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Found 286 Enz. Inhib. hit(s) with Target = 'Caspase-6'
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM222((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  120nM ΔG°:  -39.5kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM223((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  190nM ΔG°:  -38.4kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM225((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)
Affinity DataKi:  540nM ΔG°:  -35.8kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM220(5-{[(4-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl...)
Affinity DataKi:  1.00E+3nM ΔG°:  -34.2kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10298(1-benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  1.00E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM221(5-{[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl...)
Affinity DataKi:  1.40E+3nM ΔG°:  -33.4kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10297(1-methyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  1.70E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM224((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  2.30E+3nM ΔG°:  -32.2kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM227((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  2.40E+3nM ΔG°:  -32.1kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10323((S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)
Affinity DataKi: >5.00E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10315((S)-5-{1-[2-(Anilinomethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  7.50E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM226((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  9.70E+3nM ΔG°:  -28.6kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM219(5-({[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methy...)
Affinity DataKi:  2.20E+4nM ΔG°:  -26.6kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Affinity DataKi: >2.50E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10318((S)-5-{1-[2-(Phenoxymethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  2.90E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10309(5-(pyrrolidine-1-sulfonyl)-2,3-dihydro-1H-indole-2...)
Affinity DataKi: >5.00E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10316((R)-5-{1-[2-(Anilinomethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  5.70E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50200932((3S)-3-[(2S)-6-(6-{5-[(3aS,6aR)-2-oxo-hexahydro-1H...)
Affinity DataKi:  5.50E+5nMAssay Description:Inhibition of human caspase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50160974(CHEMBL366927 | [3-(2-{5-tert-Butyl-3-[(4-methyl-fu...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory concentration against caspase-6 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50160957(CHEMBL179503 | [3-(2-{5-tert-Butyl-3-[(4-methyl-fu...)
Affinity DataIC50:  3.40nMAssay Description:Inhibitory concentration against casp-6 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50119267(4-[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamo...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10356((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  8nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50340548((4S,7S,10S,13S)-10-sec-butyl-7-(2-carboxyethyl)-13...)
Affinity DataIC50:  8nMAssay Description:Inhibition of caspase 6 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50119245(4-(2-Acetylamino-2-carboxy-acetylamino)-4-[1-(2-hy...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of compound required against Caspase-6 compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50072047(4-(2-Acetylamino-3-carboxy-propionylamino)-4-[1-((...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of compound required against Caspase-6 enzyme compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50119264(4-[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamo...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  18nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-6 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50145622((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-ylamino)-ac...)
Affinity DataIC50:  37nMAssay Description:Binding affinity of the compound towards human Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50119262(4-Methyl-2-[2-(naphthalen-1-ylamino)-acetylamino]-...)
Affinity DataIC50:  37nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50161452(5-Fluoro-3-((S)-3-methyl-2-phenylcarbamoyloxy-buty...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration against Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10356((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  60.5nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50223100(2-(2-((S)-2-(benzyloxycarbonyl)-3-methylbutanamido...)
Affinity DataIC50:  61nMAssay Description:Inhibition of human caspase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10284(4-Oxo-4-piperidin-1-yl-N-(1,3,4-trioxo-1,2,3,4-tet...)
Affinity DataIC50:  124nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10287(Isoquinoline-1,3,4-trione 13f | N-(2-Methoxy-pheny...)
Affinity DataIC50:  137nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM29578(isatin Michael acceptor (IMA) analogue, 13a)
Affinity DataIC50:  151nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM29582(isatin Michael acceptor (IMA) analogue, 18a)
Affinity DataIC50:  156nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM29579(isatin Michael acceptor (IMA) analogue, 13b)
Affinity DataIC50:  188nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM29583(isatin Michael acceptor (IMA) analogue, 18b)
Affinity DataIC50:  197nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10280(3-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-y...)
Affinity DataIC50:  201nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10264(2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydro...)
Affinity DataIC50:  216nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM29580(isatin Michael acceptor (IMA) analogue, 13c)
Affinity DataIC50:  230nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM29585(isatin Michael acceptor (IMA) analogue, 19a)
Affinity DataIC50:  241nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM29584(isatin Michael acceptor (IMA) analogue, 18c)
Affinity DataIC50:  280nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10278(3-Chloro-N-(1,2,3,4-tetrahydro-1,3,4-trioxoisoquin...)
Affinity DataIC50:  283nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50119238(4-Methyl-2-[3-(naphthalen-1-yloxy)-propionylamino]...)
Affinity DataIC50:  305nMAssay Description:Inhibitory concentration required against caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50119259(4-Methyl-2-[2-(3-phenoxy-phenylamino)-acetylamino]...)
Affinity DataIC50:  308nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50119261(4-Methyl-2-[2-(naphthalen-1-ylamino)-propionylamin...)
Affinity DataIC50:  310nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM29572(isatin Michael acceptor (IMA) analogue, 11a)
Affinity DataIC50:  325nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM29586(isatin Michael acceptor (IMA) analogue, 19b)
Affinity DataIC50:  358nMAssay Description:The caspase enzymatic activity was determined by measuring the accumulation of a fluorogenic product. All assays were prepared in 96-well format. Rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50216423(2-[2-oxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl...)
Affinity DataIC50:  407nMAssay Description:Inhibition of human recombinant caspase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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