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78 similar compounds to monomer 21393

Compile data set for download or QSAR
Wt: 263.3
BDBM85091
Wt: 309.4
BDBM50010289
Purchase
Wt: 324.4
BDBM50010293
Wt: 247.3
BDBM50011247
Purchase
Wt: 245.3
BDBM50011248
Wt: 245.3
BDBM50011249
Wt: 261.4
BDBM50011252
Wt: 245.3
BDBM50011253
Wt: 245.3
BDBM50011255
Wt: 261.4
BDBM50011256
Wt: 261.4
BDBM50011257
Wt: 275.4
BDBM50011258
Wt: 261.4
BDBM50011261
Wt: 261.4
BDBM50011262
Wt: 261.4
BDBM50011263
Displayed 1 to 15 (of 78 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 56 hits for monomerid = 85091,50010289,50010293,50011247,50011248,50011249,50011252,50011253,50011255,50011256,50011257,50011258,50011261,50011262,50011263   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50010289
PNG
((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H27NO/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23/h3-10,19,23H,2,11-16H2,1H3
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0.260n/an/an/an/an/an/an/an/a



Neuroscience Research Centre

Curated by PDSP Ki Database




J Pharmacol Exp Ther 268: 417-26 (1994)


Article DOI: 10.1016/j.bioorg.2015.06.003
BindingDB Entry DOI: 10.7270/Q2C827SR
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50010289
PNG
((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H27NO/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23/h3-10,19,23H,2,11-16H2,1H3
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0.5n/an/an/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity was evaluated by calculating competition for [3H]N-0437 binding on Dopamine receptor D2L of CHO K-1 cells


J Med Chem 39: 4233-7 (1996)


Article DOI: 10.1021/jm960345l
BindingDB Entry DOI: 10.7270/Q21C1XJF
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM85091
PNG
((+/-)-2-DIPROPYLAMINO- 6,7-DIHYDROXY-1,2,3,4-TETRA...)
Show SMILES CCCN(CCC)C1CCc2cc(O)c(O)cc2C1
Show InChI InChI=1S/C16H25NO2/c1-3-7-17(8-4-2)14-6-5-12-10-15(18)16(19)11-13(12)9-14/h10-11,14,18-19H,3-9H2,1-2H3
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0.680n/an/an/an/an/an/an/an/a



Neuroscience Research Centre

Curated by PDSP Ki Database




J Pharmacol Exp Ther 268: 417-26 (1994)


Article DOI: 10.1016/j.bioorg.2015.06.003
BindingDB Entry DOI: 10.7270/Q2C827SR
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011247
PNG
(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Binding affinity to 5HT1A receptor in Sprague-Dawley rat brain cortex homogenates after 30 mins


Eur J Med Chem 46: 2206-16 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.001
BindingDB Entry DOI: 10.7270/Q2M32W4J
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011247
PNG
(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
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1.20n/an/an/an/an/an/an/an/a



Universit£ di Siena

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor of rat hippocampus tissue.


J Med Chem 42: 1556-75 (1999)


Article DOI: 10.1021/jm981112s
BindingDB Entry DOI: 10.7270/Q2D50NPW
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011247
PNG
(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
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1.80n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4036-43 (1996)


Article DOI: 10.1021/jm960329o
BindingDB Entry DOI: 10.7270/Q2XK8G6C
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011247
PNG
(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
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1.80n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibiting the binding of [3H]- 8-OH-DPAT to 5-HT1A-receptor from cerebral cortex membranes of rat


Bioorg Med Chem Lett 1: 257-262 (1991)


Article DOI: 10.1016/S0960-894X(01)81038-6
BindingDB Entry DOI: 10.7270/Q2416X0N
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011247
PNG
(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
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1.80n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.


J Med Chem 36: 4221-9 (1994)


Article DOI: 10.1021/jm00078a012
BindingDB Entry DOI: 10.7270/Q2959GJH
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011261
PNG
((+)7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-nap...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(O)c2[C@@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m1/s1
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2.10n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50011252
PNG
(7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m0/s1
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2.80n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011261
PNG
((+)7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-nap...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(O)c2[C@@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m1/s1
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2.90n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for 5-hydroxytryptamine 1A receptor in rat brain tissue using [3H]-8-OH-DPAT as radioligand


J Med Chem 38: 150-60 (1995)


Article DOI: 10.1021/jm00001a020
BindingDB Entry DOI: 10.7270/Q2W09505
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50010289
PNG
((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H27NO/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23/h3-10,19,23H,2,11-16H2,1H3
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3.40n/an/an/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D3 expressed on CHO K-1 cells.


J Med Chem 39: 4233-7 (1996)


Article DOI: 10.1021/jm960345l
BindingDB Entry DOI: 10.7270/Q21C1XJF
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50011247
PNG
(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
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4.10n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50010289
PNG
((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H27NO/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23/h3-10,19,23H,2,11-16H2,1H3
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5.90n/an/an/an/an/an/an/an/a



Neuroscience Research Centre

Curated by PDSP Ki Database




J Pharmacol Exp Ther 268: 417-26 (1994)


Article DOI: 10.1016/j.bioorg.2015.06.003
BindingDB Entry DOI: 10.7270/Q2C827SR
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011247
PNG
(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
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6.10n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50010293
PNG
((RS)6-{[2-(4-Amino-phenyl)-ethyl]-propyl-amino}-5,...)
Show SMILES CCCN(CCc1ccc(N)cc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H28N2O/c1-2-13-23(14-12-16-6-8-18(22)9-7-16)19-10-11-20-17(15-19)4-3-5-21(20)24/h3-9,19,24H,2,10-15,22H2,1H3
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6.80n/an/an/an/an/an/an/an/a



Research Biochemicals Inc.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 by using [3H]spiperone as radioligand in caudate-putamen of monkey


J Med Chem 34: 3235-41 (1991)


Article DOI: 10.1021/jm00115a012
BindingDB Entry DOI: 10.7270/Q2KS6S5V
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011247
PNG
(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
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8.40n/an/an/an/an/an/an/an/a



University of Göteborg

Curated by ChEMBL


Assay Description
In vitro binding affinity against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT


J Med Chem 36: 2059-65 (1993)


Article DOI: 10.1021/jm00067a002
BindingDB Entry DOI: 10.7270/Q2MP52CR
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM85091
PNG
((+/-)-2-DIPROPYLAMINO- 6,7-DIHYDROXY-1,2,3,4-TETRA...)
Show SMILES CCCN(CCC)C1CCc2cc(O)c(O)cc2C1
Show InChI InChI=1S/C16H25NO2/c1-3-7-17(8-4-2)14-6-5-12-10-15(18)16(19)11-13(12)9-14/h10-11,14,18-19H,3-9H2,1-2H3
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8.80n/an/an/an/an/an/an/an/a



Institut de Recherches Servier

Curated by PDSP Ki Database




J Pharmacol Exp Ther 282: 181-91 (1997)


BindingDB Entry DOI: 10.7270/Q29K48SD
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50010289
PNG
((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H27NO/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23/h3-10,19,23H,2,11-16H2,1H3
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13n/an/an/an/an/an/an/an/a



Research Biochemicals Inc.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 by using [3H]spiperone as radioligand in caudate-putamen of monkey


J Med Chem 34: 3235-41 (1991)


Article DOI: 10.1021/jm00115a012
BindingDB Entry DOI: 10.7270/Q2KS6S5V
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50010289
PNG
((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H27NO/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23/h3-10,19,23H,2,11-16H2,1H3
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19n/an/an/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D2L of CHO K-1 cells.


J Med Chem 39: 4233-7 (1996)


Article DOI: 10.1021/jm960345l
BindingDB Entry DOI: 10.7270/Q21C1XJF
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50010289
PNG
((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H27NO/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23/h3-10,19,23H,2,11-16H2,1H3
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20n/an/an/an/an/an/an/an/a



University of Texas at Austin

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2


J Med Chem 41: 4385-99 (1998)


Article DOI: 10.1021/jm9800292
BindingDB Entry DOI: 10.7270/Q2R21227
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM85091
PNG
((+/-)-2-DIPROPYLAMINO- 6,7-DIHYDROXY-1,2,3,4-TETRA...)
Show SMILES CCCN(CCC)C1CCc2cc(O)c(O)cc2C1
Show InChI InChI=1S/C16H25NO2/c1-3-7-17(8-4-2)14-6-5-12-10-15(18)16(19)11-13(12)9-14/h10-11,14,18-19H,3-9H2,1-2H3
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25n/an/an/an/an/an/an/an/a



Neuroscience Research Centre

Curated by PDSP Ki Database




J Pharmacol Exp Ther 268: 417-26 (1994)


Article DOI: 10.1016/j.bioorg.2015.06.003
BindingDB Entry DOI: 10.7270/Q2C827SR
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50011261
PNG
((+)7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-nap...)
Show SMILES CCCN(CCC)[C@@H]1CCc2cccc(O)c2[C@@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m1/s1
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30n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human Dopamine receptor D2A was determined in mouse fibroblast LtK cells using [3H]-raclopride


J Med Chem 38: 150-60 (1995)


Article DOI: 10.1021/jm00001a020
BindingDB Entry DOI: 10.7270/Q2W09505
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50010289
PNG
((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H27NO/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23/h3-10,19,23H,2,11-16H2,1H3
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54n/an/an/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D4.2 of CHO K-1 cells.


J Med Chem 39: 4233-7 (1996)


Article DOI: 10.1021/jm960345l
BindingDB Entry DOI: 10.7270/Q21C1XJF
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011248
PNG
(1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]qui...)
Show SMILES CCCN1CCC[C@H]2Cc3cccc(O)c3C[C@@H]12
Show InChI InChI=1S/C16H23NO/c1-2-8-17-9-4-6-13-10-12-5-3-7-16(18)14(12)11-15(13)17/h3,5,7,13,15,18H,2,4,6,8-11H2,1H3/t13-,15+/m0/s1
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151n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011262
PNG
(7-Dipropylamino-6-methyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES CCCN(CCC)[C@@H]1Cc2c(O)cccc2C[C@@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-9-18(10-5-2)16-12-15-14(11-13(16)3)7-6-8-17(15)19/h6-8,13,16,19H,4-5,9-12H2,1-3H3/t13-,16+/m0/s1
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394n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50011256
PNG
((+)-7-Dipropylamino-6-methyl-5,6,7,8-tetrahydro-na...)
Show SMILES CCCN(CCC)[C@H]1Cc2c(O)cccc2C[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-9-18(10-5-2)16-12-15-14(11-13(16)3)7-6-8-17(15)19/h6-8,13,16,19H,4-5,9-12H2,1-3H3/t13-,16+/m1/s1
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656n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50010293
PNG
((RS)6-{[2-(4-Amino-phenyl)-ethyl]-propyl-amino}-5,...)
Show SMILES CCCN(CCc1ccc(N)cc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H28N2O/c1-2-13-23(14-12-16-6-8-18(22)9-7-16)19-10-11-20-17(15-19)4-3-5-21(20)24/h3-9,19,24H,2,10-15,22H2,1H3
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710n/an/an/an/an/an/an/an/a



Research Biochemicals Inc.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey


J Med Chem 34: 3235-41 (1991)


Article DOI: 10.1021/jm00115a012
BindingDB Entry DOI: 10.7270/Q2KS6S5V
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50010289
PNG
((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H27NO/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23/h3-10,19,23H,2,11-16H2,1H3
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804n/an/an/an/an/an/an/an/a



Research Biochemicals Inc.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey


J Med Chem 34: 3235-41 (1991)


Article DOI: 10.1021/jm00115a012
BindingDB Entry DOI: 10.7270/Q2KS6S5V
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011252
PNG
(7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m0/s1
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1.04E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011263
PNG
(7-Dipropylamino-7-methyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES CCCN(CCC)C1(C)CCc2cccc(O)c2C1
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)17(3)10-9-14-7-6-8-16(19)15(14)13-17/h6-8,19H,4-5,9-13H2,1-3H3
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1.13E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50010289
PNG
((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H27NO/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23/h3-10,19,23H,2,11-16H2,1H3
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1.20E+3n/an/an/an/an/an/an/an/a



University of Texas at Austin

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D1


J Med Chem 41: 4385-99 (1998)


Article DOI: 10.1021/jm9800292
BindingDB Entry DOI: 10.7270/Q2R21227
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011257
PNG
(7-Dipropylamino-6-methyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES CCCN(CCC)[C@@H]1Cc2c(O)cccc2C[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-9-18(10-5-2)16-12-15-14(11-13(16)3)7-6-8-17(15)19/h6-8,13,16,19H,4-5,9-12H2,1-3H3/t13-,16-/m1/s1
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1.39E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011256
PNG
((+)-7-Dipropylamino-6-methyl-5,6,7,8-tetrahydro-na...)
Show SMILES CCCN(CCC)[C@H]1Cc2c(O)cccc2C[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-9-18(10-5-2)16-12-15-14(11-13(16)3)7-6-8-17(15)19/h6-8,13,16,19H,4-5,9-12H2,1-3H3/t13-,16+/m1/s1
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2.02E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011249
PNG
(1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]qui...)
Show SMILES CCCN1CCC[C@@H]2Cc3cccc(O)c3C[C@@H]12
Show InChI InChI=1S/C16H23NO/c1-2-8-17-9-4-6-13-10-12-5-3-7-16(18)14(12)11-15(13)17/h3,5,7,13,15,18H,2,4,6,8-11H2,1H3/t13-,15-/m1/s1
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2.81E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50011252
PNG
(7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m0/s1
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2.92E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011252
PNG
(7-Dipropylamino-8-methyl-5,6,7,8-tetrahydro-naphth...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-16(19)17(14)13(15)3/h6-8,13,15,19H,4-5,9-12H2,1-3H3/t13-,15-/m0/s1
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2.92E+3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for 5-hydroxytryptamine 1A receptor in rat brain tissue using [3H]-8-OH-DPAT as radioligand


J Med Chem 38: 150-60 (1995)


Article DOI: 10.1021/jm00001a020
BindingDB Entry DOI: 10.7270/Q2W09505
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50011247
PNG
(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol...)
Show SMILES CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m0/s1
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5.07E+3n/an/an/an/an/an/an/an/a



University of Göteborg

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from dopamine receptor D2


J Med Chem 36: 2059-65 (1993)


Article DOI: 10.1021/jm00067a002
BindingDB Entry DOI: 10.7270/Q2MP52CR
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011258
PNG
(7-Dipropylamino-6,6-dimethyl-5,6,7,8-tetrahydro-na...)
Show SMILES CCCN(CCC)C1Cc2c(O)cccc2CC1(C)C
Show InChI InChI=1S/C18H29NO/c1-5-10-19(11-6-2)17-12-15-14(13-18(17,3)4)8-7-9-16(15)20/h7-9,17,20H,5-6,10-13H2,1-4H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011253
PNG
(1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]qui...)
Show SMILES CCCN1CCC[C@H]2Cc3cccc(O)c3C[C@H]12
Show InChI InChI=1S/C16H23NO/c1-2-8-17-9-4-6-13-10-12-5-3-7-16(18)14(12)11-15(13)17/h3,5,7,13,15,18H,2,4,6,8-11H2,1H3/t13-,15-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50011255
PNG
(1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]qui...)
Show SMILES CCCN1CCC[C@@H]2Cc3cccc(O)c3C[C@H]12
Show InChI InChI=1S/C16H23NO/c1-2-8-17-9-4-6-13-10-12-5-3-7-16(18)14(12)11-15(13)17/h3,5,7,13,15,18H,2,4,6,8-11H2,1H3/t13-,15+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.


J Med Chem 34: 497-510 (1991)


Article DOI: 10.1021/jm00106a004
BindingDB Entry DOI: 10.7270/Q2PK0GRB
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50011256
PNG
((+)-7-Dipropylamino-6-methyl-5,6,7,8-tetrahydro-na...)
Show SMILES CCCN(CCC)[C@H]1Cc2c(O)cccc2C[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-9-18(10-5-2)16-12-15-14(11-13(16)3)7-6-8-17(15)19/h6-8,13,16,19H,4-5,9-12H2,1-3H3/t13-,16+/m1/s1
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n/an/a 2.42E+3n/an/an/an/an/an/a



University of Uppsala

Curated by ChEMBL


Assay Description
Inhibitory activity tested in vitro at 5-hydroxytryptamine 1A receptor binding site in rat


J Med Chem 31: 1130-40 (1988)


Article DOI: 10.1021/jm00401a012
BindingDB Entry DOI: 10.7270/Q23J3DJB
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50011256
PNG
((+)-7-Dipropylamino-6-methyl-5,6,7,8-tetrahydro-na...)
Show SMILES CCCN(CCC)[C@H]1Cc2c(O)cccc2C[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-9-18(10-5-2)16-12-15-14(11-13(16)3)7-6-8-17(15)19/h6-8,13,16,19H,4-5,9-12H2,1-3H3/t13-,16+/m1/s1
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n/an/a 774n/an/an/an/an/an/a



University of Uppsala

Curated by ChEMBL


Assay Description
In vitro Inhibitory activity tested at 5-hydroxytryptamine 1A receptor binding site in rat


J Med Chem 31: 1130-40 (1988)


Article DOI: 10.1021/jm00401a012
BindingDB Entry DOI: 10.7270/Q23J3DJB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50010289
PNG
((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H27NO/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23/h3-10,19,23H,2,11-16H2,1H3
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n/an/an/a 90n/an/an/an/an/a



University of Texas

Curated by ChEMBL


Assay Description
In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes.


J Med Chem 43: 3005-19 (2000)


Article DOI: 10.1021/jm990526y
BindingDB Entry DOI: 10.7270/Q24J0FS2
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50010289
PNG
((R)6-(Phenethyl-propyl-amino)-5,6,7,8-tetrahydro-n...)
Show SMILES CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1
Show InChI InChI=1S/C21H27NO/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23/h3-10,19,23H,2,11-16H2,1H3
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n/an/an/a 10n/an/an/an/an/a



University of Texas

Curated by ChEMBL


Assay Description
In vitro affinity at wild type Dopamine receptor D2 on C6 (glioma) cell membranes.


J Med Chem 43: 3005-19 (2000)


Article DOI: 10.1021/jm990526y
BindingDB Entry DOI: 10.7270/Q24J0FS2
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50011256
PNG
((+)-7-Dipropylamino-6-methyl-5,6,7,8-tetrahydro-na...)
Show SMILES CCCN(CCC)[C@H]1Cc2c(O)cccc2C[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-9-18(10-5-2)16-12-15-14(11-13(16)3)7-6-8-17(15)19/h6-8,13,16,19H,4-5,9-12H2,1-3H3/t13-,16+/m1/s1
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n/an/a 486n/an/an/an/an/an/a



University of Uppsala

Curated by ChEMBL


Assay Description
Inhibitory activity tested in vitro at 5-hydroxytryptamine 1A receptor binding site in rat


J Med Chem 31: 1130-40 (1988)


Article DOI: 10.1021/jm00401a012
BindingDB Entry DOI: 10.7270/Q23J3DJB
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50011256
PNG
((+)-7-Dipropylamino-6-methyl-5,6,7,8-tetrahydro-na...)
Show SMILES CCCN(CCC)[C@H]1Cc2c(O)cccc2C[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-9-18(10-5-2)16-12-15-14(11-13(16)3)7-6-8-17(15)19/h6-8,13,16,19H,4-5,9-12H2,1-3H3/t13-,16+/m1/s1
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n/an/a 2.42E+3n/an/an/an/an/an/a



University of Uppsala

Curated by ChEMBL


Assay Description
In vitro Inhibitory activity tested at 5-hydroxytryptamine 1A receptor binding site in rat


J Med Chem 31: 1130-40 (1988)


Article DOI: 10.1021/jm00401a012
BindingDB Entry DOI: 10.7270/Q23J3DJB
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50011256
PNG
((+)-7-Dipropylamino-6-methyl-5,6,7,8-tetrahydro-na...)
Show SMILES CCCN(CCC)[C@H]1Cc2c(O)cccc2C[C@H]1C
Show InChI InChI=1S/C17H27NO/c1-4-9-18(10-5-2)16-12-15-14(11-13(16)3)7-6-8-17(15)19/h6-8,13,16,19H,4-5,9-12H2,1-3H3/t13-,16+/m1/s1
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n/an/a 486n/an/an/an/an/an/a



University of Uppsala

Curated by ChEMBL


Assay Description
Inhibitory activity tested in vitro at 5-hydroxytryptamine 1A receptor binding site in rat


J Med Chem 31: 1130-40 (1988)


Article DOI: 10.1021/jm00401a012
BindingDB Entry DOI: 10.7270/Q23J3DJB
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM85091
PNG
((+/-)-2-DIPROPYLAMINO- 6,7-DIHYDROXY-1,2,3,4-TETRA...)
Show SMILES CCCN(CCC)C1CCc2cc(O)c(O)cc2C1
Show InChI InChI=1S/C16H25NO2/c1-3-7-17(8-4-2)14-6-5-12-10-15(18)16(19)11-13(12)9-14/h10-11,14,18-19H,3-9H2,1-2H3
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n/an/a 87n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic receptors in rat isolated brain membranes


J Med Chem 27: 495-503 (1984)


Article DOI: 10.1021/jm00370a011
BindingDB Entry DOI: 10.7270/Q24B31WH
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM85091
PNG
((+/-)-2-DIPROPYLAMINO- 6,7-DIHYDROXY-1,2,3,4-TETRA...)
Show SMILES CCCN(CCC)C1CCc2cc(O)c(O)cc2C1
Show InChI InChI=1S/C16H25NO2/c1-3-7-17(8-4-2)14-6-5-12-10-15(18)16(19)11-13(12)9-14/h10-11,14,18-19H,3-9H2,1-2H3
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n/an/a 2.40E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit the specific [3H]prazosin binding (0.4 nM) to rat isolated brain membr...


J Med Chem 27: 495-503 (1984)


Article DOI: 10.1021/jm00370a011
BindingDB Entry DOI: 10.7270/Q24B31WH
More data for this
Ligand-Target Pair
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