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129 similar compounds to monomer 50062005

Compile data set for download or QSAR
Wt: 681.7
BDBM50449520
Wt: 629.7
BDBM50449518
Wt: 614.7
BDBM50449627
Wt: 500.6
BDBM50449746
Wt: 614.7
BDBM50449747
Wt: 614.7
BDBM50449787
Purchase
Wt: 575.6
BDBM50451028
Wt: 616.7
BDBM50450461
Purchase
Wt: 567.7
BDBM50070410
Wt: 575.6
BDBM50456329
Wt: 557.6
BDBM50456330
Wt: 509.6
BDBM50456331
Wt: 614.7
BDBM82403
Wt: 557.6
BDBM50033600
Wt: 485.6
BDBM50005809
Displayed 1 to 15 (of 129 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 51 hits for monomerid = 50449520,50449518,50449627,50449746,50449747,50449787,50451028,50450461,50070410,50456329,50456330,50456331,82403,50033600,50005809   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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0.400n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.


J Med Chem 40: 3947-56 (1998)


Article DOI: 10.1021/jm970439a
BindingDB Entry DOI: 10.7270/Q27H1K8Z
More data for this
Ligand-Target Pair
Cholecystokinin B


(GUINEA PIG)
BDBM82403
PNG
(CAS_108186 | CI-988 | NSC_108186)
Show SMILES CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)
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0.460n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 273: 1015-22 (1995)


BindingDB Entry DOI: 10.7270/Q2QV3K1C
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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0.980n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.


Bioorg Med Chem Lett 3: 885-888 (1993)


Article DOI: 10.1016/S0960-894X(00)80686-1
BindingDB Entry DOI: 10.7270/Q2D79BWZ
More data for this
Ligand-Target Pair
Cholecystokinin B


(GUINEA PIG)
BDBM82403
PNG
(CAS_108186 | CI-988 | NSC_108186)
Show SMILES CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)
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2n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 273: 1015-22 (1995)


BindingDB Entry DOI: 10.7270/Q2QV3K1C
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM82403
PNG
(CAS_108186 | CI-988 | NSC_108186)
Show SMILES CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)
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6.30n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co. Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 269: 725-31 (1994)


BindingDB Entry DOI: 10.7270/Q2WD3Z2F
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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7.30n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.


J Med Chem 40: 3947-56 (1998)


Article DOI: 10.1021/jm970439a
BindingDB Entry DOI: 10.7270/Q27H1K8Z
More data for this
Ligand-Target Pair
CCKBR


(GUINEA PIG)
BDBM82403
PNG
(CAS_108186 | CI-988 | NSC_108186)
Show SMILES CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)
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1.44E+3n/an/an/an/an/an/an/an/a



Rhone-Poulenc Rorer Central Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 273: 1015-22 (1995)


BindingDB Entry DOI: 10.7270/Q2QV3K1C
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50070410
PNG
(CHEMBL105618 | [2-(4-Benzoyl-piperidin-1-yl)-1-(1H...)
Show SMILES CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C35H41N3O4/c1-35(20-28-21-36-30-10-6-5-9-29(28)30,37-34(41)42-32-26-16-22-15-23(18-26)19-27(32)17-22)33(40)38-13-11-25(12-14-38)31(39)24-7-3-2-4-8-24/h2-10,21-23,25-27,32,36H,11-20H2,1H3,(H,37,41)/t22-,23+,26-,27+,32?,35?
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1.70E+3n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Binding affinity against CCK-A receptor in guinea pig pancreatic membranes


Bioorg Med Chem Lett 8: 1419-24 (1999)


Article DOI: 10.1016/s0960-894x(98)00231-5
BindingDB Entry DOI: 10.7270/Q2NZ86S0
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50070410
PNG
(CHEMBL105618 | [2-(4-Benzoyl-piperidin-1-yl)-1-(1H...)
Show SMILES CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C35H41N3O4/c1-35(20-28-21-36-30-10-6-5-9-29(28)30,37-34(41)42-32-26-16-22-15-23(18-26)19-27(32)17-22)33(40)38-13-11-25(12-14-38)31(39)24-7-3-2-4-8-24/h2-10,21-23,25-27,32,36H,11-20H2,1H3,(H,37,41)/t22-,23+,26-,27+,32?,35?
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3.40E+3n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor


Bioorg Med Chem Lett 8: 1419-24 (1999)


Article DOI: 10.1016/s0960-894x(98)00231-5
BindingDB Entry DOI: 10.7270/Q2NZ86S0
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM82403
PNG
(CAS_108186 | CI-988 | NSC_108186)
Show SMILES CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)
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6.60E+3n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Co. Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 269: 725-31 (1994)


BindingDB Entry DOI: 10.7270/Q2WD3Z2F
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50449746
PNG
(CHEMBL2304063)
Show SMILES C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccn1
Show InChI InChI=1S/C30H36N4O3/c1-30(17-23-18-33-26-8-3-2-7-25(23)26,28(35)32-11-9-24-6-4-5-10-31-24)34-29(36)37-27-21-13-19-12-20(15-21)16-22(27)14-19/h2-8,10,18-22,27,33H,9,11-17H2,1H3,(H,32,35)(H,34,36)/t19-,20+,21-,22+,27?,30-/m0/s1
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n/an/a 1.85E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I]- Bolton Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreas.


Bioorg Med Chem Lett 3: 2805-2810 (1993)


Article DOI: 10.1016/S0960-894X(01)80769-1
BindingDB Entry DOI: 10.7270/Q29Z94TW
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50449747
PNG
(CHEMBL2304062)
Show SMILES C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m1/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I]- Bolton Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreas.


Bioorg Med Chem Lett 3: 2805-2810 (1993)


Article DOI: 10.1016/S0960-894X(01)80769-1
BindingDB Entry DOI: 10.7270/Q29Z94TW
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.


Bioorg Med Chem Lett 3: 881-884 (1993)


Article DOI: 10.1016/S0960-894X(00)80685-X
BindingDB Entry DOI: 10.7270/Q2WM1DC5
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CCK-8 binding to Cholecystokinin type A receptor of rat pancreas


Bioorg Med Chem Lett 3: 881-884 (1993)


Article DOI: 10.1016/S0960-894X(00)80685-X
BindingDB Entry DOI: 10.7270/Q2WM1DC5
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-A receptor in the rat pancreas


Bioorg Med Chem Lett 7: 2009-2014 (1997)


Article DOI: 10.1016/S0960-894X(97)00356-9
BindingDB Entry DOI: 10.7270/Q2DJ5FM6
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex


Bioorg Med Chem Lett 7: 2009-2014 (1997)


Article DOI: 10.1016/S0960-894X(97)00356-9
BindingDB Entry DOI: 10.7270/Q2DJ5FM6
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50450461
PNG
(CHEMBL2367718)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)O[C@@H]1C[C@@H]2CC[C@]1(C)C2(C)C)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H44N4O6/c1-33(2)24-16-17-34(33,3)28(18-24)45-32(44)39-35(4,19-23-20-36-26-13-9-8-12-25(23)26)31(43)37-21-27(22-10-6-5-7-11-22)38-29(40)14-15-30(41)42/h5-13,20,24,27-28,36H,14-19,21H2,1-4H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t24-,27-,28+,34-,35+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor


Bioorg Med Chem Lett 7: 855-860 (1997)


Article DOI: 10.1016/S0960-894X(97)00107-8
BindingDB Entry DOI: 10.7270/Q218370Q
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50450461
PNG
(CHEMBL2367718)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)O[C@@H]1C[C@@H]2CC[C@]1(C)C2(C)C)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H44N4O6/c1-33(2)24-16-17-34(33,3)28(18-24)45-32(44)39-35(4,19-23-20-36-26-13-9-8-12-25(23)26)31(43)37-21-27(22-10-6-5-7-11-22)38-29(40)14-15-30(41)42/h5-13,20,24,27-28,36H,14-19,21H2,1-4H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t24-,27-,28+,34-,35+/m0/s1
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n/an/a 1.43E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of specific [3H]propionyl-CCK-8 binding to rat pancreas membrane Cholecystokinin type A receptor


Bioorg Med Chem Lett 7: 855-860 (1997)


Article DOI: 10.1016/S0960-894X(97)00107-8
BindingDB Entry DOI: 10.7270/Q218370Q
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50005809
PNG
(CHEMBL35555 | [2-(1H-Indol-3-yl)-1-methyl-1-(phene...)
Show SMILES CC(CNCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2
Show InChI InChI=1S/C31H39N3O2/c1-31(20-32-12-11-21-7-3-2-4-8-21,18-26-19-33-28-10-6-5-9-27(26)28)34-30(35)36-29-24-14-22-13-23(16-24)17-25(29)15-22/h2-10,19,22-25,29,32-33H,11-18,20H2,1H3,(H,34,35)/t22-,23+,24-,25+,29?,31?
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n/an/a 1.08E+3n/an/an/an/an/an/a



Parke-Davis Neuroscience Research Center

Curated by ChEMBL


Assay Description
Inhibition of [125I]CCK-8 binding to Cholecystokinin type A receptor in the rat pancreas


J Med Chem 35: 1472-84 (1992)


Article DOI: 10.1021/jm00086a017
BindingDB Entry DOI: 10.7270/Q2H41S3W
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50450461
PNG
(CHEMBL2367718)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)O[C@@H]1C[C@@H]2CC[C@]1(C)C2(C)C)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H44N4O6/c1-33(2)24-16-17-34(33,3)28(18-24)45-32(44)39-35(4,19-23-20-36-26-13-9-8-12-25(23)26)31(43)37-21-27(22-10-6-5-7-11-22)38-29(40)14-15-30(41)42/h5-13,20,24,27-28,36H,14-19,21H2,1-4H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t24-,27-,28+,34-,35+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding of [3H]-propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.


Bioorg Med Chem Lett 6: 967-972 (1996)


Article DOI: 10.1016/0960-894X(96)00160-6
BindingDB Entry DOI: 10.7270/Q2736QWF
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50451028
PNG
(CHEMBL2062146 | PD-149164)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(O)=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C33H38FN3O5/c1-33(17-24-18-35-28-5-3-2-4-27(24)28,31(40)36-26(16-29(38)39)15-19-6-8-25(34)9-7-19)37-32(41)42-30-22-11-20-10-21(13-22)14-23(30)12-20/h2-9,18,20-23,26,30,35H,10-17H2,1H3,(H,36,40)(H,37,41)(H,38,39)/t20?,21?,22?,23?,26-,30?,33+/m0/s1
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n/an/a 0.0830n/an/an/an/an/an/a



CCIPE-Faculte de Pharmacie

Curated by ChEMBL


Assay Description
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membrane


Bioorg Med Chem Lett 10: 1245-8 (2000)


Article DOI: 10.1016/s0960-894x(00)00198-0
BindingDB Entry DOI: 10.7270/Q2NC61RV
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50451028
PNG
(CHEMBL2062146 | PD-149164)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(O)=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C33H38FN3O5/c1-33(17-24-18-35-28-5-3-2-4-27(24)28,31(40)36-26(16-29(38)39)15-19-6-8-25(34)9-7-19)37-32(41)42-30-22-11-20-10-21(13-22)14-23(30)12-20/h2-9,18,20-23,26,30,35H,10-17H2,1H3,(H,36,40)(H,37,41)(H,38,39)/t20?,21?,22?,23?,26-,30?,33+/m0/s1
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n/an/a 75n/an/an/an/an/an/a



CCIPE-Faculte de Pharmacie

Curated by ChEMBL


Assay Description
Compound was evaluated for the binding affinity towards rat pancreatic Cholecystokinin type A receptor


Bioorg Med Chem Lett 10: 1245-8 (2000)


Article DOI: 10.1016/s0960-894x(00)00198-0
BindingDB Entry DOI: 10.7270/Q2NC61RV
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



Parke-Davis Research Unit

Curated by ChEMBL


Assay Description
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to rat pancreas Cholecystokinin type A receptor


J Med Chem 34: 404-14 (1991)


Article DOI: 10.1021/jm00105a062
BindingDB Entry DOI: 10.7270/Q2RJ4K3V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Parke-Davis Research Unit

Curated by ChEMBL


Assay Description
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor


J Med Chem 34: 404-14 (1991)


Article DOI: 10.1021/jm00105a062
BindingDB Entry DOI: 10.7270/Q2RJ4K3V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
PDB

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n/an/a 1.05E+3n/an/an/an/an/an/a



Glaxo Research Institute

Curated by ChEMBL


Assay Description
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type A receptor expressed in CHO-K1 cells


J Med Chem 38: 3384-90 (1995)


Article DOI: 10.1021/jm00017a022
BindingDB Entry DOI: 10.7270/Q2KP83FW
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 0.138n/an/an/an/an/an/a



Glaxo Research Institute

Curated by ChEMBL


Assay Description
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells


J Med Chem 38: 3384-90 (1995)


Article DOI: 10.1021/jm00017a022
BindingDB Entry DOI: 10.7270/Q2KP83FW
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type A receptor in the rat pancreas


J Med Chem 41: 38-45 (1998)


Article DOI: 10.1021/jm970065l
BindingDB Entry DOI: 10.7270/Q2GT5NV6
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex


J Med Chem 41: 38-45 (1998)


Article DOI: 10.1021/jm970065l
BindingDB Entry DOI: 10.7270/Q2GT5NV6
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)


J Med Chem 40: 3947-56 (1998)


Article DOI: 10.1021/jm970439a
BindingDB Entry DOI: 10.7270/Q27H1K8Z
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50456329
PNG
(CHEMBL2111261)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CC(O)=O)Cc1ccccc1
Show InChI InChI=1S/C33H39N3O5.H2O/c1-33(18-25-19-34-28-10-6-5-9-27(25)28,31(39)35-26(17-29(37)38)16-20-7-3-2-4-8-20)36-32(40)41-30-23-12-21-11-22(14-23)15-24(30)13-21;/h2-10,19,21-24,26,30,34H,11-18H2,1H3,(H,35,39)(H,36,40)(H,37,38);1H2/t21-,22+,23-,24+,26-,30?,33+;/m0./s1
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n/an/a 26n/an/an/an/an/an/a



Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type A receptor in the rat pancreas.


J Med Chem 36: 552-65 (1993)


Article DOI: 10.1021/jm00057a005
BindingDB Entry DOI: 10.7270/Q2JM2B88
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50456331
PNG
(CHEMBL2111203)
Show SMILES O.CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1
Show InChI InChI=1S/C29H37N3O4.H2O/c1-20-10-6-9-15-26(20)36-28(35)32-29(2,17-22-18-30-25-14-8-7-13-24(22)25)27(34)31-23(19-33)16-21-11-4-3-5-12-21;/h3-5,7-8,11-14,18,20,23,26,30,33H,6,9-10,15-17,19H2,1-2H3,(H,31,34)(H,32,35);1H2/t20?,23?,26?,29-;/m1./s1
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n/an/a 18n/an/an/an/an/an/a



Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type A receptor in the rat pancreas.


J Med Chem 36: 552-65 (1993)


Article DOI: 10.1021/jm00057a005
BindingDB Entry DOI: 10.7270/Q2JM2B88
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50456330
PNG
(CHEMBL2304064)
Show SMILES C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CC(O)=O)Cc1ccccc1
Show InChI InChI=1S/C33H39N3O5/c1-33(18-25-19-34-28-10-6-5-9-27(25)28,31(39)35-26(17-29(37)38)16-20-7-3-2-4-8-20)36-32(40)41-30-23-12-21-11-22(14-23)15-24(30)13-21/h2-10,19,21-24,26,30,34H,11-18H2,1H3,(H,35,39)(H,36,40)(H,37,38)/t21-,22+,23-,24+,26-,30?,33-/m0/s1
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n/an/a 539n/an/an/an/an/an/a



Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type A receptor in the rat pancreas.


J Med Chem 36: 552-65 (1993)


Article DOI: 10.1021/jm00057a005
BindingDB Entry DOI: 10.7270/Q2JM2B88
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50456330
PNG
(CHEMBL2304064)
Show SMILES C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CC(O)=O)Cc1ccccc1
Show InChI InChI=1S/C33H39N3O5/c1-33(18-25-19-34-28-10-6-5-9-27(25)28,31(39)35-26(17-29(37)38)16-20-7-3-2-4-8-20)36-32(40)41-30-23-12-21-11-22(14-23)15-24(30)13-21/h2-10,19,21-24,26,30,34H,11-18H2,1H3,(H,35,39)(H,36,40)(H,37,38)/t21-,22+,23-,24+,26-,30?,33-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex


J Med Chem 36: 552-65 (1993)


Article DOI: 10.1021/jm00057a005
BindingDB Entry DOI: 10.7270/Q2JM2B88
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50456331
PNG
(CHEMBL2111203)
Show SMILES O.CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1
Show InChI InChI=1S/C29H37N3O4.H2O/c1-20-10-6-9-15-26(20)36-28(35)32-29(2,17-22-18-30-25-14-8-7-13-24(22)25)27(34)31-23(19-33)16-21-11-4-3-5-12-21;/h3-5,7-8,11-14,18,20,23,26,30,33H,6,9-10,15-17,19H2,1-2H3,(H,31,34)(H,32,35);1H2/t20?,23?,26?,29-;/m1./s1
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n/an/a 0.340n/an/an/an/an/an/a



Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex


J Med Chem 36: 552-65 (1993)


Article DOI: 10.1021/jm00057a005
BindingDB Entry DOI: 10.7270/Q2JM2B88
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50456329
PNG
(CHEMBL2111261)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CC(O)=O)Cc1ccccc1
Show InChI InChI=1S/C33H39N3O5.H2O/c1-33(18-25-19-34-28-10-6-5-9-27(25)28,31(39)35-26(17-29(37)38)16-20-7-3-2-4-8-20)36-32(40)41-30-23-12-21-11-22(14-23)15-24(30)13-21;/h2-10,19,21-24,26,30,34H,11-18H2,1H3,(H,35,39)(H,36,40)(H,37,38);1H2/t21-,22+,23-,24+,26-,30?,33+;/m0./s1
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Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex


J Med Chem 36: 552-65 (1993)


Article DOI: 10.1021/jm00057a005
BindingDB Entry DOI: 10.7270/Q2JM2B88
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Parke-Davis Neuroscience Research Center

Curated by ChEMBL


Assay Description
Inhibition of [125I]CCK-8 binding to Cholecystokinin type A receptor in the rat pancreas


J Med Chem 35: 1472-84 (1992)


Article DOI: 10.1021/jm00086a017
BindingDB Entry DOI: 10.7270/Q2H41S3W
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



Parke-Davis Neuroscience Research Center

Curated by ChEMBL


Assay Description
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex


J Med Chem 35: 1472-84 (1992)


Article DOI: 10.1021/jm00086a017
BindingDB Entry DOI: 10.7270/Q2H41S3W
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50033600
PNG
(Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 | CHEMBL...)
Show SMILES C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(O)=O)Cc1ccccc1
Show InChI InChI=1S/C33H39N3O5/c1-33(18-25-19-34-28-10-6-5-9-27(25)28,31(39)35-26(17-29(37)38)16-20-7-3-2-4-8-20)36-32(40)41-30-23-12-21-11-22(14-23)15-24(30)13-21/h2-10,19,21-24,26,30,34H,11-18H2,1H3,(H,35,39)(H,36,40)(H,37,38)/t21-,22+,23-,24+,26-,30?,33+/m1/s1
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Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex


J Med Chem 36: 552-65 (1993)


Article DOI: 10.1021/jm00057a005
BindingDB Entry DOI: 10.7270/Q2JM2B88
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50033600
PNG
(Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 | CHEMBL...)
Show SMILES C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(O)=O)Cc1ccccc1
Show InChI InChI=1S/C33H39N3O5/c1-33(18-25-19-34-28-10-6-5-9-27(25)28,31(39)35-26(17-29(37)38)16-20-7-3-2-4-8-20)36-32(40)41-30-23-12-21-11-22(14-23)15-24(30)13-21/h2-10,19,21-24,26,30,34H,11-18H2,1H3,(H,35,39)(H,36,40)(H,37,38)/t21-,22+,23-,24+,26-,30?,33+/m1/s1
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Parke-Davis Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type A receptor in the rat pancreas.


J Med Chem 36: 552-65 (1993)


Article DOI: 10.1021/jm00057a005
BindingDB Entry DOI: 10.7270/Q2JM2B88
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50005809
PNG
(CHEMBL35555 | [2-(1H-Indol-3-yl)-1-methyl-1-(phene...)
Show SMILES CC(CNCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2
Show InChI InChI=1S/C31H39N3O2/c1-31(20-32-12-11-21-7-3-2-4-8-21,18-26-19-33-28-10-6-5-9-27(26)28)34-30(35)36-29-24-14-22-13-23(16-24)17-25(29)15-22/h2-10,19,22-25,29,32-33H,11-18,20H2,1H3,(H,34,35)/t22-,23+,24-,25+,29?,31?
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n/an/a 4.06E+3n/an/an/an/an/an/a



Parke-Davis Neuroscience Research Center

Curated by ChEMBL


Assay Description
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex


J Med Chem 35: 1472-84 (1992)


Article DOI: 10.1021/jm00086a017
BindingDB Entry DOI: 10.7270/Q2H41S3W
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50449746
PNG
(CHEMBL2304063)
Show SMILES C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccn1
Show InChI InChI=1S/C30H36N4O3/c1-30(17-23-18-33-26-8-3-2-7-25(23)26,28(35)32-11-9-24-6-4-5-10-31-24)34-29(36)37-27-21-13-19-12-20(15-21)16-22(27)14-19/h2-8,10,18-22,27,33H,9,11-17H2,1H3,(H,32,35)(H,34,36)/t19-,20+,21-,22+,27?,30-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.


Bioorg Med Chem Lett 3: 2805-2810 (1993)


Article DOI: 10.1016/S0960-894X(01)80769-1
BindingDB Entry DOI: 10.7270/Q29Z94TW
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50449747
PNG
(CHEMBL2304062)
Show SMILES C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.


Bioorg Med Chem Lett 3: 2805-2810 (1993)


Article DOI: 10.1016/S0960-894X(01)80769-1
BindingDB Entry DOI: 10.7270/Q29Z94TW
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound measured for half-maximal inhibition of specific binding of [125I]-Bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.


Bioorg Med Chem Lett 3: 989-992 (1993)


Article DOI: 10.1016/S0960-894X(00)80273-5
BindingDB Entry DOI: 10.7270/Q2XD11M0
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound measured for half-maximal inhibition of specific binding of [125I]-Bolton Hunter CCK-26-33 to CCK-A receptor in the rat pancreas.


Bioorg Med Chem Lett 3: 989-992 (1993)


Article DOI: 10.1016/S0960-894X(00)80273-5
BindingDB Entry DOI: 10.7270/Q2XD11M0
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50449627
PNG
(CHEMBL2021374)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21?,22?,24?,25?,29?,32?,35-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Evaluated for in vitro binding affinity to cholecystokinin-A (CCK-A) receptor in homogenized rat pancreas using [125I]bolton hunter CCK-26-33 as radi...


Bioorg Med Chem Lett 2: 403-406 (1992)


Article DOI: 10.1016/S0960-894X(00)80156-0
BindingDB Entry DOI: 10.7270/Q27H1JHP
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50449627
PNG
(CHEMBL2021374)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21?,22?,24?,25?,29?,32?,35-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as ra...


Bioorg Med Chem Lett 2: 403-406 (1992)


Article DOI: 10.1016/S0960-894X(00)80156-0
BindingDB Entry DOI: 10.7270/Q27H1JHP
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50449518
PNG
(CHEMBL2304156)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)NO)c1ccccc1
Show InChI InChI=1S/C35H43N5O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)46-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(41)11-12-31(42)40-45/h2-10,19,21-22,24-25,29,32,36,45H,11-18,20H2,1H3,(H,37,43)(H,38,41)(H,39,44)(H,40,42)/t21?,22?,24?,25?,29-,32?,35+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cor...


Bioorg Med Chem Lett 2: 45-8 (1992)


BindingDB Entry DOI: 10.7270/Q2K0746W
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(MOUSE)
BDBM50449520
PNG
(CHEMBL2304154)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C36H42F3N5O5/c1-35(18-26-19-41-28-10-6-5-9-27(26)28,44-34(48)49-31-24-14-21-13-22(16-24)17-25(31)15-21)32(46)42-20-29(23-7-3-2-4-8-23)43-30(45)11-12-40-33(47)36(37,38)39/h2-10,19,21-22,24-25,29,31,41H,11-18,20H2,1H3,(H,40,47)(H,42,46)(H,43,45)(H,44,48)/t21?,22?,24?,25?,29-,31?,35+/m0/s1
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n/an/a 89n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cor...


Bioorg Med Chem Lett 2: 45-8 (1992)


BindingDB Entry DOI: 10.7270/Q2K0746W
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50449518
PNG
(CHEMBL2304156)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)NO)c1ccccc1
Show InChI InChI=1S/C35H43N5O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)46-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(41)11-12-31(42)40-45/h2-10,19,21-22,24-25,29,32,36,45H,11-18,20H2,1H3,(H,37,43)(H,38,41)(H,39,44)(H,40,42)/t21?,22?,24?,25?,29-,32?,35+/m0/s1
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Similars

n/an/a 1.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the rat pancreas (CCK-...


Bioorg Med Chem Lett 2: 45-8 (1992)


BindingDB Entry DOI: 10.7270/Q2K0746W
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50449520
PNG
(CHEMBL2304154)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C36H42F3N5O5/c1-35(18-26-19-41-28-10-6-5-9-27(26)28,44-34(48)49-31-24-14-21-13-22(16-24)17-25(31)15-21)32(46)42-20-29(23-7-3-2-4-8-23)43-30(45)11-12-40-33(47)36(37,38)39/h2-10,19,21-22,24-25,29,31,41H,11-18,20H2,1H3,(H,40,47)(H,42,46)(H,43,45)(H,44,48)/t21?,22?,24?,25?,29-,31?,35+/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
n/an/a 800n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the rat pancreas (CCK-...


Bioorg Med Chem Lett 2: 45-8 (1992)


BindingDB Entry DOI: 10.7270/Q2K0746W
More data for this
Ligand-Target Pair
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