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22 similar compounds to monomer 9385

Compile data set for download or QSAR
Wt: 336.4
BDBM9386
Wt: 336.4
BDBM9387
Wt: 336.4
BDBM9388
Wt: 350.4
BDBM9393
Wt: 364.4
BDBM9396
Wt: 336.4
BDBM9405
Wt: 350.4
BDBM9406
Wt: 412.5
BDBM9407
Wt: 350.4
BDBM9412
Wt: 350.4
BDBM9413
Wt: 350.4
BDBM9414
Wt: 350.4
BDBM9420
Wt: 300.4
BDBM9422
Wt: 342.5
BDBM9423
Wt: 394.5
BDBM9424
Displayed 1 to 15 (of 22 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 9386,9387,9388,9393,9396,9405,9406,9407,9412,9413,9414,9420,9422,9423,9424   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9386
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-methylbenzam...)
Show SMILES Cc1ccccc1C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H28N2O/c1-18-7-5-6-10-21(18)22(25)23-14-11-19-12-15-24(16-13-19)17-20-8-3-2-4-9-20/h2-10,19H,11-17H2,1H3,(H,23,25)
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n/an/a 1.00E+3n/an/an/an/a7.425



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9387
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-3-methylbenzam...)
Show SMILES Cc1cccc(c1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H28N2O/c1-18-6-5-9-21(16-18)22(25)23-13-10-19-11-14-24(15-12-19)17-20-7-3-2-4-8-20/h2-9,16,19H,10-15,17H2,1H3,(H,23,25)
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n/an/a 470n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9388
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-methylbenzam...)
Show SMILES Cc1ccc(cc1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H28N2O/c1-18-7-9-21(10-8-18)22(25)23-14-11-19-12-15-24(16-13-19)17-20-5-3-2-4-6-20/h2-10,19H,11-17H2,1H3,(H,23,25)
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n/an/a 180n/an/an/an/a7.425



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9393
PNG
(CHEMBL56586 | N-[2-(1-benzylpiperidin-4-yl)ethyl]-...)
Show SMILES O=Cc1ccc(cc1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H26N2O2/c25-17-20-6-8-21(9-7-20)22(26)23-13-10-18-11-14-24(15-12-18)16-19-4-2-1-3-5-19/h1-9,17-18H,10-16H2,(H,23,26)
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n/an/a 120n/an/an/an/a7.425



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9396
PNG
(CHEMBL56001 | N-[2-(1-benzylpiperidin-4-yl)ethyl]-...)
Show SMILES CC(=O)c1ccc(cc1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H28N2O2/c1-18(26)21-7-9-22(10-8-21)23(27)24-14-11-19-12-15-25(16-13-19)17-20-5-3-2-4-6-20/h2-10,19H,11-17H2,1H3,(H,24,27)
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n/an/a 51n/an/an/an/a7.425



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9405
PNG
(CHEMBL56470 | N-[2-(1-Benzyl-piperidin-4-yl)-ethyl...)
Show SMILES CN(CCC1CCN(Cc2ccccc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C22H28N2O/c1-23(22(25)21-10-6-3-7-11-21)15-12-19-13-16-24(17-14-19)18-20-8-4-2-5-9-20/h2-11,19H,12-18H2,1H3
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n/an/a 170n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9406
PNG
(CHEMBL57696 | N-[2-(1-benzylpiperidin-4-yl)ethyl]-...)
Show SMILES CCN(CCC1CCN(Cc2ccccc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-2-25(23(26)22-11-7-4-8-12-22)18-15-20-13-16-24(17-14-20)19-21-9-5-3-6-10-21/h3-12,20H,2,13-19H2,1H3
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n/an/a 130n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9407
PNG
(1-Benzyl-4-[2-(N-benzoyl-N-benzylamino)ethyl]-pipe...)
Show SMILES O=C(N(CCC1CCN(Cc2ccccc2)CC1)Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H32N2O/c31-28(27-14-8-3-9-15-27)30(23-26-12-6-2-7-13-26)21-18-24-16-19-29(20-17-24)22-25-10-4-1-5-11-25/h1-15,24H,16-23H2
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n/an/a 940n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9412
PNG
(CHEMBL126304 | N-methyl-N-(2-{1-[(2-methylphenyl)m...)
Show SMILES CN(CCC1CCN(Cc2ccccc2C)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-19-8-6-7-11-22(19)18-25-16-13-20(14-17-25)12-15-24(2)23(26)21-9-4-3-5-10-21/h3-11,20H,12-18H2,1-2H3
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n/an/a 770n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9413
PNG
(CHEMBL127750 | N-methyl-N-(2-{1-[(3-methylphenyl)m...)
Show SMILES CN(CCC1CCN(Cc2cccc(C)c2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-19-7-6-8-21(17-19)18-25-15-12-20(13-16-25)11-14-24(2)23(26)22-9-4-3-5-10-22/h3-10,17,20H,11-16,18H2,1-2H3
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n/an/a 145n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9414
PNG
(CHEMBL127097 | N-methyl-N-(2-{1-[(4-methylphenyl)m...)
Show SMILES CN(CCC1CCN(Cc2ccc(C)cc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-19-8-10-21(11-9-19)18-25-16-13-20(14-17-25)12-15-24(2)23(26)22-6-4-3-5-7-22/h3-11,20H,12-18H2,1-2H3
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n/an/a 4.10E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9420
PNG
(N-[2-(1-benzoylpiperidin-4-yl)ethyl]-N-methylbenza...)
Show SMILES CN(CCC1CCN(CC1)C(=O)c1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C22H26N2O2/c1-23(21(25)19-8-4-2-5-9-19)15-12-18-13-16-24(17-14-18)22(26)20-10-6-3-7-11-20/h2-11,18H,12-17H2,1H3
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n/an/a 5.20E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9422
PNG
(CHEMBL126457 | N-{2-[1-(cyclopropylmethyl)piperidi...)
Show SMILES CN(CCC1CCN(CC2CC2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C19H28N2O/c1-20(19(22)18-5-3-2-4-6-18)12-9-16-10-13-21(14-11-16)15-17-7-8-17/h2-6,16-17H,7-15H2,1H3
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n/an/a 3.80E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9423
PNG
(CHEMBL419782 | N-{2-[1-(cyclohexylmethyl)piperidin...)
Show SMILES CN(CCC1CCN(CC2CCCCC2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C22H34N2O/c1-23(22(25)21-10-6-3-7-11-21)15-12-19-13-16-24(17-14-19)18-20-8-4-2-5-9-20/h3,6-7,10-11,19-20H,2,4-5,8-9,12-18H2,1H3
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n/an/a 410n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9424
PNG
(N-{2-[1-(adamantan-1-ylmethyl)piperidin-4-yl]ethyl...)
Show SMILES CN(CCC1CCN(CC23CC4CC(CC(C4)C2)C3)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C26H38N2O/c1-27(25(29)24-5-3-2-4-6-24)10-7-20-8-11-28(12-9-20)19-26-16-21-13-22(17-26)15-23(14-21)18-26/h2-6,20-23H,7-19H2,1H3
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n/an/a 2.40E+4n/an/an/an/an/an/a



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9405
PNG
(CHEMBL56470 | N-[2-(1-Benzyl-piperidin-4-yl)-ethyl...)
Show SMILES CN(CCC1CCN(Cc2ccccc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C22H28N2O/c1-23(22(25)21-10-6-3-7-11-21)15-12-19-13-16-24(17-14-19)18-20-8-4-2-5-9-20/h2-11,19H,12-18H2,1H3
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n/an/a 170n/an/an/an/an/an/a



Eisai Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.


J Med Chem 35: 4542-8 (1993)


Article DOI: 10.1021/jm00102a005
BindingDB Entry DOI: 10.7270/Q25M64P8
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Homo sapiens (Human))
BDBM9405
PNG
(CHEMBL56470 | N-[2-(1-Benzyl-piperidin-4-yl)-ethyl...)
Show SMILES CN(CCC1CCN(Cc2ccccc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C22H28N2O/c1-23(22(25)21-10-6-3-7-11-21)15-12-19-13-16-24(17-14-19)18-20-8-4-2-5-9-20/h2-11,19H,12-18H2,1H3
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n/an/a 170n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of AChE


Eur J Med Chem 45: 1167-72 (2010)


Article DOI: 10.1016/j.ejmech.2009.12.038
BindingDB Entry DOI: 10.7270/Q25H7GFM
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9405
PNG
(CHEMBL56470 | N-[2-(1-Benzyl-piperidin-4-yl)-ethyl...)
Show SMILES CN(CCC1CCN(Cc2ccccc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C22H28N2O/c1-23(22(25)21-10-6-3-7-11-21)15-12-19-13-16-24(17-14-19)18-20-8-4-2-5-9-20/h2-11,19H,12-18H2,1H3
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n/an/a 170n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acetylcholinesterase


J Med Chem 38: 4821-9 (1996)


Article DOI: 10.1021/jm00024a009
BindingDB Entry DOI: 10.7270/Q2QC045T
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9388
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-methylbenzam...)
Show SMILES Cc1ccc(cc1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H28N2O/c1-18-7-9-21(10-8-18)22(25)23-14-11-19-12-15-24(16-13-19)17-20-5-3-2-4-6-20/h2-10,19H,11-17H2,1H3,(H,23,25)
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n/an/a 180n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9422
PNG
(CHEMBL126457 | N-{2-[1-(cyclopropylmethyl)piperidi...)
Show SMILES CN(CCC1CCN(CC2CC2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C19H28N2O/c1-20(19(22)18-5-3-2-4-6-18)12-9-16-10-13-21(14-11-16)15-17-7-8-17/h2-6,16-17H,7-15H2,1H3
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n/an/a 3.80E+4n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9407
PNG
(1-Benzyl-4-[2-(N-benzoyl-N-benzylamino)ethyl]-pipe...)
Show SMILES O=C(N(CCC1CCN(Cc2ccccc2)CC1)Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H32N2O/c31-28(27-14-8-3-9-15-27)30(23-26-12-6-2-7-13-26)21-18-24-16-19-29(20-17-24)22-25-10-4-1-5-11-25/h1-15,24H,16-23H2
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n/an/a 940n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9413
PNG
(CHEMBL127750 | N-methyl-N-(2-{1-[(3-methylphenyl)m...)
Show SMILES CN(CCC1CCN(Cc2cccc(C)c2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-19-7-6-8-21(17-19)18-25-15-12-20(13-16-25)11-14-24(2)23(26)22-9-4-3-5-10-22/h3-10,17,20H,11-16,18H2,1-2H3
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n/an/a 145n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9423
PNG
(CHEMBL419782 | N-{2-[1-(cyclohexylmethyl)piperidin...)
Show SMILES CN(CCC1CCN(CC2CCCCC2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C22H34N2O/c1-23(22(25)21-10-6-3-7-11-21)15-12-19-13-16-24(17-14-19)18-20-8-4-2-5-9-20/h3,6-7,10-11,19-20H,2,4-5,8-9,12-18H2,1H3
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n/an/a 410n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9414
PNG
(CHEMBL127097 | N-methyl-N-(2-{1-[(4-methylphenyl)m...)
Show SMILES CN(CCC1CCN(Cc2ccc(C)cc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-19-8-10-21(11-9-19)18-25-16-13-20(14-17-25)12-15-24(2)23(26)22-6-4-3-5-7-22/h3-11,20H,12-18H2,1-2H3
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n/an/a 4.10E+4n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9396
PNG
(CHEMBL56001 | N-[2-(1-benzylpiperidin-4-yl)ethyl]-...)
Show SMILES CC(=O)c1ccc(cc1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H28N2O2/c1-18(26)21-7-9-22(10-8-21)23(27)24-14-11-19-12-15-25(16-13-19)17-20-5-3-2-4-6-20/h2-10,19H,11-17H2,1H3,(H,24,27)
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n/an/a 51.0n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9386
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-methylbenzam...)
Show SMILES Cc1ccccc1C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H28N2O/c1-18-7-5-6-10-21(18)22(25)23-14-11-19-12-15-24(16-13-19)17-20-8-3-2-4-9-20/h2-10,19H,11-17H2,1H3,(H,23,25)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9393
PNG
(CHEMBL56586 | N-[2-(1-benzylpiperidin-4-yl)ethyl]-...)
Show SMILES O=Cc1ccc(cc1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H26N2O2/c25-17-20-6-8-21(9-7-20)22(26)23-13-10-18-11-14-24(15-12-18)16-19-4-2-1-3-5-19/h1-9,17-18H,10-16H2,(H,23,26)
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n/an/a 120n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9406
PNG
(CHEMBL57696 | N-[2-(1-benzylpiperidin-4-yl)ethyl]-...)
Show SMILES CCN(CCC1CCN(Cc2ccccc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-2-25(23(26)22-11-7-4-8-12-22)18-15-20-13-16-24(17-14-20)19-21-9-5-3-6-10-21/h3-12,20H,2,13-19H2,1H3
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n/an/a 130n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9412
PNG
(CHEMBL126304 | N-methyl-N-(2-{1-[(2-methylphenyl)m...)
Show SMILES CN(CCC1CCN(Cc2ccccc2C)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-19-8-6-7-11-22(19)18-25-16-13-20(14-17-25)12-15-24(2)23(26)21-9-4-3-5-10-21/h3-11,20H,12-18H2,1-2H3
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n/an/a 769n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9420
PNG
(N-[2-(1-benzoylpiperidin-4-yl)ethyl]-N-methylbenza...)
Show SMILES CN(CCC1CCN(CC1)C(=O)c1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C22H26N2O2/c1-23(21(25)19-8-4-2-5-9-19)15-12-18-13-16-24(17-14-18)22(26)20-10-6-3-7-11-20/h2-11,18H,12-17H2,1H3
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n/an/a 5.20E+4n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9405
PNG
(CHEMBL56470 | N-[2-(1-Benzyl-piperidin-4-yl)-ethyl...)
Show SMILES CN(CCC1CCN(Cc2ccccc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C22H28N2O/c1-23(22(25)21-10-6-3-7-11-21)15-12-19-13-16-24(17-14-19)18-20-8-4-2-5-9-20/h2-11,19H,12-18H2,1H3
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n/an/a 170n/an/an/an/an/an/a



University of Missouri-St. Louis

Curated by ChEMBL


Assay Description
Inhibition against Acetylcholinesterase (AChE)


J Med Chem 39: 380-7 (1996)


Article DOI: 10.1021/jm950704x
BindingDB Entry DOI: 10.7270/Q25D8T1Q
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Mus musculus (mouse))
BDBM9387
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-3-methylbenzam...)
Show SMILES Cc1cccc(c1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H28N2O/c1-18-6-5-9-21(16-18)22(25)23-13-10-19-11-14-24(15-12-19)17-20-7-3-2-4-8-20/h2-9,16,19H,10-15,17H2,1H3,(H,23,25)
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n/an/a 470n/an/an/an/a7.425



Tsukuba Research Laboratories



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The amount of a yellow substance formed after incubation was d...


J Med Chem 33: 1880-7 (1990)


Article DOI: 10.1021/jm00169a008
BindingDB Entry DOI: 10.7270/Q20Z71H2
More data for this
Ligand-Target Pair