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Found 12 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 144'
TargetCytochrome P450 144(Mycobacterium tuberculosis)
Manchester Interdisciplinary Biocentre

LigandPNGBDBM31773(ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...)
Affinity DataKd:  780nMAssay Description:Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 144(Mycobacterium tuberculosis)
Manchester Interdisciplinary Biocentre

LigandPNGBDBM31774(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Affinity DataKd:  370nMAssay Description:Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 144(Mycobacterium tuberculosis)
Manchester Interdisciplinary Biocentre

LigandPNGBDBM31772(1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl...)
Affinity DataKd:  980nMAssay Description:Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 144(Mycobacterium tuberculosis)
Manchester Interdisciplinary Biocentre

LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Affinity DataKd:  1.34E+5nMAssay Description:Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 144(Mycobacterium tuberculosis)
Manchester Interdisciplinary Biocentre

LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataKd:  1.74E+5nMAssay Description:Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 144 [31-434](Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM222349(CYP144A1 ligand, 4)
Affinity DataKd:  2.30E+5nMpH: 7.0Assay Description:Optical titrations to determine the binding affinity (KD values) of ligands were carried out on a Cary 60 UV−visible spectrophotometer (Varian,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 144 [31-434](Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM222346(CYP144A1 ligand, 1)
Affinity DataKd:  8.20E+4nMpH: 7.0Assay Description:Optical titrations to determine the binding affinity (KD values) of ligands were carried out on a Cary 60 UV−visible spectrophotometer (Varian,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 144 [31-434](Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM222347(CYP144A1 ligand, 2)
Affinity DataKd:  2.00E+5nMpH: 7.0Assay Description:Optical titrations to determine the binding affinity (KD values) of ligands were carried out on a Cary 60 UV−visible spectrophotometer (Varian,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 144 [31-434](Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM222348(CYP144A1 ligand, 3)
Affinity DataKd:  1.40E+5nMpH: 7.5 T: 2°CAssay Description:ITC binding isotherms were recorded on a MicroCal ITC200 instrument (MalvernInstruments). Titrations were conducted at 25 °C by injecting aliquots (2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 144 [31-434](Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataKd:  2.98E+6nMpH: 7.0Assay Description:Optical titrations to determine the binding affinity (KD values) of ligands were carried out on a Cary 60 UV−visible spectrophotometer (Varian,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 144 [31-434](Mycobacterium tuberculosis)
University Of Cambridge

LigandPNGBDBM7886(1-PIM | 1-phenyl-1H-imidazole | 1-phenylimidazole ...)
Affinity DataKd:  2.90E+5nMpH: 7.0Assay Description:Optical titrations to determine the binding affinity (KD values) of ligands were carried out on a Cary 60 UV−visible spectrophotometer (Varian,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 144(Mycobacterium tuberculosis)
Manchester Interdisciplinary Biocentre

LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataKd:  2.80E+5nMAssay Description:Substrate and ligand binding assay using UV- visible absorbance analysis of CYP142 was done on a Cary UV-50 UV-visible scanning spectrophotometer (Va...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed