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38 similar compounds to monomer 50321365

Compile data set for download or QSAR
Wt: 403.4
BDBM97727
Wt: 417.4
BDBM97737
Wt: 431.4
BDBM97728
Wt: 332.3
BDBM119065
Wt: 417.5
BDBM120076
Wt: 403.4
BDBM50321363
Wt: 431.4
BDBM50321364
Wt: 460.5
BDBM50355499
Wt: 361.4
BDBM50377057
Wt: 375.4
BDBM50377058
Wt: 389.4
BDBM50377071
Wt: 428.5
BDBM50393537
Wt: 466.5
BDBM50393538
Wt: 419.5
BDBM50393539
Wt: 449.5
BDBM50393540
Displayed 1 to 15 (of 38 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 506 hits for monomerid = 97727,97737,97728,119065,120076,50321363,50321364,50355499,50377057,50377058,50377071,50393537,50393538,50393539,50393540   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 88n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of LCK


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FLT3 in human MV411 cells assessed as inhibition of cell proliferation after 72 hrs by CellTiter-Glo assay


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50377058
PNG
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCNCC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H25N5O/c23-13-18-14-25-21(26-18)22(28)27-20-7-6-17(15-8-10-24-11-9-15)12-19(20)16-4-2-1-3-5-16/h4,6-7,12,14-15,24H,1-3,5,8-11H2,(H,25,26)(H,27,28)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50393537
PNG
(CHEMBL2158223)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCN(CCC#N)CC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C25H28N6O/c26-11-4-12-31-13-9-18(10-14-31)20-7-8-23(22(15-20)19-5-2-1-3-6-19)30-25(32)24-28-17-21(16-27)29-24/h5,7-8,15,17-18H,1-4,6,9-10,12-14H2,(H,28,29)(H,30,32)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50393538
PNG
(CHEMBL2158224)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCN(Cc2ccccn2)CC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C28H30N6O/c29-17-24-18-31-27(32-24)28(35)33-26-10-9-22(16-25(26)21-6-2-1-3-7-21)20-11-14-34(15-12-20)19-23-8-4-5-13-30-23/h4-6,8-10,13,16,18,20H,1-3,7,11-12,14-15,19H2,(H,31,32)(H,33,35)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50393539
PNG
(CHEMBL2158225 | US8697716, 26)
Show SMILES OCCN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H29N5O2/c25-15-20-16-26-23(27-20)24(31)28-22-7-6-19(14-21(22)18-4-2-1-3-5-18)17-8-10-29(11-9-17)12-13-30/h4,6-7,14,16-17,30H,1-3,5,8-13H2,(H,26,27)(H,28,31)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50393540
PNG
(CHEMBL2158226)
Show SMILES OCC(CO)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C25H31N5O3/c26-13-20-14-27-24(28-20)25(33)29-23-7-6-19(12-22(23)18-4-2-1-3-5-18)17-8-10-30(11-9-17)21(15-31)16-32/h4,6-7,12,14,17,21,31-32H,1-3,5,8-11,15-16H2,(H,27,28)(H,29,33)
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n/an/a 1.60n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 0.690n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarization


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50377058
PNG
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCNCC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H25N5O/c23-13-18-14-25-21(26-18)22(28)27-20-7-6-17(15-8-10-24-11-9-15)12-19(20)16-4-2-1-3-5-16/h4,6-7,12,14-15,24H,1-3,5,8-11H2,(H,25,26)(H,27,28)
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n/an/a 7.20n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50393537
PNG
(CHEMBL2158223)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCN(CCC#N)CC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C25H28N6O/c26-11-4-12-31-13-9-18(10-14-31)20-7-8-23(22(15-20)19-5-2-1-3-6-19)30-25(32)24-28-17-21(16-27)29-24/h5,7-8,15,17-18H,1-4,6,9-10,12-14H2,(H,28,29)(H,30,32)
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n/an/a 11n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50393538
PNG
(CHEMBL2158224)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCN(Cc2ccccn2)CC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C28H30N6O/c29-17-24-18-31-27(32-24)28(35)33-26-10-9-22(16-25(26)21-6-2-1-3-7-21)20-11-14-34(15-12-20)19-23-8-4-5-13-30-23/h4-6,8-10,13,16,18,20H,1-3,7,11-12,14-15,19H2,(H,31,32)(H,33,35)
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n/an/a 4.90n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50393539
PNG
(CHEMBL2158225 | US8697716, 26)
Show SMILES OCCN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H29N5O2/c25-15-20-16-26-23(27-20)24(31)28-22-7-6-19(14-21(22)18-4-2-1-3-5-18)17-8-10-29(11-9-17)12-13-30/h4,6-7,14,16-17,30H,1-3,5,8-13H2,(H,26,27)(H,28,31)
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n/an/a 4.70n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50393540
PNG
(CHEMBL2158226)
Show SMILES OCC(CO)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C25H31N5O3/c26-13-20-14-27-24(28-20)25(33)29-23-7-6-19(12-22(23)18-4-2-1-3-5-18)17-8-10-30(11-9-17)21(15-31)16-32/h4,6-7,12,14,17,21,31-32H,1-3,5,8-11,15-16H2,(H,27,28)(H,29,33)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (c-Fms)


(Mus musculus (Mouse))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS-mediated proliferation in CSF1-stimulated bone marrow-derived mouse macrophages assessed as inhibition of incorporation of bromodeo...


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM50377058
PNG
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCNCC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H25N5O/c23-13-18-14-25-21(26-18)22(28)27-20-7-6-17(15-8-10-24-11-9-15)12-19(20)16-4-2-1-3-5-16/h4,6-7,12,14-15,24H,1-3,5,8-11H2,(H,25,26)(H,27,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM50393538
PNG
(CHEMBL2158224)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCN(Cc2ccccn2)CC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C28H30N6O/c29-17-24-18-31-27(32-24)28(35)33-26-10-9-22(16-25(26)21-6-2-1-3-7-21)20-11-14-34(15-12-20)19-23-8-4-5-13-30-23/h4-6,8-10,13,16,18,20H,1-3,7,11-12,14-15,19H2,(H,31,32)(H,33,35)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50377058
PNG
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCNCC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H25N5O/c23-13-18-14-25-21(26-18)22(28)27-20-7-6-17(15-8-10-24-11-9-15)12-19(20)16-4-2-1-3-5-16/h4,6-7,12,14-15,24H,1-3,5,8-11H2,(H,25,26)(H,27,28)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50393537
PNG
(CHEMBL2158223)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCN(CCC#N)CC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C25H28N6O/c26-11-4-12-31-13-9-18(10-14-31)20-7-8-23(22(15-20)19-5-2-1-3-6-19)30-25(32)24-28-17-21(16-27)29-24/h5,7-8,15,17-18H,1-4,6,9-10,12-14H2,(H,28,29)(H,30,32)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50393538
PNG
(CHEMBL2158224)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCN(Cc2ccccn2)CC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C28H30N6O/c29-17-24-18-31-27(32-24)28(35)33-26-10-9-22(16-25(26)21-6-2-1-3-7-21)20-11-14-34(15-12-20)19-23-8-4-5-13-30-23/h4-6,8-10,13,16,18,20H,1-3,7,11-12,14-15,19H2,(H,31,32)(H,33,35)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50393539
PNG
(CHEMBL2158225 | US8697716, 26)
Show SMILES OCCN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H29N5O2/c25-15-20-16-26-23(27-20)24(31)28-22-7-6-19(14-21(22)18-4-2-1-3-5-18)17-8-10-29(11-9-17)12-13-30/h4,6-7,14,16-17,30H,1-3,5,8-13H2,(H,26,27)(H,28,31)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (Human))
BDBM50377058
PNG
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCNCC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H25N5O/c23-13-18-14-25-21(26-18)22(28)27-20-7-6-17(15-8-10-24-11-9-15)12-19(20)16-4-2-1-3-5-16/h4,6-7,12,14-15,24H,1-3,5,8-11H2,(H,25,26)(H,27,28)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (Human))
BDBM50393537
PNG
(CHEMBL2158223)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCN(CCC#N)CC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C25H28N6O/c26-11-4-12-31-13-9-18(10-14-31)20-7-8-23(22(15-20)19-5-2-1-3-6-19)30-25(32)24-28-17-21(16-27)29-24/h5,7-8,15,17-18H,1-4,6,9-10,12-14H2,(H,28,29)(H,30,32)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (Human))
BDBM50393538
PNG
(CHEMBL2158224)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCN(Cc2ccccn2)CC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C28H30N6O/c29-17-24-18-31-27(32-24)28(35)33-26-10-9-22(16-25(26)21-6-2-1-3-7-21)20-11-14-34(15-12-20)19-23-8-4-5-13-30-23/h4-6,8-10,13,16,18,20H,1-3,7,11-12,14-15,19H2,(H,31,32)(H,33,35)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (Human))
BDBM50393539
PNG
(CHEMBL2158225 | US8697716, 26)
Show SMILES OCCN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H29N5O2/c25-15-20-16-26-23(27-20)24(31)28-22-7-6-19(14-21(22)18-4-2-1-3-5-18)17-8-10-29(11-9-17)12-13-30/h4,6-7,14,16-17,30H,1-3,5,8-13H2,(H,26,27)(H,28,31)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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n/an/a 9.20E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50377058
PNG
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCNCC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H25N5O/c23-13-18-14-25-21(26-18)22(28)27-20-7-6-17(15-8-10-24-11-9-15)12-19(20)16-4-2-1-3-5-16/h4,6-7,12,14-15,24H,1-3,5,8-11H2,(H,25,26)(H,27,28)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50393538
PNG
(CHEMBL2158224)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCN(Cc2ccccn2)CC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C28H30N6O/c29-17-24-18-31-27(32-24)28(35)33-26-10-9-22(16-25(26)21-6-2-1-3-7-21)20-11-14-34(15-12-20)19-23-8-4-5-13-30-23/h4-6,8-10,13,16,18,20H,1-3,7,11-12,14-15,19H2,(H,31,32)(H,33,35)
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n/an/a 5.60E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50393539
PNG
(CHEMBL2158225 | US8697716, 26)
Show SMILES OCCN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H29N5O2/c25-15-20-16-26-23(27-20)24(31)28-22-7-6-19(14-21(22)18-4-2-1-3-5-18)17-8-10-29(11-9-17)12-13-30/h4,6-7,14,16-17,30H,1-3,5,8-13H2,(H,26,27)(H,28,31)
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Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 41n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of KIT in human Mo7e cells assessed as inhibition of SCF-induced cell proliferation after 72 hrs by CellTiter-Glo assay


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 150n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of TRKA in human TF1 cells assessed as inhibition of NGF-induced cell proliferation after 72 hrs by CellTiter-Glo assay


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 3.90E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of LCK in human Jurkat cells assessed as inhibition of PMA and antiCD3-induced IL2 secretion after 24 hrs by ELISA


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of AXL overexpressed in human HEK cells assessed as inhibition of GAS6-induced autophosphorylation by immunoblot assay


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50377058
PNG
(CHEMBL2158221 | CHEMBL257154 | US8697716, 14)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCNCC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H25N5O/c23-13-18-14-25-21(26-18)22(28)27-20-7-6-17(15-8-10-24-11-9-15)12-19(20)16-4-2-1-3-5-16/h4,6-7,12,14-15,24H,1-3,5,8-11H2,(H,25,26)(H,27,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG potassium channel


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50393538
PNG
(CHEMBL2158224)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCN(Cc2ccccn2)CC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C28H30N6O/c29-17-24-18-31-27(32-24)28(35)33-26-10-9-22(16-25(26)21-6-2-1-3-7-21)20-11-14-34(15-12-20)19-23-8-4-5-13-30-23/h4-6,8-10,13,16,18,20H,1-3,7,11-12,14-15,19H2,(H,31,32)(H,33,35)
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n/an/a 7.70E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG potassium channel


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50393539
PNG
(CHEMBL2158225 | US8697716, 26)
Show SMILES OCCN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H29N5O2/c25-15-20-16-26-23(27-20)24(31)28-22-7-6-19(14-21(22)18-4-2-1-3-5-18)17-8-10-29(11-9-17)12-13-30/h4,6-7,14,16-17,30H,1-3,5,8-13H2,(H,26,27)(H,28,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG potassium channel


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM120076
PNG
(CHEMBL256712 | US8697716, 16)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-11-9-17(10-12-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(31)23-26-15-20(14-25)27-23/h5,7-8,13,15,17H,2-4,6,9-12H2,1H3,(H,26,27)(H,28,31)
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n/an/a>3.20E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG potassium channel


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG potassium channel


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 0.690n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of FMS


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of KIT


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 12n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of AXL


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 15n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of TRKA


J Med Chem 54: 7860-83 (2011)


Article DOI: 10.1021/jm200900q
BindingDB Entry DOI: 10.7270/Q2VD70JB
More data for this
Ligand-Target Pair
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