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Found 535 Enz. Inhib. hit(s) with Target = 'Sentrin-specific protease 1'
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50437693(VIALININ A)
Affinity DataKi:  930nMAssay Description:Binding affinity to recombinant human 6His-tagged SENP1 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50437693(VIALININ A)
Affinity DataKi:  1.07E+3nMAssay Description:Binding affinity to full-length recombinant human 6His-tagged SENP1 expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of SENP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM46568((2Z)-7-chloranyl-2-[(2E)-1-chloranyl-2-(3-chlorany...)
Affinity DataIC50:  428nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50599421(CHEMBL5185218)
Affinity DataIC50:  510nMAssay Description:Inhibition of recombinant human SENP1 catalytic domain using RanGAP1 as substrate preincubated for 10 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50:  520nMAssay Description:Inhibition of SENP1 (unknown origin) using AMC-tagged SUMO1 as fluorogenic substrate preincubated for 10 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50447758(CHEBI:9287 | NSC-45383 | Nigrin | Rufocromomycin |...)
Affinity DataIC50:  520nMAssay Description:Inhibition of human SENP1 using AMC-tagged SUMO1 as substrate incubated for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM46568((2Z)-7-chloranyl-2-[(2E)-1-chloranyl-2-(3-chlorany...)
Affinity DataIC50:  654nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50565393(CHEMBL4780770)
Affinity DataIC50:  760nMAssay Description:Inhibition of recombinant human SNEP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50565392(CHEMBL4791433)
Affinity DataIC50:  790nMAssay Description:Inhibition of recombinant human SNEP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM94843((5R)-5-(1,3-benzodioxol-5-yl)-3-(3-chloranyl-2-oxi...)
Affinity DataIC50:  993nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50565391(CHEMBL4792569)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant human SNEP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM94870((2Z)-2-(1-cyclopentyl-2H-1,2,3,4-tetrazol-5-yliden...)
Affinity DataIC50:  1.05E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50394464(CHEMBL2159857)
Affinity DataIC50:  1.08E+3nMAssay Description:Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherihcia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM94847((5R)-3-(3-chloranyl-2-oxidanyl-phenyl)-5-(4-fluoro...)
Affinity DataIC50:  1.14E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM94846((5R)-3-(3-chloranyl-2-oxidanyl-phenyl)-5-(4-chloro...)
Affinity DataIC50:  1.15E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50394465(CHEMBL2159858)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherihcia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM75839((5Z)-2-anilino-5-(5-bromo-3-ethoxy-2-hydroxy-benzy...)
Affinity DataIC50:  1.18E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50346606(CHEMBL1797137)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of recombinant human SENP1 catalytic domain using RanGAP1 as substrate preincubated for 10 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM94869((2Z)-2-(1-amyl-2H-tetrazol-5-ylidene)benzo[g]quino...)
Affinity DataIC50:  1.29E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50565378(CHEMBL4793952)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant human SNEP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50565398(CHEMBL4776158)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant human SNEP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50591767(CHEMBL5206456)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of SENP1 (unknown origin) assessed as reduction in deSUMOylation of RanGAP1-SUMO2 using RanGAP1-SUMO2 as substrate preincubated for 10 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50536673(CHEMBL4587307)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of recombinant human 6His-tagged SENP1 catalytic domain expressed in Escherichia coli preincubated for 15 mins followed by addition of SUM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50437693(VIALININ A)
Affinity DataIC50:  1.64E+3nMAssay Description:Inhibition of full-length recombinant human 6His-tagged SENP1 expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins followed by addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50394468(CHEMBL2159859)
Affinity DataIC50:  1.74E+3nMAssay Description:Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherihcia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM94810(6-chloranyl-2-oxidanylidene-N-(1,3-thiazol-2-yl)ch...)
Affinity DataIC50:  1.84E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50394466(CHEMBL2159862)
Affinity DataIC50:  1.86E+3nMAssay Description:Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherihcia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM103828(SPI-03 | US11041859, Code SPI-03)
Affinity DataIC50:  1.86E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50565346(CHEMBL4781794)
Affinity DataIC50:  1.88E+3nMAssay Description:Inhibition of human His-tagged SENP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using DUB-Glo as substrate preincubated for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM103826(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Affinity DataIC50:  1.88E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50437693(VIALININ A)
Affinity DataIC50:  1.89E+3nMAssay Description:Inhibition of recombinant human 6His-tagged SENP1 catalytic domain expressed in Escherichia coli preincubated for 15 mins followed by addition of SUM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM94843((5R)-5-(1,3-benzodioxol-5-yl)-3-(3-chloranyl-2-oxi...)
Affinity DataIC50:  1.93E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM94872((2E)-2-[1-(2,6-dimethylphenyl)-2H-1,2,3,4-tetrazol...)
Affinity DataIC50:  1.93E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.08E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50565390(CHEMBL4780586)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of recombinant human SNEP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.10E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of His-tagged human SENP1 (419 to 644 residues) expressed in Escherichia coli (DE3) using YFP-SUMO-ECFP as substrate incubated for 15 mins...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Affinity DataIC50:  2.10E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM94870((2Z)-2-(1-cyclopentyl-2H-1,2,3,4-tetrazol-5-yliden...)
Affinity DataIC50:  2.21E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM49568(4-chloro-2-[2-(2-quinolinyl)vinyl]phenyl acetate |...)
Affinity DataIC50:  2.22E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM103829(SPI-04 | US11041859, Code SPI-04 | US9791447, Comp...)
Affinity DataIC50:  2.32E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50394467(CHEMBL2159861)
Affinity DataIC50:  2.39E+3nMAssay Description:Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherihcia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  2.40E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM103835(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Affinity DataIC50:  2.40E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM103829(SPI-04 | US11041859, Code SPI-04 | US9791447, Comp...)
Affinity DataIC50:  2.40E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM50565350(CHEMBL4796113)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of recombinant human SNEP1 (419 to 644 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM103829(SPI-04 | US11041859, Code SPI-04 | US9791447, Comp...)
Affinity DataIC50:  2.40E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM65599(MLS001215303 | N-[(5Z)-5-(3-ethoxy-4-hydroxy-benzy...)
Affinity DataIC50:  2.41E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSentrin-specific protease 1(Homo sapiens (Human))
Tokyo University Of Agriculture

Curated by ChEMBL
LigandPNGBDBM94827(2-Imino-6-nitro-2H-chromene-3-carboxylic acid benz...)
Affinity DataIC50:  2.45E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
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