19(25-18)24-11-7-17(8-12-24)23-9-2-1-3-10-23/h4-6,13,17H,1-3,7-12H2
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42.6n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333509
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(3-chlorophenyl)-1,3,...)
Show SMILES Clc1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H23ClN4S/c19-15-6-4-5-14(13-15)17-20-21-18(24-17)23-11-7-16(8-12-23)22-9-2-1-3-10-22/h4-6,13,16H,1-3,7-12H2
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49n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333508
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(3-fluorophenyl)-1,3,...)
Show SMILES Fc1cccc(c1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H23FN4S/c19-15-6-4-5-14(13-15)17-20-21-18(24-17)23-11-7-16(8-12-23)22-9-2-1-3-10-22/h4-6,13,16H,1-3,7-12H2
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62n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333539
PNG
(1-(4-(5-(1,4'-bipiperidin-1'-yl)-1,3,4-thiadiazol-...)
Show SMILES CC(=O)c1ccc(cc1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C20H26N4OS/c1-15(25)16-5-7-17(8-6-16)19-21-22-20(26-19)24-13-9-18(10-14-24)23-11-3-2-4-12-23/h5-8,18H,2-4,9-14H2,1H3
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65n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333505
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-phenyl-1,3,4-thiadiaz...)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C18H24N4S/c1-3-7-15(8-4-1)17-19-20-18(23-17)22-13-9-16(10-14-22)21-11-5-2-6-12-21/h1,3-4,7-8,16H,2,5-6,9-14H2
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80.1n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333537
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-(4-chlorophenyl)-1,3,...)
Show SMILES Clc1ccc(cc1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C18H23ClN4S/c19-15-6-4-14(5-7-15)17-20-21-18(24-17)23-12-8-16(9-13-23)22-10-2-1-3-11-22/h4-7,16H,1-3,8-13H2
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161n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333538
PNG
(2-(1,4'-bipiperidin-1'-yl)-5-p-tolyl-1,3,4-thiadia...)
Show SMILES Cc1ccc(cc1)-c1nnc(s1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C19H26N4S/c1-15-5-7-16(8-6-15)18-20-21-19(24-18)23-13-9-17(10-14-23)22-11-3-2-4-12-22/h5-8,17H,2-4,9-14H2,1H3
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163n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50333529
PNG
(2-(4-methoxyphenyl)-5-(4-(pyrrolidin-1-yl)piperidi...)
Show SMILES COc1ccc(cc1)-c1nnc(s1)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C18H24N4OS/c1-23-16-6-4-14(5-7-16)17-19-20-18(24-17)22-12-8-15(9-13-22)21-10-2-3-11-21/h4-7,15H,2-3,8-13H2,1H3
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601n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK cells after 30 mins by scintillation count...


Bioorg Med Chem Lett 21: 861-4 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.065
BindingDB Entry DOI: 10.7270/Q20V8D24
More data for this
Ligand-Target Pair