Compile Data Set for Download or QSAR
maximum 50k data
Found 807 Enz. Inhib. hit(s) with Target = 'Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha'
LigandPNGBDBM50143597((S)-2-(2-[2-(4-Fluoro-phenyl)-ethyl]-5-{[(1S,4S)-4...)
Affinity DataKi:  8nMAssay Description:Inhibition binding constant against Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50115916(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of [1-3H]-GGPP incorporation into biotinylated K4B-Ras peptide by geranylgeranyl transferase in the presence of 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50098037(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against human Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50115911(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of [1-3H]-GGPP incorporation into biotinylated K4B-Ras peptide by geranylgeranyl transferase in the presence of 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50115919(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of [1-3H]-GGPP incorporation into biotinylated K4B-Ras peptide by geranylgeranyl transferase in the presence of 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50115914(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of geranyl-geranylation of C-terminal CAAX sequence of Rap 1a in PSN-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130374(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  0.810nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50115925(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of [1-3H]-GGPP incorporation into biotinylated K4B-Ras peptide by geranylgeranyl transferase in the presence of 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50059858((S)-2-((3Z,6E)-(2S,5S,8R)-8-Amino-2-benzyl-5-isopr...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13382(3-(3-chlorophenyl)-4-{[(4-cyanophenyl)(1-methyl-1H...)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048966((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130373(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  1.40nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50139187(4-(2-cyclohexylethyl)-23-oxo-8-oxa-1,15,17,21-tetr...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human Geranylgeranyl transferase type I incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-terminus of human K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040692((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propyl...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against bovine type-1 geranylgeranyl transferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50139188(4-(3,3-dimethylbutyl)-23-oxo-8-oxa-1,15,17,21-tetr...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human Geranylgeranyl transferase type I incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-terminus of human K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130372(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  2.10nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50139184(4-(2-cyclohexyl-1-ethynyl)-23-oxo-8-oxa-1,15,17,21...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human Geranylgeranyl transferase type I incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-terminus of human K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130365(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  2.5nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135353(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)
Affinity DataIC50:  2.70nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130378(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  2.90nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50143599(2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition binding constant Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
LigandPNGBDBM50143599(2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]...)
Affinity DataIC50:  3.60nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
LigandPNGBDBM50409707(CHEMBL2111612)
Affinity DataIC50:  4.5nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50115928(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of [1-3H]-GGPP incorporation into biotinylated K4B-Ras peptide by geranylgeranyl transferase in the presence of 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50112372(17-(5,5,5-trifluoro-1-pentynyl)-19-oxa-2,5,10,12-t...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048963((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)
Affinity DataIC50:  4.80nMAssay Description:In vitro inhibition of Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50128463((S)-2-{[1-((R)-2-Amino-3-mercapto-propionyl)-4-phe...)
Affinity DataIC50: <5nMAssay Description:Inhibition of Candida albicans Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50128465((S)-2-{[1-((R)-2-Amino-3-mercapto-propionyl)-4-phe...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Candida albicans Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076128((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  5nMAssay Description:Inhibition of GGTase1 isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]H]geranylgeranyl from [3H]geranylgeranyl P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076128((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human GGTase1 in human Burkitt lymphoma (Daudi) cell supernatant using [3H]geranylgeranylMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130367((RR)-4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethy...)
Affinity DataIC50:  5.10nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
LigandPNGBDBM50370231(CHEMBL1907916)
Affinity DataIC50:  5.80nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031179((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031169((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50100279(2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50100279(2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]...)
Affinity DataIC50:  7.20nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50109937((R)-2-[(Indane-2-carbonyl)-amino]-3-naphthalen-1-y...)
Affinity DataIC50:  7.30nMAssay Description:Tested for the inhibition of Candida GGTase I in Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076142((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  7.30nMAssay Description:In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130381(4-[Amino-(3-methyl-3H-imidazol-4-yl)-methyl]-2-[3-...)
Affinity DataIC50:  8nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031167((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50115912(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of [1-3H]-GGPP incorporation into biotinylated K4B-Ras peptide by geranylgeranyl transferase in the presence of 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130375(2-[3-(1-Acetyl-3-ethyl-azepan-3-yl)-phenoxy]-4-imi...)
Affinity DataIC50:  8.90nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50115924(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of [1-3H]-GGPP incorporation into biotinylated K4B-Ras peptide by geranylgeranyl transferase in the presence of 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50496833(CHEMBL3218390)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of human GGTase1 in human Burkitt lymphoma (Daudi) cell supernatant using [3H]geranylgeranylMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031170((S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methy...)
Affinity DataIC50:  10nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50369371(CHEMBL1790750)
Affinity DataIC50:  10nMAssay Description:Inhibition of bovine Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130366(2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]...)
Affinity DataIC50:  10nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50128464((S)-2-((S)-2-{[1-((R)-2-Amino-3-mercapto-propionyl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Candida albicans Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50109938(9H-Xanthene-9-carboxylic acid {(R)-2-(3,4-dichloro...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Candida geranylgeranyl transferase I at 3 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50079803((S)-2-{[(2S,4S)-1-((E)-(2S,5R)-5-Amino-2-isopropyl...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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