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Found 212 Enz. Inhib. hit(s) with Target = 'Complement C1r subcomponent'
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108110(US8598206, Table 6, 19)
Affinity DataKi: >130nMAssay Description:Inhibition of human Complement C1r subcomponent using Val-Ser-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108098(US8598206, Table 6, 7)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of human Complement C1r subcomponent using Val-Ser-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50369774(SEPIMOSTAT MESYLATE | Sepimostat)
Affinity DataKi:  6.40E+3nMAssay Description:Binding affinity against factor C1r.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108106(US8598206, Table 6, 15)
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108095(US8598206, Table 6, 4)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108105(US8598206, Table 6, 14)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108107(US8598206, Table 6, 16)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM47178(BDBM108103 | US8598206, Table 6, 12)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108116(US8598206, Table 6, 3)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108108(US8598206, 117 | US8598206, 123)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108109(US8598206, 118 | US8598206, 122)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108109(US8598206, 118 | US8598206, 122)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108108(US8598206, 117 | US8598206, 123)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108099(US8598206, Table 6, 8)
Affinity DataKi: >3.50E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50425648(CHEMBL2315243)
Affinity DataKi: >3.50E+4nMAssay Description:Inhibition of human C1rMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108096(US8598206, Table 6, 5)
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108117(US8598206, Table 6, 2)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108104(US8598206, Table 6, 13)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108112(US8598206, Table 6, 21)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50425649(CHEMBL2315239)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human C1rMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108102(US8598206, Table 6, 11)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108097(US8598206, Table 6, 6)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108098(US8598206, Table 6, 7)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM47177(BDBM108100 | US8598206, Table 6, 9)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108101(US8598206, Table 6, 10)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM108115(US8598206, Table 6, 24)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human C1r was determined by the method described in [0092]-[0098] using native human activated C1r complement component from Calbiochem...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063701(2-(2-Iodo-phenylamino)-naphtho[2,3-d][1,3]oxazin-4...)
Affinity DataIC50:  200nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063745(2-(2-Iodo-phenylamino)-7-trifluoromethyl-benzo[d][...)
Affinity DataIC50:  400nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063745(2-(2-Iodo-phenylamino)-7-trifluoromethyl-benzo[d][...)
Affinity DataIC50:  400nMAssay Description:Compound was evaluated in vitro for inhibitory activity against purified human C1r protease proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063726(7-Chloro-2-(2,6-dichloro-phenylamino)-benzo[d][1,3...)
Affinity DataIC50:  400nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063722(6,7-Dichloro-2-(2-iodo-phenylamino)-benzo[d][1,3]o...)
Affinity DataIC50:  500nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50462100(CHEMBL4247936)
Affinity DataIC50:  600nMAssay Description:Inhibition of human plasma C1r using Cbz-Gly-Arg-S-Bzl as substrate preincubated for 10 mins followed by substrate addition and measured after 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50075982(4-Methoxy-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin...)
Affinity DataIC50:  700nMAssay Description:In vitro inhibition of purified human C1r protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063711(7-Chloro-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazi...)
Affinity DataIC50:  700nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50289007(2-(2-Iodo-phenyl)-naphtho[2,3-d][1,3]oxazin-4-one ...)
Affinity DataIC50:  700nMAssay Description:Inhibition of C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063723(2-(2-Iodo-phenylamino)-7-methyl-benzo[d][1,3]oxazi...)
Affinity DataIC50:  800nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063717(7-Chloro-2-(2-chloro-phenylamino)-benzo[d][1,3]oxa...)
Affinity DataIC50:  800nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063721(2-(2-Iodo-phenylamino)-7-nitro-benzo[d][1,3]oxazin...)
Affinity DataIC50:  800nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human serum C1r using AAME as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063717(7-Chloro-2-(2-chloro-phenylamino)-benzo[d][1,3]oxa...)
Affinity DataIC50:  800nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063732(2-(2-Chloro-phenylamino)-7-methyl-benzo[d][1,3]oxa...)
Affinity DataIC50:  900nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063724(2-(2,6-Dichloro-phenylamino)-benzo[d][1,3]oxazin-4...)
Affinity DataIC50:  900nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063711(7-Chloro-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazi...)
Affinity DataIC50:  900nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063726(7-Chloro-2-(2,6-dichloro-phenylamino)-benzo[d][1,3...)
Affinity DataIC50:  900nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063724(2-(2,6-Dichloro-phenylamino)-benzo[d][1,3]oxazin-4...)
Affinity DataIC50:  900nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50:  1.04E+3nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063732(2-(2-Chloro-phenylamino)-7-methyl-benzo[d][1,3]oxa...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Philipps University Marburg

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
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