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22 similar compounds to monomer 5880

Compile data set for download or QSAR
Wt: 358.4
BDBM5860
Wt: 392.8
BDBM5861
Wt: 392.8
BDBM5862
Wt: 383.4
BDBM5863
Wt: 388.4
BDBM5864
Wt: 376.4
BDBM5865
Purchase
Wt: 388.4
BDBM5866
Wt: 392.8
BDBM5867
Wt: 376.4
BDBM5868
Wt: 383.4
BDBM5869
Wt: 386.4
BDBM5871
Wt: 400.4
BDBM5872
Wt: 440.5
BDBM5873
Wt: 440.5
BDBM5874
Wt: 435.4
BDBM5875
Displayed 1 to 15 (of 22 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 5860,5861,5862,5863,5864,5865,5866,5867,5868,5869,5871,5872,5873,5874,5875   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5860
PNG
(2-Anilino-5-aryloxazole 21 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C18H18N2O4S/c1-3-25(21,22)14-9-10-16(23-2)15(11-14)20-18-19-12-17(24-18)13-7-5-4-6-8-13/h4-12H,3H2,1-2H3,(H,19,20)
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n/an/a 50n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5875
PNG
(2-Anilino-5-aryloxazole 39 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccccn2)c1
Show InChI InChI=1S/C23H21N3O4S/c1-3-31(27,28)18-10-11-21(29-2)20(14-18)26-23-25-15-22(30-23)17-8-6-7-16(13-17)19-9-4-5-12-24-19/h4-15H,3H2,1-2H3,(H,25,26)
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n/an/a 22n/an/an/an/an/an/a



Comenius University in Bratislava

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) using substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation counting


Eur J Med Chem 126: 754-761 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.003
BindingDB Entry DOI: 10.7270/Q2S75JJV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5862
PNG
(2-Anilino-5-aryloxazole 25 | 5-(3-Chlorophenyl)-N-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(Cl)c2)c1
Show InChI InChI=1S/C18H17ClN2O4S/c1-3-26(22,23)14-7-8-16(24-2)15(10-14)21-18-20-11-17(25-18)12-5-4-6-13(19)9-12/h4-11H,3H2,1-2H3,(H,20,21)
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n/an/a 22n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5863
PNG
(2-Anilino-5-aryloxazole 26 | 3-(2-{[5-(ethanesulfo...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)C#N)c1
Show InChI InChI=1S/C19H17N3O4S/c1-3-27(23,24)15-7-8-17(25-2)16(10-15)22-19-21-12-18(26-19)14-6-4-5-13(9-14)11-20/h4-10,12H,3H2,1-2H3,(H,21,22)
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n/an/a 141n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5864
PNG
(2-Anilino-5-aryloxazole 27 | 5-(3-Methoxyphenyl)-N...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(OC)c2)c1
Show InChI InChI=1S/C19H20N2O5S/c1-4-27(22,23)15-8-9-17(25-3)16(11-15)21-19-20-12-18(26-19)13-6-5-7-14(10-13)24-2/h5-12H,4H2,1-3H3,(H,20,21)
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n/an/a 36n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5865
PNG
(2-Anilino-5-aryloxazole 28 | 5-(3-Fluorophenyl)-N-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(F)c2)c1
Show InChI InChI=1S/C18H17FN2O4S/c1-3-26(22,23)14-7-8-16(24-2)15(10-14)21-18-20-11-17(25-18)12-5-4-6-13(19)9-12/h4-11H,3H2,1-2H3,(H,20,21)
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n/an/a 93n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5866
PNG
(2-Anilino-5-aryloxazole 29 | 5-(4-Methoxyphenyl)-N...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccc(OC)cc2)c1
Show InChI InChI=1S/C19H20N2O5S/c1-4-27(22,23)15-9-10-17(25-3)16(11-15)21-19-20-12-18(26-19)13-5-7-14(24-2)8-6-13/h5-12H,4H2,1-3H3,(H,20,21)
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n/an/a 87n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5867
PNG
(2-Anilino-5-aryloxazole 30 | 5-(4-Chlorophenyl)-N-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C18H17ClN2O4S/c1-3-26(22,23)14-8-9-16(24-2)15(10-14)21-18-20-11-17(25-18)12-4-6-13(19)7-5-12/h4-11H,3H2,1-2H3,(H,20,21)
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n/an/a 81n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5868
PNG
(2-Anilino-5-aryloxazole 31 | 5-(4-Fluorophenyl)-N-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccc(F)cc2)c1
Show InChI InChI=1S/C18H17FN2O4S/c1-3-26(22,23)14-8-9-16(24-2)15(10-14)21-18-20-11-17(25-18)12-4-6-13(19)7-5-12/h4-11H,3H2,1-2H3,(H,20,21)
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n/an/a 79n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5869
PNG
(2-Anilino-5-aryloxazole 32 | 4-(2-{[5-(ethanesulfo...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccc(cc2)C#N)c1
Show InChI InChI=1S/C19H17N3O4S/c1-3-27(23,24)15-8-9-17(25-2)16(10-15)22-19-21-12-18(26-19)14-6-4-13(11-20)5-7-14/h4-10,12H,3H2,1-2H3,(H,21,22)
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n/an/a 51n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5871
PNG
(2-Anilino-5-aryloxazole 35 | 5-(3-Ethylphenyl)-N-[...)
Show SMILES CCc1cccc(c1)-c1cnc(Nc2cc(ccc2OC)S(=O)(=O)CC)o1
Show InChI InChI=1S/C20H22N2O4S/c1-4-14-7-6-8-15(11-14)19-13-21-20(26-19)22-17-12-16(27(23,24)5-2)9-10-18(17)25-3/h6-13H,4-5H2,1-3H3,(H,21,22)
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n/an/a 29n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5872
PNG
(1-[3-(2-{[5-(Ethylsulfonyl)-2-methoxyphenyl]amino}...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)C(C)=O)c1
Show InChI InChI=1S/C20H20N2O5S/c1-4-28(24,25)16-8-9-18(26-3)17(11-16)22-20-21-12-19(27-20)15-7-5-6-14(10-15)13(2)23/h5-12H,4H2,1-3H3,(H,21,22)
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n/an/a 91n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5873
PNG
(2-Anilino-5-aryloxazole 37 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2cccs2)c1
Show InChI InChI=1S/C22H20N2O4S2/c1-3-30(25,26)17-9-10-19(27-2)18(13-17)24-22-23-14-20(28-22)15-6-4-7-16(12-15)21-8-5-11-29-21/h4-14H,3H2,1-2H3,(H,23,24)
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n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5874
PNG
(2-Anilino-5-aryloxazole 38 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccsc2)c1
Show InChI InChI=1S/C22H20N2O4S2/c1-3-30(25,26)18-7-8-20(27-2)19(12-18)24-22-23-13-21(28-22)16-6-4-5-15(11-16)17-9-10-29-14-17/h4-14H,3H2,1-2H3,(H,23,24)
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n/an/a 15n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5875
PNG
(2-Anilino-5-aryloxazole 39 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccccn2)c1
Show InChI InChI=1S/C23H21N3O4S/c1-3-31(27,28)18-10-11-21(29-2)20(14-18)26-23-25-15-22(30-23)17-8-6-7-16(13-17)19-9-4-5-12-24-19/h4-15H,3H2,1-2H3,(H,25,26)
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n/an/a 22n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5875
PNG
(2-Anilino-5-aryloxazole 39 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccccn2)c1
Show InChI InChI=1S/C23H21N3O4S/c1-3-31(27,28)18-10-11-21(29-2)20(14-18)26-23-25-15-22(30-23)17-8-6-7-16(13-17)19-9-4-5-12-24-19/h4-15H,3H2,1-2H3,(H,25,26)
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n/an/a 17n/an/an/an/an/an/a



Comenius University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf9 cells by radiometric assay


Eur J Med Chem 72: 146-59 (2014)


Article DOI: 10.1016/j.ejmech.2013.11.023
BindingDB Entry DOI: 10.7270/Q2K93919
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5875
PNG
(2-Anilino-5-aryloxazole 39 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccccn2)c1
Show InChI InChI=1S/C23H21N3O4S/c1-3-31(27,28)18-10-11-21(29-2)20(14-18)26-23-25-15-22(30-23)17-8-6-7-16(13-17)19-9-4-5-12-24-19/h4-15H,3H2,1-2H3,(H,25,26)
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n/an/a 22n/an/an/an/an/an/a



University of Strasburg

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant VEGFR2 kinase expressed in Sf9 insect cells by radiometric protein kinase assay


Eur J Med Chem 103: 105-22 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.012
BindingDB Entry DOI: 10.7270/Q2P84DQG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5861
PNG
(2-Anilino-5-aryloxazole 24 | 5-(2-Chlorophenyl)-N-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2ccccc2Cl)c1
Show InChI InChI=1S/C18H17ClN2O4S/c1-3-26(22,23)12-8-9-16(24-2)15(10-12)21-18-20-11-17(25-18)13-6-4-5-7-14(13)19/h4-11H,3H2,1-2H3,(H,20,21)
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n/an/a 360n/an/an/an/a7.522



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair