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Found 444 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 6'
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50299153((Z)-5-{2-[3,5-bis(trifluoromethyl)benzyloxy]-5-bro...)
Affinity DataKi:  2.20E+3nMAssay Description:Inhibition of SHP1 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50219479(3,3'-dicarboxy-2,2'-dihydroxy-5,5'-diphenyldipheny...)
Affinity DataKi:  9.70E+3nMAssay Description:Inhibition of SHP-1 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50208362(3-benzyl-5-[(5-benzyl-3-carboxy-4-hydroxycyclohexa...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of SHP-1 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50118796(6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID | 6-(...)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50208359(5,5'-methylenebis(2-hydroxybiphenyl-3-carboxylic a...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of SHP-1 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50118751(6-(Oxalyl-amino)-1H-indole-7-carboxylic acid | 6-(...)
Affinity DataKi:  2.80E+4nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50119679(2-[(S)-2-(2-{2-[4-(2-Bromo-acetyl)-phenoxy]-acetyl...)
Affinity DataKi:  2.90E+4nMAssay Description:Dissociation constant of the compound towards SHP 1 receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50118749(2-(Oxalyl-amino)-thiophene-3-carboxylic acid | 2-(...)
Affinity DataKi:  6.00E+4nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50118778(5-iodo-2-(oxaloamino)benzoic acid | CHEMBL336908)
Affinity DataKi:  8.00E+4nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50299462(2-(3-(dihydroxymethyl)naphthalen-2-ylamino)-2-oxoa...)
Affinity DataKi:  9.40E+4nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50118762(2-(Oxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thioph...)
Affinity DataKi:  1.00E+5nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50119683(2-[(S)-2-(2-{[4'-(2-Bromo-acetyl)-biphenyl-2-carbo...)
Affinity DataKi: >2.00E+5nMAssay Description:Dissociation constant of the compound towards SHP 1 receptor-inhibitor complex was determined using PNP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50299461((S)-7-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-...)
Affinity DataKi:  2.89E+5nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50118744(2-(Oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran...)
Affinity DataKi:  3.50E+5nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50118789(2-(oxaloamino)benzoic acid | CHEMBL139050)
Affinity DataKi:  5.10E+5nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50118779(3-(Oxalyl-amino)-thiophene-2-carboxylic acid | 3-(...)
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50118792(2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]P...)
Affinity DataKi: >2.00E+6nMAssay Description:Inhibition of PTPN6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50556732(CHEMBL4750435)
Affinity DataIC50:  130nMAssay Description:Inhibition of PTPN6 (unknown origin) pre-incubated for 20 mins followed by fluorescence substrate addition and measured after 120 mins by DiFMUP assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50594492(CHEMBL3322530)
Affinity DataIC50:  290nMAssay Description:Inhibition of human SHP1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50335865(6-Hydroxy-2-(4-methoxyphenyl)-3-(1-(4-(naphthalen-...)
Affinity DataIC50:  335nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM152210(US8987474, NSC-87877)
Affinity DataIC50:  355nMAssay Description:NSC-87877 ranked among top 10% (175th) of the compounds with the best GLIDE scores for the docking to the human Shp2 PTP domain in our virtual screen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50087879(CHEMBL472004 | NSC-87877)
Affinity DataIC50:  360nMAssay Description:Inhibition of human SHP1 catalytic domain (205 to 597 residues) expressed in Escherichia coli DH5alpha using 6,8-difluoro-4-methylumbelliferyl phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50335867(3-(1-(4-(4-Chloronaphthalen-1-ylamino)-4-oxobutyl)...)
Affinity DataIC50:  378nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50335868(6-Hydroxy-3-(1-(4-(naphthalen-1-ylamino)-4-oxobuty...)
Affinity DataIC50:  408nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50335870(6-Hydroxy-3-(1-(4-(6-methoxybenzo[d]thiazol-2-ylam...)
Affinity DataIC50:  486nMAssay Description:Inhibition of Shp1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50246668(3-(benzo[d][1,3]dioxol-5-yl)-2-(5-((4aR,6aS,6bR,8a...)
Affinity DataIC50:  710nMAssay Description:Inhibition of human recombinant SHP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50425815(CHEMBL2316908)
Affinity DataIC50:  760nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50290925(CHEMBL4175748)
Affinity DataIC50:  850nMAssay Description:Inhibition of human GST-tagged SHP1 (244 to 570 residues) expressed in Escherichia coli BL21-CondenPlus (DE3) using pNNP as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50246745(3-(4-Carboxy-benzyloxy)-28-[4-butyric ((S)-1-carbo...)
Affinity DataIC50:  890nMAssay Description:Inhibition of human recombinant SHP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50436358(CHEMBL2396718)
Affinity DataIC50:  910nMAssay Description:Inhibition of recombinant SHP-1 (unknown origin) using pNPP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM124262(Bis(4-chloro-2-((phenylimino)methyl)phenolate)-oxo...)
Affinity DataIC50:  1.00E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50290909(CHEMBL4164960)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of human GST-tagged SHP1 (244 to 570 residues) expressed in Escherichia coli BL21-CondenPlus (DE3) using pNNP as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50512278(CHEMBL4475724)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50054344(CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50054344(CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...)
Affinity DataIC50:  1.44E+3nMAssay Description:For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50512277(CHEMBL4445615)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50546233(CHEMBL4757579)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of N-terminal His6-tagged TEV cleavage site-fused human SHP1 (222 to 535 residues) expressed in Escherichia coli BL21(DE3)RILcodon+ or BL2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM124261(2-((5-Bromo-2-oxybenzylidene)amino)benzoato-diaqua...)
Affinity DataIC50:  1.90E+3nMpH: 7.2Assay Description:The assays were performed in 20 mM MOPS buffer, pH 7.2, containing 50 mM NaCl and 2 mM GSH. Compounds were dissolved in DMSO and diluted to various c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM51317(1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dion...)
Affinity DataIC50:  1.97E+3nMAssay Description:Inhibition of GST-tagged SHP1 PTP domain (unknown origin) using phospho-EGFR Asp-Ala-Asp-Glu-Tyr[PO3H2]-Leu-Ile-Pro-Gln-Gln-Gly as substrate preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50546232(CHEMBL4762771)
Affinity DataIC50:  2.08E+3nMAssay Description:Inhibition of SHP1 (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50546229(CHEMBL4780471)
Affinity DataIC50:  2.14E+3nMAssay Description:Inhibition of SHP1 (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM83922(1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]be...)
Affinity DataIC50:  2.14E+3nMAssay Description:Inhibition of GST-tagged SHP1 PTP domain (unknown origin) using phospho-EGFR Asp-Ala-Asp-Glu-Tyr[PO3H2]-Leu-Ile-Pro-Gln-Gln-Gly as substrate preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50425807(CHEMBL2316902)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50425808(CHEMBL2316906)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50133021(CHEMBL3634592)
Affinity DataIC50:  2.31E+3nMAssay Description:Inhibition of SHP1 (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50096222(CHEMBL3593818)
Affinity DataIC50:  2.31E+3nMAssay Description:Inhibition of SHP1 (unknown origin) using pNPP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50351780(CHEMBL1823762)
Affinity DataIC50:  2.43E+3nMpH: 8.0Assay Description:Inhibition of human recombinant SHP1 in Tris buffer at pH 8 using OMPF as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50184997(CHEMBL3822604)
Affinity DataIC50:  2.45E+3nMAssay Description:Inhibition of human SHP1 using pNPP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Inha University

Curated by ChEMBL
LigandPNGBDBM50425806(CHEMBL2316907)
Affinity DataIC50:  2.49E+3nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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