Compile Data Set for Download or QSAR
maximum 50k data
Found 395 Enz. Inhib. hit(s) with Target = 'Voltage-dependent L-type calcium channel subunit alpha-1S'
LigandPNGBDBM50029417(CHEMBL277363 | [4-(4-Methoxy-phenyl)-4H-benzo[b]py...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50226128(CHEMBL2093893)
Affinity DataKi:  0.205nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel from rat brain cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50469633(CHEMBL21906)
Affinity DataKi:  0.290nMAssay Description:Inhibitory constant against calcium channel receptors (CCRs) from rat cortex homogenateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
LigandPNGBDBM50226129(CHEMBL1314450)
Affinity DataKi:  0.499nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel from rat brain cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50101815(CHEBI:7550 | Nicardipine)
Affinity DataKi:  0.840nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel from rat brain cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226130(CHEMBL558616)
Affinity DataKi:  3.10nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel from rat brain cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50101817(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel from rat brain cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053877(Allyl-(9-allyl-2-{4-[2,2-bis-(4-fluoro-phenyl)-eth...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280077(CHEMBL18988 | sec-Butyl-[4-(2,4-dimethoxy-phenyl)-...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50226131(CHEMBL1598680)
Affinity DataKi:  7.10nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel from rat brain cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053873(Allyl-(9-allyl-2-{4-[(2-methoxy-10,11-dihydro-5H-d...)
Affinity DataKi:  12nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226127(CHEMBL542169)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel from rat brain cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataKi:  16nMAssay Description:Inhibitory constant against calcium channel receptors (CCRs)More data for this Ligand-Target Pair
LigandPNGBDBM50029426(CHEMBL24675 | [2-(3,4-Dimethoxy-phenyl)-ethyl]-[4-...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair
In DepthDetails
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281270(Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-8-me...)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscleMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50053900(Allyl-(9-allyl-2-{4-[(10,11-dihydro-5H-dibenzo[a,d...)
Affinity DataKi:  46nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053872(Allyl-(2-{4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohe...)
Affinity DataKi:  48nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50226126(CHEMBL553553)
Affinity DataKi:  50nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel from rat brain cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50029418(CHEMBL275195 | [4-(2,4-Dimethoxy-phenyl)-4H-benzo[...)
Affinity DataKi:  56nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataKi:  58nMAssay Description:Inhibition of [3H]D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
LigandPNGBDBM50473868(CHEMBL339108)
Affinity DataKi:  60nMAssay Description:Displacement of verapamil from L-type calcium channel binding siteMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50053880(Allyl-(9-allyl-6-{4-[(10,11-dihydro-5H-dibenzo[a,d...)
Affinity DataKi:  62nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053892(Allyl-(9-allyl-2-{4-[(6,7,8,9-tetrahydro-5H-benzoc...)
Affinity DataKi:  62nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053891((9-Allyl-2-{4-[(10,11-dihydro-5H-dibenzo[a,d]cyclo...)
Affinity DataKi:  84nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataKi:  85nMAssay Description:Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation countingMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281272((2R,3S)-5-(2-Dimethylamino-ethyl)-8-methoxy-2-(4-m...)
Affinity DataKi:  85nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscleMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50053885(Allyl-(9-allyl-2-{4-[(8-chloro-11-methyl-10,10-dio...)
Affinity DataKi:  87nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053888(CHEMBL85156 | N,N'-Diallyl-6-{4-[2,2-bis-(4-fluoro...)
Affinity DataKi:  89nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053871(Allyl-(9-allyl-6-{4-[(5H-dibenzo[a,d]cyclohepten-5...)
Affinity DataKi:  90nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053896(Allyl-(9-allyl-6-{4-[(6,11-dihydro-dibenzo[b,e]oxe...)
Affinity DataKi:  93nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053895(Allyl-(9-allyl-2-{4-[(2,3,4-trimethoxy-10,11-dihyd...)
Affinity DataKi:  99nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053893(Allyl-(9-allyl-6-{4-[(2-methoxy-10,11-dihydro-5H-d...)
Affinity DataKi:  110nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50029431(CHEMBL277293 | Dimethyl-(4-phenyl-4H-benzo[b]pyrro...)
Affinity DataKi:  118nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50053870(Allyl-(9-allyl-2-{4-[(6,11-dihydro-dibenzo[b,e]oxe...)
Affinity DataKi:  120nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053875(Allyl-(9-allyl-2-{4-[(5H-dibenzo[a,d]cyclohepten-5...)
Affinity DataKi:  170nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053898(Allyl-(9-allyl-6-{4-[(8-chloro-11-methyl-10,10-dio...)
Affinity DataKi:  170nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212320(CHEMBL274514)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50479923(CHEMBL521744)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50053883(Allyl-(7-allyl-2-{4-[(10,11-dihydro-5H-dibenzo[a,d...)
Affinity DataKi:  200nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50473868(CHEMBL339108)
Affinity DataKi:  217nMAssay Description:Displacement of diltiazem from L-type calcium channel binding siteMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50053884(Allyl-(1-allyl-6-{4-[(10,11-dihydro-5H-dibenzo[a,d...)
Affinity DataKi:  270nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50479922(CHEMBL489002)
Affinity DataKi:  290nMAssay Description:Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50471693(CHEMBL92322)
Affinity DataKi:  372nMAssay Description:Binding affinity at the L-type [Ca2+] channel from rat brain homogenate by [3H]nitrendipine displacement.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataKi:  380nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscleMore data for this Ligand-Target Pair
LigandPNGBDBM50473890(CHEMBL2111820)
Affinity DataKi:  391nMAssay Description:Displacement of diltiazem from L-type calcium channel binding siteMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50053881(Allyl-(1-allyl-6-{4-[(2-methoxy-10,11-dihydro-5H-d...)
Affinity DataKi:  400nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053874(Allyl-{9-allyl-2-[4-(2,2,2-triphenyl-ethylamino)-p...)
Affinity DataKi:  410nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053890((1-Allyl-6-{4-[(2-methoxy-10,11-dihydro-5H-dibenzo...)
Affinity DataKi:  420nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50053901(Allyl-(9-allyl-2-{4-[(naphthalen-1-ylmethyl)-amino...)
Affinity DataKi:  440nMAssay Description:Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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