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Found 20 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit beta-3'
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214664(5-chloromethyl-1-(2,6-dichloro-4-trifluoromethylph...)
Affinity DataKi:  0.659nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214659(1-(2,6-dichloro-4-trifluoromethylphenyl)-5-methyl-...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214673(1-(2,6-dichloro-4-trifluoromethylphenyl)-5-hydroxy...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214650(1-(2,6-dichloro-4-trifluoromethylphenyl)-4,5-dieth...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214662(1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethyl-5...)
Affinity DataKi:  7.10nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214670(1-(2,6-dichloro-4-trifluoromethylphenyl)-5-ethyl-4...)
Affinity DataKi:  8.10nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214665(1-(2,6-dibromo-4-trifluoromethylphenyl)-5-methyl-4...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214653(1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethyl-5...)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214661(4-chloromethyl-1-(2,6-dichloro-4-trifluoromethylph...)
Affinity DataKi:  67nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214647(1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-5-ethyl...)
Affinity DataKi:  70.1nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214648(1-(2,6-dichloro-4-trifluoromethylphenyl)-4,5-di-np...)
Affinity DataKi:  128nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214666(1-(2,6-dichloro-4-trifluoromethylphenyl)-4-methyl-...)
Affinity DataKi:  539nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50214651(1-(2,6-dichloro-4-trifluoromethylphenyl)-4-hydroxy...)
Affinity DataKi:  3.45E+3nMAssay Description:Displacement of [3H]EBOB from human recombinant GABAbeta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50106148(5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]...)
Affinity DataIC50:  28nMAssay Description:Inhibition of [3H]-EBOB binding to drosophila GABA-A receptor (range 1-28)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50106149(1-(2,6-Dichloro-4-trifluoromethyl-phenyl)-4-(3-tri...)
Affinity DataIC50:  28nMAssay Description:Inhibition of [3H]-EBOB binding to human GABA-A receptor beta3 subunit (range 1-28)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50106148(5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]...)
Affinity DataIC50:  28nMAssay Description:Inhibition of [3H]-EBOB binding to drosophila GABA-A receptor (range 1-28)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50106149(1-(2,6-Dichloro-4-trifluoromethyl-phenyl)-4-(3-tri...)
Affinity DataIC50:  28nMAssay Description:Inhibition of [3H]-EBOB binding to human GABA-A receptor beta3 subunit (range 1-28)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50395121(CHEMBL2163548)
Affinity DataIC50:  3.90E+3nMAssay Description:Displacement of [3H]R-(-)-14 from human FLAG-tagged beta3 GABA A receptor expressed in HEK293S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50055935(5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidi...)
Affinity DataIC50:  8.80E+4nMAssay Description:Displacement of [3H]R-(-)-14 from human FLAG-tagged beta3 GABA A receptor expressed in HEK293S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGamma-aminobutyric acid receptor subunit beta-3(Homo sapiens (Human))
Shimane University

Curated by ChEMBL
LigandPNGBDBM50395120(CHEMBL2163549)
Affinity DataIC50:  1.70E+5nMAssay Description:Displacement of [3H]R-(-)-14 from human FLAG-tagged beta3 GABA A receptor expressed in HEK293S cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed