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13 similar compounds to monomer 50321373

Compile data set for download or QSAR
Wt: 414.4
BDBM97735
Wt: 446.5
BDBM97732
Wt: 418.4
BDBM97731
Wt: 390.4
BDBM97726
Wt: 390.4
BDBM50321366
Wt: 418.4
BDBM50321367
Wt: 446.5
BDBM50321368
Wt: 432.5
BDBM50321369
Wt: 442.5
BDBM50321372
Wt: 523.6
BDBM50321374
Wt: 502.6
BDBM50443156
Wt: 432.5
BDBM97733
Wt: 470.5
BDBM97739

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 97735,97732,97731,97726,50321366,50321367,50321368,50321369,50321372,50321374,50443156,97733,97739   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 (CSF-1)


(Mus musculus (Mouse))
BDBM97726
PNG
(US8481564, 4)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CNC(=O)NC1)c1nc(c[nH]1)C#N
Show InChI InChI=1S/C21H22N6O2/c22-9-16-12-23-19(26-16)20(28)27-18-7-6-14(15-10-24-21(29)25-11-15)8-17(18)13-4-2-1-3-5-13/h4,6-8,12,15H,1-3,5,10-11H2,(H,23,26)(H,27,28)(H2,24,25,29)
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n/an/a 3n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8481564 (2013)


BindingDB Entry DOI: 10.7270/Q2QV3K4Q
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321374
PNG
(4-cyano-N-(4-(1,3-dimethyl-2-(methylsulfonylimino)...)
Show SMILES CN1CC(CN(C)C1=NS(C)(=O)=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H33N7O3S/c1-26(2)10-8-17(9-11-26)21-12-18(19-15-32(3)25(33(4)16-19)31-37(5,35)36)6-7-22(21)30-24(34)23-28-14-20(13-27)29-23/h6-8,12,14,19H,9-11,15-16H2,1-5H3,(H,28,29)(H,30,34)/b31-25-
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n/an/a 1.90n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 (CSF-1)


(Mus musculus (Mouse))
BDBM97732
PNG
(US8481564, 8)
Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H30N6O2/c1-25(2)9-7-16(8-10-25)20-11-17(18-14-30(3)24(33)31(4)15-18)5-6-21(20)29-23(32)22-27-13-19(12-26)28-22/h5-7,11,13,18H,8-10,14-15H2,1-4H3,(H,27,28)(H,29,32)
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n/an/a 0.400n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8481564 (2013)


BindingDB Entry DOI: 10.7270/Q2QV3K4Q
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 (CSF-1)


(Mus musculus (Mouse))
BDBM97733
PNG
(US8481564, 9)
Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCCC1
Show InChI InChI=1S/C24H28N6O2/c1-29-14-18(15-30(2)24(29)32)17-9-10-21(20(11-17)16-7-5-3-4-6-8-16)28-23(31)22-26-13-19(12-25)27-22/h7,9-11,13,18H,3-6,8,14-15H2,1-2H3,(H,26,27)(H,28,31)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8481564 (2013)


BindingDB Entry DOI: 10.7270/Q2QV3K4Q
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 (CSF-1)


(Mus musculus (Mouse))
BDBM97735
PNG
(US8481564, 12)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CNC(NC1)=NC#N)c1nc(c[nH]1)C#N
Show InChI InChI=1S/C22H22N8O/c23-9-17-12-25-20(29-17)21(31)30-19-7-6-15(8-18(19)14-4-2-1-3-5-14)16-10-26-22(27-11-16)28-13-24/h4,6-8,12,16H,1-3,5,10-11H2,(H,25,29)(H,30,31)(H2,26,27,28)
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n/an/a 3n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8481564 (2013)


BindingDB Entry DOI: 10.7270/Q2QV3K4Q
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 (CSF-1)


(Mus musculus (Mouse))
BDBM97739
PNG
(US8481564, 54)
Show SMILES CN1CC(CN(C)C1=NC#N)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H30N8O/c1-26(2)9-7-17(8-10-26)21-11-18(19-14-33(3)25(30-16-28)34(4)15-19)5-6-22(21)32-24(35)23-29-13-20(12-27)31-23/h5-7,11,13,19H,8-10,14-15H2,1-4H3,(H,29,31)(H,32,35)/b30-25-
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n/an/a 0.420n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8481564 (2013)


BindingDB Entry DOI: 10.7270/Q2QV3K4Q
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443156
PNG
(CHEMBL3085971 | US8674100, 143)
Show SMILES CC(=O)N1CCN(CC(C)(C)c2ccc(NC(=O)c3ncc([nH]3)C#N)c(c2)C2=CCC(C)(C)CC2)CC1
Show InChI InChI=1S/C29H38N6O2/c1-20(36)35-14-12-34(13-15-35)19-29(4,5)22-6-7-25(33-27(37)26-31-18-23(17-30)32-26)24(16-22)21-8-10-28(2,3)11-9-21/h6-8,16,18H,9-15,19H2,1-5H3,(H,31,32)(H,33,37)
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n/an/a 5.70n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8674100 (2014)


BindingDB Entry DOI: 10.7270/Q23777CF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50443156
PNG
(CHEMBL3085971 | US8674100, 143)
Show SMILES CC(=O)N1CCN(CC(C)(C)c2ccc(NC(=O)c3ncc([nH]3)C#N)c(c2)C2=CCC(C)(C)CC2)CC1
Show InChI InChI=1S/C29H38N6O2/c1-20(36)35-14-12-34(13-15-35)19-29(4,5)22-6-7-25(33-27(37)26-31-18-23(17-30)32-26)24(16-22)21-8-10-28(2,3)11-9-21/h6-8,16,18H,9-15,19H2,1-5H3,(H,31,32)(H,33,37)
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n/an/a 5.70n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS (unknown origin)


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50443156
PNG
(CHEMBL3085971 | US8674100, 143)
Show SMILES CC(=O)N1CCN(CC(C)(C)c2ccc(NC(=O)c3ncc([nH]3)C#N)c(c2)C2=CCC(C)(C)CC2)CC1
Show InChI InChI=1S/C29H38N6O2/c1-20(36)35-14-12-34(13-15-35)19-29(4,5)22-6-7-25(33-27(37)26-31-18-23(17-30)32-26)24(16-22)21-8-10-28(2,3)11-9-21/h6-8,16,18H,9-15,19H2,1-5H3,(H,31,32)(H,33,37)
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n/an/a 29n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of FMS in mouse BMDM cells


Bioorg Med Chem Lett 23: 6363-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.061
BindingDB Entry DOI: 10.7270/Q2MP54RH
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321366
PNG
(4-cyano-N-(2-cyclohexenyl-4-(2-oxohexahydropyrimid...)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CNC(=O)NC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C21H22N6O2/c22-9-16-12-23-19(26-16)20(28)27-18-7-6-14(15-10-24-21(29)25-11-15)8-17(18)13-4-2-1-3-5-13/h4,6-8,12,15H,1-3,5,10-11H2,(H,23,26)(H,27,28)(H2,24,25,29)
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n/an/a 2.30n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321367
PNG
(4-cyano-N-(2-cyclohexenyl-4-(1,3-dimethyl-2-oxohex...)
Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H26N6O2/c1-28-13-17(14-29(2)23(28)31)16-8-9-20(19(10-16)15-6-4-3-5-7-15)27-22(30)21-25-12-18(11-24)26-21/h6,8-10,12,17H,3-5,7,13-14H2,1-2H3,(H,25,26)(H,27,30)
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n/an/a 0.5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321368
PNG
(4-cyano-N-(4-(1,3-dimethyl-2-oxohexahydropyrimidin...)
Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H30N6O2/c1-25(2)9-7-16(8-10-25)20-11-17(18-14-30(3)24(33)31(4)15-18)5-6-21(20)29-23(32)22-27-13-19(12-26)28-22/h5-7,11,13,18H,8-10,14-15H2,1-4H3,(H,27,28)(H,29,32)
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n/an/a 0.300n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321369
PNG
(4-cyano-N-(2-cycloheptenyl-4-(1,3-dimethyl-2-oxohe...)
Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCCC1
Show InChI InChI=1S/C24H28N6O2/c1-29-14-18(15-30(2)24(29)32)17-9-10-21(20(11-17)16-7-5-3-4-6-8-16)28-23(31)22-26-13-19(12-25)27-22/h7,9-11,13,18H,3-6,8,14-15H2,1-2H3,(H,26,27)(H,28,31)
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n/an/a 0.900n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50321372
PNG
(4-cyano-N-(4-(2-(cyanoimino)hexahydropyrimidin-5-y...)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CNC(NC1)=NC#N
Show InChI InChI=1S/C24H26N8O/c1-24(2)7-5-15(6-8-24)19-9-16(17-11-28-23(29-12-17)30-14-26)3-4-20(19)32-22(33)21-27-13-18(10-25)31-21/h3-5,9,13,17H,6-8,11-12H2,1-2H3,(H,27,31)(H,32,33)(H2,28,29,30)
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n/an/a 2.5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human FMS by fluorescence polarization


Bioorg Med Chem Lett 20: 3925-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.05.013
BindingDB Entry DOI: 10.7270/Q22Z16HG
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 (CSF-1)


(Mus musculus (Mouse))
BDBM97731
PNG
(US8481564, 7)
Show SMILES CN1CC(CN(C)C1=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H26N6O2/c1-28-13-17(14-29(2)23(28)31)16-8-9-20(19(10-16)15-6-4-3-5-7-15)27-22(30)21-25-12-18(11-24)26-21/h6,8-10,12,17H,3-5,7,13-14H2,1-2H3,(H,25,26)(H,27,30)
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Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8481564 (2013)


BindingDB Entry DOI: 10.7270/Q2QV3K4Q
More data for this
Ligand-Target Pair