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22 similar compounds to monomer 50005463

Compile data set for download or QSAR
Wt: 426.4
BDBM82387
Wt: 426.4
BDBM50019261
Wt: 408.4
BDBM50452486
Wt: 428.4
BDBM50019241
Wt: 426.4
BDBM50019249
Wt: 394.4
BDBM50019252
Wt: 412.4
BDBM50019260
Wt: 408.4
BDBM50019272
Wt: 498.5
BDBM50019178
Wt: 470.4
BDBM50019182
Wt: 491.3
BDBM50019184
Wt: 426.4
BDBM50019187
Wt: 422.4
BDBM50019191
Wt: 440.4
BDBM50019207
Wt: 430.4
BDBM50019217
Displayed 1 to 15 (of 22 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 62 hits for monomerid = 82387,50019261,50452486,50019241,50019249,50019252,50019260,50019272,50019178,50019182,50019184,50019187,50019191,50019207,50019217   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholecystokinin


(RAT)
BDBM82387
PNG
(CCK antagonist synthetic 22)
Show SMILES CN1c2ccc(F)cc2C(=NC(NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1
Show InChI InChI=1S/C25H19FN4O2/c1-30-21-12-11-17(26)14-18(21)22(15-7-3-2-4-8-15)28-23(25(30)32)29-24(31)20-13-16-9-5-6-10-19(16)27-20/h2-14,23,27H,1H3,(H,29,31)
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1.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 83: 4918-22 (1986)


Article DOI: 10.1073/pnas.83.13.4918
BindingDB Entry DOI: 10.7270/Q2445K05
More data for this
Ligand-Target Pair
Cholecystokinin


(RAT)
BDBM50019260
PNG
(1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2...)
Show SMILES Fc1ccccc1C1=NC(NC(=O)c2cc3ccccc3[nH]2)C(=O)Nc2ccccc12
Show InChI InChI=1S/C24H17FN4O2/c25-17-10-4-2-8-15(17)21-16-9-3-6-12-19(16)27-24(31)22(28-21)29-23(30)20-13-14-7-1-5-11-18(14)26-20/h1-13,22,26H,(H,27,31)(H,29,30)
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2.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 83: 4918-22 (1986)


Article DOI: 10.1073/pnas.83.13.4918
BindingDB Entry DOI: 10.7270/Q2445K05
More data for this
Ligand-Target Pair
Cholecystokinin


(RAT)
BDBM50019252
PNG
(1H-Indole-2-carboxylic acid (2-oxo-5-phenyl-2,3-di...)
Show SMILES O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C24H18N4O2/c29-23(20-14-16-10-4-6-12-18(16)25-20)28-22-24(30)26-19-13-7-5-11-17(19)21(27-22)15-8-2-1-3-9-15/h1-14,22,25H,(H,26,30)(H,28,29)
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4.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 83: 4918-22 (1986)


Article DOI: 10.1073/pnas.83.13.4918
BindingDB Entry DOI: 10.7270/Q2445K05
More data for this
Ligand-Target Pair
GABA A Benzodiazepine


(GUINEA PIG)
BDBM50019260
PNG
(1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2...)
Show SMILES Fc1ccccc1C1=NC(NC(=O)c2cc3ccccc3[nH]2)C(=O)Nc2ccccc12
Show InChI InChI=1S/C24H17FN4O2/c25-17-10-4-2-8-15(17)21-16-9-3-6-12-19(16)27-24(31)22(28-21)29-23(30)20-13-14-7-1-5-11-18(14)26-20/h1-13,22,26H,(H,27,31)(H,29,30)
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3.00E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 83: 4918-22 (1986)


Article DOI: 10.1073/pnas.83.13.4918
BindingDB Entry DOI: 10.7270/Q2445K05
More data for this
Ligand-Target Pair
GABA A Benzodiazepine


(GUINEA PIG)
BDBM82387
PNG
(CCK antagonist synthetic 22)
Show SMILES CN1c2ccc(F)cc2C(=NC(NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1
Show InChI InChI=1S/C25H19FN4O2/c1-30-21-12-11-17(26)14-18(21)22(15-7-3-2-4-8-15)28-23(25(30)32)29-24(31)20-13-16-9-5-6-10-19(16)27-20/h2-14,23,27H,1H3,(H,29,31)
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7.80E+3n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 83: 4918-22 (1986)


Article DOI: 10.1073/pnas.83.13.4918
BindingDB Entry DOI: 10.7270/Q2445K05
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) alpha-1)


(Rattus norvegicus (Rat))
BDBM50019252
PNG
(1H-Indole-2-carboxylic acid (2-oxo-5-phenyl-2,3-di...)
Show SMILES O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C24H18N4O2/c29-23(20-14-16-10-4-6-12-18(16)25-20)28-22-24(30)26-19-13-7-5-11-17(19)21(27-22)15-8-2-1-3-9-15/h1-14,22,25H,(H,26,30)(H,28,29)
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 83: 4918-22 (1986)


Article DOI: 10.1073/pnas.83.13.4918
BindingDB Entry DOI: 10.7270/Q2445K05
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019187
PNG
((R)-1H-Indole-2-carboxylic acid [5-(2-fluoro-pheny...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1F
Show InChI InChI=1S/C25H19FN4O2/c1-30-21-13-7-4-10-17(21)22(16-9-3-5-11-18(16)26)28-23(25(30)32)29-24(31)20-14-15-8-2-6-12-19(15)27-20/h2-14,23,27H,1H3,(H,29,31)
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n/an/a 190n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019241
PNG
(5-Hydroxy-1H-indole-2-carboxylic acid [5-(2-fluoro...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O
Show InChI InChI=1S/C24H17FN4O3/c25-17-7-3-1-5-15(17)21-16-6-2-4-8-19(16)27-24(32)22(28-21)29-23(31)20-12-13-11-14(30)9-10-18(13)26-20/h1-12,22,26,30H,(H,27,32)(H,29,31)
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n/an/a 2.90E+4n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019191
PNG
(1-Methyl-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3n2C)C1=O)c1ccccc1
Show InChI InChI=1S/C26H22N4O2/c1-29-20-14-8-6-12-18(20)16-22(29)25(31)28-24-26(32)30(2)21-15-9-7-13-19(21)23(27-24)17-10-4-3-5-11-17/h3-16,24H,1-2H3,(H,28,31)
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n/an/a 1.40n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019249
PNG
(1-Methyl-1H-indole-2-carboxylic acid [5-(2-fluoro-...)
Show SMILES Cn1c(cc2ccccc12)C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O
Show InChI InChI=1S/C25H19FN4O2/c1-30-20-13-7-2-8-15(20)14-21(30)24(31)29-23-25(32)27-19-12-6-4-10-17(19)22(28-23)16-9-3-5-11-18(16)26/h2-14,23H,1H3,(H,27,32)(H,29,31)
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n/an/a 4.70n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019249
PNG
(1-Methyl-1H-indole-2-carboxylic acid [5-(2-fluoro-...)
Show SMILES Cn1c(cc2ccccc12)C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O
Show InChI InChI=1S/C25H19FN4O2/c1-30-20-13-7-2-8-15(20)14-21(30)24(31)29-23-25(32)27-19-12-6-4-10-17(19)22(28-23)16-9-3-5-11-18(16)26/h2-14,23H,1H3,(H,27,32)(H,29,31)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019260
PNG
(1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2...)
Show SMILES Fc1ccccc1C1=NC(NC(=O)c2cc3ccccc3[nH]2)C(=O)Nc2ccccc12
Show InChI InChI=1S/C24H17FN4O2/c25-17-10-4-2-8-15(17)21-16-9-3-6-12-19(16)27-24(31)22(28-21)29-23(30)20-13-14-7-1-5-11-18(14)26-20/h1-13,22,26H,(H,27,31)(H,29,30)
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n/an/a 2.10n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019182
PNG
(CHEMBL307661 | {5-(2-Fluoro-phenyl)-3-[(1H-indole-...)
Show SMILES OC(=O)CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1F
Show InChI InChI=1S/C26H19FN4O4/c27-18-10-4-2-8-16(18)23-17-9-3-6-12-21(17)31(14-22(32)33)26(35)24(29-23)30-25(34)20-13-15-7-1-5-11-19(15)28-20/h1-13,24,28H,14H2,(H,30,34)(H,32,33)
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n/an/a 390n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019182
PNG
(CHEMBL307661 | {5-(2-Fluoro-phenyl)-3-[(1H-indole-...)
Show SMILES OC(=O)CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1F
Show InChI InChI=1S/C26H19FN4O4/c27-18-10-4-2-8-16(18)23-17-9-3-6-12-21(17)31(14-22(32)33)26(35)24(29-23)30-25(34)20-13-15-7-1-5-11-19(15)28-20/h1-13,24,28H,14H2,(H,30,34)(H,32,33)
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n/an/a 1.5n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019272
PNG
(1H-Indole-2-carboxylic acid methyl-(2-oxo-5-phenyl...)
Show SMILES CN(C1N=C(c2ccccc2)c2ccccc2NC1=O)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C25H20N4O2/c1-29(25(31)21-15-17-11-5-7-13-19(17)26-21)23-24(30)27-20-14-8-6-12-18(20)22(28-23)16-9-3-2-4-10-16/h2-15,23,26H,1H3,(H,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019207
PNG
(1-Methyl-1H-indole-2-carboxylic acid [5-(2-fluoro-...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3n2C)C1=O)c1ccccc1F
Show InChI InChI=1S/C26H21FN4O2/c1-30-20-13-7-3-9-16(20)15-22(30)25(32)29-24-26(33)31(2)21-14-8-5-11-18(21)23(28-24)17-10-4-6-12-19(17)27/h3-15,24H,1-2H3,(H,29,32)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019241
PNG
(5-Hydroxy-1H-indole-2-carboxylic acid [5-(2-fluoro...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O
Show InChI InChI=1S/C24H17FN4O3/c25-17-7-3-1-5-15(17)21-16-6-2-4-8-19(16)27-24(32)22(28-21)29-23(31)20-12-13-11-14(30)9-10-18(13)26-20/h1-12,22,26,30H,(H,27,32)(H,29,31)
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n/an/a 71n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019187
PNG
((R)-1H-Indole-2-carboxylic acid [5-(2-fluoro-pheny...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1F
Show InChI InChI=1S/C25H19FN4O2/c1-30-21-13-7-4-10-17(21)22(16-9-3-5-11-18(16)26)28-23(25(30)32)29-24(31)20-14-15-8-2-6-12-19(15)27-20/h2-14,23,27H,1H3,(H,29,31)
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n/an/a 1.40n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019252
PNG
(1H-Indole-2-carboxylic acid (2-oxo-5-phenyl-2,3-di...)
Show SMILES O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C24H18N4O2/c29-23(20-14-16-10-4-6-12-18(16)25-20)28-22-24(30)26-19-13-7-5-11-17(19)21(27-22)15-8-2-1-3-9-15/h1-14,22,25H,(H,26,30)(H,28,29)
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n/an/a 4.70n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019217
PNG
(5-Fluoro-1H-indole-2-carboxylic acid [5-(2-fluoro-...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O
Show InChI InChI=1S/C24H16F2N4O2/c25-14-9-10-18-13(11-14)12-20(27-18)23(31)30-22-24(32)28-19-8-4-2-6-16(19)21(29-22)15-5-1-3-7-17(15)26/h1-12,22,27H,(H,28,32)(H,30,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019207
PNG
(1-Methyl-1H-indole-2-carboxylic acid [5-(2-fluoro-...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3n2C)C1=O)c1ccccc1F
Show InChI InChI=1S/C26H21FN4O2/c1-30-20-13-7-3-9-16(20)15-22(30)25(32)29-24-26(33)31(2)21-14-8-5-11-18(21)23(28-24)17-10-4-6-12-19(17)27/h3-15,24H,1-2H3,(H,29,32)
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n/an/a 1.30n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019191
PNG
(1-Methyl-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3n2C)C1=O)c1ccccc1
Show InChI InChI=1S/C26H22N4O2/c1-29-20-14-8-6-12-18(20)16-22(29)25(31)28-24-26(32)30(2)21-15-9-7-13-19(21)23(27-24)17-10-4-3-5-11-17/h3-16,24H,1-2H3,(H,28,31)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019261
PNG
((S)-N-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1F
Show InChI InChI=1S/C25H19FN4O2/c1-30-21-13-7-4-10-17(21)22(16-9-3-5-11-18(16)26)28-23(25(30)32)29-24(31)20-14-15-8-2-6-12-19(15)27-20/h2-14,23,27H,1H3,(H,29,31)/t23-/m0/s1
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n/an/a 240n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019261
PNG
((S)-N-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1F
Show InChI InChI=1S/C25H19FN4O2/c1-30-21-13-7-4-10-17(21)22(16-9-3-5-11-18(16)26)28-23(25(30)32)29-24(31)20-14-15-8-2-6-12-19(15)27-20/h2-14,23,27H,1H3,(H,29,31)/t23-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]CCK-8 binding to cholecystokinin receptor from rat pancreatic tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019191
PNG
(1-Methyl-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3n2C)C1=O)c1ccccc1
Show InChI InChI=1S/C26H22N4O2/c1-29-20-14-8-6-12-18(20)16-22(29)25(31)28-24-26(32)30(2)21-15-9-7-13-19(21)23(27-24)17-10-4-3-5-11-17/h3-16,24H,1-2H3,(H,28,31)
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for its activity to inhibit the binding of [125I]-gastrin to gastric glands (gastrin) in guinea pig


Bioorg Med Chem Lett 3: 867-870 (1993)


Article DOI: 10.1016/S0960-894X(00)80682-4
BindingDB Entry DOI: 10.7270/Q28S4PTK
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019217
PNG
(5-Fluoro-1H-indole-2-carboxylic acid [5-(2-fluoro-...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O
Show InChI InChI=1S/C24H16F2N4O2/c25-14-9-10-18-13(11-14)12-20(27-18)23(31)30-22-24(32)28-19-8-4-2-6-16(19)21(29-22)15-5-1-3-7-17(15)26/h1-12,22,27H,(H,28,32)(H,30,31)
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n/an/a 5n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019184
PNG
(5-Bromo-1H-indole-2-carboxylic acid [5-(2-fluoro-p...)
Show SMILES Fc1ccccc1C1=NC(NC(=O)c2cc3cc(Br)ccc3[nH]2)C(=O)Nc2ccccc12
Show InChI InChI=1S/C24H16BrFN4O2/c25-14-9-10-18-13(11-14)12-20(27-18)23(31)30-22-24(32)28-19-8-4-2-6-16(19)21(29-22)15-5-1-3-7-17(15)26/h1-12,22,27H,(H,28,32)(H,30,31)
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n/an/a 120n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019252
PNG
(1H-Indole-2-carboxylic acid (2-oxo-5-phenyl-2,3-di...)
Show SMILES O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C24H18N4O2/c29-23(20-14-16-10-4-6-12-18(16)25-20)28-22-24(30)26-19-13-7-5-11-17(19)21(27-22)15-8-2-1-3-9-15/h1-14,22,25H,(H,26,30)(H,28,29)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019260
PNG
(1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2...)
Show SMILES Fc1ccccc1C1=NC(NC(=O)c2cc3ccccc3[nH]2)C(=O)Nc2ccccc12
Show InChI InChI=1S/C24H17FN4O2/c25-17-10-4-2-8-15(17)21-16-9-3-6-12-19(16)27-24(31)22(28-21)29-23(30)20-13-14-7-1-5-11-18(14)26-20/h1-13,22,26H,(H,27,31)(H,29,30)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019272
PNG
(1H-Indole-2-carboxylic acid methyl-(2-oxo-5-phenyl...)
Show SMILES CN(C1N=C(c2ccccc2)c2ccccc2NC1=O)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C25H20N4O2/c1-29(25(31)21-15-17-11-5-7-13-19(17)26-21)23-24(30)27-20-14-8-6-12-18(20)22(28-23)16-9-3-2-4-10-16/h2-15,23,26H,1H3,(H,27,30)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019187
PNG
((R)-1H-Indole-2-carboxylic acid [5-(2-fluoro-pheny...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1F
Show InChI InChI=1S/C25H19FN4O2/c1-30-21-13-7-4-10-17(21)22(16-9-3-5-11-18(16)26)28-23(25(30)32)29-24(31)20-14-15-8-2-6-12-19(15)27-20/h2-14,23,27H,1H3,(H,29,31)
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n/an/a 1.41n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity against cholecystokinin type A receptor of rat pancreas


J Med Chem 37: 3639-54 (1994)


Article DOI: 10.1021/jm00047a021
BindingDB Entry DOI: 10.7270/Q2SB46ZR
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019191
PNG
(1-Methyl-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3n2C)C1=O)c1ccccc1
Show InChI InChI=1S/C26H22N4O2/c1-29-20-14-8-6-12-18(20)16-22(29)25(31)28-24-26(32)30(2)21-15-9-7-13-19(21)23(27-24)17-10-4-3-5-11-17/h3-16,24H,1-2H3,(H,28,31)
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n/an/a 1.41n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity against cholecystokinin type A receptor of rat pancreas


J Med Chem 37: 3639-54 (1994)


Article DOI: 10.1021/jm00047a021
BindingDB Entry DOI: 10.7270/Q2SB46ZR
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019207
PNG
(1-Methyl-1H-indole-2-carboxylic acid [5-(2-fluoro-...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3n2C)C1=O)c1ccccc1F
Show InChI InChI=1S/C26H21FN4O2/c1-30-20-13-7-3-9-16(20)15-22(30)25(32)29-24-26(33)31(2)21-14-8-5-11-18(21)23(28-24)17-10-4-6-12-19(17)27/h3-15,24H,1-2H3,(H,29,32)
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n/an/a 1.38n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity against cholecystokinin type A receptor of rat pancreas


J Med Chem 37: 3639-54 (1994)


Article DOI: 10.1021/jm00047a021
BindingDB Entry DOI: 10.7270/Q2SB46ZR
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019184
PNG
(5-Bromo-1H-indole-2-carboxylic acid [5-(2-fluoro-p...)
Show SMILES Fc1ccccc1C1=NC(NC(=O)c2cc3cc(Br)ccc3[nH]2)C(=O)Nc2ccccc12
Show InChI InChI=1S/C24H16BrFN4O2/c25-14-9-10-18-13(11-14)12-20(27-18)23(31)30-22-24(32)28-19-8-4-2-6-16(19)21(29-22)15-5-1-3-7-17(15)26/h1-12,22,27H,(H,28,32)(H,30,31)
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n/an/a 120n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity against cholecystokinin type A receptor of rat pancreas


J Med Chem 37: 3639-54 (1994)


Article DOI: 10.1021/jm00047a021
BindingDB Entry DOI: 10.7270/Q2SB46ZR
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019217
PNG
(5-Fluoro-1H-indole-2-carboxylic acid [5-(2-fluoro-...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O
Show InChI InChI=1S/C24H16F2N4O2/c25-14-9-10-18-13(11-14)12-20(27-18)23(31)30-22-24(32)28-19-8-4-2-6-16(19)21(29-22)15-5-1-3-7-17(15)26/h1-12,22,27H,(H,28,32)(H,30,31)
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n/an/a 5.01n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity against cholecystokinin type A receptor of rat pancreas


J Med Chem 37: 3639-54 (1994)


Article DOI: 10.1021/jm00047a021
BindingDB Entry DOI: 10.7270/Q2SB46ZR
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019241
PNG
(5-Hydroxy-1H-indole-2-carboxylic acid [5-(2-fluoro...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O
Show InChI InChI=1S/C24H17FN4O3/c25-17-7-3-1-5-15(17)21-16-6-2-4-8-19(16)27-24(32)22(28-21)29-23(31)20-12-13-11-14(30)9-10-18(13)26-20/h1-12,22,26,30H,(H,27,32)(H,29,31)
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n/an/a 70.8n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity against cholecystokinin type A receptor of rat pancreas


J Med Chem 37: 3639-54 (1994)


Article DOI: 10.1021/jm00047a021
BindingDB Entry DOI: 10.7270/Q2SB46ZR
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019249
PNG
(1-Methyl-1H-indole-2-carboxylic acid [5-(2-fluoro-...)
Show SMILES Cn1c(cc2ccccc12)C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O
Show InChI InChI=1S/C25H19FN4O2/c1-30-20-13-7-2-8-15(20)14-21(30)24(31)29-23-25(32)27-19-12-6-4-10-17(19)22(28-23)16-9-3-5-11-18(16)26/h2-14,23H,1H3,(H,27,32)(H,29,31)
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n/an/a 4.68n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity against cholecystokinin type A receptor of rat pancreas


J Med Chem 37: 3639-54 (1994)


Article DOI: 10.1021/jm00047a021
BindingDB Entry DOI: 10.7270/Q2SB46ZR
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019252
PNG
(1H-Indole-2-carboxylic acid (2-oxo-5-phenyl-2,3-di...)
Show SMILES O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C24H18N4O2/c29-23(20-14-16-10-4-6-12-18(16)25-20)28-22-24(30)26-19-13-7-5-11-17(19)21(27-22)15-8-2-1-3-9-15/h1-14,22,25H,(H,26,30)(H,28,29)
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n/an/a 4.57n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity against cholecystokinin type A receptor of rat pancreas


J Med Chem 37: 3639-54 (1994)


Article DOI: 10.1021/jm00047a021
BindingDB Entry DOI: 10.7270/Q2SB46ZR
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50019260
PNG
(1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2...)
Show SMILES Fc1ccccc1C1=NC(NC(=O)c2cc3ccccc3[nH]2)C(=O)Nc2ccccc12
Show InChI InChI=1S/C24H17FN4O2/c25-17-10-4-2-8-15(17)21-16-9-3-6-12-19(16)27-24(31)22(28-21)29-23(30)20-13-14-7-1-5-11-18(14)26-20/h1-13,22,26H,(H,27,31)(H,29,30)
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n/an/a 2.09n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Binding affinity against cholecystokinin type A receptor of rat pancreas


J Med Chem 37: 3639-54 (1994)


Article DOI: 10.1021/jm00047a021
BindingDB Entry DOI: 10.7270/Q2SB46ZR
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019249
PNG
(1-Methyl-1H-indole-2-carboxylic acid [5-(2-fluoro-...)
Show SMILES Cn1c(cc2ccccc12)C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O
Show InChI InChI=1S/C25H19FN4O2/c1-30-20-13-7-2-8-15(20)14-21(30)24(31)29-23-25(32)27-19-12-6-4-10-17(19)22(28-23)16-9-3-5-11-18(16)26/h2-14,23H,1H3,(H,27,32)(H,29,31)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]-CCK-8(+) binding to cholecystokinin receptor from guinea pig brain tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019260
PNG
(1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-2...)
Show SMILES Fc1ccccc1C1=NC(NC(=O)c2cc3ccccc3[nH]2)C(=O)Nc2ccccc12
Show InChI InChI=1S/C24H17FN4O2/c25-17-10-4-2-8-15(17)21-16-9-3-6-12-19(16)27-24(31)22(28-21)29-23(30)20-13-14-7-1-5-11-18(14)26-20/h1-13,22,26H,(H,27,31)(H,29,30)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]-CCK-8(+) binding to cholecystokinin receptor from guinea pig brain tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019241
PNG
(5-Hydroxy-1H-indole-2-carboxylic acid [5-(2-fluoro...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O
Show InChI InChI=1S/C24H17FN4O3/c25-17-7-3-1-5-15(17)21-16-6-2-4-8-19(16)27-24(32)22(28-21)29-23(31)20-12-13-11-14(30)9-10-18(13)26-20/h1-12,22,26,30H,(H,27,32)(H,29,31)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]-CCK-8(+) binding to cholecystokinin receptor from guinea pig brain tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019191
PNG
(1-Methyl-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3n2C)C1=O)c1ccccc1
Show InChI InChI=1S/C26H22N4O2/c1-29-20-14-8-6-12-18(20)16-22(29)25(31)28-24-26(32)30(2)21-15-9-7-13-19(21)23(27-24)17-10-4-3-5-11-17/h3-16,24H,1-2H3,(H,28,31)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]-CCK-8(+) binding to cholecystokinin receptor from guinea pig brain tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019178
PNG
(CHEMBL70883 | {5-(2-Fluoro-phenyl)-3-[(1H-indole-2...)
Show SMILES CCOC(=O)CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1F
Show InChI InChI=1S/C28H23FN4O4/c1-2-37-24(34)16-33-23-14-8-5-11-19(23)25(18-10-4-6-12-20(18)29)31-26(28(33)36)32-27(35)22-15-17-9-3-7-13-21(17)30-22/h3-15,26,30H,2,16H2,1H3,(H,32,35)
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n/an/a 200n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]-CCK-8(+) binding to cholecystokinin receptor from guinea pig brain tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019217
PNG
(5-Fluoro-1H-indole-2-carboxylic acid [5-(2-fluoro-...)
Show SMILES Fc1ccc2[nH]c(cc2c1)C(=O)NC1N=C(c2ccccc2F)c2ccccc2NC1=O
Show InChI InChI=1S/C24H16F2N4O2/c25-14-9-10-18-13(11-14)12-20(27-18)23(31)30-22-24(32)28-19-8-4-2-6-16(19)21(29-22)15-5-1-3-7-17(15)26/h1-12,22,27H,(H,28,32)(H,30,31)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]-CCK-8(+) binding to cholecystokinin receptor from guinea pig brain tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50452486
PNG
(CHEMBL39263 | Rac-Devazepide)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1
Show InChI InChI=1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)
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n/an/a 800n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]-CCK-8(+) binding to cholecystokinin receptor from guinea pig brain tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019252
PNG
(1H-Indole-2-carboxylic acid (2-oxo-5-phenyl-2,3-di...)
Show SMILES O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C24H18N4O2/c29-23(20-14-16-10-4-6-12-18(16)25-20)28-22-24(30)26-19-13-7-5-11-17(19)21(27-22)15-8-2-1-3-9-15/h1-14,22,25H,(H,26,30)(H,28,29)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]-CCK-8(+) binding to cholecystokinin receptor from guinea pig brain tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019272
PNG
(1H-Indole-2-carboxylic acid methyl-(2-oxo-5-phenyl...)
Show SMILES CN(C1N=C(c2ccccc2)c2ccccc2NC1=O)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C25H20N4O2/c1-29(25(31)21-15-17-11-5-7-13-19(17)26-21)23-24(30)27-20-14-8-6-12-18(20)22(28-23)16-9-3-2-4-10-16/h2-15,23,26H,1H3,(H,27,30)
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n/an/a 3.30E+4n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]-CCK-8(+) binding to cholecystokinin receptor from guinea pig brain tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019261
PNG
((S)-N-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1F
Show InChI InChI=1S/C25H19FN4O2/c1-30-21-13-7-4-10-17(21)22(16-9-3-5-11-18(16)26)28-23(25(30)32)29-24(31)20-14-15-8-2-6-12-19(15)27-20/h2-14,23,27H,1H3,(H,29,31)/t23-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]-CCK-8(+) binding to cholecystokinin receptor from guinea pig brain tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50019207
PNG
(1-Methyl-1H-indole-2-carboxylic acid [5-(2-fluoro-...)
Show SMILES CN1c2ccccc2C(=NC(NC(=O)c2cc3ccccc3n2C)C1=O)c1ccccc1F
Show InChI InChI=1S/C26H21FN4O2/c1-30-20-13-7-3-9-16(20)15-22(30)25(32)29-24-26(33)31(2)21-14-8-5-11-18(21)23(28-24)17-10-4-6-12-19(17)27/h3-15,24H,1-2H3,(H,29,32)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Half-maximal inhibition of [125I]-CCK-8(+) binding to cholecystokinin receptor from guinea pig brain tissue


J Med Chem 31: 2235-46 (1989)


Article DOI: 10.1021/jm00120a002
BindingDB Entry DOI: 10.7270/Q2PG1S9K
More data for this
Ligand-Target Pair
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