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Found 235 Enz. Inhib. hit(s) with Target = '5-lipoxygenase'
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)
Affinity DataIC50:  180nMAssay Description:Inhibition of 5-lipoxygenase in bovine PMNL cell assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50038646(2-(6-(4-tert-butylphenyl)-2,2-dimethyl-7-phenyl-2,...)
Affinity DataIC50:  180nMAssay Description:Inhibition of 5-lipoxygenase in bovine PMNL cell assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50038647(CHEMBL56161 | [2-(4-Methoxy-phenyl)-6,6-dimethyl-1...)
Affinity DataIC50:  240nMAssay Description:Inhibition of 5-lipoxygenase in bovine PMNL cell assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50043360(1,8-Dihydroxy-10-(4-phenyl-butyryl)-10H-anthracen-...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50043362(1,8-Dihydroxy-10-[2-(3,4,5-trihydroxy-phenyl)-acet...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50043353(1,8-Dihydroxy-10-(3,4,5-trihydroxy-benzylidene)-10...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).More data for this Ligand-Target Pair
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50059631(6-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Affinity DataIC50:  400nMAssay Description:5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50004677(Acetic acid 4-acetoxy-6-chloro-2,3-dimethoxy-napht...)
Affinity DataIC50:  500nMAssay Description:Inhibition of 5-lipoxygenase in bovine polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50043352(10-(3,4-Dihydroxy-benzylidene)-1,8-dihydroxy-10H-a...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50004677(Acetic acid 4-acetoxy-6-chloro-2,3-dimethoxy-napht...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50043357(1,8-Dihydroxy-10-(3-phenyl-propionyl)-10H-anthrace...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50059608(5-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Affinity DataIC50:  500nMAssay Description:5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50043371(1,8-Dihydroxy-10-[2-(4-methoxy-phenyl)-acetyl]-10H...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50387594(CHEMBL2057741)
Affinity DataIC50:  510nMAssay Description:Inhibition of bovine 5-LOX assessed as inhibition of calcium ionophore A23187-induced leukotrine B4 formation by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50059616(3-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Affinity DataIC50:  600nMAssay Description:5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50059604(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Affinity DataIC50:  600nMAssay Description:5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50043355(10-[2-(4-Benzyloxy-phenyl)-acetyl]-1,8-dihydroxy-1...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50041799(1,8-Dihydroxy-2-[3-(3,4,5-trihydroxy-phenyl)-propy...)
Affinity DataIC50:  600nMAssay Description:Inhibition of 5-lipoxygenase in bovine polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50059599(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Affinity DataIC50:  700nMAssay Description:5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)
Affinity DataIC50:  760nMAssay Description:Inhibition of bovine 5-LOX assessed as inhibition of calcium ionophore A23187-induced leukotrine B4 formation by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50041780(2-(2,5-Dihydroxy-benzyl)-1,8-dihydroxy-10H-anthrac...)
Affinity DataIC50:  900nMAssay Description:Inhibition of 5-lipoxygenase in bovine polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50387596(CHEMBL2057740)
Affinity DataIC50:  970nMAssay Description:Inhibition of bovine 5-LOX assessed as inhibition of calcium ionophore A23187-induced leukotrine B4 formation by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataIC50:  1.00E+3nMAssay Description:Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomesMore data for this Ligand-Target Pair
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50043368(1,8-Dihydroxy-10-[3-(4-methoxy-phenyl)-propionyl]-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50041782(3-(2,5-Dihydroxy-benzyl)-1,8-dihydroxy-10H-anthrac...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of 5-lipoxygenase in bovine polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50059627(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Affinity DataIC50:  1.00E+3nMAssay Description:5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50043373(10-[2-(3,4-Dihydroxy-phenyl)-acetyl]-1,8-dihydroxy...)
Affinity DataIC50:  1.00E+3nMAssay Description:Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50059634(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Affinity DataIC50:  1.00E+3nMAssay Description:5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50043363(1,8-Dihydroxy-10-[3-(4-hydroxy-phenyl)-propionyl]-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50038653(2-(2,2-dimethyl-6-(4-nitrophenyl)-7-phenyl-2,3-dih...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of 5-lipoxygenase in bovine PMNL cell assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50038645(CHEMBL55414 | [6,6-Dimethyl-2-(4-phenoxy-phenyl)-1...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of 5-lipoxygenase in bovine PMNL cell assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50038654(2-(6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrr...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of 5-lipoxygenase in bovine PMNL cell assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50038657(CHEMBL301693 | [2-(3-Chloro-phenyl)-6,6-dimethyl-1...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of 5-lipoxygenase in bovine PMNL cell assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50038655(CHEMBL54485 | [2-(3,4-Dichloro-phenyl)-6,6-dimethy...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of 5-lipoxygenase in bovine PMNL cell assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50038656(CHEMBL54486 | [6,6-Dimethyl-1-phenyl-2-(2,3,4-tric...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of 5-lipoxygenase in bovine PMNL cell assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50052457(1,8-Dihydroxy-10-(2-hydroxy-ethylsulfanyl)-10H-ant...)
Affinity DataIC50:  2.00E+3nMAssay Description:Tested for inhibition of 5-lipoxygenase as inhibition of 5-HETE and LTB4 biosynthesis in bovine PMNLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50052462(10-(2-Amino-phenylsulfanyl)-1,8-dihydroxy-10H-anth...)
Affinity DataIC50:  2.00E+3nMAssay Description:Tested for inhibition of 5-lipoxygenase as inhibition of 5-HETE and LTB4 biosynthesis in bovine PMNLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50052466(3-(4,5-Dihydroxy-10-oxo-9,10-dihydro-anthracen-9-y...)
Affinity DataIC50:  2.00E+3nMAssay Description:Tested for inhibition of 5-lipoxygenase as inhibition of 5-HETE and LTB4 biosynthesis in bovine PMNLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50052464(1,8-Dihydroxy-10-(4-hydroxy-phenylsulfanyl)-10H-an...)
Affinity DataIC50:  2.00E+3nMAssay Description:Tested for inhibition of 5-lipoxygenase as inhibition of 5-HETE and LTB4 biosynthesis in bovine PMNLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50059606(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Affinity DataIC50:  2.00E+3nMAssay Description:5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50059619(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Affinity DataIC50:  2.00E+3nMAssay Description:5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50041803(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Affinity DataIC50:  2.00E+3nMAssay Description:5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50059621(5-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Affinity DataIC50:  2.00E+3nMAssay Description:5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50059623(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracene-2-c...)
Affinity DataIC50:  2.00E+3nMAssay Description:5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50060860(9(10H)-anthracenone | 9,10-dihydro-9-oxoanthracene...)
Affinity DataIC50:  2.00E+3nMAssay Description:5-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50060871(4-Hydroxy-5-methoxy-10H-anthracen-9-one | CHEMBL12...)
Affinity DataIC50:  2.00E+3nMAssay Description:5-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50043357(1,8-Dihydroxy-10-(3-phenyl-propionyl)-10H-anthrace...)
Affinity DataIC50:  2.00E+3nMAssay Description:Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50043352(10-(3,4-Dihydroxy-benzylidene)-1,8-dihydroxy-10H-a...)
Affinity DataIC50:  2.00E+3nMAssay Description:Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-lipoxygenase(Bos taurus)
Merckle

Curated by ChEMBL
LigandPNGBDBM50043348(1,8-Dihydroxy-10-(4-nitro-benzylidene)-10H-anthrac...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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