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Found 18 Enz. Inhib. hit(s) with Target = 'Ubiquitin-like modifier-activating enzyme 6'
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299240(US9593121, I-03 | {(1S,2S,4R)-2-hydroxy-4-[4-(5-me...)
Affinity DataIC50: <50nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299259(US9593121, I-08 | {(1S,2S,4R)-2-hydroxy-4-[4-(1H-i...)
Affinity DataIC50: <50nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299243(US9593121, I-06 | {(1S,2S,4R)-2-hydroxy-4-[4-(6-me...)
Affinity DataIC50: <50nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299242(US9593121, I-05 | {(1S,2S,4R)-4-[4-(6-cyano-1H-ind...)
Affinity DataIC50: <50nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299241(US9593121, I-04 | {(1S,2S,4R)-4-[4-(6-chloro-1H-in...)
Affinity DataIC50: <50nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299236(((1S,2S,4R)-4-(4-(1H-indol-2-yl)-7H-pyrrolo[2,3- d...)
Affinity DataIC50: <50nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299257(US9593121, I-07 | {(1S,2S,4R)-2-hydroxy-4-[4-(6-me...)
Affinity DataIC50: <50nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM50427035(CHEMBL2017005)
Affinity DataIC50:  920nMAssay Description:Inhibition of UBA6 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of UBA6 (unknown origin) assessed as decrease in formation of E2-UBL thioester reaction productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299322(US9593121, I-14 | [(1S,2S,4R)-2-hydroxy-4-{4-[6-(t...)
Affinity DataIC50:  1.03E+3nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299284(US9593121, I-13 | {(1S,2S,4R)-2-hydroxy-4-[4-(3-me...)
Affinity DataIC50:  1.03E+3nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299282(US9593121, I-12 | {(1S,2S,4R)-2-hydroxy-4-[4-(7-me...)
Affinity DataIC50:  1.03E+3nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299276(US9593121, I-11 | {(1S,2S,4R)-4-[4-(5-fluoro-1H-in...)
Affinity DataIC50:  1.03E+3nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299265(US9593121, I-10 | tert-butyl 2-(7-{(1R,3S,4S)-3-hy...)
Affinity DataIC50:  1.03E+3nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299263(US9593121, I-09 | {(1S,2S,4R)-4-[4-(6-chloro-5-flu...)
Affinity DataIC50:  1.03E+3nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM299237(US9593121, I-02 | {(1S,2S,4R)-2-hydroxy-4-[4-(1-me...)
Affinity DataIC50:  1.03E+3nMAssay Description:The UBA6 enzmatic reaction totals 20 μL and contains 50 mM HEPES (pH 7.5), 0.05% BSA, 0.02% Tween 20, 0.1 mM TCEP, 5 mM MgCl2, 2 μM ATP, 60...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of His-tagged UBA6 (unknown origin) expressed in sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUbiquitin-like modifier-activating enzyme 6(Homo sapiens (Human))
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM50427034(CHEMBL2322194)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of UBA6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed