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15 similar compounds to monomer 50129105

Compile data set for download or QSAR
Wt: 236.2
BDBM5364
Wt: 266.2
BDBM5851
Wt: 261.2
BDBM5847
Wt: 250.2
BDBM5853
Wt: 261.2
BDBM5849
Wt: 328.3
BDBM5855
Wt: 296.3
BDBM5857
Wt: 287.3
BDBM50126275
Wt: 337.7
BDBM50129097
Wt: 319.3
BDBM50129114
Wt: 317.3
BDBM50129119
Wt: 286.7
BDBM50312863
Wt: 252.2
BDBM50312883
Wt: 282.2
BDBM50312886
Wt: 323.3
BDBM50312865

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 5364,5851,5847,5853,5849,5855,5857,50126275,50129097,50129114,50129119,50312863,50312883,50312886,50312865   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5364
PNG
(2-Anilino-5-aryloxazole 5 | N,5-diphenyl-1,3-oxazo...)
Show SMILES N(c1ncc(o1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H12N2O/c1-3-7-12(8-4-1)14-11-16-15(18-14)17-13-9-5-2-6-10-13/h1-11H,(H,16,17)
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PubMed
n/an/a 134n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...


Bioorg Med Chem Lett 14: 2941-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.052
BindingDB Entry DOI: 10.7270/Q25H7DG7
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50312886
PNG
(4-(5-(3-methoxyphenyl)oxazol-2-ylamino)phenol | CH...)
Show SMILES COc1cccc(c1)-c1cnc(Nc2ccc(O)cc2)o1
Show InChI InChI=1S/C16H14N2O3/c1-20-14-4-2-3-11(9-14)15-10-17-16(21-15)18-12-5-7-13(19)8-6-12/h2-10,19H,1H3,(H,17,18)
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n/an/a 170n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assay


Bioorg Med Chem Lett 20: 1677-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.058
BindingDB Entry DOI: 10.7270/Q2CJ8DMM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5847
PNG
(2-Anilino-5-aryloxazole 8 | 2-[(5-phenyl-1,3-oxazo...)
Show SMILES N#Cc1ccccc1Nc1ncc(o1)-c1ccccc1
Show InChI InChI=1S/C16H11N3O/c17-10-13-8-4-5-9-14(13)19-16-18-11-15(20-16)12-6-2-1-3-7-12/h1-9,11H,(H,18,19)
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n/an/a 870n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5849
PNG
(2-Anilino-5-aryloxazole 10 | 3-[(5-phenyl-1,3-oxaz...)
Show SMILES N#Cc1cccc(Nc2ncc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C16H11N3O/c17-10-12-5-4-8-14(9-12)19-16-18-11-15(20-16)13-6-2-1-3-7-13/h1-9,11H,(H,18,19)
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n/an/a 930n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5851
PNG
(2-Anilino-5-aryloxazole 12 | N-(3-Hydroxymethylphe...)
Show SMILES OCc1cccc(Nc2ncc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C16H14N2O2/c19-11-12-5-4-8-14(9-12)18-16-17-10-15(20-16)13-6-2-1-3-7-13/h1-10,19H,11H2,(H,17,18)
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n/an/a 500n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5853
PNG
(2-Anilino-5-aryloxazole 14 | N-(3-Methylphenyl)-5-...)
Show SMILES Cc1cccc(Nc2ncc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C16H14N2O/c1-12-6-5-9-14(10-12)18-16-17-11-15(19-16)13-7-3-2-4-8-13/h2-11H,1H3,(H,17,18)
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n/an/a 870n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5855
PNG
(2-Anilino-5-aryloxazole 16 | N-(4-Phenoxyphenyl)-5...)
Show SMILES N(c1ncc(o1)-c1ccccc1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C21H16N2O2/c1-3-7-16(8-4-1)20-15-22-21(25-20)23-17-11-13-19(14-12-17)24-18-9-5-2-6-10-18/h1-15H,(H,22,23)
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n/an/a>1.00E+4n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5857
PNG
(2-Anilino-5-aryloxazole 18 | N-(3,5-Dimethoxypheny...)
Show SMILES COc1cc(Nc2ncc(o2)-c2ccccc2)cc(OC)c1
Show InChI InChI=1S/C17H16N2O3/c1-20-14-8-13(9-15(10-14)21-2)19-17-18-11-16(22-17)12-6-4-3-5-7-12/h3-11H,1-2H3,(H,18,19)
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n/an/a 170n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50126275
PNG
(CHEMBL280793 | Isoquinolin-6-yl-(5-phenyl-oxazol-2...)
Show SMILES N(c1ncc(o1)-c1ccccc1)c1ccc2cnccc2c1
Show InChI InChI=1S/C18H13N3O/c1-2-4-13(5-3-1)17-12-20-18(22-17)21-16-7-6-15-11-19-9-8-14(15)10-16/h1-12H,(H,20,21)
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n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II)


Bioorg Med Chem Lett 13: 1345-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00107-0
BindingDB Entry DOI: 10.7270/Q2CV4H3Q
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50129097
PNG
((3-Chloro-4-oxazol-5-yl-phenyl)-(5-phenyl-oxazol-2...)
Show SMILES Clc1cc(Nc2ncc(o2)-c2ccccc2)ccc1-c1cnco1
Show InChI InChI=1S/C18H12ClN3O2/c19-15-8-13(6-7-14(15)17-9-20-11-23-17)22-18-21-10-16(24-18)12-4-2-1-3-5-12/h1-11H,(H,21,22)
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n/an/a 88n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2.


Bioorg Med Chem Lett 13: 2059-63 (2003)


Article DOI: 10.1016/s0960-894x(03)00258-0
BindingDB Entry DOI: 10.7270/Q22Z14X1
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50129114
PNG
(2-Oxazol-5-yl-5-(5-phenyl-oxazol-2-ylamino)-phenol...)
Show SMILES Oc1cc(Nc2ncc(o2)-c2ccccc2)ccc1-c1cnco1
Show InChI InChI=1S/C18H13N3O3/c22-15-8-13(6-7-14(15)17-9-19-11-23-17)21-18-20-10-16(24-18)12-4-2-1-3-5-12/h1-11,22H,(H,20,21)
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n/an/a>1.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2.


Bioorg Med Chem Lett 13: 2059-63 (2003)


Article DOI: 10.1016/s0960-894x(03)00258-0
BindingDB Entry DOI: 10.7270/Q22Z14X1
More data for this
Ligand-Target Pair
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)


(Homo sapiens (Human))
BDBM50129119
PNG
(CHEMBL64898 | [4-(4-Methyl-oxazol-5-yl)-phenyl]-(5...)
Show SMILES Cc1ncoc1-c1ccc(Nc2ncc(o2)-c2ccccc2)cc1
Show InChI InChI=1S/C19H15N3O2/c1-13-18(23-12-21-13)15-7-9-16(10-8-15)22-19-20-11-17(24-19)14-5-3-2-4-6-14/h2-12H,1H3,(H,20,22)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2.


Bioorg Med Chem Lett 13: 2059-63 (2003)


Article DOI: 10.1016/s0960-894x(03)00258-0
BindingDB Entry DOI: 10.7270/Q22Z14X1
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50312863
PNG
(4-(5-(4-chlorophenyl)oxazol-2-ylamino)phenol | CHE...)
Show SMILES Oc1ccc(Nc2ncc(o2)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C15H11ClN2O2/c16-11-3-1-10(2-4-11)14-9-17-15(20-14)18-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18)
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n/an/a 330n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assay


Bioorg Med Chem Lett 20: 1677-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.058
BindingDB Entry DOI: 10.7270/Q2CJ8DMM
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50312865
PNG
(4-(5-(4-(diethylamino)phenyl)oxazol-2-ylamino)phen...)
Show SMILES CCN(CC)c1ccc(cc1)-c1cnc(Nc2ccc(O)cc2)o1
Show InChI InChI=1S/C19H21N3O2/c1-3-22(4-2)16-9-5-14(6-10-16)18-13-20-19(24-18)21-15-7-11-17(23)12-8-15/h5-13,23H,3-4H2,1-2H3,(H,20,21)
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n/an/a 230n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assay


Bioorg Med Chem Lett 20: 1677-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.058
BindingDB Entry DOI: 10.7270/Q2CJ8DMM
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM50312883
PNG
(4-(5-phenyloxazol-2-ylamino)phenol | CHEMBL1076570)
Show SMILES Oc1ccc(Nc2ncc(o2)-c2ccccc2)cc1
Show InChI InChI=1S/C15H12N2O2/c18-13-8-6-12(7-9-13)17-15-16-10-14(19-15)11-4-2-1-3-5-11/h1-10,18H,(H,16,17)
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n/an/a 91n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of VCP assessed as conversion of ATP to ADP by enzyme coupled glucokinase assay


Bioorg Med Chem Lett 20: 1677-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.058
BindingDB Entry DOI: 10.7270/Q2CJ8DMM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5364
PNG
(2-Anilino-5-aryloxazole 5 | N,5-diphenyl-1,3-oxazo...)
Show SMILES N(c1ncc(o1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H12N2O/c1-3-7-12(8-4-1)14-11-16-15(18-14)17-13-9-5-2-6-10-13/h1-11H,(H,16,17)
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n/an/a 1.20E+3n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair