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2 similar compounds to monomer 77970

Compile data set for download or QSAR
Wt: 421.4
BDBM77944

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 77944   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-RAF


(Homo sapiens (Human))
BDBM77944
PNG
(US9694016, 381)
Show SMILES Cc1cc(C(=O)Nc2ccc(C)c(c2)-c2cc(N3CCOCC3)c(=O)n(C)c2)n(C)n1
Show InChI InChI=1S/C23H27N5O3/c1-15-5-6-18(24-22(29)20-11-16(2)25-27(20)4)13-19(15)17-12-21(23(30)26(3)14-17)28-7-9-31-10-8-28/h5-6,11-14H,7-10H2,1-4H3,(H,24,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 26n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...


US Patent US9694016 (2017)


BindingDB Entry DOI: 10.7270/Q2MC8X6W
More data for this
Ligand-Target Pair
B-RAF V600E


(Homo sapiens (Human))
BDBM77944
PNG
(US9694016, 381)
Show SMILES Cc1cc(C(=O)Nc2ccc(C)c(c2)-c2cc(N3CCOCC3)c(=O)n(C)c2)n(C)n1
Show InChI InChI=1S/C23H27N5O3/c1-15-5-6-18(24-22(29)20-11-16(2)25-27(20)4)13-19(15)17-12-21(23(30)26(3)14-17)28-7-9-31-10-8-28/h5-6,11-14H,7-10H2,1-4H3,(H,24,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 100n/an/an/an/a7.525



NOVARTIS AG

US Patent


Assay Description
Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...


US Patent US9694016 (2017)


BindingDB Entry DOI: 10.7270/Q2MC8X6W
More data for this
Ligand-Target Pair