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4 similar compounds to monomer 50371915

Compile data set for download or QSAR
Wt: 363.8
BDBM50371914
Wt: 326.3
BDBM50371926
Wt: 312.3
BDBM50371927
Wt: 321.7
BDBM50371928

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50371914,50371926,50371927,50371928   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50371914
PNG
(CHEMBL403661)
Show SMILES CCc1ccc(cc1)-c1c(-c2c[nH]c(C)n2)c(=O)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C21H18ClN3O/c1-3-13-4-6-14(7-5-13)19-16-10-15(22)8-9-17(16)25-21(26)20(19)18-11-23-12(2)24-18/h4-11H,3H2,1-2H3,(H,23,24)(H,25,26)
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Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FLT3


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
BindingDB Entry DOI: 10.7270/Q23779JH
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50371914
PNG
(CHEMBL403661)
Show SMILES CCc1ccc(cc1)-c1c(-c2c[nH]c(C)n2)c(=O)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C21H18ClN3O/c1-3-13-4-6-14(7-5-13)19-16-10-15(22)8-9-17(16)25-21(26)20(19)18-11-23-12(2)24-18/h4-11H,3H2,1-2H3,(H,23,24)(H,25,26)
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GoogleScholar
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 67n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of KIT


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
BindingDB Entry DOI: 10.7270/Q23779JH
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50371914
PNG
(CHEMBL403661)
Show SMILES CCc1ccc(cc1)-c1c(-c2c[nH]c(C)n2)c(=O)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C21H18ClN3O/c1-3-13-4-6-14(7-5-13)19-16-10-15(22)8-9-17(16)25-21(26)20(19)18-11-23-12(2)24-18/h4-11H,3H2,1-2H3,(H,23,24)(H,25,26)
PDB
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PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
BindingDB Entry DOI: 10.7270/Q23779JH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371928
PNG
(CHEMBL258088)
Show SMILES Clc1ccc2[nH]c(=O)c(-c3c[nH]cn3)c(-c3ccccc3)c2c1
Show InChI InChI=1S/C18H12ClN3O/c19-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)17(18(23)22-14)15-9-20-10-21-15/h1-10H,(H,20,21)(H,22,23)
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n/an/a 180n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
BindingDB Entry DOI: 10.7270/Q23779JH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371926
PNG
(CHEMBL273011)
Show SMILES Cn1cnc(c1)-c1c(-c2ccccc2)c2cc(ccc2[nH]c1=O)C#N
Show InChI InChI=1S/C20H14N4O/c1-24-11-17(22-12-24)19-18(14-5-3-2-4-6-14)15-9-13(10-21)7-8-16(15)23-20(19)25/h2-9,11-12H,1H3,(H,23,25)
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PubMed
n/an/a 550n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
BindingDB Entry DOI: 10.7270/Q23779JH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371927
PNG
(CHEMBL401736)
Show SMILES O=c1[nH]c2ccc(cc2c(-c2ccccc2)c1-c1c[nH]cn1)C#N
Show InChI InChI=1S/C19H12N4O/c20-9-12-6-7-15-14(8-12)17(13-4-2-1-3-5-13)18(19(24)23-15)16-10-21-11-22-16/h1-8,10-11H,(H,21,22)(H,23,24)
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PubMed
n/an/a 280n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
BindingDB Entry DOI: 10.7270/Q23779JH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50371914
PNG
(CHEMBL403661)
Show SMILES CCc1ccc(cc1)-c1c(-c2c[nH]c(C)n2)c(=O)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C21H18ClN3O/c1-3-13-4-6-14(7-5-13)19-16-10-15(22)8-9-17(16)25-21(26)20(19)18-11-23-12(2)24-18/h4-11H,3H2,1-2H3,(H,23,24)(H,25,26)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization


Bioorg Med Chem Lett 18: 2097-102 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.088
BindingDB Entry DOI: 10.7270/Q23779JH
More data for this
Ligand-Target Pair