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Found 1095 Enz. Inhib. hit(s) with Target = 'Leucyl-cystinyl aminopeptidase'
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50346448(2-(2-(((2S,6S,13S,E)-13-Amino-2-(4-hydroxybenzyl)-...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of catalytic activity of recombinant human IRAP transfected in human HEK-293 cells assessed as clevage of substrate L-leucine-p-nitroanili...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331042(2-(2-(((4R,8S,11S)-11-amino-8-(4-hydroxybenzyl)-6,...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of catalytic activity of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50346455(2-(2-(((2S,5S,13S,E)-13-Amino-2-(4-hydroxybenzyl)-...)
Affinity DataKi:  4.10nMAssay Description:Inhibition of catalytic activity of recombinant human IRAP transfected in human HEK-293 cells assessed as clevage of substrate L-leucine-p-nitroanili...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331046(2-(2-(((5S,9S,12S)-12-amino-9-(4-hydroxybenzyl)-7,...)
Affinity DataKi:  5.20nMAssay Description:Inhibition of catalytic activity of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM85550(Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]Angiotensin 4 from human recombinant IRAP expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331035((S)-2-((S)-1-((S)-2-((2S,3S)-2-((S)-2-amino-3-meth...)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]AL-11 from human IRAP expressed in CHO-K1 cells after 30 mins by liquid scintillation counting in presence of 30 mM EDTA/600 uM 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331046(2-(2-(((5S,9S,12S)-12-amino-9-(4-hydroxybenzyl)-7,...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]AL-11 from human IRAP expressed in CHO-K1 cells after 30 mins by liquid scintillation counting in presence of 30 mM EDTA/600 uM 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50236826(CHEMBL4065841)
Affinity DataKi:  18nMAssay Description:Inhibition of recombinant human IRAP expressed in GnT1 deficient HEK293S cells using L-leucine 7-amido-4-methyl coumarin as substrate after 5 to 10 m...More data for this Ligand-Target Pair
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331044((4R,8S,11S)-11-amino-N-benzyl-8-(4-hydroxybenzyl)-...)
Affinity DataKi:  19nMAssay Description:Inhibition of catalytic activity of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50478359(CHEMBL408871)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331048(CHEMBL1277437 | ethyl 2-acetamido-7-hydroxy-4-(qui...)
Affinity DataKi:  20nMAssay Description:Inhibition of catalytic activity of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataKi:  20nMAssay Description:Inhibition of leucine aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331048(CHEMBL1277437 | ethyl 2-acetamido-7-hydroxy-4-(qui...)
Affinity DataKi:  20nMAssay Description:Inhibition of catalytic activity of recombinant human IRAP transfected in human HEK-293 cells assessed as clevage of substrate L-leucine-p-nitroanili...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50017478(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  20nMAssay Description:Inhibition of aminopeptidase M or membrane leucine aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331038(2-(2-(((5R,8S,11R)-11-amino-8-(4-hydroxybenzyl)-7,...)
Affinity DataKi:  23nMAssay Description:Inhibition of catalytic activity of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331044((4R,8S,11S)-11-amino-N-benzyl-8-(4-hydroxybenzyl)-...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]AL-11 from human IRAP expressed in CHO-K1 cells after 30 mins by liquid scintillation counting in presence of 30 mM EDTA/600 uM 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331038(2-(2-(((5R,8S,11R)-11-amino-8-(4-hydroxybenzyl)-7,...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]AL-11 from human IRAP expressed in CHO-K1 cells after 30 mins by liquid scintillation counting in presence of 30 mM EDTA/600 uM 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50346461(2-(2-(((2S,5S,13S)-13-amino-2-(4-hydroxybenzyl)-3,...)
Affinity DataKi:  25nMAssay Description:Inhibition of catalytic activity of recombinant human IRAP transfected in human HEK-293 cells assessed as clevage of substrate L-leucine-p-nitroanili...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50415633(CHEMBL259019)
Affinity DataKi:  28nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331048(CHEMBL1277437 | ethyl 2-acetamido-7-hydroxy-4-(qui...)
Affinity DataKi:  30nMAssay Description:Inhibition of IRAP in HEKT cells assessed as hydrolysis of L-leucine-4-methyl-7-coumarinylamide after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50346452(2-(2-(((2S,6S,13S,Z)-13-amino-2-(4-hydroxybenzyl)-...)
Affinity DataKi:  30.4nMAssay Description:Inhibition of catalytic activity of recombinant human IRAP transfected in human HEK-293 cells assessed as clevage of substrate L-leucine-p-nitroanili...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331047(2-(2-(((5R,9S,12S)-12-amino-9-(4-hydroxybenzyl)-7,...)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]AL-11 from human IRAP expressed in CHO-K1 cells after 30 mins by liquid scintillation counting in presence of 30 mM EDTA/600 uM 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331042(2-(2-(((4R,8S,11S)-11-amino-8-(4-hydroxybenzyl)-6,...)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]AL-11 from human IRAP expressed in CHO-K1 cells after 30 mins by liquid scintillation counting in presence of 30 mM EDTA/600 uM 1...More data for this Ligand-Target Pair
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50346456(2-(2-(((2S,5S,12S,Z)-12-amino-2-(4-hydroxybenzyl)-...)
Affinity DataKi:  41.1nMAssay Description:Inhibition of catalytic activity of recombinant human IRAP transfected in human HEK-293 cells assessed as clevage of substrate L-leucine-p-nitroanili...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50346451(2-(2-(((2S,5S,12S,E)-12-amino-2-(4-hydroxybenzyl)-...)
Affinity DataKi:  50nMAssay Description:Inhibition of catalytic activity of recombinant human IRAP transfected in human HEK-293 cells assessed as clevage of substrate L-leucine-p-nitroanili...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50047222(2-[2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-...)
Affinity DataKi:  52nMAssay Description:Inhibitory activity against Leucine aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331040((5S,8S,11S)-11-amino-N-benzyl-8-(4-hydroxybenzyl)-...)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]AL-11 from human IRAP expressed in CHO-K1 cells after 30 mins by liquid scintillation counting in presence of 30 mM EDTA/600 uM 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM85550(Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...)
Affinity DataKi:  56nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM85550(Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...)
Affinity DataKi:  60nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331035((S)-2-((S)-1-((S)-2-((2S,3S)-2-((S)-2-amino-3-meth...)
Affinity DataKi:  62nMAssay Description:Inhibition of catalytic activity of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM85550(Ang IV | CAS_12676-15-2 | CHEMBL261120 | cid_12381...)
Affinity DataKi:  62.4nMAssay Description:Inhibition of catalytic activity of recombinant human IRAP transfected in human HEK-293 cells assessed as clevage of substrate L-leucine-p-nitroanili...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50346453(2-(2-(((2S,5S,12S)-12-amino-2-(4-hydroxybenzyl)-3,...)
Affinity DataKi:  64.2nMAssay Description:Inhibition of catalytic activity of recombinant human IRAP transfected in human HEK-293 cells assessed as clevage of substrate L-leucine-p-nitroanili...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50478364(CHEMBL248592)
Affinity DataKi:  81nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331045((4R,8S,11S)-11-amino-8-(4-hydroxybenzyl)-6,10-diox...)
Affinity DataKi:  94nMAssay Description:Inhibition of catalytic activity of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331040((5S,8S,11S)-11-amino-N-benzyl-8-(4-hydroxybenzyl)-...)
Affinity DataKi:  96nMAssay Description:Inhibition of catalytic activity of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50415634(CHEMBL260622)
Affinity DataKi:  100nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50478356(CHEMBL408132)
Affinity DataKi:  110nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50478362(CHEMBL261417)
Affinity DataKi:  145nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50478360(CHEMBL261731)
Affinity DataKi:  148nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50478354(CHEMBL261422)
Affinity DataKi:  166nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50478367(CHEMBL259382)
Affinity DataKi:  174nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50478357(CHEMBL428457)
Affinity DataKi:  177nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50478357(CHEMBL428457)
Affinity DataKi:  178nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50346458((2S,5S,12S)-12-amino-N-benzyl-2-(4-hydroxybenzyl)-...)
Affinity DataKi:  193nMAssay Description:Inhibition of catalytic activity of recombinant human IRAP transfected in human HEK-293 cells assessed as clevage of substrate L-leucine-p-nitroanili...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331037((S)-2-((S)-1-((S)-2-((5R,8S,11R)-11-amino-8-(4-hyd...)
Affinity DataKi:  196nMAssay Description:Displacement of [3H]AL-11 from human IRAP expressed in CHO-K1 cells after 30 mins by liquid scintillation counting in presence of 30 mM EDTA/600 uM 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Rattus norvegicus)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50017478(Amastatin | CHEMBL28650 | Leu[1psi,CHOHCONH]ValVal...)
Affinity DataKi:  220nMAssay Description:Inhibition of leucine aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331047(2-(2-(((5R,9S,12S)-12-amino-9-(4-hydroxybenzyl)-7,...)
Affinity DataKi:  230nMAssay Description:Inhibition of catalytic activity of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331043(2-(2-(((4S,8S,11S)-11-amino-8-(4-hydroxybenzyl)-6,...)
Affinity DataKi:  242nMAssay Description:Inhibition of catalytic activity of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331039(2-(2-(((5R,8S,11S)-11-amino-8-(4-hydroxybenzyl)-7,...)
Affinity DataKi:  282nMAssay Description:Inhibition of catalytic activity of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50331037((S)-2-((S)-1-((S)-2-((5R,8S,11R)-11-amino-8-(4-hyd...)
Affinity DataKi:  303nMAssay Description:Inhibition of catalytic activity of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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